Increased capacity and density of choline transporters situated in synaptic membranes of the right medial prefrontal cortex of attentional task-performing rats

Journal of Neuroscience

Volumn 25, Issue 15, 2005, Pages 3851-3856

  Apparsundaram, Subbu ^a   Martinez, Vicente ^b   Parikh, Vinay ^b   Kozak, Rouba ^b   Sarter, Martin ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Acetylcholine; Attention; Choline transporter; Prefrontal cortex; Synaptosome; Trafficking

Indexed keywords

CARRIER PROTEIN; CHOLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENTION; CHOLINERGIC SYSTEM; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; HYPOTHESIS; LEFT HEMISPHERE; MALE; MEMBRANE TRANSPORT; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; SYNAPSE; SYNAPTIC MEMBRANE; SYNAPTIC TRANSMISSION; TASK PERFORMANCE;

ANALYSIS OF VARIANCE; ANIMALS; ATTENTION; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CHOLINE; FUNCTIONAL LATERALITY; MALE; MEMBRANE TRANSPORT PROTEINS; NEURONS; NEUROPSYCHOLOGICAL TESTS; PREFRONTAL CORTEX; PRESYNAPTIC TERMINALS; PSYCHOMOTOR PERFORMANCE; RANDOM ALLOCATION; RATS; REACTION TIME; SUBCELLULAR FRACTIONS; SYNAPTIC MEMBRANES;

EID: 17644381290     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0205-05.2005     Document Type: Article

References (28)

1. Apparsundaram S, Ferguson SM, George Jr AL, Blakely RD (2000) Molecular cloning of a human, hemicholinium-3-sensitive choline transporter. Biochem Biophys Res Commun 276:862-867.
2. Arnold HM, Burk JA, Hodgson EM, Sarter M, Bruno JP (2002) Differential cortical acetylcholine release in rats performing a sustained attention task versus behavioral control tasks that do not explicitly tax attention. Neuroscience 114:451-460.
3. Bucci DJ, Holland PC, Gallagher M (1998) Removal of cholinergic input to rat posterior parietal cortex disrupts incremental processing of conditioned stimuli. J Neurosci 18:8030-8046.
4. Bunge SA, Hazeltine E, Scanlon MD, Rosen AC, Gabrieli JDE (2002) Dissociable contributions of prefrontal and parietal cortices to response selection. NeuroImage 17:1562-1571.
5. Corbetta M, Shulman GL (2002) Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci 3:201-215.
6. Corbetta M, Kincade JM, Ollinger JM, McAvoy MP, Shulman GL (2000) Voluntary orienting is dissociated from target detection in human posterior parietal cortex. Nat Neurosci 3:292-297.
7. Coull JT (1998) Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology. Prog Neurobiol 55:343-361.
8. Dalley JW, Theobald DE, Bouger P, Chudasama Y, Cardinal RN, Robbins TW (2004) Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex. Cereb Cortex 14:922-932.
9. Everitt BJ, Robbins TW (1997) Central cholinergic systems and cognition. Annu Rev Psychol 48:649-684.
10. Ferguson SM, Blakely RD (2004) The choline transporter resurfaces: new roles for synaptic vesicles? Mol Interv 4:22-37.
11. Ferguson SM, Savchenko V, Apparsundaram S, Zwick M, Wright J, Heilman CJ, Yi H, Levey AI, Blakely RD (2003) Vesicular localization and activity-dependent trafficking of presynaptic choline transporters. J Neurosci 23:9697-9709.
12. Gates Jr J, Ferguson SM, Blakely RD, Apparsundaram S (2004) Regulation of choline transporter surface expression and phosphorylation by protein kinase C and protein phosphatase 1/2A. J Pharmacol Exp Ther 310:536-545.
13. Gill TM, Sarter M, Givens B (2000) Sustained visual attention performance-associated prefrontal neuronal activity: evidence for cholinergic modulation. J Neurosci 20:4745-4757.
14. Himmelheber AM, Sarter M, Bruno JP (1997) Operant performance and cortical acetylcholine release: role of response rate, reward density, and non-contingent stimuli. Brain Res Cogn Brain Res 6:23-36.
15. Himmelheber AM, Sarter M, Bruno JP (2001) The effects of manipulations of attentional demand on cortical acetylcholine release. Brain Res Cogn Brain Res 12:353-370.
16. Iidaka T, Anderson ND, Kapur S, Cabeza R, Craik FIM (2000) The effect of divided attention on encoding and retrieval in episodic memory revealed by positron emission tomography. J Cognit Neurosci 12:267-280.
17. Martinez V, Sarter M (2004) Lateralized attentional functions of cortical cholinergic inputs. Behav Neurosci 118:984-991.
18. McGaughy J, Sarter M (1995) Behavioral vigilance in rats: task validation and effects of age, amphetamine, and benzodiazepine receptor ligands. Psychopharmacology (Berl) 117:340-357.
19. McGaughy J, Kaiser T, Sarter M (1996) Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110:247-265.
20. Moore H, Dudchenko P, Bruno JP, Sarter M (1992) Toward modeling age-related changes of attentional abilities in rats: simple and choice reaction time tasks and vigilance. Neurobiol Aging 13:759-772.
21. Nelson CL, Sarter M, Bruno JP (2005) Prefrontal cortical modulation of acetylcholine release in the posterior parietal cortex. Neuroscience, in press.
22. Parasuraman R, Warm JS, Dember WN (1987) Vigilance: taxonomy and utility. In: Ergonomics and human factors. (Mark LS, Warm JS, Huston RL, eds), pp 11-32. New York: Springer.
23. Passetti F, Dalley JW, O'Connell MT, Everitt BJ, Robbins TW (2000) Increased acetylcholine release in the rat medial prefrontal cortex during performance of a visual attentional task. Eur J Neurosci 12:3051-3058.
24. Posner MI, Dehaene S (1994) Attentional networks. Trends Neurosci 17:75-79.
25. Posner MI, Snyder CRR, Davidson BJ (1980) Attention and the detection of signals. J Exp Psychol Gen 109:160-174.
26. Sarter M, Parikh V (2005) Choline transporters, cholinergic transmission and cognition. Nat Rev Neurosci 6:48-56.
27. Sarter M, Givens B, Bruno JP (2001) The cognitive neuroscience of sustained attention: where top-down meets bottom-up. Brain Res Rev 35:146-160.
28. Sarter M, Hasselmo ME, Bruno JP, Givens B (2005) Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and top-down cholinergic modulation of signal detection. Brain Res Rev 48:98-111.