Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth

European Journal of Cancer

Volumn 50, Issue 18, 2014, Pages 3187-3197

  Rios M ^a   Foretz, M ^b   Viollet, B ^b   Prieto, A ^c   Fraga, M ^a   Garcia Caballero T ^a   Costoya, J A ^a   Senaris R ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b INSERM   (France)

^c HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

AMPK; Glioma; Lipid metabolism; Lipoprotein receptors

Indexed keywords

FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPOPROTEIN; LIPOPROTEIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RAF PROTEIN; PTEN PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTOMA; CANCER GROWTH; CANCER TISSUE; CELL ORGANELLE; CONTROLLED STUDY; ENERGY EXPENDITURE; ENZYME ACTIVATION; FATTY ACID SYNTHESIS; GENE DELETION; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; INTERNALIZATION; LIPID METABOLISM; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; ASTROCYTE; BIOSYNTHESIS; BRAIN TUMOR; CELL PROLIFERATION; ENZYMOLOGY; GENETIC TRANSFECTION; GLIOBLASTOMA; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL CULTURE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ASTROCYTES; BRAIN NEOPLASMS; CELL PROLIFERATION; FATTY ACIDS; GLIOBLASTOMA; HUMANS; LIPID METABOLISM; MICE, KNOCKOUT; PTEN PHOSPHOHYDROLASE; RECEPTORS, LIPOPROTEIN; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 84925223796     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2014.09.014     Document Type: Article

References (36)

