Right ventricular remodeling in idiopathic pulmonary arterial hypertension: Adaptive versus maladaptive morphology

Journal of Heart and Lung Transplantation

Volumn 34, Issue 3, 2015, Pages 395-403

  Badagliacca, Roberto ^a   Poscia, Roberto ^a   Pezzuto, Beatrice ^a   Nocioni, Martina ^a   Mezzapesa, Mario ^a   Francone, Marco ^a   Giannetta, Elisa ^b   Papa, Silvia ^a   Gambardella, Cristina ^a   Sciomer, Susanna ^a   Volterrani, Maurizio ^c   Fedele, Francesco ^a   Dario Vizza, Carmine ^a,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

cardiac magnetic resonance; echocardiography; pulmonary arterial hypertension; right ventricle remodeling

Indexed keywords

6 MINUTE WALK TEST; ADULT; ARTERY COMPLIANCE; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FEMALE; HEART AFTERLOAD; HEART INDEX; HEART RIGHT ATRIUM PRESSURE; HEART RIGHT VENTRICLE EJECTION FRACTION; HEART RIGHT VENTRICLE ENDDIASTOLIC VOLUME; HEART RIGHT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE VOLUME; HEART VENTRICLE REMODELING; HEMODYNAMIC PARAMETERS; HUMAN; ISOVOLUMIC CONTRACTION VELOCITY; LEFT VENTRICULAR ENDSYSTOLIC ECCENTRICITY INDEX; LUNG COMPLIANCE; LUNG FUNCTION TEST; LUNG HEMODYNAMICS; LUNG PRESSURE; LUNG VASCULAR RESISTANCE; LUNG WEDGE PRESSURE; MAJOR CLINICAL STUDY; MALE; PEAK SYSTOLIC VELOCITY; PERICARDIAL EFFUSION; PRIORITY JOURNAL; PULMONARY ARTERIAL COUPLING; PULMONARY HYPERTENSION; RIGHT VENTRICULAR ENDSYSTOLIC VOLUME; RIGHT VENTRICULAR REMODELING; SYSTOLIC FUNCTION PARAMETER; WORLD HEALTH ORGANIZATION; ADAPTATION; DOPPLER ECHOCARDIOGRAPHY; ECHOGRAPHY; EXERCISE TEST; FAMILIAL PRIMARY PULMONARY HYPERTENSION; HEART CATHETERIZATION; HEART VENTRICLE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETROSPECTIVE STUDY;

ADAPTATION, PHYSIOLOGICAL; CARDIAC CATHETERIZATION; ECHOCARDIOGRAPHY, DOPPLER; EXERCISE TEST; FAMILIAL PRIMARY PULMONARY HYPERTENSION; FEMALE; HEART VENTRICLES; HUMANS; MAGNETIC RESONANCE IMAGING, CINE; MALE; MIDDLE AGED; PULMONARY WEDGE PRESSURE; RETROSPECTIVE STUDIES; VENTRICULAR FUNCTION, RIGHT; VENTRICULAR REMODELING;

EID: 84925296451     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2014.11.002     Document Type: Article

References (35)

