메뉴 건너뛰기




Volumn 52, Issue 2, 2015, Pages 86-96

The Epigenetic Basis of Diffuse Large B-Cell Lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYTOSINE; E1A ASSOCIATED P300 PROTEIN; HISTONE DEACETYLASE INHIBITOR; PROTEIN BCL 6; PROTEIN INHIBITOR; TRANSCRIPTION FACTOR EZH2;

EID: 84925281562     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2015.01.003     Document Type: Review
Times cited : (49)

References (74)
  • 1
    • 77953995002 scopus 로고    scopus 로고
    • Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers
    • Chi P., Allis C.D., Wang G.G. Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer 2010, 10:457-469.
    • (2010) Nat Rev Cancer , vol.10 , pp. 457-469
    • Chi, P.1    Allis, C.D.2    Wang, G.G.3
  • 2
    • 84899415723 scopus 로고    scopus 로고
    • Every amino acid matters: essential contributions of histone variants to mammalian development and disease
    • Maze I., Noh K.M., Soshnev A.A., Allis C.D. Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Nat Rev Genet 2014, 15:259-271.
    • (2014) Nat Rev Genet , vol.15 , pp. 259-271
    • Maze, I.1    Noh, K.M.2    Soshnev, A.A.3    Allis, C.D.4
  • 3
    • 84875745673 scopus 로고    scopus 로고
    • Interplay between the cancer genome and epigenome
    • Shen H., Laird P.W. Interplay between the cancer genome and epigenome. Cell 2013, 153:38-55.
    • (2013) Cell , vol.153 , pp. 38-55
    • Shen, H.1    Laird, P.W.2
  • 4
    • 80053376487 scopus 로고    scopus 로고
    • DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation
    • Shaknovich R., Cerchietti L., Tsikitas L., et al. DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Blood 2011, 118:3559-3569.
    • (2011) Blood , vol.118 , pp. 3559-3569
    • Shaknovich, R.1    Cerchietti, L.2    Tsikitas, L.3
  • 5
    • 84890450749 scopus 로고    scopus 로고
    • DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation
    • Lai A.Y., Mav D., Shah R., et al. DNA methylation profiling in human B cells reveals immune regulatory elements and epigenetic plasticity at Alu elements during B-cell activation. Genome Res 2013, 23:2030-2041.
    • (2013) Genome Res , vol.23 , pp. 2030-2041
    • Lai, A.Y.1    Mav, D.2    Shah, R.3
  • 6
    • 84873519286 scopus 로고    scopus 로고
    • Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity
    • De S., Shaknovich R., Riester M., et al. Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity. PLoS Genet 2013, 9:e1003137.
    • (2013) PLoS Genet , vol.9 , pp. e1003137
    • De, S.1    Shaknovich, R.2    Riester, M.3
  • 7
    • 77956240630 scopus 로고    scopus 로고
    • DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas
    • Lai A.Y., Fatemi M., Dhasarathy A., et al. DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exper Med 2010, 207:1939-1950.
    • (2010) J Exper Med , vol.207 , pp. 1939-1950
    • Lai, A.Y.1    Fatemi, M.2    Dhasarathy, A.3
  • 8
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein B.E., Mikkelsen T.S., Xie X., et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006, 125:315-326.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3
  • 9
    • 33846023317 scopus 로고    scopus 로고
    • Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells
    • Gan Q., Yoshida T., McDonald O.G., Owens G.K. Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells. Stem Cells 2007, 25:2-9.
    • (2007) Stem Cells , vol.25 , pp. 2-9
    • Gan, Q.1    Yoshida, T.2    McDonald, O.G.3    Owens, G.K.4
  • 10
    • 84877815031 scopus 로고    scopus 로고
    • EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
    • Beguelin W., Popovic R., Teater M., et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell 2013, 23:677-692.
