In search of neural endophenotypes of postpartum psychopathology and disrupted maternal caregiving

Journal of Neuroendocrinology

Volumn 26, Issue 10, 2014, Pages 665-684

  Moses Kolko, E L ^a   Horner, M S ^a   Phillips, M L ^a,b,c   Hipwell, A E ^a,b   Swain, J E ^d,e  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^d UNIVERSITY OF MICHIGAN   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Attachment; Brain imaging; Caregiving; Postpartum depression

Indexed keywords

ANXIETY DISORDER; BOLD SIGNAL; BRAIN REGION; CHILD PARENT RELATION; DEFAULT MODE NETWORK; DISEASE ASSOCIATION; EMOTIONAL ATTACHMENT; ENDOPHENOTYPE; EXECUTIVE FUNCTION; FEAR; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; GENETICS; HUMAN; MATERNAL BEHAVIOR; MATERNAL CARE; MATERNAL DISEASE; MENTAL DISEASE; META ANALYSIS (TOPIC); MOLECULAR BIOLOGY; MOOD CHANGE; MOOD DISORDER; NERVE CELL NETWORK; NERVE POTENTIAL; NONHUMAN; OUTCOME ASSESSMENT; PERSONAL EXPERIENCE; PHENOTYPIC VARIATION; POSTPARTUM PSYCHOPATHOLOGY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PUERPERAL DEPRESSION; PUERPERIUM; REGULATORY MECHANISM; REVIEW; SOCIAL COGNITION; SOCIAL INTERACTION; TREATMENT INDICATION; TREATMENT RESPONSE; CAREGIVER; FEMALE; MOTHER; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PREGNANCY;

CAREGIVERS; DEPRESSION, POSTPARTUM; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MOTHERS; PHENOTYPE; PREGNANCY;

EID: 84925235022     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/jne.12183     Document Type: Review

References (222)

1. Swain JE, Lorberbaum JP, Kose S, Strathearn L. Brain basis of early parent-infant interactions: psychology, physiology, and in vivo functional neuroimaging studies. J Child Psychol Psychiatry 2007; 48: 262-287.
2. Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, Reiss AL, Greicius MD. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 2007; 27: 2349-2356.
3. Etkin A, Wager TD. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 2007; 164: 1476-1488.
4. Milad MR, Quirk GJ, Pitman RK, Orr SP, Fischl B, Rauch SL. A role for the human dorsal anterior cingulate cortex in fear expression. Biol Psychiatry 2007; 62: 1191-1194.
5. Somerville LH, Whalen PJ, Kelley WM. Human bed nucleus of the stria terminalis indexes hypervigilant threat monitoring. Biol Psychiatry 2010; 68: 416-424.
6. Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ. Neural systems supporting interoceptive awareness. Nat Neurosci 2004; 7: 189-195.
7. Paulus MP, Stein MB. An Insular View of Anxiety. Biol Psychiatry 2006; 60: 383-387.
8. Davis M, Walker DL, Miles L, Grillon C. Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology 2010; 35: 105-135.
9. LeDoux JE. Clues from the brain. Ann Rev Psychol 1995; 46: 209-235.
10. Disner SG, Beevers CG, Haigh EA, Beck AT. Neural mechanisms of the cognitive model of depression. Nat Rev Neurosci 2011; 12: 467-477.
11. Anand A, Li Y, Wang Y, Gardner K, Lowe MJ Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit. J Neuropsychiatry Clin Neurosci 2007; 19: 274-282.
12. Dannlowski U, Ohrmann P, Bauer J, Kugel H, Arolt V, Heindel W, Kersting A, Baune BT, Suslow T. Amygdala reactivity to masked negative faces is associated with automatic judgmental bias in major depression: a 3 T fMRI study. J Psychiatry Neurosci 2007; 32: 423-429.
13. Fales CL, Barch DM, Rundle MM, Mintun MA, Snyder AZ, Cohen JD, Mathews J, Sheline YI. Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression. Biol Psychiatry 2008; 63: 377-384.
14. Fu CH, Williams SC, Cleare AJ, Brammer MJ, Walsh ND, Kim J, Andrew CM, Pich EM, Williams PM, Reed LJ. Attenuation of the neural response to sad faces in major depressionby antidepressant treatment: a prospective, event-related functional magnetic resonance imagingstudy. Arch Gen Psychiatry 2004; 61: 877-889.
15. Fu CH, Williams SC, Brammer MJ, Suckling J, Kim J, Cleare AJ, Walsh ND, Mitterschiffthaler MT, Andrew CM, Pich EM, Bullmore ET. Neural responses to happy facial expressions in major depression following antidepressant treatment.[see comment]. Am J Psychiatry 2007; 164: 599-607.
16. Neumeister A, Drevets WC, Belfer I, Luckenbaugh DA, Henry S, Bonne O, Herscovitch P, Goldman D, Charney DS. Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression. Neuropsychopharmacology 2006; 31: 1550-1556.
17. Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ, Mintun MA. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol Psychiatry 2001; 50: 651-658.
18. Surguladze SA, Brammer MJ, Young AW, Keedwell P, Travis MJ, Williams S, Phillips ML. A differential pattern of neural response towards sad versus happy facial facial expressions in Major Depressive Disorder. Biol Psychiatry 2005; 57: 201-209.
19. Siegle GJ, Steinhauer SR, Thase ME, Stenger VA, Carter CS. Can't shake that feeling: fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol Psychiatry 2002; 51: 693-707.
20. Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol Psychiatry 2003; 54: 515-528.
21. Neumeister A, Drevets WC, Belfer I, Luckenbaugh DA, Henry S, Bonne O, Herscovitch P, Goldman D, Charney DS. Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression. Neuropsychopharmacology 2006; 31: 1750-1756.
22. Victor TA, Furey ML, Fromm SJ, Ohman A, Drevets WC. Relationship between amygdala responses to masked faces and mood state and treatment in major depressive disorder. Arch Gen Psychiatry 2010; 67: 1128-1138.