1. V.V. McLaughlin, and M.D. McGoon Pulmonary arterial hypertension Circulation 114 2006 1417 1431
2. N.F. Voelkel, R.A. Quaife, and L.A. Leinwand Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure Circulation 114 2006 1883 1891
3. S.M. Kawut, N. Al-Naamani, and C. Agerstrand Determinants of right ventricular ejection fraction in pulmonary arterial hypertension Chest 135 2009 752 759
4. A. Vonk Noordegraaf, and N. Galiè The role of the right ventricle in pulmonary arterial hypertension Eur Respir Rev 20 2011 243 253
5. M. Humbert, O. Sitbon, and A. Chaouat Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era Circulation 122 2010 156 163
6. R.L. Benza, D.P. Miller, and M. Gomberg-Maitland Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) Circulation 122 2010 164 172
7. G.E. D'Alonzo, R.J. Barst, and S.M. Ayres Survival in patients with primary pulmonary hypertension. Results from a national prospective registry Ann Intern Med 115 1991 343 349
8. G.-J. Mauritz, T. Kind, and J.T. Marcus Progressive changes in right ventricular geometric shortening and long-term survival in pulmonary arterial hypertension Chest 141 2012 935 943
9. M.C. van de Veerdonk, T. Kind, and J.T. Marcus Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy J Am Coll Cardiol 58 2011 2511 2519
10. N. Galiè, M.M. Hoeper, and M. Humbert ESC Committee for Practice Guidelines (CPG). Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT) Eur Heart J 30 2009 2493 2537
11. L.G. Rudski, W.W. Lai, and J. Afilalo Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography. Endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography J Am Soc Echocardiogr 23 2010 685 713
12. H.C. Champion, E.D. Michelakis, and P.M. Hassoun Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications Circulation 120 2009 992 1007
13. M.H. Drazner The progression of hypertensive heart disease Circulation 123 2011 327 334
14. T. Ryan, O. Petrovic, J.C. Dillon, H. Feigenbaum, M.J. Conley, and W.F. Armstrong An echocardiographic index for separation of right ventricular volume and pressure overload J Am Coll Cardiol 5 1985 918 924
15. A.L. Hinderliter, P.W. Willis IV, and R.J. Barst Effects of long-term infusion of prostacyclin (epoprostenol) on echocardiographic measures of right ventricular structure and function in primary pulmonary hypertension Circulation 95 1997 1479 1486
16. R.J. Raymond, A.L. Hinderliter, and P.W. Willis IV Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension J Am Coll Cardiol 39 2002 1214 1219
17. O. Sitbon, M. Humbert, and H. Nunes Long-term intravenous epoprostenol infusion in primary pulmonary hypertension. Prognostic factors and survival J Am Coll Cardiol 40 2002 780 788
18. V.V. McLaughlin, A. Shillington, and S. Rich Survival in primary pulmonary hypertension. The impact of epoprostenol therapy Circulation 106 2002 1477 1482
19. B.D. Lowes, W. Minobe, and W.T. Abraham Changes in gene expression in the intact human heart: downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium J Clin Invest 100 1997 2315 2324
20. T.J. Herron, and K.S. McDonald Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments Circ Res 90 2002 1150 1152
21. M. Adamcova, M. Sterba, and T. Simunek Myocardial regulatory proteins and heart failure Eur J Heart Fail 8 2006 333 342
22. H.J. Bogaard, K. Abe, A. Vonk Noordegraaf, and N.F. Voelkel The right ventricle under pressure. Cellular and molecular mechanisms of right heart failure in pulmonary hypertension Chest 135 2009 794 804
23. H. Tagawa, M. Koide, H. Sato, M.R. Zile, B.A. Carabello, and G. Cooper Cytoskeletal role in the transition from compensated to decompensated hypertrophy during adult canine left ventricular pressure overloading Circ Res 82 1998 751 761
24. S.A. Van Wolferen, J.T. Marcus, and N. Westerhof Right coronary artery flow impairment in patients with pulmonary hypertension Eur Heart J 29 2008 120 127
25. A. Gomez, D. Bialostozky, and A. Zajarias Right ventricular ischemia in patients with primary pulmonary hypertension J Am Coll Cardiol 38 2001 1137 1142
26. S. Hein, E. Arnon, and S. Kostin Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms Circulation 107 2003 984 991
27. G. Olivetti, R. Abbi, and F. Quaini Apoptosis in the failing human heart N Engl J Med 336 1997 1131 1141
28. M.U. Braun, P. Szalai, and R.H. Strasser Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes Cardiovasc Res 59 2003 658 667
29. K. Dimopoulos, R. Inuzuka, and S. Goletto Improved survival among patients with Eisenmenger syndrome receiving advanced therapy for pulmonary arterial hypertension Circulation 121 2010 20 25
30. W.E. Hopkins, and A.D. Waggoner Severe pulmonary hypertension without right ventricular failure: the unique hearts of patients with Eisenmenger syndrome Am J Cardiol 89 2002 34 38
31. G.P. Diller, K. Dimopoulos, H. Kafka, H.o.S. Yen, and M.A. Gatzoulis Model of chronic adaptation: right ventricular function in Eisenmenger syndrome. Eur Heart J 9 Suppl H 2007 H54 H60
32. S. Giusca, V. Dambrauskaite, and C. Scheurwegs Deformation imaging describes right ventricular function better than longitudinal displacement of the tricuspid ring Heart 96 2010 281 288
33. P. Wauthy, S. Abdel Kafi, W.J. Mooi, R. Naeije, and S. Brimioulle Inhaled nitric oxide versus prostacyclin in chronic shunt-induced pulmonary hypertension J Thorac Cardiovasc Surg 126 2003 1434 1441
34. T. Kuehne, S. Yilmaz, and P. Steendijk Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertension Circulation 110 2004 2010 2016
35. Y.Y. Wong, G. Ruiter, and M. Lubberink Right ventricular failure in idiopathic pulmonary arterial hypertension is associated with inefficient myocardial oxygen utilization Circ Heart Fail 4 2011 700 706