    • (2013) Cancer Cell , vol.23 , pp. 677-692
    • Beguelin, W.1    Popovic, R.2    Teater, M.3
  • 11
    • 65549104157 scopus 로고    scopus 로고
    • Histone modifications at human enhancers reflect global cell-type-specific gene expression
    • Heintzman N.D., Hon G.C., Hawkins R.D., et al. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 2009, 459:108-112.
    • (2009) Nature , vol.459 , pp. 108-112
    • Heintzman, N.D.1    Hon, G.C.2    Hawkins, R.D.3
  • 12
    • 78650304236 scopus 로고    scopus 로고
    • Charting histone modifications and the functional organization of mammalian genomes
    • Zhou V.W., Goren A., Bernstein B.E. Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet 2011, 12:7-18.
    • (2011) Nat Rev Genet , vol.12 , pp. 7-18
    • Zhou, V.W.1    Goren, A.2    Bernstein, B.E.3
  • 13
    • 78650758676 scopus 로고    scopus 로고
    • Histone H3K27ac separates active from poised enhancers and predicts developmental state
    • Creyghton M.P., Cheng A.W., Welstead G.G., et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A 2010, 107:21931-21936.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 21931-21936
    • Creyghton, M.P.1    Cheng, A.W.2    Welstead, G.G.3
  • 14
    • 80052942443 scopus 로고    scopus 로고
    • Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
    • Tan M., Luo H., Lee S., et al. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 2011, 146:1016-1028.
    • (2011) Cell , vol.146 , pp. 1016-1028
    • Tan, M.1    Luo, H.2    Lee, S.3
  • 15
    • 84901585384 scopus 로고    scopus 로고
    • Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis
    • Hatzi K., Melnick A. Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis. Trend Molec Med 2014, 20:343-352.
    • (2014) Trend Molec Med , vol.20 , pp. 343-352
    • Hatzi, K.1    Melnick, A.2
  • 16
    • 78650062951 scopus 로고    scopus 로고
    • EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
    • Velichutina I., Shaknovich R., Geng H., et al. EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood 2010, 116:5247-5255.
    • (2010) Blood , vol.116 , pp. 5247-5255
    • Velichutina, I.1    Shaknovich, R.2    Geng, H.3
  • 17
    • 0034492916 scopus 로고    scopus 로고
    • Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin[U+05F3]s disease
    • Raaphorst F.M., van Kemenade F.J., Blokzijl T., et al. Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin[U+05F3]s disease. Am J Pathol 2000, 157:709-715.
    • (2000) Am J Pathol , vol.157 , pp. 709-715
    • Raaphorst, F.M.1    van Kemenade, F.J.2    Blokzijl, T.3
  • 18
    • 79955513100 scopus 로고    scopus 로고
    • Aberrations of EZH2 in cancer
    • Chase A., Cross N.C. Aberrations of EZH2 in cancer. Clin Cancer Res 2011, 17:2613-2618.
    • (2011) Clin Cancer Res , vol.17 , pp. 2613-2618
    • Chase, A.1    Cross, N.C.2
  • 19
    • 84890046467 scopus 로고    scopus 로고
    • Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis
    • Caganova M., Carrisi C., Varano G., et al. Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. J Clin Invest 2013, 123:5009-5022.
    • (2013) J Clin Invest , vol.123 , pp. 5009-5022
    • Caganova, M.1    Carrisi, C.2    Varano, G.3
  • 20
    • 84877807808 scopus 로고    scopus 로고
    • Non-coding RNAs and EZH2 interactions in cancer: long and short tales from the transcriptome
    • Benetatos L., Voulgaris E., Vartholomatos G., Hatzimichael E. Non-coding RNAs and EZH2 interactions in cancer: long and short tales from the transcriptome. Int J Cancer 2013, 133:267-274.
    • (2013) Int J Cancer , vol.133 , pp. 267-274
    • Benetatos, L.1    Voulgaris, E.2    Vartholomatos, G.3    Hatzimichael, E.4
  • 21
    • 84881615483 scopus 로고    scopus 로고
    • A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters
    • Hatzi K., Jiang Y., Huang C., et al. A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Cell Rep 2013, 4:578-588.
