Radiosynthesis and pre-clinical evaluation of [18F]fluoro-[1,2-2H4]choline

Nuclear Medicine and Biology

Volumn 38, Issue 1, 2011, Pages 39-51

  Smith, Graham ^a   Zhao, Yongjun ^a   Leyton, Julius ^a   Shan, Bo ^a   Nguyen, Quang de ^a   Perumal, Meg ^a   Turton, David ^a   Årstad, Erik ^a   Luthra, Sajinder K ^a   Robins, Edward G ^a   Aboagye, Eric O ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Choline; Choline kinase; Fluorine 18; Fluorocholine; Isotope effect; Quantum tunneling

Indexed keywords

CHOLINE DERIVATIVE; CHOLINE OXIDASE; FLUORO[1 2H2]CHOLINE F 18; FLUORO[1,2 2H4]CHOLINE F 18; FLUOROBROMOMETHANE F 18; FLUOROCHOLINE F 18; FLUOROMETHYL TOSYLATE F 18; PERMANGANATE POTASSIUM; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HCT116; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TUMOR LEVEL; DRUG UPTAKE; ENZYME MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATION; POSITRON EMISSION TOMOGRAPHY; RELIABILITY; STRUCTURE ACTIVITY RELATION; TISSUE LEVEL;

ANIMALS; CHOLINE; DEUTERIUM; DRUG STABILITY; HCT116 CELLS; HUMANS; MALE; MICE; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY;

EID: 78650989828     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2010.06.012     Document Type: Article

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