23. Pulcu E, Lythe K, Elliott R, Green S, Moll J, Deakin JF, Zahn R. Increased amygdala response to shame in remitted major depressive disorder. PLoS ONE 2014; 9: e86900.
24. Arnone D, McKie S, Elliott R, Thomas EJ, Downey D, Juhasz G, Williams SR, Deakin JFW, Anderson IM. Increased amygdala responses to sad but not fearful faces in major depression: relation to mood state and pharmacological treatment. Am J Psychiatry 2012; 169: 841-850.
25. Norbury R, Selvaraj S, Taylor M, Harmer C, Cowen P. Increased neural response to fear in patients recovered from depression: a 3T functional magnetic resonance imaging study. Psychol Med 2010; 40: 425.
26. Etkin A, Prater KE, Schatzberg AF, Menon V, Greicius MD. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry 2009; 66: 1361-1372.
27. Etkin A, Schatzberg AF. Common abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety and major depressive disorders. Am J Psychiatry 2011; 168: 968-978.
28. Robinson OJ, Charney DR, Overstreet C, Vytal K, Grillon C. The adaptive threat bias in anxiety: amygdala-dorsomedial prefrontal cortex coupling and aversive amplification. NeuroImage 2012; 60: 523-529.
29. Wartella J, Amory E, Lomas LM, Macbeth A, McNamara I, Stevens L, Lambert KG, Kinsley CH. Single or multiple reproductive experiences attenuate neurobehavioral stress and fear responses in the female rat. Physiol Behav 2003; 79: 373-381.
30. Neumann ID. Brain mechanisms underlying emotionalalterations in the peripartum period in rats. Depress Anxiety 2003; 17: 111-121.
31. Torner L, Neumann ID. The brain prolactin system: involvement in stress response adaptations in lactation. Stress 2002; 5: 249-257.
32. Bosch OJ, Meddle SL, Beiderbeck DI, Douglas AJ, Neumann ID. Brain oxytocin correlates with maternal aggression: link to anxiety. J Neurosci 2005; 25: 6807-6815.
33. Febo M, Shields J, Ferris CF, King JA. Oxytocin modulates unconditioned fear response in lactating dams: an fMRI study. Brain Res 2009; 1302: 183-193.
34. Caffrey MK, Nephew BC, Febo M. Central vasopressin V1a receptors modulate neural processing in mothers facing intruder threat to pups. Neuropharmacology 2010; 58: 107-116.
35. Hillerer KM, Neumann ID, Slattery DA. From stress to postpartum mood and anxiety disorders: how chronic peripartum stress can impair maternal adaptations. Neuroendocrinology 2011; 95: 22-38.
36. Ferris CF, Stolberg T, Kulkarni P, Murugavel M, Blanchard R, Blanchard DC, Febo M, Brevard M, Simon NG. Imaging the neural circuitry and chemical control of aggressive motivation. BMC Neurosci 2008; 9: 111.
37. Noriuchi M, Kikuchi Y, Senoo A. The functional neuroanatomy of maternal love: mother's response to infant's attachment behaviors. Biol Psychiatry 2008; 63: 415-423.
38. Strathearn L, Li J, Fonagy P, Montague PR What's in a smile? maternal brain responses to infant facial cues. Pediatrics 2008; 122: 40-51.
39. Barrett J, Wonch KE, Gonzalez A, Ali N, Steiner M, Hall GB, Fleming AS. Maternal affect and quality of parenting experiences are related to amygdala response to infant faces. Soc Neurosci 2011; 252-268.
40. Seifritz E, Esposito F, Neuhoff JG, Luthi A, Mustovic H, Dammann G, von Bardeleben U, Radue EW, Cirillo S, Tedeschi G, Di Salle F. Differential sex-independent amygdala response to infant crying and laughing in parents versus nonparents. Biol Psychiatry 2003; 54: 1367-1375.
41. Lorberbaum JP, Newman JD, Horwitz AR, Dubno JR, Lydiard RB, Hammer MB, Bohning DE, George MS. A potential role for thalamocingulate circuitry in human maternal behavior. Biol Psychiatry 2002; 51: 431-445.
42. Swain JE, Tasgin E, Mayes LC, Feldman R, Constable RT, Leckman JF. Maternal brain response to own baby-cry is affected by cesarean section delivery. J Child Psychol Psychiatry 2008; 49: 1042-1052.
43. Laurent HK, Ablow JC. A cry in the dark: depressed mothers show reduced neural activation to their own infant's cry. Soc Cogn Affect Neurosci 2012; 7: 125-134.
44. Leibenluft E, Gobbini MI, Harrison T, Haxby JV. Mothers' neural activation in reponse to pictures of their children and other children. Biol Psychiatry 2004; 56: 225-232.
45. Bartels A, Zeki S. The neural correlates of maternal and romantic love. Neuroimage 2004; 21: 155-1166.
46. Strathearn L, Fonagy P, Amico J, Montague PR. Adult attachment predicts maternal brain and oxytocin response to infant cues. Neuropsychopharmacology 2009; 34: 2655-2666.
47. Swain J, Ho S, Rosenblum K, Finegood E, Richardson P, Dayton C, Akce L, Marcus S, Phan K, Muzik M. Maternal brain responses to baby stimuli are modulated by mood disorders. Paper Presented at: Biological Psychiatry 2012.
48. Kim P, Feldman R, Mayes LC, Eicher V, Thompson N, Leckman JF, Swain JE. Breastfeeding, brain activation to own infant cry, and maternal sensitivity. J Child Psychol Psychiatry 2011; 52: 907-915.
49. Silverman ME, Loudon H, Safier M, Protopopescu X, Leiter G, Liu X, Goldstein M. Neural dysfunction in postpartum depression: an fMRI pilot study. CNS Spectr 2007; 12: 853-862.
