Angiopoietin-like protein 3 promotes preservation of stemness during Ex Vivo expansion of murine hematopoietic stem cells

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Farahbakhshian, Elnaz ^a   Verstegen, Monique M ^a   Visser, Trudi P ^a   Kheradmandkia, Sima ^a   Geerts, Dirk ^a   Arshad, Shazia ^a   Riaz, Noveen ^a   Grosveld, Frank ^a   Van Til, Niek P ^a   Meijerink, Jules P P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE PROTEIN 3; CD135 ANTIGEN; FIBROBLAST GROWTH FACTOR 1; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; SOMATOMEDIN B; STEM CELL ANTIGEN 1; STEM CELL FACTOR; THROMBOPOIETIN; UNCLASSIFIED DRUG; ANGPTL3 PROTEIN, MOUSE; LY ANTIGEN; LY6A PROTEIN, MOUSE; MEMBRANE PROTEIN; STEM CELL FACTOR RECEPTOR;

ACCESSORY CELL; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA THALASSEMIA; CELL DIFFERENTIATION; CELL ISOLATION; CELL POPULATION; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; FOLLOW UP; GENE OVEREXPRESSION; HEMATOLOGICAL PROCEDURE; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; STEM CELL CULTURE; STEM CELL EXPANSION; STEMNESS PRESERVATION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; FLOW CYTOMETRY; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; METABOLISM; PROCEDURES;

ANGIOPOIETINS; ANIMALS; ANTIGENS, LY; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; FIBROBLAST GROWTH FACTOR 1; FLOW CYTOMETRY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HELA CELLS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR II; LENTIVIRUS; MALE; MEMBRANE PROTEINS; MICE, INBRED BALB C; PROTO-ONCOGENE PROTEINS C-KIT; STEM CELL FACTOR; THROMBOPOIETIN; TRANSFECTION;

EID: 84925221464     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105642     Document Type: Article

References (53)

