Identification and characterization of ml352: A novel, noncompetitive inhibitor of the presynaptic choline transporter

ACS Chemical Neuroscience

Volumn 6, Issue 3, 2015, Pages 417-427

  Ennis, Elizabeth A ^a   Wright, Jane ^a   Retzlaff, Cassandra L ^a   McManus, Owen B ^c   Lin, Zhinong ^c   Huang, Xiaofang ^c   Wu, Meng ^c   Li, Min ^c   Daniels, J Scott ^a,b   Lindsley, Craig W ^a,b   Hopkins, Corey R ^a,b   Blakely, Randy D ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

acetylcholine; Choline; drug development; hemicholinium 3; transport

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CHOLINE; CHOLINE ACETYLTRANSFERASE; CHOLINERGIC RECEPTOR STIMULATING AGENT; DOPAMINE; HEMICHOLINIUM 3; ION CHANNEL; ML 352; NORADRENALIN TRANSPORTER; SEROTONIN; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; CARRIER PROTEIN; CHOLINE TRANSPORTER; ENZYME INHIBITOR; ISOXAZOLE DERIVATIVE; N-((3-ISOPROPYLISOXAZOL-5-YL)METHYL)-4-METHOXY-3-((1-METHYLPIPERIDIN-4-YL)OXY)BENZAMIDE; PROTEIN BINDING;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CHOLINE UPTAKE; DRUG ANALYSIS; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENCY; DRUG SPECIFICITY; HEK293 CELL LINE; IN VITRO STUDY; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; NERVE ENDING; NONHUMAN; PRESYNAPTIC CHOLINE TRANSPORTER; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT; SYNAPTOSOME; SYNTHESIS; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; FOREBRAIN; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; MOUSE; MUTATION; NERVE CELL INHIBITION; SPRAGUE DAWLEY RAT;

ANIMALS; BENZAMIDES; CHOLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HEK293 CELLS; HEMICHOLINIUM 3; HUMANS; ISOXAZOLES; MALE; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MUTATION; NEURAL INHIBITION; PROSENCEPHALON; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTOSOMES;

EID: 84925135076     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn5001809     Document Type: Article

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