    • (2013) Cell Rep , vol.4 , pp. 578-588
    • Hatzi, K.1    Jiang, Y.2    Huang, C.3
  • 22
    • 84902674289 scopus 로고    scopus 로고
    • EZH2 and BCL6 cooperate to create the germinal center B-cell phenotype and induce lymphomas through formation and repression of bivalent chromatin domains
    • Beguelin W., Teater M., Hatzi K., et al. EZH2 and BCL6 cooperate to create the germinal center B-cell phenotype and induce lymphomas through formation and repression of bivalent chromatin domains. Blood 2013, 122(21):1.
    • (2013) Blood , vol.122 , Issue.21 , pp. 1
    • Beguelin, W.1    Teater, M.2    Hatzi, K.3
  • 23
    • 78649826886 scopus 로고    scopus 로고
    • BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy
    • Cerchietti L.C., Hatzi K., Caldas-Lopes E., et al. BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. J Clin Invest 2010, 120:4569-4582.
    • (2010) J Clin Invest , vol.120 , pp. 4569-4582
    • Cerchietti, L.C.1    Hatzi, K.2    Caldas-Lopes, E.3
  • 24
    • 50949097945 scopus 로고    scopus 로고
    • Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells
    • Polo J.M., Ci W., Licht J.D., Melnick A. Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells. Blood 2008, 112:644-651.
    • (2008) Blood , vol.112 , pp. 644-651
    • Polo, J.M.1    Ci, W.2    Licht, J.D.3    Melnick, A.4
  • 25
    • 80052029516 scopus 로고    scopus 로고
    • Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
    • Morin R.D., Mendez-Lago M., Mungall A.J., et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 2011, 476:298-303.
    • (2011) Nature , vol.476 , pp. 298-303
    • Morin, R.D.1    Mendez-Lago, M.2    Mungall, A.J.3
  • 26
    • 80052269038 scopus 로고    scopus 로고
    • Analysis of the coding genome of diffuse large B-cell lymphoma
    • Pasqualucci L., Trifonov V., Fabbri G., et al. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet 2011, 43:830-837.
    • (2011) Nat Genet , vol.43 , pp. 830-837
    • Pasqualucci, L.1    Trifonov, V.2    Fabbri, G.3
  • 27
    • 84891603187 scopus 로고    scopus 로고
    • EZH2 mutations are frequent and represent an early event in follicular lymphoma
    • Bodor C., Grossmann V., Popov N., et al. EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood 2013, 122:3165-3168.
    • (2013) Blood , vol.122 , pp. 3165-3168
    • Bodor, C.1    Grossmann, V.2    Popov, N.3
  • 28
    • 84895815322 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
    • Okosun J., Bodor C., Wang J., et al. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nat Genet 2014, 46:176-181.
    • (2014) Nat Genet , vol.46 , pp. 176-181
    • Okosun, J.1    Bodor, C.2    Wang, J.3
  • 29
    • 84924584659 scopus 로고    scopus 로고
    • Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas
    • Jiang Y., Redmond D., Nie K., et al. Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas. Genome Biol 2014, 15:432.
    • (2014) Genome Biol , vol.15 , pp. 432
    • Jiang, Y.1    Redmond, D.2    Nie, K.3
  • 30
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • Morin R.D., Johnson N.A., Severson T.M., et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010, 42:181-185.
    • (2010) Nat Genet , vol.42 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3
  • 31
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
    • Sneeringer C.J., Scott M.P., Kuntz K.W., et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci U S A 2010, 107:20980-20985.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 20980-20985
    • Sneeringer, C.J.1    Scott, M.P.2    Kuntz, K.W.3
  • 32
    • 79952167230 scopus 로고    scopus 로고
    • Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
    • Yap D.B., Chu J., Berg T., et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 2011, 117:2451-2459.
