Limbic brain responses in mothers with post-traumatic stress disorder and comorbid dissociation to video clips of their children

Stress

Volumn 16, Issue 5, 2013, Pages 493-502

  Moser, Dominik Andreas ^a,b   Aue, Tatjana ^b   Wang, Zhishun ^c   Rusconi Serpa, Sandra ^a,b   Favez, Nicolas ^b   Peterson, Bradley Scott ^c   Schechter, Daniel Scott ^a,b,c  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Dissociation; Emotion regulation; Functional neuroimaging; Interpersonal violence; Parenting; PTSD

Indexed keywords

AROUSAL; ARTICLE; BOLD SIGNAL; BRAIN FUNCTION; CEREBELLUM; CINGULATE GYRUS; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DISEASE SEVERITY; DISSOCIATIVE DISORDER; DISSOCIATIVE EXPERIENCES SCALE; DISTRESS SYNDROME; EMOTIONALITY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; FUSIFORM GYRUS; HIPPOCAMPUS; HUMAN; INTERPERSONAL STRESS; LIMBIC CORTEX; LIMBIC SYSTEM; MATERNAL DISEASE; MENTAL DISSOCIATION; MESENCEPHALON; MIDDLE TEMPORAL GYRUS; MOTHER CHILD RELATION; PARAHIPPOCAMPAL GYRUS; POSTCENTRAL GYRUS; POSTTRAUMATIC STRESS DISORDER; PREFRONTAL CORTEX; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; SUPERIOR TEMPORAL GYRUS; SUPPLEMENTARY MOTOR AREA; VIDEORECORDING;

EID: 84881274168     PISSN: 10253890     EISSN: 16078888     Source Type: Journal    
DOI: 10.3109/10253890.2013.816280     Document Type: Article

References (46)

