Hyperpolarized choline as an MR imaging molecular probe: Feasibility of in vivo imaging in a rat model

Journal of Magnetic Resonance Imaging

Volumn 41, Issue 4, 2015, Pages 917-923

  Friesen Waldner, Lanette J ^a   Wade, Trevor P ^a,b   Thind, Kundan ^a,b   Chen, Albert P ^c   Gomori, J Moshe ^d   Sosna, Jacob ^d   McKenzie, Charles A ^a   Katz Brull, Rachel ^d,e  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c GE HEALTHCARE   (Canada)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^e BrainWatch Ltd   (Israel)

Author keywords

choline; magnetic resonance imaging; metabolism

Indexed keywords

CHOLINE; CHOLINE C 11; CARBON; MOLECULAR PROBE; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; AORTA; ARTICLE; DRUG DISTRIBUTION; HEART; HYPERPOLARIZATION; IN VIVO STUDY; INFERIOR CAVA VEIN; KIDNEY; MALE; MOLECULAR PROBE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; ORGAN DISTRIBUTION; PRIORITY JOURNAL; RAT; ANIMAL; ANTIBODY SPECIFICITY; COMPUTER ASSISTED DIAGNOSIS; FEASIBILITY STUDY; GENETIC PROCEDURES; METABOLIC CLEARANCE RATE; PHARMACOKINETICS; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; WHOLE BODY IMAGING;

ANIMALS; CARBON ISOTOPES; CHOLINE; FEASIBILITY STUDIES; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; METABOLIC CLEARANCE RATE; MOLECULAR PROBE TECHNIQUES; MOLECULAR PROBES; ORGAN SPECIFICITY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; WHOLE BODY IMAGING;

EID: 84925254232     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.24659     Document Type: Article

References (33)