    • (2011) Blood , vol.117 , pp. 2451-2459
    • Yap, D.B.1    Chu, J.2    Berg, T.3
  • 33
    • 84902665681 scopus 로고    scopus 로고
    • A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis
    • Berg T., Thoene S., Yap D., et al. A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis. Blood 2014, 123:3914-3924.
    • (2014) Blood , vol.123 , pp. 3914-3924
    • Berg, T.1    Thoene, S.2    Yap, D.3
  • 35
    • 78751611793 scopus 로고    scopus 로고
    • Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation
    • Jin Q., Yu L.R., Wang L., et al. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J 2011, 30:249-262.
    • (2011) EMBO J , vol.30 , pp. 249-262
    • Jin, Q.1    Yu, L.R.2    Wang, L.3
  • 36
    • 77950022029 scopus 로고    scopus 로고
    • Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8
    • Garbati M.R., Alco G., Gilmore T.D. Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8. Cancer Lett 2010, 291:237-245.
    • (2010) Cancer Lett , vol.291 , pp. 237-245
    • Garbati, M.R.1    Alco, G.2    Gilmore, T.D.3
  • 37
    • 79952430906 scopus 로고    scopus 로고
    • Inactivating mutations of acetyltransferase genes in B-cell lymphoma
    • Pasqualucci L., Dominguez-Sola D., Chiarenza A., et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 2011, 471:189-195.
    • (2011) Nature , vol.471 , pp. 189-195
    • Pasqualucci, L.1    Dominguez-Sola, D.2    Chiarenza, A.3
  • 38
    • 84870490787 scopus 로고    scopus 로고
    • Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4
    • Herz H.M., Mohan M., Garruss A.S., et al. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Devel 2012, 26:2604-2620.
    • (2012) Genes Devel , vol.26 , pp. 2604-2620
    • Herz, H.M.1    Mohan, M.2    Garruss, A.S.3
  • 39
    • 84891541640 scopus 로고    scopus 로고
    • H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation
    • Lee J.E., Wang C., Xu S., et al. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. eLife 2013, 2:e01503.
    • (2013) eLife , vol.2 , pp. e01503
    • Lee, J.E.1    Wang, C.2    Xu, S.3
  • 40
    • 33847219608 scopus 로고    scopus 로고
    • Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
    • Issaeva I., Zonis Y., Rozovskaia T., et al. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Molec Cell Biol 2007, 27:1889-1903.
    • (2007) Molec Cell Biol , vol.27 , pp. 1889-1903
    • Issaeva, I.1    Zonis, Y.2    Rozovskaia, T.3
  • 42
    • 84857942952 scopus 로고    scopus 로고
    • Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
    • Lohr J.G., Stojanov P., Lawrence M.S., et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A 2012, 109:3879-3884.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3879-3884
    • Lohr, J.G.1    Stojanov, P.2    Lawrence, M.S.3
  • 43
    • 84872856782 scopus 로고    scopus 로고
    • Genetic heterogeneity of diffuse large B-cell lymphoma
    • Zhang J., Grubor V., Love C.L., et al. Genetic heterogeneity of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A 2013, 110:1398-1403.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1398-1403
    • Zhang, J.1    Grubor, V.2    Love, C.L.3
  • 44
    • 84890220219 scopus 로고    scopus 로고
    • KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation
    • Guo C., Chen L.H., Huang Y., et al. KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. Oncotarget 2013, 4:2144-2153.
    • (2013) Oncotarget , vol.4 , pp. 2144-2153
    • Guo, C.1    Chen, L.H.2    Huang, Y.3
  • 45
    • 84896536423 scopus 로고    scopus 로고
    • UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells
    • Kim J.H., Sharma A., Dhar S.S., et al. UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Res 2014, 74:1705-1717.