50. Moses-Kolko EL, Perlman SB, Wisner KL, James J, Saul AT, Phillips ML. Abnormally reduced dorsomedial prefrontal cortical activity and effective connectivity with amygdala in response to negative emotional faces in postpartum depression. Am J Psychiatry 2010; 167: 1373-1380.
51. Swain JE, Lorberbaum JP. Imaging the human parental brain. Neurobiology of the parental brain. 2008; 83-100.
52. Swain JE, Leckman JF, Mayes LC, Feldman R, Hoyt E, Kang H, Kim P, David D, Nguyen S, Constable RT, Schultz RT. Functional brain activations of parents listening to their own baby-cry change over the early postpartum. Dev Psychobiol 2014; under review.
53. Kim P, Leckman JF, Mayes LC, Feldman R, Wang X, Swain JE. The plasticity of human maternal brain: longitudinal changes in brain anatomy during the early postpartum period. Behav Neurosci 2010; 124: 695-700.
54. Kinsley CH, Meyer EA. The construction of the maternal brain: theoretical comment on Kim et al. (2010). Behav Neurosci 2010; 124: 710-714.
55. Hopper JW, Frewen PA, van der Kolk BA, Lanius RA. Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: Symptom dimensions and emotion dysregulation in responses to script-driven trauma imagery. J Trauma Stress 2007; 20: 713-725.
56. Herringa RJ, Phillips ML, Fournier JC, Kronhaus DM, Germain A. Childhood and adult trauma both correlate with dorsal anterior cingulate activation to threat in combat veterans. Psychol Med 2013; 43: 1533-1542.
57. Lanius RA, Vermetten E, Loewenstein RJ, Brand B, Schmahl C, Bremner JD, Spiegel D. Emotion modulation in PTSD: clinical and neurobiological evidence for a dissociative subtype. Am J Psychiatry 2010; 167: 640-647.
58. Meewisse ML, Reitsma JB, de Vries GJ, Gersons BP, Olff M. Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis. Br J Psychiatry 2007; 191: 387-392.
59. Shea A, Walsh C, Macmillan H, Steiner M. Child maltreatment and HPA axis dysregulation: relationship to major depressive disorder and post traumatic stress disorder in females. Psychoneuroendocrinology 2005; 30: 162-178.
60. Morris MC, Compas BE, Garber J. Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta-analysis. Clin Psychol Rev 2012; 32: 301-315.
61. Schechter DS, Moser DA, Wang Z, Marsh R, Hao X, Duan Y, Yu S, Gunter B, Murphy D, McCaw J, Kangarlu A, Willheim E, Myers MM, Hofer MA, Peterson BS. An fMRI study of the brain responses of traumatized mothers to viewing their toddlers during separation and play. Soc Cogn Affect Neurosci 2012; 7: 969-979.
62. Schechter DS, Willheim E, Hinojosa C, Scholfield-Kleinman K, Turner JB, McCaw J, Zeanah CH, Myers MM. Subjective and objective measures of parent-child relationship dysfunction, child separation distress, and joint attention. Psychiatry 2010; 73: 130-144.
63. Moser DA, Aue T, Wang Z, Rusconi SS, Favez N, Peterson BS, Schechter DS. Limbic brain responses in mothers with post-traumatic stress disorder and comorbid dissociation to video clips of their children. Stress 2013; 16: 493-502.
64. Lanius RA, Frewen PA, Girotti M, Neufeld RWJ, Stevens TK, Densmore M. Neural correlates of trauma script-imagery in posttraumatic stress disorder with and without comorbid major depression: a functional MRI investigation. Psychiatry Res 2007; 155: 45-56.
65. Korgaonkar MS, Grieve SM, Etkin A, Koslow SH, Williams LM. Using standardized fMRI protocols to identify patterns of prefrontal circuit dysregulation that are common and specific to cognitive and emotional tasks in major depressive disorder: first wave results from the iSPOT-D study. Neuropsychopharmacology 2013; 38: 863-871.
66. Harvey P-O, Fossati P, Pochon J-B, Levy R, LeBastard G, Lehéricy S, Allilaire J-F, Dubois B. Cognitive control and brain resources in major depression: an fMRI study using the n-back task. NeuroImage 2005; 26: 860-869.
67. Liotti M, Mayberg HS, McGinnis S, Brannan SL, Jerabek P. Unmasking disease -specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depression. Am J Psychatry 2002; 159: 1830-1840.
68. Elliott R, Baker SC, Rogers RD, O'Leary DA, Paykel ES, Frith CD, Dolan RJ, Sahakian BJ. Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography. Psychol Med 1997; 27: 931-942.
69. Goethals I, Audenaert K, Jacobs F, Van de Wiele C, Ham H, Pyck H, Vandierendonck A, Van Heeringen C, Dierckx R. Blunted prefrontal perfusion in depressed patients performing the Tower of London task. Psychiatry Res 2005; 139: 31-40.
70. Okada G, Okamoto Y, Morinobu S, Yamawaki S, Yokota N. Attenuated left prefrontal activation during a verbal fluency task in patients with depression. Neuropsychopharmacology 2003; 47: 21-26.
71. Versace A, Thompson WK, Zhou D, Almeida JR, Hassel S, Klein CR, Kupfer DJ, Phillips ML. Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder. Biol Psychiatry 2010; 67: 422-431.
72. Almeida JR, Versace A, Mechelli A, Hassel S, Quevedo K, Kupfer DJ, Phillips ML. Abnormal amygdala-prefrontal effective connectivity to happy faces differentiates bipolar from major depression. Biol Psychiatry 2009; 66: 451-459.
73. Hamilton JP, Chen MC, Gotlib IH. Neural systems approaches to understanding major depressive disorder: an intrinsic functional organization perspective. Neurobiol Dis 2013; 52: 4-11.
74. de Groot RH, Vuurman EF, Hornstra G, Jolles J. Differences in cognitive performance during pregnancy and early motherhood. Psychol Med 2006; 36: 1023-1032.
