GSK3β-Dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 307, Issue 10, 2014, Pages L735-L745

  Park, Dae Won ^a,b   Jiang, Shaoning ^a   Liu, Yanping ^a   Siegal, Gene P ^c   Inoki, Ken ^d   Abraham, Edward ^e   Zmijewski, Jaroslaw W ^a  

^a University of Alabama at Birmingham   (United States)

^b Korea University College of Medicine   (South Korea)

^c University of Alabama at Birmingham   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Acute lung injury; AMPK; GSK3 ; IKK; Inflammation

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; 6 BROMOINDIRUBIN 3' OXIME; 6 CHLORO 8 NICOTINAMIDO BETA CARBOLINE; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; HIGH MOBILITY GROUP B1 PROTEIN; HISTONE H3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; I KAPPA B ALPHA; I KAPPA B BETA; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; CXCL2 CHEMOKINE; CXCL2 PROTEIN, MOUSE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HMGB1 PROTEIN, MOUSE; I KAPPA B KINASE; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; MORPHOLINE DERIVATIVE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEPHOSPHORYLATION; DISEASE SEVERITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; INFLAMMATION; LEUKOCYTE ACTIVATION; LUNG EDEMA; MACROPHAGE ACTIVATION; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; MACROPHAGE; METABOLISM; NEUTROPHIL; PATHOLOGY; PHOSPHORYLATION;

ACUTE LUNG INJURY; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL LINE; CHEMOKINE CXCL2; CHROMONES; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HMGB1 PROTEIN; I-KAPPA B KINASE; INDOLES; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MALEIMIDES; MICE; MORPHOLINES; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHOSPHORYLATION; PULMONARY EDEMA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84925121037     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00165.2014     Document Type: Article

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