    • (2014) Cancer Res , vol.74 , pp. 1705-1717
    • Kim, J.H.1    Sharma, A.2    Dhar, S.S.3
  • 46
    • 84881476513 scopus 로고    scopus 로고
    • AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes
    • Kumar R., DiMenna L., Schrode N., et al. AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes. Nature 2013, 500:89-92.
    • (2013) Nature , vol.500 , pp. 89-92
    • Kumar, R.1    DiMenna, L.2    Schrode, N.3
  • 47
    • 77249148019 scopus 로고    scopus 로고
    • Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
    • Popp C., Dean W., Feng S., et al. Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature 2010, 463:1101-1105.
    • (2010) Nature , vol.463 , pp. 1101-1105
    • Popp, C.1    Dean, W.2    Feng, S.3
  • 48
    • 77649104794 scopus 로고    scopus 로고
    • Reprogramming towards pluripotency requires AID-dependent DNA demethylation
    • Bhutani N., Brady J.J., Damian M., Sacco A., Corbel S.Y., Blau H.M. Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 2010, 463:1042-1047.
    • (2010) Nature , vol.463 , pp. 1042-1047
    • Bhutani, N.1    Brady, J.J.2    Damian, M.3    Sacco, A.4    Corbel, S.Y.5    Blau, H.M.6
  • 49
    • 10644282845 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming
    • Morgan H.D., Dean W., Coker H.A., Reik W., Petersen-Mahrt S.K. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J Biol Chem 2004, 279:52353-52360.
    • (2004) J Biol Chem , vol.279 , pp. 52353-52360
    • Morgan, H.D.1    Dean, W.2    Coker, H.A.3    Reik, W.4    Petersen-Mahrt, S.K.5
  • 50
    • 84879415206 scopus 로고    scopus 로고
    • A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells
    • Fritz E.L., Rosenberg B.R., Lay K., Mihailovic A., Tuschl T., Papavasiliou F.N. A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells. Nat Immunol 2013, 14:749-755.
    • (2013) Nat Immunol , vol.14 , pp. 749-755
    • Fritz, E.L.1    Rosenberg, B.R.2    Lay, K.3    Mihailovic, A.4    Tuschl, T.5    Papavasiliou, F.N.6
  • 51
    • 84925232778 scopus 로고    scopus 로고
    • Demethylase activity of aid during germinal center B cell maturation could contribute to lymphomagenesis
    • Dominguez M., Teater M., Chambwe N., et al. Demethylase activity of aid during germinal center B cell maturation could contribute to lymphomagenesis. Blood 2014, 124(21):59.
    • (2014) Blood , vol.124 , Issue.21 , pp. 59
    • Dominguez, M.1    Teater, M.2    Chambwe, N.3
  • 52
    • 78549270488 scopus 로고    scopus 로고
    • DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma
    • Shaknovich R., Geng H., Johnson N.A., et al. DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma. Blood 2010, 116:e81-e89.
    • (2010) Blood , vol.116 , pp. e81-e89
    • Shaknovich, R.1    Geng, H.2    Johnson, N.A.3
  • 53
    • 64049094683 scopus 로고    scopus 로고
    • New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling
    • Martin-Subero J.I., Kreuz M., Bibikova M., et al. New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. Blood 2009, 113:2488-2497.
    • (2009) Blood , vol.113 , pp. 2488-2497
    • Martin-Subero, J.I.1    Kreuz, M.2    Bibikova, M.3
  • 54
    • 84880425891 scopus 로고    scopus 로고
    • Mechanisms of epigenetic deregulation in lymphoid neoplasms
    • Jiang Y., Hatzi K., Shaknovich R. Mechanisms of epigenetic deregulation in lymphoid neoplasms. Blood 2013, 121:4271-4279.
    • (2013) Blood , vol.121 , pp. 4271-4279
    • Jiang, Y.1    Hatzi, K.2    Shaknovich, R.3
  • 55
    • 84925232760 scopus 로고    scopus 로고
    • Epigenomic evolution in diffuse large B-cell lymphomas
    • Pan H., Jiang Y., Redmond D., et al. Epigenomic evolution in diffuse large B-cell lymphomas. Blood 2013, 122(21):634.