75. Buckwalter JG, Stanczyk FZ, McCleary CA, Bluestein BW, Buckwalter DK, Rankin KP, Chang L, Goodwin TM. Pregnancy, the postpartum, and steroid hormones: effects on cognition and mood. Psychoneuroendocrinology 1999; 24: 69-84.
76. Bannbers E, Gingnell M, Engman J, Morell A, Sylven S, Skalkidou A, Kask K, Backstrom T, Wikstrom J, Poromaa IS. Prefrontal activity during response inhibition decreases over time in the postpartum period. Behav Brain Res 2013; 241: 132-138.
77. Amin Z, Epperson CN, Constable RT, Canli T. Effects of estrogen variation on neural correlates of emotional response inhibition. NeuroImage 2006; 32: 457-464.
78. Swain JE, Kim P, Ho SS. Neuroendocrinology of parental response to baby-cry. J Neuroendocrinol 2011; 23: 1036-1041.
79. Swain JE, Mayes LC, Leckman JF. The development of parent-infant attachment through dynamic and interactive signaling loops of care and cry. Behav Brain Sci 2004; 27: 472-473.
80. Robbins TW, Everitt BJ. Motivation and Reward. In: Squire LR, Bloom FE, McConnell SK, Roberts JL, Spitzer NC, Zigmond MJ, eds. Fundamental Neuroscience. San Diego: Elsevier Science, 2003; 1109-1126.
81. Schultz W. Dopamine neurons and their role in reward mechanisms. Curr Opin Neurobiol 1997; 7: 191-197.
82. Schultz W. Behavioral theories and the neurophysiology of reward. Annu Rev Psychol 2006; 57: 87-115.
83. Delgado MR, Locke HM, Stenger VA, Fiez JA. Dorsal striatum responses to reward and punishment: effects of valence and magnitude manipulations. Cogn Affect Behav Neurosci 2003; 3: 27-38.
84. O'Doherty JP. Reward representations and reward-related learning in the human brain: insights from neuroimaging. Curr Opin Neurobiol 2004; 14: 769-776.
85. Forbes EE, Dahl RE. Neural systems of positive affect: relevance to understanding child and adolescent depression? Dev Psychopathol 2005; 17: 827-850.
86. Dunlop BW, Nemeroff CB. The role of dopamine in the pathophysiology of depression. Arch Gen Psych 2007; 64: 327-337.
87. Pizzagalli DA, Holmes AJ, Dillon DG, Goetz EL, Birk JL, Bogdan R, Dougherty DD, Iosifescu DV, Rauch SL, Fava M. Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder. Am J Psychiatry 2009; 166: 702-710.
88. Forbes EE, Hariri AR, Martin SL, Silk JS, Moyles DL, Fisher PM, Brown SM, Ryan ND, Birmaher B, Axelson DA, Dahl RE. Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder. Am J Psychiatry 2009; 166: 64-73.
89. Keedwell PA, Andrew C, Williams SC, Brammer MJ, Phillips ML. The neural correlates of anhedonia in major depressive disorder. Biol Psychiatry 2005; 58: 843-853.
90. Lawrence NS, Williams AM, Surguladze S, Giampietro V, Brammer MJ, Andrew C, Frangou S, Ecker C, Phillips ML. Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biol Psychiatry 2004; 55: 578-587.
91. Epstein J, Pan H, Kocsis JH, Yang Y, Butler T, Chusid J, Hochberg H, Murrough J, Strohmayer E, Stern E, Silbersweig DA. Lack of ventral striatal response to positive stimuli in depressed versus normal subjects. Am J Psychiatry 2006; 163: 1784-1790.
92. Mourao-Miranda J, Oliveira L, Ladouceur CD, Marquand A, Brammer M, Birmaher B, Axelson D, Phillips ML. Pattern recognition and functional neuroimaging help to discriminate healthy adolescents at risk for mood disorders from low risk adolescents. PLoS ONE 2012; 7: e29482.
93. Keedwell PA, Andrew C, Williams SC, Brammer MJ, Phillips ML. A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals. Biol Psychiatry 2005; 58: 495-503.
94. Moses-Kolko EL, Meltzer CC, Berga SL, Wisner KL. Postpartum depression: the clinical disorder and application of PET imaging research methods. In: Bridges RS, ed. Neurobiology of the Parental Brain. Burlington: Academic Press, 2008; 175-199.
95. Champagne FA, Chretien P, Stevenson CW, Zhang TY, Gratton A, Meaney MJ. Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat. J Neurosci 2004; 24: 4113-4123.
96. Ferris CF, Kulkarni P, Sullivan JM Jr, Harder JA, Messenger TL, Febo M. Pup suckling is more rewarding than cocaine: evidence from functional magnetic resonance imaging and three-dimensional computational analysis. J Neurosci 2005; 25: 149-156.
97. Shahrokh DK, Zhang TY, Diorio J, Gratton A, Meaney MJ. Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat. Endocrinology 2010; 151: 2276-2286.
98. Pavesi E, Enck MC, De Toledo CAB, Terenzi MG. Disruption of maternal behaviour by acute conspecific interaction induces selective activation of the lateral periaqueductal grey. Eur J Neurosci 2007; 26: 2055-2065.
99. Sukikara MH, Mota-Ortiz SR, Baldo MV, Felicio LF, Canteras NS. The periaqueductal gray and its potential role in maternal behavior inhibition in response to predatory threats. Behav Brain Res 2010; 209: 226-233.
100. Nephew BC, Caffrey MK, Felix-Ortiz AC, Ferris CF, Febo M. Blood oxygen level-dependent signal responses in corticolimbic 'emotions' circuitry of lactating rats facing intruder threat to pups. Eur J Neurosci 2009; 30: 934-945.
101. Ranote S, Elliott R, Abel KM, Mitchell R, Deakin JFW, Appleby L. The neural basis of maternal responsiveness to infants: an fMRI study. NeuroReport 2004; 15: 1825-1829.
