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Volumn 18, Issue 1, 2015, Pages 10-16

PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR; TOUCH RECEPTOR; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ION CHANNEL; NERVE PROTEIN; NEUROG2 PROTEIN, HUMAN; PIEZO2 PROTEIN, HUMAN; PIEZO2 PROTEIN, MOUSE;

EID: 84925283541     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3894     Document Type: Article
Times cited : (100)

References (37)
  • 1
    • 84882727832 scopus 로고    scopus 로고
    • The sensory neurons of touch
    • Abraira, V.E. & Ginty, D.D. The sensory neurons of touch. Neuron 79, 618-639 (2013).
    • (2013) Neuron , vol.79 , pp. 618-639
    • Abraira, V.E.1    Ginty, D.D.2
  • 2
    • 70349845440 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of pain
    • Basbaum, A.I., Bautista, D.M., Scherrer, G. & Julius, D. Cellular and molecular mechanisms of pain. Cell 139, 267-284 (2009).
    • (2009) Cell , vol.139 , pp. 267-284
    • Basbaum, A.I.1    Bautista, D.M.2    Scherrer, G.3    Julius, D.4
  • 3
    • 84861704266 scopus 로고    scopus 로고
    • Molecular interactions underlying the specifcation of sensory neurons
    • Lallemend, F. & Ernfors, P. Molecular interactions underlying the specifcation of sensory neurons. Trends Neurosci. 35, 373-381 (2012).
    • (2012) Trends Neurosci. , vol.35 , pp. 373-381
    • Lallemend, F.1    Ernfors, P.2
  • 4
    • 84863671840 scopus 로고    scopus 로고
    • Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors
    • Chambers, S.M. et al. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat. Biotechnol. 30, 715-720 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 715-720
    • Chambers, S.M.1
  • 5
    • 84905491563 scopus 로고    scopus 로고
    • Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research
    • Young, G.T. et al. Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research. Mol. Ther. 22, 1530-1543 (2014).
    • (2014) Mol. Ther. , vol.22 , pp. 1530-1543
    • Young, G.T.1
  • 6
    • 77957332682 scopus 로고    scopus 로고
    • Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels
    • Coste, B. et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330, 55-60 (2010).
    • (2010) Science , vol.330 , pp. 55-60
    • Coste, B.1
  • 7
    • 84862777142 scopus 로고    scopus 로고
    • Piezo proteins are pore-forming subunits of mechanically activated channels
    • Coste, B. et al. Piezo proteins are pore-forming subunits of mechanically activated channels. Nature 483, 176-181 (2012).
    • (2012) Nature , vol.483 , pp. 176-181
    • Coste, B.1
  • 8
    • 84901663308 scopus 로고    scopus 로고
    • Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
    • Maksimovic, S. et al. Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature 509, 617-621 (2014).
    • (2014) Nature , vol.509 , pp. 617-621
    • Maksimovic, S.1
  • 9
    • 84901680112 scopus 로고    scopus 로고
    • Piezo2 is required for Merkel-cell mechanotransduction
    • Woo, S.H. et al. Piezo2 is required for Merkel-cell mechanotransduction. Nature 509, 622-626 (2014).
    • (2014) Nature , vol.509 , pp. 622-626
    • Woo, S.H.1
  • 10
    • 84899576140 scopus 로고    scopus 로고
    • Merkel cells transduce and encode tactile stimuli to drive Abeta-afferent impulses
    • Ikeda, R. et al. Merkel cells transduce and encode tactile stimuli to drive Abeta-afferent impulses. Cell 157, 664-675 (2014).
    • (2014) Cell , vol.157 , pp. 664-675
    • Ikeda, R.1
  • 11
    • 33846447430 scopus 로고    scopus 로고
    • Specifcation and connectivity of neuronal subtypes in the sensory lineage
    • Marmigère, F. & Ernfors, P. Specifcation and connectivity of neuronal subtypes in the sensory lineage. Nat. Rev. Neurosci. 8, 114-127 (2007).
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 114-127
    • Marmigère, F.1    Ernfors, P.2
  • 12
    • 0033166408 scopus 로고    scopus 로고
    • Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia
    • Ma, Q., Fode, C., Guillemot, F. & Anderson, D.J. Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes Dev. 13, 1717-1728 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1717-1728
    • Ma, Q.1    Fode, C.2    Guillemot, F.3    Anderson, D.J.4
  • 13
    • 45849093327 scopus 로고    scopus 로고
    • Differentiation of neural lineage cells from human pluripotent stem cells
    • Schwartz, P.H., Brick, D.J., Stover, A.E., Loring, J.F. & Muller, F.J. Differentiation of neural lineage cells from human pluripotent stem cells. Methods 45, 142-158 (2008).