    • (2013) Blood , vol.122 , Issue.21 , pp. 634
    • Pan, H.1    Jiang, Y.2    Redmond, D.3
  • 56
    • 84897498688 scopus 로고    scopus 로고
    • Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes
    • Chambwe N., Kormaksson M., Geng H., et al. Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes. Blood 2014, 123:1699-1708.
    • (2014) Blood , vol.123 , pp. 1699-1708
    • Chambwe, N.1    Kormaksson, M.2    Geng, H.3
  • 57
    • 84901285464 scopus 로고    scopus 로고
    • CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer
    • Kemp C.J., Moore J.M., Moser R., et al. CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer. Cell Rep 2014, 7:1020-1029.
    • (2014) Cell Rep , vol.7 , pp. 1020-1029
    • Kemp, C.J.1    Moore, J.M.2    Moser, R.3
  • 58
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe M.T., Ott H.M., Ganji G., et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012, 492:108-112.
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1    Ott, H.M.2    Ganji, G.3
  • 59
    • 84884587225 scopus 로고    scopus 로고
    • Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma
    • Clozel T., Yang S., Elstrom R.L., et al. Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma. Cancer Discov 2013, 3:1002-1019.
    • (2013) Cancer Discov , vol.3 , pp. 1002-1019
    • Clozel, T.1    Yang, S.2    Elstrom, R.L.3
  • 60
    • 84892771471 scopus 로고    scopus 로고
    • Integrative genomic analysis of temozolomide resistance in diffuse large B-cell lymphoma
    • Leshchenko V.V., Kuo P.Y., Jiang Z., Thirukonda V.K., Parekh S. Integrative genomic analysis of temozolomide resistance in diffuse large B-cell lymphoma. Clin Cancer REs 2014, 20:382-392.
    • (2014) Clin Cancer REs , vol.20 , pp. 382-392
    • Leshchenko, V.V.1    Kuo, P.Y.2    Jiang, Z.3    Thirukonda, V.K.4    Parekh, S.5
  • 61
    • 77954325193 scopus 로고    scopus 로고
    • Phase I trial of low dose decitabine targeting DNA hypermethylation in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: dose-limiting myelosuppression without evidence of DNA hypomethylation
    • Blum K.A., Liu Z., Lucas D.M., et al. Phase I trial of low dose decitabine targeting DNA hypermethylation in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: dose-limiting myelosuppression without evidence of DNA hypomethylation. Br J Haematol 2010, 150:189-195.
    • (2010) Br J Haematol , vol.150 , pp. 189-195
    • Blum, K.A.1    Liu, Z.2    Lucas, D.M.3
  • 62
    • 84855471990 scopus 로고    scopus 로고
    • HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications
    • Khan O., La Thangue N.B. HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications. Immunol Cell Biol 2012, 90:85-94.
    • (2012) Immunol Cell Biol , vol.90 , pp. 85-94
    • Khan, O.1    La Thangue, N.B.2
  • 63
    • 84876338104 scopus 로고    scopus 로고
    • Histone deacetylase inhibition: an important mechanism in the treatment of lymphoma
    • Guo S.Q., Zhang Y.Z. Histone deacetylase inhibition: an important mechanism in the treatment of lymphoma. Cancer Biol Med 2012, 9:85-89.
    • (2012) Cancer Biol Med , vol.9 , pp. 85-89
    • Guo, S.Q.1    Zhang, Y.Z.2
  • 64
    • 84904532915 scopus 로고    scopus 로고
    • Targeting the epigenome and other new strategies in diffuse large B-cell lymphoma: beyond R-CHOP
    • Cerchietti L., Leonard J.P. Targeting the epigenome and other new strategies in diffuse large B-cell lymphoma: beyond R-CHOP. Hematology Am Soc Hematol Educ Program 2013, 2013:591-595.