102. Nitschke JB, Nelson EE, Rusch BD, Fox AS, Oakes TR, Davidson RJ. Orbitofrontal cortex tracks positive mood in mothers viewing pictures of their newborn infants. Neuroimage 2004; 21: 583-592.
103. Wieck A, Kumar R, Hirst AD, Marks MN, Campbell IC, Checkley SA. Increased sensitivity of dopamine receptors and recurrence of affective psychosis after childbirth. Br Med J 1991; 303: 613-616.
104. Moses-Kolko EL, Price JC, Wisner KL, Hanusa BH, Meltzer CC, Berga SL, Grace AA, di Scalea TL, Kaye WH, Becker C, Drevets WC. Postpartum and depression status are associated with lower [(11)C]raclopride BP(ND) in reproductive-age women. Neuropsychopharmacology 2012; 37: 1422-1432.
105. Moses-Kolko EL, Fraser D, Wisner KL, James JA, Saul AT, Fiez JA, Phillips ML. Rapid habituation of ventral striatal response to reward receipt in postpartum depression. Biol Psychiatry 2011; 70: 395-399.
106. Frith U, Frith CD. Development and neurophysiology of mentalizing. Philos Trans R Soc Lond B Biol Sci 2003; 358: 459-473.
107. Hein G, Singer T. I feel how you feel but not always: the empathic brain and its modulation. Curr Opin Neurobiol 2008; 18: 153-158.
108. Gallese V, Keysers C, Rizzolatti G. A unifying view of the basis of social cognition. Trends Cogn Sci 2004; 8: 396-403.
109. Uddin LQ, Iacoboni M, Lange C, Keenan JP. The self and social cognition: the role of cortical midline structures and mirror neurons. Trends Cogn Sci 2007; 11: 153-157.
110. Iacoboni M. Neurobiology of imitation. Curr Opin Neurobiol 2009; 19: 661-665.
111. Bernhardt BC, Singer T. The neural basis of empathy. Annu Rev Neurosci 2012; 35: 1-23.
112. Frith CD, Frith U. The neural basis of mentalizing. Neuron 2006; 50: 531-534.
113. Mitchell JP. Inferences about mental states. Philos Trans R Soc Lond B Biol Sci 2009; 364: 1309-1316.
114. Lenzi D, Trentini C, Pantano P, Macaluso E, Iacoboni M, Lenzi GL, Ammaniti M. Neural basis of maternal communication and emotional expression processing during infant preverbal stage. Cereb Cortex 2009; 19: 1124-1133.
115. Eisenberger NI, Cole SW. Social neuroscience and health: neurophysiological mechanisms linking social ties with physical health. Nat Neurosci 2012; 15: 669-674.
116. Poulin MJ, Brown SL, Dillard AJ, Smith DM. Giving to others and the association between stress and mortality. Am J Public Health 2013; 103: 1649-1655.
117. Bowlby J. Loss: Sadness and Depression, vol. 3. New York: Basic Books, 1980.
118. Meaney MJ. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu Rev Neurosci 2001; 24: 1161-1192.
119. Buss C, Lord C, Wadiwalla M, Hellhammer DH, Lupien SJ, Meaney MJ, Pruessner JC. Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men. J Neurosci 2007; 27: 2592-2595.
120. Kim P, Leckman JF, Mayes LC, Newman MA, Feldman R, Swain JE. Perceived quality of maternal care in childhood and structure and function of mothers' brain. Dev Sci 2010; 13: 662-673.
121. Beckes L, Coan JA. Social baseline theory: the role of social proximity in emotion and economy of action. Soc Pers Psychol Compass 2011; 5: 976-988.
122. Coan JA, Schaefer HS, Davidson RJ. Lending a hand: social regulation of the neural response to threat. Psychol Sci 2006; 17: 1032-1039.
123. Hyde LW, Gorka A, Manuck SB, Hariri AR. Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety. Neuropsychologia 2011; 49: 651-656.
124. Insel TR. A neurobiological basis of social attachment. Am J Psychiatry 1997; 154: 726-735.
125. Atzil S, Hendler T, Feldman R. Specifying the neurobiological basis of human attachment: brain, hormones, and behavior in synchronous and intrusive mothers. Neuropsychopharmacology 2011; 36: 2603-2615.
126. Atzil S, Hendler T, Zagoory-Sharon O, Winetraub Y, Feldman R. Synchrony and specificity in the maternal and the paternal brain: relations to oxytocin and vasopressin. J Am Acad Child Adolesc Psychiatry 2012; 51: 798-811.
127. Molitor A, Mayes LC. Problematic dyadic interaction among toddlers and their polydrug-cocaine-using mothers. Infant Ment Health J 2010; 31: 121-140.
128. Landi N, Montoya J, Kober H, Rutherford HJ, Mencl WE, Worhunsky PD, Potenza MN, Mayes LC. Maternal neural responses to infant cries and faces: relationships with substance use. Front Psychiatry; 2011; 2: 32.
129. Swain J, Ho S, Rosenblum K, Marcus S, Muzik M Maternal Brain Physiology in Health, Mood Disorders and Opiate Exposure. Paper presented at: 60th American Academy of Child and Adolescent Psychiatry 2013; Orlando, FL.
130. Fox MD, Raichle ME. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 2007; 8: 700-711.
131. Shulman GL, Corbetta M, Fiez JA, Buckner RL, Miezin FM, Raichle ME, Petersen SE. Searching for activations that generalize over tasks. Hum Brain Mapp 1997; 5: 317-322.
132. Mazoyer B, Zago L, Mellet E, Bricogne S, Etard O, Houde O, Crivello F, Joliot M, Petit L, Tzourio-Mazoyer N. Cortical networks for working memory and executive functions sustain the conscious resting state in man. Brain Res Bull 2001; 54: 287-298.
133. Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 2003; 100: 253-258.
134. Menon V. Large-scale brain networks and psychopathology: a unifying triple network model. Trends Cogn Sci 2011; 15: 483-506.
135. Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci 2008; 1124: 1-38.