    • (2008) Methods , vol.45 , pp. 142-158
    • Schwartz, P.H.1    Brick, D.J.2    Stover, A.E.3    Loring, J.F.4    Muller, F.J.5
  • 14
    • 77249117148 scopus 로고    scopus 로고
    • CHD7 cooperates with PBAF to control multipotent neural crest formation
    • Bajpai, R. et al. CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature 463, 958-962 (2010).
    • (2010) Nature , vol.463 , pp. 958-962
    • Bajpai, R.1
  • 15
    • 13344277362 scopus 로고    scopus 로고
    • Specifc subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation
    • Airaksinen, M.S. et al. Specifc subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron 16, 287-295 (1996).
    • (1996) Neuron , vol.16 , pp. 287-295
    • Airaksinen, M.S.1
  • 16
    • 72149107326 scopus 로고    scopus 로고
    • Low-threshold mechanoreceptor subtypes selectively express MafA and are specifed by Ret signaling
    • Bourane, S. et al. Low-threshold mechanoreceptor subtypes selectively express MafA and are specifed by Ret signaling. Neuron 64, 857-870 (2009).
    • (2009) Neuron , vol.64 , pp. 857-870
    • Bourane, S.1
  • 18
    • 72149102676 scopus 로고    scopus 로고
    • Molecular identifcation of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling
    • Luo, W., Enomoto, H., Rice, F.L., Milbrandt, J. & Ginty, D.D. Molecular identifcation of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron 64, 841-856 (2009).
    • (2009) Neuron , vol.64 , pp. 841-856
    • Luo, W.1    Enomoto, H.2    Rice, F.L.3    Milbrandt, J.4    Ginty, D.D.5
  • 19
    • 54949152207 scopus 로고    scopus 로고
    • A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs
    • Sun, Y. et al. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat. Neurosci. 11, 1283-1293 (2008).
    • (2008) Nat. Neurosci. , vol.11 , pp. 1283-1293
    • Sun, Y.1
  • 20
    • 66249101833 scopus 로고    scopus 로고
    • Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development
    • Lechner, S.G., Frenzel, H., Wang, R. & Lewin, G.R. Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. EMBO J. 28, 1479-1491 (2009).
    • (2009) EMBO J. , vol.28 , pp. 1479-1491
    • Lechner, S.G.1    Frenzel, H.2    Wang, R.3    Lewin, G.R.4
  • 21
    • 84858333682 scopus 로고    scopus 로고
    • The transcription factor c-Maf controls touch receptor development and function
    • Wende, H. et al. The transcription factor c-Maf controls touch receptor development and function. Science 335, 1373-1376 (2012).
    • (2012) Science , vol.335 , pp. 1373-1376
    • Wende, H.1
  • 22
    • 84555198875 scopus 로고    scopus 로고
    • KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man
    • Heidenreich, M. et al. KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. Nat. Neurosci. 15, 138-145 (2012).
    • (2012) Nat. Neurosci. , vol.15 , pp. 138-145
    • Heidenreich, M.1
  • 23
    • 84878849645 scopus 로고    scopus 로고
    • Rapid single-step induction of functional neurons from human pluripotent stem cells
    • Zhang, Y. et al. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron 78, 785-798 (2013).
    • (2013) Neuron , vol.78 , pp. 785-798
    • Zhang, Y.1
  • 24
    • 50849142559 scopus 로고    scopus 로고
    • A high-effciency system for the generation and study of human induced pluripotent stem cells
    • Maherali, N. et al. A high-effciency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell 3, 340-345 (2008).
    • (2008) Cell Stem Cell , vol.3 , pp. 340-345
    • Maherali, N.1
  • 25
    • 77958082207 scopus 로고    scopus 로고
    • Generation of transgene-free lung disease-specifc human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette
    • Somers, A. et al. Generation of transgene-free lung disease-specifc human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells 28, 1728-1740 (2010).