    • (2013) Hematology Am Soc Hematol Educ Program , vol.2013 , pp. 591-595
    • Cerchietti, L.1    Leonard, J.P.2
  • 65
    • 84908377130 scopus 로고    scopus 로고
    • Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome
    • 256ra135
    • Bjornsson H.T., Benjamin J.S., Zhang L., et al. Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome. Sci Transl Med 2014, 6:256ra135.
    • (2014) Sci Transl Med , vol.6
    • Bjornsson, H.T.1    Benjamin, J.S.2    Zhang, L.3
  • 66
    • 84888303259 scopus 로고    scopus 로고
    • Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth
    • Garapaty-Rao S., Nasveschuk C., Gagnon A., et al. Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth. Chem Biol 2013, 20:1329-1339.
    • (2013) Chem Biol , vol.20 , pp. 1329-1339
    • Garapaty-Rao, S.1    Nasveschuk, C.2    Gagnon, A.3
  • 67
    • 84867632489 scopus 로고    scopus 로고
    • A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
    • Knutson S.K., Wigle T.J., Warholic N.M., et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol 2012, 8:890-896.
    • (2012) Nat Chem Biol , vol.8 , pp. 890-896
    • Knutson, S.K.1    Wigle, T.J.2    Warholic, N.M.3
  • 68
    • 84879750981 scopus 로고    scopus 로고
    • An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1
    • Konze K.D., Ma A., Li F., et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol 2013, 8:1324-1334.
    • (2013) ACS Chem Biol , vol.8 , pp. 1324-1334
    • Konze, K.D.1    Ma, A.2    Li, F.3
  • 69
    • 84871841675 scopus 로고    scopus 로고
    • Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
    • Qi W., Chan H., Teng L., et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A 2012, 109:21360-21365.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 21360-21365
    • Qi, W.1    Chan, H.2    Teng, L.3
  • 70
    • 84921318899 scopus 로고    scopus 로고
    • Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma
    • Knutson S.K., Kawano S., Minoshima Y., et al. Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Molec Cancer Ther 2014, 13:842-854.
    • (2014) Molec Cancer Ther , vol.13 , pp. 842-854
    • Knutson, S.K.1    Kawano, S.2    Minoshima, Y.3
  • 71
    • 84916881910 scopus 로고    scopus 로고
    • Synergistic anti-tumor activity of EZH2 inhibitors and glucocorticoid receptor agonists in models of germinal center non-Hodgkin lymphomas
    • Knutson S.K., Warholic N.M., Johnston L.D., et al. Synergistic anti-tumor activity of EZH2 inhibitors and glucocorticoid receptor agonists in models of germinal center non-Hodgkin lymphomas. PloS One 2014, 9:e111840.
    • (2014) PloS One , vol.9 , pp. e111840
    • Knutson, S.K.1    Warholic, N.M.2    Johnston, L.D.3
  • 72
    • 77950486830 scopus 로고    scopus 로고
    • A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo
    • Cerchietti L.C., Ghetu A.F., Zhu X., et al. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell 2010, 17:400-411.
    • (2010) Cancer Cell , vol.17 , pp. 400-411
    • Cerchietti, L.C.1    Ghetu, A.F.2    Zhu, X.3
  • 73
    • 65349119454 scopus 로고    scopus 로고
    • A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo
    • Cerchietti L.C., Yang S.N., Shaknovich R., et al. A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo. Blood 2009, 113:3397-3405.
    • (2009) Blood , vol.113 , pp. 3397-3405
    • Cerchietti, L.C.1    Yang, S.N.2    Shaknovich, R.3
  • 74
    • 84891953718 scopus 로고    scopus 로고
    • Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma
    • Chapuy B., McKeown M.R., Lin C.Y., et al. Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. Cancer Cell 2013, 24:777-790.
    • (2013) Cancer Cell , vol.24 , pp. 777-790
    • Chapuy, B.1    McKeown, M.R.2    Lin, C.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.