136. Johnson MK, Raye CL, Mitchell KJ, Touryan SR, Greene EJ, Nolen-Hoeksema S. Dissociating medial frontal and posterior cingulate activity during self-reflection. Soc Cogn Affect Neurosci 2006; 1: 56-64.
137. Northoff G, Heinzel A, de Greck M, Bermpohl F, Dobrowolny H, Panksepp J. Self-referential processing in our brain-a meta-analysis of imaging studies on the self. NeuroImage 2006; 31: 440-457.
138. Greicius MD, Flores BH, Menon V, Glover GH, Solvason HB, Kenna H, Reiss AL, Schatzberg AF. Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol Psychiatry 2007; 62: 429-437.
139. Berman MG, Peltier S, Nee DE, Kross E, Deldin PJ, Jonides J. Depression, rumination and the default network. Soc Cogn Affect Neurosci 2011; 6: 548-555.
140. Sheline YI, Price JL, Yan Z, Mintun MA. Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proc Natl Acad Sci USA 2010; 107: 11020-11025.
141. Hamilton JP, Furman DJ, Chang C, Thomason ME, Dennis E, Gotlib IH. Default-mode and task-positive network activity in major depressive disorder: implications for adaptive and maladaptive rumination. Biol Psychiatry 2011; 70: 327-333.
142. Hamilton JP, Glover GH, Hsu JJ, Johnson RF, Gotlib IH. Modulation of subgenual anterior cingulate cortex activity with real-time neurofeedback. Hum Brain Mapp 2011; 32: 22-31.
143. Johnson MK, Nolen-Hoeksema S, Mitchell KJ, Levin Y. Medial cortex activity, self-reflection and depression. Soc Cogn Affect Neurosci 2009; 4: 313-327.
144. Chase HW, Moses-Kolko EL, Zevallos C, Wisner KL, Phillips ML. Disrupted posterior cingulate-amygdala connectivity in postpartum depressed women as measured with resting BOLD fMRI. Soc Cogn Affect Neurosci 2013; 9: 1069-1075.
145. Mars RB, Neubert FX, Noonan MP, Sallet J, Toni I, Rushworth MF. On the relationship between the "default mode network" and the "social brain". Front Hum Neurosci 2012; 6: 189.
146. Deligiannidis KM, Sikoglu EM, Shaffer SA, Frederick B, Svenson AE, Kopoyan A, Kosma CA, Rothschild AJ, Moore CM. GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study. J Psychiatr Res 2013; 47: 816-828.
147. Xiao-juan W, Jian W, Zhi-hong L, Yan M, Shi-wei Z. Increased posterior cingulate, medial frontal and decreased temporal regional homogeneity in depressed mothers. Procedia Environ Sci 2011; 8: 737-743.
148. Huprich SK, Pouliot GS, Bruner R. Self-other representations mediate the relationship between Five-Factor Model depression and depressive states. Psychiatry 2012; 75: 176-189.
149. Bifulco A, Kwon J, Jacobs C, Moran PM, Bunn A, Beer N. Adult attachment style as mediator between childhood neglect/abuse and adult depression and anxiety. Soc Psychiatry Psychiatr Epidemiol 2006; 41: 796-805.
150. Fonagy P, Leigh T, Steele M, Steele H, Kennedy R, Mattoon G, Target M, Gerber A. The relation of attachment status, psychiatric classification, and response to psychotherapy. J Consult Clin Psychol 1996; 64: 22-31.
151. Fonagy P, Steele H, Steele M. Maternal representations of attachment during pregnancy predict the organization of infant-mother attachment at one year of age. Child Dev 1991; 62: 891-905.
152. Van IJzendoorn MH. Adult attachment representations, parental responsiveness, and infant attachment: a meta-analysis on the predictive validity of the Adult Attachment Interview. Psychol Bull 1995; 117: 387-403.
153. Mayes LC, Swain JE, Leckman JF. Parental attachment systems: neural circuits, genes, and experiential contributions to parental engagement. Clin Neurosci Res 2005; 4: 301-313.
154. Swain JE. The human parental brain: in vivo neuroimaging. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 1242-1254.
155. Swain JE, Konrath S, Brown SL, Finegood ED, Akce LB, Dayton CJ, Ho SS. Parenting and beyond: common neurocircuits underlying parental and altruistic caregiving. Parent Sci Pract 2012; 12: 115-123.
156. Laurent HK, Ablow JC. The missing link: mothers' neural response to infant cry related to infant attachment behaviors. Infant Behav Dev 2012; 35: 761-772.
157. Musser ED, Kaiser-Laurent H, Ablow JC. The neural correlates of maternal sensitivity: an fMRI study. Dev Cogn Neurosci 2012; 2: 428-436.
158. Lemche E, Giampietro VP, Surguladze SA, Amaro EJ, Andrew CM, Williams SC, Brammer MJ, Lawrence N, Maier MA, Russell TA, Simmons A, Ecker C, Joraschky P, Phillips ML. Human attachment security is mediated by the amygdala: evidence from combined fMRI and psychophysiological measures. Hum Brain Mapp 2006; 27: 623-635.
159. Wan MW, Downey D, Strachan H, Elliott R, Williams SR, Abel KM. The neural basis of maternal bonding. PLoS ONE 2014; 9: e88436.
160. Maccari S, Morley-Fletcher S, Szyf M. The consequences of early life adversity: neurobiological, behavioural and epigenetic adaptations. J Neuroendocrinol 2014; 26: 707-723.
161. Lupien SJ, McEwen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 2009; 10: 434-445.
162. Clark DA, Beck AT, Stewart B. Cognitive specificity and positive-negative affectivity: complementary or contradictory views on anxiety and depression? J Abnorm Psychol 1990; 99: 148-155.
163. Gotlib IH, Whiffen VE, Wallace PM, Mount JH. Prospective investigation of postpartum depression: factors involved in onset and recovery. J Abnorm Psychol 1991; 100: 122-132.