    • (2010) Stem Cells , vol.28 , pp. 1728-1740
    • Somers, A.1
  • 26
    • 0022655552 scopus 로고
    • Somal action potential duration differs in identifed primary afferents
    • Rose, R.D., Koerber, H.R., Sedivec, M.J. & Mendell, L.M. Somal action potential duration differs in identifed primary afferents. Neurosci. Lett. 63, 259-264 (1986).
    • (1986) Neurosci. Lett. , vol.63 , pp. 259-264
    • Rose, R.D.1    Koerber, H.R.2    Sedivec, M.J.3    Mendell, L.M.4
  • 27
    • 78650870302 scopus 로고    scopus 로고
    • Single-cell analysis of sodium channel expression in dorsal root ganglion neurons
    • Ho, C. & O'Leary, M.E. Single-cell analysis of sodium channel expression in dorsal root ganglion neurons. Mol. Cell. Neurosci. 46, 159-166 (2011).
    • (2011) Mol. Cell. Neurosci. , vol.46 , pp. 159-166
    • Ho, C.1    O'Leary, M.E.2
  • 28
    • 0033363999 scopus 로고    scopus 로고
    • The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
    • Akopian, A.N. et al. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat. Neurosci. 2, 541-548 (1999).
    • (1999) Nat. Neurosci. , vol.2 , pp. 541-548
    • Akopian, A.N.1
  • 29
    • 33845631301 scopus 로고    scopus 로고
    • v1.9 is an effector of peripheral infammatory pain hypersensitivity
    • v1.9 is an effector of peripheral infammatory pain hypersensitivity. J. Neurosci. 26, 12852-12860 (2006).
    • (2006) J. Neurosci. , vol.26 , pp. 12852-12860
    • Amaya, F.1
  • 30
    • 84902599773 scopus 로고    scopus 로고
    • Tuning Piezo ion channels to detect molecular-scale movements relevant for fne touch
    • Poole, K., Herget, R., Lapatsina, L., Ngo, H.D. & Lewin, G.R. Tuning Piezo ion channels to detect molecular-scale movements relevant for fne touch. Nat. Commun. 5, 3520 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 3520
    • Poole, K.1    Herget, R.2    Lapatsina, L.3    Ngo, H.D.4    Lewin, G.R.5
  • 31
    • 79960836456 scopus 로고    scopus 로고
    • Genetic engineering of human pluripotent cells using TALE nucleases
    • Hockemeyer, D. et al. Genetic engineering of human pluripotent cells using TALE nucleases. Nat. Biotechnol. 29, 731-734 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , pp. 731-734
    • Hockemeyer, D.1
  • 32
    • 84884856342 scopus 로고    scopus 로고
    • Cas9 as a versatile tool for engineering biology
    • Mali, P., Esvelt, K.M. & Church, G.M. Cas9 as a versatile tool for engineering biology. Nat. Methods 10, 957-963 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 957-963
    • Mali, P.1    Esvelt, K.M.2    Church, G.M.3
  • 33
    • 84875262455 scopus 로고    scopus 로고
    • Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of distal arthrogryposis
    • Coste, B. et al. Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of distal arthrogryposis. Proc. Natl. Acad. Sci. USA 110, 4667-4672 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 4667-4672
    • Coste, B.1
  • 34
    • 84899963553 scopus 로고    scopus 로고
    • Mutations in piezo2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5
    • McMillin, M.J. et al. Mutations in piezo2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5. Am. J. Hum. Genet. 94, 734-744 (2014).
    • (2014) Am. J. Hum. Genet. , vol.94 , pp. 734-744
    • McMillin, M.J.1
  • 35
    • 68549104404 scopus 로고    scopus 로고
    • The Sequence Alignment/Map format and SAMtools
    • Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1
  • 36
    • 84928987900 scopus 로고    scopus 로고
    • HTSeq -A Python framework to work with high-throughput sequencing data
    • Anders, S., Pyl, P.T. & Huber, W. HTSeq-a Python framework to work with high-throughput sequencing data. Bioinformatics doi:10.1093/bioinformatics/btu638 (2014).
    • (2014) Bioinformatics
    • Anders, S.1    Pyl, P.T.2    Huber, W.3
  • 37
    • 77958471357 scopus 로고    scopus 로고
    • Differential expression analysis for sequence count data
    • Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome Biol. 11, R106 (2010).
    • (2010) Genome Biol. , vol.11 , pp. R106
    • Anders, S.1    Huber, W.2


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