1. Attar EC, Scadden DT (2004) Regulation of hematopoietic stem cell growth. Leukemia 18: 1760-1768. (Pubitemid 39530003)
2. Reya T (2003) Regulation of Hematopoietic Stem Cell Self-Renewal. Recent Prog Horm Res 58: 283-295.
3. Boyiadzis M, Pavletic S (2004) Haematopoietic stem cell transplantation: indications, clinical developments and future directions. Expert Opinion on Pharmacotherapy 5: 97-108. (Pubitemid 38072722)
4. Gratwohl A, Passweg J, Bocelli-Tyndall C, Fassas A, van Laar JM, et al. (2005) Autologous hematopoietic stem cell transplantation for autoimmune diseases. Bone Marrow Transplant 35: 869-879. (Pubitemid 40667629)
5. Samantha L, Ginn JAC, Kramer B, Smyth CM, Wong M, et al. (2005) Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia. MJA 182 (9): 458-463. (Pubitemid 40667812)
6. Shizuru JA, Negrin RS, Weissman IL (2005) Hematopoietic Stem and Progenitor Cells: Clinical and Preclinical Regeneration of the Hematolymphoid System. Annual Review of Medicine 56: 509-538. (Pubitemid 40305275)
7. Sauvageau G, Iscove NN, Humphries RK (2004) In vitro and in vivo expansion of hematopoietic stem cells. Oncogene 23: 7223-7232. (Pubitemid 39382156)
8. Sorrentino BP (2004) Clinical strategies for expansion of haematopoietic stem cells. Nat Rev Immunol 4: 878-888.
9. Goff JP, Shields DS, Greenberger JS (1998) Influence of Cytokines on the Growth Kinetics and Immunophenotype of Daughter Cells Resulting From the First Division of Single CD34+Thy-1+lin2 Cells. Blood 92: 4098-4107. (Pubitemid 28544326)
10. Antonchuk J, Sauvageau G, Humphries RK (2002) HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109: 39.
11. Sauvageau G, Thorsteinsdottir U, Eaves CJ (1995) Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9: 1753.
12. Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, et al. (2003) LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1. Science 302: 415-419. (Pubitemid 37296260)
13. Matthews JM, Lester K, Joseph S, Curtis DJ (2013) LIM-domain-only proteins in cancer. Nat Rev Cancer 13: 111-122.
14. McCormack MP, Rabbitts TH (2004) Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined Immunodeficiency. New England Journal of Medicine 350: 913-922. (Pubitemid 38252539)
15. Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, et al. (2007) Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy. Leukemia 21: 754-763. (Pubitemid 46444560)
16. Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT (2002) Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood 99: 2369-2378. (Pubitemid 34525422)
17. Linnekin D, Keller JR, Ferris DK, Mou SM, Broudy V, et al. (1995) Stem cell factor induces phosphorylation of a 200 kDa protein which associates with c-kit. Growth Factors 12: 57-67.
18. Mouthon MA, Van der Meeren A, Gaugler MH, Visser TP, Squiban C, et al. (1999) Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation. Int J Radiat Oncol Biol Phys 43: 867-875. (Pubitemid 29152660)
19. Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, et al. (2007) Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche. Cell Stem Cell 1: 685-697. (Pubitemid 350215333)
20. Lisovsky M, Estrov Z, Zhang X, Consoli U, Sanchez-Williams G, et al. (1996) Flt3 ligand stimulates proliferation and inhibits apoptosis of acute myeloid leukemia cells: regulation of Bcl-2 and Bax. pp. 3987-3997.
21. Yeoh JSG, van Os R, Weersing E, Ausema A, Dontje B, et al. (2006) Fibroblast Growth Factor-1 and -2 Preserve Long-Term Repopulating Ability of Hematopoietic Stem Cells in Serum-Free Cultures. pp. 1564-1572.
22. de Haan G, Weersing E, Dontje B, van Os R, Bystrykh LV, et al. (2003) In Vitro Generation of Long-Term Repopulating Hematopoietic Stem Cells by Fibroblast Growth Factor-1. Developmental Cell 4: 241-251. (Pubitemid 36221800)
23. Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423: 409-414. (Pubitemid 36626987)
24. Chou S, Lodish HF (2010) Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells. Proc Nat Aca Sciences 107: 7799-7804.
25. Zhang CC, Lodish HF (2004) Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells. Blood 103: 2513-2521. (Pubitemid 38393001)
26. Zhang CC, Kaba M, Ge G, Xie K, Tong W, et al. (2006) Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med 12: 240-245. (Pubitemid 43214753)
27. Zheng J, Huynh H, Umikawa M, Silvany R, Zhang CC (2011) Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche. Blood 117: 470-479.
28. Zheng J, Umikawa M, Cui C, Li J, Chen X, et al. (2012) Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature 485: 656-660.
29. Broxmeyer HE, Srour EF, Cooper S, Wallace CT, Hangoc G, et al. (2012) Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors. Blood Cells, Molecules, and Diseases 48: 25-29.
30. Amendola M, Venneri MA, Biffi A, Vigna E, Naldini L (2005) Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters. Nat Biotech 23: 108-116. (Pubitemid 41724633)
31. Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, et al. (1998) A Third-Generation Lentivirus Vector with a Conditional Packaging System. Journal of Virology 72: 8463-8471. (Pubitemid 28471781)
32. Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, et al. (1998) Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery. Journal of Virology 72: 9873-9880. (Pubitemid 28520853)
33. Merchav S, Wagemaker G (1984) Detection of murine bone marrow granulocyte/macrophage progenitor cells (GM-CFU) in serum-free cultures stimulated with purified M-CSF or GM-CSF. Int J Cell Cloning 2: 356-367. (Pubitemid 15217389)
34. Wagemaker G, Visser TP (1980) Erythropoietin-independent regeneration of erythroid progenitor cells following multiple injections of hydroxyurea. Cell Tissue Kinet 13: 505-517. (Pubitemid 10039537)
35. Guilbert LJ, Iscove NN (1976) Partial replacement of serum by selenite, transferrin, albumin and lecithin in haemopoietic cell cultures. Nature 263: 594-595.
36. van den Bos C, van Gils FC, Bartstra RW, Wagemaker G (1992) Flow cytometric analysis of peripheral blood erythrocyte chimerism in alpha-thalassemic mice. Cytometry 13: 659-662.
37. Wognum AW, Visser TP, Peters K, Bierhuizen MF, Wagemaker G (2000) Stimulation of mouse bone marrow cells with kit ligand, FLT3 ligand, and thrombopoietin leads to efficient retrovirus-mediated gene transfer to stem cells, whereas interleukin 3 and interleukin 11 reduce transduction of short- and long-term repopulating cells. Hum Gene Ther 11: 2129-2141.
38. Luens KM, Travis MA, Chen BP, Hill BL, Scollay R, et al. (1998) Thrombopoietin, kit Ligand, and flk2/flt3 Ligand Together Induce Increased Numbers of Primitive Hematopoietic Progenitors From Human CD34+Thy-1+ Lin2 Cells With Preserved Ability to Engraft SCID-hu Bone. Blood 91: 1206-1215. (Pubitemid 28086873)
39. Huynh H, Iizuka S, Kaba M, Kirak O, Zheng J, et al. (2008) Insulin-Like Growth Factor-Binding Protein 2 Secreted by a Tumorigenic Cell Line Supports Ex Vivo Expansion of Mouse Hematopoietic Stem Cells. Stem Cells 26: 1628-1635.
40. Li CL, Johnson GR (1994) Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells. Blood 84: 408-414. (Pubitemid 24215938)
41. Broudy VC, Lin NL, Kaushansky K (1995) Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85: 1719-1726.
42. Zhang CC (2008) Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood 111: 3415-3423.
43. Willert K, Brown JD, Danenberg E (2003) Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423: 448.
44. Varnum-Finney B, Brashem-Stein C, Bernstein ID (2003) Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood 101: 1784-1789. (Pubitemid 36237574)
45. Masuda S, Li M, Izpisua Belmonte JC (2013) Niche-less maintenance of HSCs by 2i. Cell Res 23: 458-459.
46. Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, et al. (2010) Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med 16: 475-482.
47. Purton LE, Bernstein ID, Collins SJ (2000) All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells. Blood 95: 470-477. (Pubitemid 30041658)
48. Peled T, Landau E, Mandel J, Glukhman E, Goudsmid NR, et al. (2004) Linear polyamine copper chelator tetraethylenepentamine augments long-term ex vivo expansion of cord blood-derived CD34+ cells and increases their engraftment potential in NOD/SCID mice. Experimental Hematology 32: 547-555. (Pubitemid 38739466)
49. Bug G, Gül H, Schwarz K, Pfeifer H, Kampfmann M, et al. (2005) Valproic Acid Stimulates Proliferation and Self-renewal of Hematopoietic Stem Cells. Cancer Research 65: 2537-2541. (Pubitemid 40490047)
50. Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, et al. (2010) Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. Science 329: 1345-1348.
51. Ikushima YM, Arai F, Hosokawa K, Toyama H, Takubo K, et al. (2013) Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells. Blood 121: 1995-2007.
52. North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, et al. (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447: 1007-1011. (Pubitemid 46975751)
53. Mullighan CG, Su X, Zhang J, Radtke I, Phillips LAA, et al. (2009) Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia. New England Journal of Medicine 360: 470-480.