164. Kim P, Evans GW, Angstadt M, Ho SS, Sripada CS, Swain JE, Liberzon I, Phan KL. Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood. Proc Natl Acad Sci USA 2013; 110: 18442-18447.
165. Kinsley CH, Lambert KG. Reproduction-induced neuroplasticity: natural behavioural and neuronal alterations associated with the production and care of offspring. J Neuroendocrinol 2008; 20: 515-525.
166. Galea LA, Leuner B, Slattery D. Hippocampal plasticity during the peripartum period: influence of sex steroids, stress and ageing. J Neuroendocrinol 2014; 26: 641-648.
167. Lonstein JS, Maguire J, Meinlschmidt G, Neumann I. Emotion and mood adaptations in the peripartum female: complementary contributions of gamma-aminobutyric acid and oxytocin. J Neuroendocrinol 2014; 26: 649-664.
168. Numan M, Insel TR. Neurochemistry and molecular biology of maternal behavior. In: Numan M, Insel TR, eds. The Neurobiology of Parental Behavior, vol. 1. New York: Springer-Verlag, 2003; 190-245.
169. Chong S, Vickaryous N, Ashe A, Zamudio N, Youngson N, Hemley S, Stopka T, Skoultchi A, Matthews J, Scott HS, de Kretser D, O'Bryan M, Blewitt M, Whitelaw E. Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet 2007; 39: 614-622.
170. Dietz DM, Laplant Q, Watts EL, Hodes GE, Russo SJ, Feng J, Oosting RS, Vialou V, Nestler EJ. Paternal transmission of stress-induced pathologies. Biol Psychiatry 2011; 70: 408-414.
171. Dietz DM, Nestler EJ. From father to offspring: paternal transmission of depressive-like behaviors. Neuropsychopharmacology 2012; 37: 311-312.
172. Belsky JJSR, Sligo J, Woodward L, Silva PA. Intergenerational transmission of warm-sensitive-stimulating parenting: a prospective study of mothers and fathers of 3-year-olds. Child Dev 2005; 76: 384-396.
173. Fleming AS, Kraemer GW, Gonzalez A, Lovic V, Rees S, Melo A. Mothering begets mothering: the transmission of behavior and its neurobiology across generations. Pharmacol Biochem Behav 2002; 73: 61-75.
174. Maestripieri D. Early experience affects the intergenerational transmission of infant abuse in rhesus monkeys. Proc Natl Acad Sci USA 2005; 102: 9726-9729.
175. Champagne F, Meaney MJ. Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity. Prog Brain Res 2001; 133: 287-302.
176. Knutson JF. Psychological characteristics of maltreated children: putative risk factors and consequences. Annu Rev Psychol 1995; 46: 401-431.
177. Benoit D, Parker KC. Stability and transmission of attachment across three generations. Child Dev 1994; 65: 1444-1456.
178. Benoit D, Parker KC, Zeanah CH. Mothers' representations of their infants assessed prenatally: stability and association with infants' attachment classifications. J Child Psychol Psychiatry 1997; 38: 307-313.
179. Miller L, Kramer R, Warner V, Wickramaratne P, Weissman M. Intergenerational transmission of parental bonding among women. J Am Acad Child Adolesc Psychiatry 1997; 36: 1134-1139.
180. Serbin LA, Karp J. The intergenerational transfer of psychosocial risk: mediators of vulnerability and resilience. Annu Rev Psychol 2004; 55: 333-363.
181. Van Ijzendoorn MH. Intergenerational transmission of attachment. Int J Psychol 1992; 27: 208-208.
182. Moehler E, Biringen Z, Poustka L. Emotional availability in a sample of mothers with a history of abuse. Am J Orthopsychiatry 2007; 77: 624-628.
183. Herrenkohl TI, Kosterman R, Mason WA, Hawkins JD, McCarty CA, McCauley E. Effects of childhood conduct problems and family adversity on health, health behaviors, and service use in early adulthood: tests of developmental pathways involving adolescent risk taking and depression. Dev Psychopathol 2010; 22: 655-665.
184. Martin G, Bergen HA, Roeger L, Allison S. Depression in young adolescents - Investigations using 2 and 3 factor versions of the parental bonding instrument. J Nerv Ment Dis 2004; 192: 650-657.
185. Rey JM. Perceptions of poor maternal-care are associated with adolescent depression. J Affect Disord 1995; 34: 95-100.
186. Enns MW, Cox BJ, Clara I. Parental bonding and adult psychopathology: results from the US National Comorbidity Survey. Psychol Med 2002; 32: 997-1008.
187. Putnam FW. Ten-year research update review: child sexual abuse. J Am Acad Child Adolesc Psychiatry 2003; 42: 269-278.
188. Spertus IL, Yehuda R, Wong CM, Halligan S, Seremetis SV. Childhood emotional abuse and neglect as predictors of psychological and physical symptoms in women presenting to a primary care practice. Child Abuse Negl 2003; 27: 1247-1258.
189. Jaffee SR, Caspi A, Moffitt TE, Polo-Tomas M, Taylor A. Individual, family, and neighborhood factors distinguish resilient from non-resilient maltreated children: a cumulative stressors model. Child Abuse Negl 2007; 31: 231-253.
190. Hankin BL, Nederhof E, Oppenheimer CW, Jenness J, Young JF, Abela JRZ, Smolen A, Ormel J, Oldehinkel AJ. Differential susceptibility in youth: evidence that 5-HTTLPR x positive parenting is associated with positive affect 'for better and worse'. Transl Psychiat 2011; 1: e44.
191. Oppenheimer CW, Hankin BL, Jenness JL, Young JF, Smolen A. Observed positive parenting behaviors and youth genotype: evidence for gene-environment correlations and moderation by parent personality traits. Dev Psychopathol 2013; 25: 175-191.
192. Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proc Natl Acad Sci USA 2004; 101: 17316-17321.
193. Wind TW, Silvern L. Parenting and family stress as mediators of the long-term effects of child-abuse. Child Abuse Negl 1994; 18: 439-453.
