Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation

American Journal of Pathology

Volumn 185, Issue 3, 2015, Pages 808-819

  Patel, Krutika ^a,b   Trivedi, Ram N ^a,b   Durgampudi, Chandra ^a   Noel, Pawan ^a,b   Cline, Rachel A ^a   Delany, James P ^a   Navina, Sarah ^a   Singh, Vijay P ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; CALCIUM; CERULETIDE; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RESISTIN; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; TUMOR NECROSIS FACTOR ALPHA; UNSATURATED FATTY ACID; ENZYME INHIBITOR; LACTONE;

3T3 CELL LINE; ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FAT NECROSIS; FATTY ACID ANALYSIS; HYPOCALCEMIA; IMMUNOHISTOCHEMISTRY; INTRAABDOMINAL FAT; LIPOLYSIS; LIPOTOXICITY; MILD ACUTE PANCREATITIS; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; OBESITY; PANCREAS NECROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEVERE ACUTE PANCREATITIS; UREA NITROGEN BLOOD LEVEL; ADIPOCYTE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; INFLAMMATION; METABOLISM; MOUSE MUTANT; NECROSIS; PANCREAS; PANCREATITIS; PATHOLOGY; PHYSIOLOGY;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CERULETIDE; ENZYME INHIBITORS; INFLAMMATION; INTRA-ABDOMINAL FAT; LACTONES; LIPASE; LIPOLYSIS; MICE; MICE, OBESE; NECROSIS; PANCREAS; PANCREATITIS; TRIGLYCERIDES;

EID: 84925061154     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.11.019     Document Type: Article

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