1. Abidin R. (1990). Parenting stress index test manual. Charlottesville, VA: Pediatric Psychology Press
2. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: APA
3. Ashburner J, Neelin P, Collins DL, Evans A, Friston K. 1997. Incorporating prior knowledge into image registration. Neuroimage 6:344-52
4. Bailey HN, Moran G, Pederson DR. (2007). Childhood maltreatment, complex trauma symptoms, and unresolved attachment in an at-risk sample of adolescent mothers. Attach Hum Dev 9:139-61
5. Barrett J, Wonch KE, Gonzalez A, Ali N, Steiner M, Hall GB, Fleming AS. (2011). Maternal affect and quality of parenting experiences are related to amygdala response to infant faces. Soc Neurosci 7:252-68
6. Benjamin LR, Benjamin R, Rind B. (1996). Dissociative mothers' subjective experience of parenting. Child Abuse Negl 20:933-42
7. Bernstein EM, Putnam FW. (1986). Development, reliability, and validity of a dissociation scale. J Nerv Ment Dis 174:727-35
8. Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, Keane TM. (1995). The development of a Clinician-Administered PTSD Scale. J Trauma Stress 8(1):75-90
9. Bremner JD. (1999). Acute and chronic responses to psychological trauma: Where do we go from here? Am J Psychiatry 156:349-51
10. Bremner JD, Southwick S, Brett E, Fontana A, Rosenheck R, Charney DS. (1992). Dissociation and posttraumatic stress disorder in Vietnam combat veterans. Am J Psychiatry 149:328-32
11. Breslau N, Lucia VC, Alvarado GF. (2006). Intelligence and other predisposing factors in exposure to trauma and posttraumatic stress disorder: A follow-up study at age 17 years. Arch Gen Psychiatry 63: 1238-45
12. Butler LD, Duran RE, Jasiukaitis P, Koopman C, Spiegel D. (1996). Hypnotizability and traumatic experience: A diathesis-stress model of dissociative symptomatology. Am J Psychiatry 153:42-63
13. Cohen LR, Hien DA, Batchelder S. (2008). The impact of cumulative maternal trauma and diagnosis on parenting behavior. Child Maltreat 13(1):27-38
14. Dubester KA, Braun BG. (1995). Psychometric properties of the Dissociative Experiences Scale. J Nerv Ment Dis 183:231-5
15. Dutra L, Bureau JF, Holmes B, Lyubchik A, Lyons-Ruth K. (2009). Quality of early care and childhood trauma: A prospective study of developmental pathways to dissociation. J Nerv Ment Dis 197: 383-90
16. Etkin A, Wager TD. (2007). Functional neuroimaging of anxiety: A metaanalysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 164:1476-88
17. Felmingham K, Kemp AH, Williams L, Falconer E, Olivieri G, Peduto A, Bryant R. (2008). Dissociative responses to conscious and non-conscious fear impact underlying brain function in posttraumatic stress disorder. Psychol Med 38:1771-80
18. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC. (1995). Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): Use of a cluster-size threshold. Magn Reson Med 33:636-47
19. Gilboa A, Shalev AY, Laor L, Lester H, Louzoun Y, Chisin R, Bonne O. (2004). Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorder. Biol Psychiatry 55:263-72
20. Hopper JW, Frewen PA, van der Kolk BA, Lanius RA. (2007). Neural correlates of reexperiencing, avoidance, and dissociation in PTSD: Symptom dimensions and emotion dysregulation in responses to script-driven trauma imagery. J Trauma Stress 20:713-25
21. Lanius RA, Vermetten E, Loewenstein RJ, Brand B, Schmahl C, Bremner JD, Spiegel D. (2010). Emotion modulation in PTSD: Clinical and neurobiological evidence for a dissociative subtype. Am J Psychiatry 167:640-7
22. Lanius RA, Williamson PC, Bluhm RL, Densmore M, Boksman K, Neufeld RW, Gati JS, Menon RS. (2005). Functional connectivity of dissociative responses in posttraumatic stress disorder: A functional magnetic resonance imaging investigation. Biol Psychiatry 57: 873-84
23. Lanius RA, Williamson PC, Boksman K, Densmore M, Gupta M, Neufeld RW, Gati JS, Menon RS. (2002). Brain activation during script-driven imagery induced dissociative responses in PTSD: A functional magnetic resonance imaging investigation. Biol Psychiatry 52:305-11
24. Lieberman MD, Cunningham WA. (2009). Type I and Type II error concerns in fMRI research: Re-balancing the scale. Soc Cogn Affect Neurosci 4:423-8
25. Ludascher P, Valerius G, Stiglmayr C, Mauchnik J, Lanius RA, Bohus M, Schmahl C. (2010). Pain sensitivity and neural processing during dissociative states in patients with borderline personality disorder with and without comorbid posttraumatic stress disorder: A pilot study. J Psychiatry Neurosci 35:177-84
26. Lyons-Ruth K, Block D. (1996). The disturbed caregiving system: Relations among childhood trauma, maternal caregiving, and infant affect and attachment. Infant Mental Health J 17:257-75
27. New AS, Fan J, Murrough JW, Liu X, Liebman RE, Guise KG, Tang CY, Charney DS. (2009). A functional magnetic resonance imaging study of deliberate emotion regulation in resilience and posttraumatic stress disorder. Biol Psychiatry 66:656-64
28. Noriuchi M, Kikuchi Y, Senoo A. (2008). The functional neuroanatomy of maternal love: Mother's response to infant's attachment behaviors. Biol Psychiatry 63:415-23
29. Sapolsky RM. (1990). Glucocorticoids, hippocampal damage and the glutamatergic synapse. Prog Brain Res 86:13-23
30. Schalinski I, Elbert T, Schauer M. (2011). Female dissociative responding to extreme sexual violence in a chronic crisis setting: The case of Eastern Congo. J Trauma Stress 24:235-8
31. Schechter DS, Coates S, Kaminer T, Coots T, Zeanah C, Davies M, Schonfeld IS, et al. (2008). Distorted maternal mental representations and atypical behavior in a clinical sample of violence-exposed mothers and their toddlers. J Trauma Dissociation 9(2):123-47
32. Schechter DS, Gross A, Willheim E, McCaw J, Turner JB, Myers MM, Zeanah CH, Gleason MM. (2009). Is maternal PTSD associated with greater exposure of very young children to violent media? J Trauma Stress 22:658-62
33. Schechter DS, Moser DA, McCaw J, Myers MM. (2013). Autonomic functioning in mothers with interpersonal violence-related posttraumatic stress disorder in response to separation-reunion. Dev Psychobiol. [Epub ahead of print]. doi: 10.1002/dev.21144
34. Schechter DS, Moser DA, Wang Z, Marsh R, Hao X, Duan Y, Yu S, et al. (2012). An fMRI study of the brain responses of traumatized mothers to viewing their toddlers during separation and play. Soc Cogn Affect Neurosci 7:969-79
35. Schechter DS, Willheim E. (2009). Disturbances of attachment and parental psychopathology in early childhood. Child Adolesc Psychiatr Clin N Am 18:665-86
36. Schechter DS, Willheim E, Hinojosa C, Scholfield-Kleinman K, Turner JB, McCaw J, Zeanah CH, Myers MM. (2010). Subjective and objective measures of parent-child relationship dysfunction, child separation distress, and joint attention. Psychiatry 73:130-44
37. Simeon D, Knutelska M, Yehuda R, Putnam F, Schmeidler J, Smith LM. (2007). Hypothalamic-Pituitary-Adrenal axis function in dissociative disorders, post-Traumatic stress disorder, and healthy volunteers. Biol Psychiatry 61:966-73
38. Singer T, Critchley HD, Preuschoff K. (2009). A common role of insula in feelings, empathy and uncertainty. Trends Cogn 13:334-40
39. Spiegel D, Cardena E. (1991). Disintegrated experience: The dissociative disorders revisited. J Abnorm Psychol 100:366-78
40. Strathearn L, Li J, Fonagy P, Montague PR. (2008). What's in a smile? Maternal brain responses to infant facial cues. Pediatrics 122:40-51
41. Sturge-Apple ML, Davies PT, Cicchetti D, Manning LG. (2012). Interparental violence, maternal emotional unavailability and children's cortisol functioning in family contexts. Dev Psychol 48: 237-49
42. Viinikainen M, Jaaskelainen IP, Alexandrov Y, Balk MH, Autti T, Sams M. (2010). Nonlinear relationship between emotional valence and brain activity: Evidence of separate negative and positive valence dimensions. Hum Brain Mapp 31:1030-40
43. Vrticka P, Bondolfi G, Sander D, Vuilleumier P. (2012). The neural substrates of social emotion perception and regulation are modulated by adult attachment style. Soc Neurosci 7:473-93
44. Weathers FW, Keane TM, Davidson Jr. (2001). Clinician-Administered PTSD scale: A review of the first ten years of research. Depress Anxiety 13:132-56
45. Weniger G, Lange C, Sachsse U, Irle E. (2008). Amygdala and hippocampal volumes and cognition in adult survivors of childhood abuse with dissociative disorders. Acta Psychiatr Scand 118:281-90
46. World Medical Association. (1999). Proposed revision of the Declaration of Helsinki. BME 147:18-22