194. Seeman TE, Singer BH, Ryff CD, Love GD, Levy-Storms L. Social relationships, gender, and allostatic load across two age cohorts. Psychosom Med 2002; 64: 395-406.
195. Francis DD, Diorio J, Liu D, Meaney MJ. Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 1999; 286: 1155-1158.
196. Dawson G, Ashman SB, Carver LJ. The role of early experience in shaping behavioral and brain development and its implications for social policy. Dev Psychopathol 2000; 12: 695-712.
197. Segman RH, Goltser-Dubner T, Weiner I, Canetti L, Galili-Weisstub E, Milwidsky A, Pablov V, Friedman N, Hochner-Celnikier D. Blood mononuclear cell gene expression signature of postpartum depression. Mol Psychiatry 2010; 15: 102.
198. Mahon PB, Payne JL, MacKinnon DF, Mondimore FM, Goes FS, Schweizer B, Jancic D, Consortium NGIBD, Bi GSC, Coryell WH, Holmans PA, Shi J, Knowles JA, Scheftner WA, Weissman MM, Levinson DF, DePaulo JR Jr, Zandi PP, Potash JB. Genome-wide linkage and follow-up association study of postpartum mood symptoms. Am J Psychiatry 2009; 166: 1229-1237.
199. O'Hara MW, McCabe JE. Postpartum depression: current status and future directions. Annu Rev Clin Psychol 2013; 9: 379-407.
200. Cooper PJ, Murray L. Course and recurrence of postnatal depression evidence for the specificity of the diagnostic concept. Br J Psychiatry 1995; 166: 191-195.
201. Altemus M, Neeb CC, Davis A, Occhiogrosso M, Nguyen T, Bleiberg KL. Phenotypic differences between pregnancy-onset and postpartum-onset major depressive disorder. J Clin Psychiatry 2012; 73: e1485-e1491.
202. Carter FA, Frampton CM, Mulder RT. Cesarean section and postpartum depression: a review of the evidence examining the link. Psychosom Med 2006; 68: 321-330.
203. Dennis CL, McQueen K. The relationship between infant-feeding outcomes and postpartum depression: a qualitative systematic review. Pediatrics 2009; 123: e736-e751.
204. Stuebe AM, Grewen K, Pedersen CA, Propper C, Meltzer-Brody S. Failed lactation and perinatal depression: common problems with shared neuroendocrine mechanisms? J Women's Health 2012; 21: 264-272.
205. O'Hara MW, Schlechte JA, Lewis DA, Wright EJ. Prospective study of postpartum blues. Biologic and psychosocial factors. Arch Gen Psychiatry 1991; 48: 801-806.
206. Workman JL, Barha CK, Galea LAM. Endocrine substrates of cognitive and affective changes during pregnancy and postpartum. Behav Neurosci 2012; 126: 54-72.
207. Bloch M, Rubinow DR, Schmidt PJ, Lotsikas A, Chrousos GP, Cizza G. Cortisol response to ovine corticotropin-releasing hormone in a model of pregnancy and parturition in euthymic women with and without a history of postpartum depression. J Clin Endocr Metab 2005; 90: 695-699.
208. Brummelte S, Galea LA. Depression during pregnancy and postpartum: contribution of stress and ovarian hormones. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34: 766-776.
209. Meltzer-Brody S, Stuebe A, Dole N, Savitz D, Rubinow D, Thorp J. Elevated corticotropin releasing hormone (CRH) during pregnancy and risk of postpartum depression (PPD). J Clin Endocrinol Metab 2011; 96: E40-E47.
210. Bloch M, Schmidt PJ, Danaceau M, Murphy J, Nieman L, Rubinow DR. Effects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry 2000; 157: 924-930.
211. Bloch M, Daly RC, Rubinow DR. Endocrine factors in the etiology of postpartum depression. Compr Psychiatry 2003; 44: 234-246.
212. Daly RC, Kim MY, Bloch M, Schmidt PJ, Purdy RM, Rubinow DR. Neurosteroids in reproductive endocrine-related mood disorders. Biol Psychiatry 2000; 47: 5S-5S.
213. Schiller CE, O'Hara MW, Johnson AK, Rubinow DR. Estradiol withdrawal triggers postpartum depression across species. Biol Psychiatry 2012; 71: 279s-279s.
214. Schiller CE, O'Hara MW, Rubinow DR, Johnson AK. Estradiol modulates anhedonia and behavioral despair in rats and negative affect in a subgroup of women at high risk for postpartum depression. Physiol Behav 2013; 119: 137-144.
215. Moses-Kolko EL, Berga SL, Kalro B, Sit DKY, Wisner KL. Transdermal estradiol for postpartum depression: a promising treatment option. Clin Obstet Gynecol 2009; 52: 516-529.
216. Ho SS, Konrath S, Brown S, Swain JE. Empathy and stress related neural responses in maternal decision making. Front Neurosci 2014; 8: 152.
217. Wisner KL, Hanusa BH, Perel JM, Peindl KS, Piontek CM, Sit DKY, Findling RL, Moses-Kolko EL. Postpartum depression: a randomized trial of sertraline vs nortriptyline. J Clin Psychopharmacol 2006; 26: 353-360.
218. Sacher J, Wilson AA, Houle S, Rusjan P, Hassan S, Bloomfield PM, Stewart DE, Meyer JH. Elevated brain monoamine oxidase a binding in the early postpartum period. Arch Gen Psychiatry 2010; 67: 468-474.
219. Van Essen DC, Ugurbil K. The future of the human connectome. NeuroImage 2012; 62: 1299-1310.
220. Soper D The free statistics calculators website. 2010; http://www.danielsoper.com/statcalc.
221. Miller GA, Rockstroh B. Endophenotypes in psychopathology research: where do we stand? Ann Rev Clin Psychol 2013; 9: 177-213.
222. Phillips ML, Ladoucer CD, Drevets WC. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 2008; 13: 833-857.