1. Y.K. Adlakha, S. Khanna, R. Singh, V.P. Singh, A. Agrawal, and N. Saini Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis Cell Death Dis 4 2013 e780
2. F.D. Battey, M.E. Gåfvels, D.J. FitzGerald, W.S. Argraves, D.A. Chappell, and J.F. Strauss 3rd The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor J Biol Chem 269 1994 23268 23273
3. E.G. Bligh, and W.J. Dyer A rapid method of total lipid extraction and purification Can J Biochem Physiol 37 1959 911 917
4. D. Bungard, B.J. Fuerth, P.Y. Zeng, B. Faubert, N.L. Maas, and B. Viollet Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation Science 329 2010 1201 1205
5. V. Chajès, M. Cambot, K. Moreau, G.M. Lenoir, and V. Joulin Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival Cancer Res 66 2006 5287 5294
6. D. Cheng, C.H. Chu, L. Chen, J.N. Feder, G.A. Mintier, and Y. Wu Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes Protein Expr Purif 51 2007 11 21
7. E. Currie, A. Schulze, R. Zechner, T.C. Walther, and R.V. Farese Jr. Cellular fatty acid metabolism and cancer Cell Metab S1550-4131 13 2013 00207 00306
8. Y. Di, Z. Liu, J. Tian, Y. Zong, P. Yang, and S. Qu TFPI or uPA-PAI-1 complex affect cell function through expression variation of type II very low density lipoprotein receptor FEBS Lett 584 2010 3469 3473
9. J.I. Epstein, M. Carmichael, and A.W. Partin OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate Urology 45 1995 81 86
10. S. Fogarty, and D.G. Hardie Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer Biochim Biophys Acta 1804 2010 581 591
11. F.B. Furnari, T. Fenton, R.M. Bachoo, A. Mukasa, J.M. Stommel, and A. Stegh Malignant astrocytic glioma: genetics, biology, and paths to treatment Genes Dev 21 2007 2683 2710
12. L. He, Y. Lu, P. Wang, J. Zhang, C. Yin, and S. Qu Up-regulated expression of type II very low density lipoprotein receptor correlates with cancer metastasis and has a potential link to β-catenin in different cancers BMC Cancer 10 2010 601
13. T.A. Hembrough, J.F. Ruiz, A.E. Papathanassiu, S.J. Green, and D.K. Strickland Tissue factor pathway inhibitor inhibits endothelial cell proliferation via association with the very low density lipoprotein receptor J Biol Chem 276 2001 12241 12248
14. T.A. Hembrough, J.F. Ruiz, B.M. Swerdlow, G.M. Swartz, H.J. Hammers, and L. Zhang Identification and characterization of a very low density lipoprotein receptor-binding peptide from tissue factor pathway inhibitor that has antitumor and antiangiogenic activity Blood 103 2004 3374 3380
15. K. Inoki, H. Ouyang, T. Zhu, C. Lindvall, Y. Wang, and X. Zhang TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth Cell 126 2006 955 968
16. T. Jang, J.M. Calaoagan, E. Kwon, S. Samuelsson, L. Recht, and K.R. Laderoute 5-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat Int J Cancer 128 2011 2230 2239
17. R.G. Jones, D.R. Plas, S. Kubek, M. Buzzai, J. Mu, and Y. Xu AMP-activated protein kinase induces a p53-dependent metabolic checkpoint Mol Cell 18 2005 283 293
18. A.J. Levine, and A.M. Puzio-Kuter The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes Science 330 2010 1340 1344
19. D. Li, D. Wang, Y. Wang, W. Ling, X. Feng, and M. Xia Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice J Biol Chem 285 2010 33499 33509
20. C.C. Liu, J. Prior, D. Piwnica-Worms, and G. Bu LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy Proc Natl Acad Sci USA 107 2010 5136 5141
21. J.D. Medh, G.L. Fry, S.L. Bowen, M.W. Pladet, D.K. Strickland, and D.A. Chappell The 39-kDa receptor-associated protein modulates lipoprotein catabolism by binding to LDL receptors J Biol Chem 270 1995 536 540
22. L.Z. Milgraum, L.A. Witters, G.R. Pasternack, and F.P. Kuhajda Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma Clin Cancer Res 3 1997 2115 2120
23. C. Muñoz-Pinedo, N. El Mjiyad, and J.E. Ricci Cancer metabolism: current perspectives and future directions Cell Death Dis 3 2012 e248
24. C.M. Nepokroeff, M.R. Lakshmanan, and J.W. Porter Fatty-acid synthase from rat liver Methods Enzymol 35 1975 37 44
25. H. Ohgaki, and P. Kleihues Genetic pathways to primary and secondary glioblastoma Am J Pathol 170 2007 1445 1453
26. H.U. Park, S. Suy, M. Danner, V. Dailey, Y. Zhang, and H. Li AMP-activated protein kinase promotes human prostate cancer cell growth and survival Mol Cancer Ther 8 2009 733 741
27. M. Ríos, M. Foretz, B. Viollet, A. Prieto, M. Fraga, and J.A. Costoya AMPK activation by oncogenesis is required to maintain cancer cell proliferation in astrocytic tumors Cancer Res 73 2013 2628 2638
28. R. Seethala, Z. Ma, R. Golla, and D. Cheng A homogeneous scintillation proximity assay for acetyl coenzyme A carboxylase coupled to fatty acid synthase Anal Biochem 358 2006 257 265
29. R.J. Shaw, N. Bardeesy, B.D. Manning, L. Lopez, M. Kosmatka, and R.A. DePinho The LKB1 tumor suppressor negatively regulates mTOR signalling Cancer Cell 6 2004 91 99
30. H. Song, Y. Li, J. Lee, A.L. Schwartz, and G. Bu Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9 Cancer Res 69 2009 879 886
31. S. Vitols, C. Peterson, O. Larsson, P. Holm, and B. Aberg Elevated uptake of low density lipoproteins by human lung cancer tissue in vivo Cancer Res 52 1992 6244 6247
32. S.J. Wakil Fatty acid synthase, a proficient multifunctional enzyme Biochemistry 28 1983 4523 4530
33. O. Warburg, F. Wind, and E. Negelein The metabolism of tumors in the body J Gen Physiol 8 1927 519 530
34. Y. Zenimaru, S. Takahashi, M. Takahashi, K. Yamada, T. Iwasaki, and H. Hattori Glucose deprivation accelerates VLDL receptor-mediated TG-rich lipoprotein uptake by AMPK activation in skeletal muscle cells Biochem Biophys Res Commun 368 2008 716 722
35. Y. Zhao, E.B. Butler, and M. Tan Targeting cellular metabolism to improve cancer therapeutics Cell Death and Disease 4 2013 e532
36. W. Zhao, S. Kridel, A. Thorburn, M. Kooshki, J. Little, and S. Hebbar Fatty acid synthase: a novel target for antigliomatherapy Br J Cancer 95 2006 869 878