1. Blusztajn JK,. Choline, a vital amine. Science 1998; 281: 794-795.
2. Ridgway ND,. The role of phosphatidylcholine and choline metabolites to cell proliferation and survival. Crit Rev Biochem Mol Biol 2013; 48: 20-38.
3. Salem N, Kuang Y, Wang F, MacLennan GT, Lee Z,. PET imaging of hepatocellular carcinoma with 2-deoxy-2[F-18]fluoro-D-glucose, 6-deoxy-6[F-18]fluoro-D-glucose, [C1-11]-acetate and [N-methyl-C-11]-choline. Q J Nucl Med Mol Imaging 2009; 53: 144-156.
4. Awwad HM, Geisel J, Obeid R,. The role of choline in prostate cancer. Clin Biochem 2012; 45: 1548-1553.
5. Contractor KB, Kenny LM, Stebbing J, et al. [C-11]Choline positron emission tomography in estrogen receptor-positive breast cancer. Clin Cancer Res 2009; 15: 5503-5510.
6. Torizuka T, Kanno T, Futatsubashi M, et al. Imaging of gynecologic tumors: comparison of C-11-choline PET with F-18-FDG PET. J Nucl Med 2003; 44: 1051-1056.
7. Burg MB,. Molecular basis of osmotic regulation. Am J Physiol 1995; 268 (Pt 2): F983-F996.
8. Grunewald RW, Oppermann M, Muller GA,. Choline transport and its osmotic regulation in renal cells derived from the rabbit outer medullary thick ascending limb of Henle. Pflugers Arch 1997; 434: 815-821.
9. Katz-Brull R, Seger D, Rivenson-Segal D, Rushkin E, Degani H,. Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether phospholipid synthesis. Cancer Res 2002; 62: 1966-1970.
10. Ardenkjaer-Larsen JH, Fridlund B, Gram A, et al. Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proc Natl Acad Sci U S A 2003; 100: 10158-10163.
11. Kurhanewicz J, Vigneron DB, Brindle K, et al. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia 2011; 13: 81-97.
12. Cudalbu C, Comment A, Kurdzesau F, et al. Feasibility of in vivo N-15 MRS detection of hyperpolarized N-15 labeled choline in rats. Phys Chem Chem Phys 2010; 12: 5818-5823.
13. Allouche-Arnon H, Lerche MH, Karlsson M, Lenkinski RE, Katz-Brull R,. Deuteration of a molecular probe for DNP hyperpolarization-a new approach and validation for choline chloride Contrast Media Mol Imaging 2011; 6: 499-506.
14. Allouche-Arnon H, Gamliel A, Barzilay CM, et al. A hyperpolarized choline molecular probe for monitoring acetylcholine synthesis. Contrast Media Mol Imaging 2011; 6: 139-147.
15. Allouche-Arnon H, Gamliel A, Sosna J, Gomori JM, Katz-Brull R,. In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy. Chem Commun 2013; 49: 7076-7078.
16. Gabellieri C, Reynolds S, Lavie A, Payne GS, Leach MO, Eykyn TR,. Therapeutic target metabolism observed using hyperpolarized N-15 choline. J Am Chem Soc 2008; 130: 4598-4599.
17. Taconic.com. Sprague-Dawley one year growth. Available at: http://www.taconic.com/SD. Accessed March 2014.
18. Ardenkjaer-Larsen JH, Macholl S, Johannesson H,. Dynamic nuclear polarization with trityls at 1.2 K. Appl Magn Reson 2008; 34: 509-522.
19. Friesen-Waldner L, Chen A, Mander W, Scholl TJ, McKenzie CA,. Optimisation of dynamic nuclear polarisation of 1-C-13 pyruvate by addition of gadolinium-based contrast agents. J Magn Reson 2012; 223: 85-89.
20. Allouche-Arnon H, Hovav Y, Friesen-Waldner L, et al. Quantification of rate constants for successive enzymatic reactions with DNP hyperpolarized MR. NMR Biomed 2014. (in press).
21. Santyr GE, Lam WW, Ouriadov A,. Rapid and efficient mapping of regional ventilation in the rat lung using hyperpolarized 3He with Flip Angle Variation for Offset of RF and Relaxation (FAVOR). Magn Reson Med 2008; 59: 1304-1310.
22. Kuang Y, Salem N, Tian HB, et al. Imaging Lipid synthesis in hepatocellular carcinoma with methyl-C-11 choline: correlation with in vivo metabolic studies. J Nucl Med 2011; 52: 98-106.
23. Katz-Brull R, Margalit R, Degani H,. Differential routing of choline in implanted breast cancer and normal organs. Magn Reson Med 2001; 46: 31-38.
24. Hara T, Kosaka N, Shinoura N, Kondo T,. PET imaging of brain tumor with [methyl-C-11]choline. J Nucl Med 1997; 38: 842-847.
25. Moseley RH, Takeda H, Zugger LJ,. Choline transport in rat liver basolateral plasma membrane vesicles. Hepatology 1996; 24: 192-197.
26. Antai AB, Eyong EU, Eteng MU, Itam EH, Eko ME, Ita SO,. Serum protein and enzyme levels in rats following administration of ethanolic leaf extract of Ageratum conyzoides (goat weed). Niger J Physiol Sci 2009; 24: 117-120.
27. Plathow C, Weber WA,. Tumor cell metabolism imaging. J Nucl Med 2008; 49: 43-63.
28. Allen DD, Smith QR,. Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique. J Neurochem 2001; 76: 1032-1041.
29. Muller SA, Holzapfel K, Seidl C, Treiber U, Krause BJ, Senekowitsch-Schmidtke R,. Characterization of choline uptake in prostate cancer cells following bicalutamide and docetaxel treatment. Eur J Nuc Med Mol Imaging 2009; 36: 1434-1442.
30. Smith G, Zhao YJ, Leyton J, et al. Radiosynthesis and pre-clinical evaluation of [F-18]fluoro-[1,2-H-2(4)]choline. Nucl Med Biol 2011; 38: 39-51.
31. Hara T, Kondo T, Hara T, Kosaka N,. Use of F-18-choline and C-11-choline as contrast agents in positron emission tomography imaging-guided stereotactic biopsy sampling of gliomas. J Neurosurg 2003; 99: 474-479.
32. Agut J, Font E, Sacristan A, Ortiz JA,. Dissimilar effects in acute toxicity studies of CDP-choline and choline. Arzneimittelforschung 1983; 33: 1016-1018.
33. Allouche-Arnon H, Wade T, Waldner LF, et al. In vivo magnetic resonance imaging of glucose-initial experience. Contrast Media Mol Imaging 2013; 8: 72-82.