Obesity and fat distribution imply a greater systemic inflammatory response and a worse prognosis in acute pancreatitis

Pancreatology

Volumn 8, Issue 3, 2008, Pages 257-264

  Sempere, Laura ^a   Martinez, Juan ^a   De Madaria, Enrique ^a   Lozano, Beatriz ^a   Sanchez Paya, Jose ^a   Jover, Rodrigo ^a   Perez Mateo, Miguel ^a  

^a HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

Author keywords

Acute pancreatitis; Adipokines; Obesity; Systemic inflammatory response

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; ADULT; AGED; ARTICLE; BODY FAT DISTRIBUTION; COMORBIDITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; REGULATORY MECHANISM; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 45149099877     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000134273     Document Type: Article

References (46)

1. Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P, et al: Pathophysiology of acute pancreatitis. Pancreatology 2005;5:132-144.
2. Renzulli P, Jakob SM, Täuber M, Candinas D, Gloor B: Severe acute pancreatitis: case-oriented discussion of interdisciplinary management. Pancreatology 2005;5:145-156.
3. Weber CK, Adler G: From acinar cell damage to systemic inflammatory response: current concepts in pancreatitis. Pancreatology 2001;1:356-362.
4. Zyromski N, Murr MM: Evolving concepts in the pathophysiology of acute pancreatitis. Surgery 2003;133:235-237.
5. Bentrem DJ, Joehl RJ: Pancreas: healing response in critical illness. Crit Care Med 2003;31:S582-S589.
6. Day CP: From fat to inflammation. Gastroenterology 2006;130:207-210.
7. Norman J: The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998;175:76-83.
8. Chen CC, Wang SS, Lee FY, Chang FY, Lee SD: Proinflammatory cytokines in early assessment of the prognosis of acute pancreatitis. Am J Gastroenterol 1999;94:213-218.
9. Mayer J, Rau B, Gansauge F, Beger HG: Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications. Gut 2000;47:546-552.
10. Martinez J, Sanchez-Paya J, Palazon JM, Aparicio JR, Pico A, Perez-Mateo M: Obesity: a prognostic factor of severity in acute pancreatitis. Pancreas 1999;19:15-20.
11. Johnson CD, Toh SK, Campbell MJ: Combination of APACHE-II score and an obesity score (APACHE-O) for the prediction of severe acute pancreatitis. Pancreatology 2004;4:1-6.
12. Martinez J, Johnson CD, Sanchez-Paya J, de Madaria E, Robles-Diaz G, Perez-Mateo M: Obesity is a definitive risk factor of severity and mortality in acute pancreatitis: an updated meta-analysis. Pancreatology 2006;6:206-209.
13. Martinez J, Sanchez-Paya J, Palazon JM, Suazo-Barahona J, Robles-Diaz G, Perez-Mateo M: Is obesity a risk factor in acute pancreatitis? A meta-analysis. Pancreatology 2004;4:42-48.
14. Papachristou GI, Papachristou DJ, Avula H, Slivka A, Whitcomb DC: Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory response. Pancreatology 2006;6:279-285.
15. Mery CM, Rubio V, Duarte-Rojo A, Suazo-Barahona J, Pelaez-Luna M, Milke P, Robles-Diaz G: Android fat distribution as predictor of severity in acute pancreatitis. Pancreatology 2002;2:543-549.
16. Trayhurn P, Wood IS: Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004;92:347-355.
17. Vettor R, Milan G, Rossato M, Federspil G: Review article: adipocytokines and insulin resistance. Aliment Pharmacol Ther 2005;22(suppl 2):3-10.
18. World Health Organization: Obesity: preventing and managing the global epidemic. Report of WHO Convention, Geneva 1999. WHO Tech Rep Ser 894. Geneva, WHO, 2000.
19. National Institutes of Health, National Heart, Lung and Blood Institute: Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report. National Institutes of Health. Obes Res 1998;6(suppl 2):51S-209S.
20. Bradley EL: A clinically based classification system for acute pancreatitis. Ann Chir 1993;47:537-541.
21. Rothman KJ, Greenland S: Modern Epidemiology, ed 2. Boston, Lippincott-Raven, 1997.
22. Rabeneck L, Feinstein AR, Horwitz RI, Wells CK: A new clinical prognostic staging system for acute pancreatitis. Am J Med 1993;95:61-70.
23. Tran DD, Cuesta MA, Schneider AJ, Wesdorp RI: Prevalence and prediction of multiple organ system failure and mortality in acute pancreatitis. J Crit Care 1993;8:145-153.
24. Martinez J, Sanchez-Paya J, Palazon JM, Gutierrez A, Perez-Mateo M: The value of age as a prognostic factor of severity in acute pancreatitis. Gastroenterol Hepatol 1997;20:49-54.
25. Gupta R, Rajani R, Primrose JN, Johnson CD: Body composition, physiological function and psychological changes in patients with predicted severe acute pancreatitis. Pancreatology 2001;1:58-62.
26. Simovic MO, Bonham MJ, Abu-Zidan FM, Windsor JA: Anti-inflammatory cytokine response and clinical outcome in acute pancreatitis. Crit Care Med 1999;27:2662-2665.
27. Laveda R, Martinez J, Munoz C, Penalva JC, Saez J, Belda G, et al: Different profile of cytokine synthesis according to the severity of acute pancreatitis. World J Gastroenterol 2005;11:5309-5313.
28. Pezzilli R, Miniero R, Cappelletti O, Barakat B: Behavior of serum interleukin-12 in human acute pancreatitis. Pancreas 1999;18:247-251.
29. Banks RE, Evans SW, Alexander D, McMahon MJ, Whicher JT: Is fatal pancreatitis a consequence of excessive leukocyte stimulation? The role of tumor necrosis factor-α. Cytokine 1991;3:12-16.
30. Exley AR, Leese T, Holliday MP, Swann RA, Cohen J: Endotoxaemia and serum tumour necrosis factor as prognostic markers in severe acute pancreatitis. Gut 1992;33:1126-1128.
31. Paajanen H, Laato M, Jaakkola M, Pulkki K, Niinikoski J, Nordback I: Serum tumour necrosis factor compared with C-reactive protein in the early assessment of severity of acute pancreatitis. Br J Surg 1995;82:271-273.
32. McKay CJ, Gallagher G, Brooks B, Imrie CW, Baxter JN: Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. Br J Surg 1996;83:919-923.
33. Hirota M, Nozawa F, Okabe A, Shibata M, Beppu T, Shimada S, et al: Relationship between plasma cytokine concentration and multiple organ failure in patients with acute pancreatitis. Pancreas 2000;21:141-146.
34. Lean ME, Han TS, Seidell JC: Impairment of health and quality of life using new US federal guidelines for the identification of obesity. Arch Intern Med 1999;159:837-843.
35. Janssen I, Katzmarzyk PT, Ross R: Waist circumference and not body mass index explains obesity-related health risk. Am J Clin Nutr 2004;79:379-384.
36. Tsigos C, Kyrou I, Chala E, Tsapogas P, Stavridis JC, Raptis SA, Katsilambros N: Circulating tumor necrosis factor-α concentrations are higher in abdominal versus peripheral obesity. Metabolism 1999;48:1332-1335.
37. Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, et al: Elevated levels of interleukin-6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 2000;85:3338-3342.
38. Meier CA, Bobbioni E, Gabay C, Assimacopoulos-Jeannet F, Golay A, Dayer JM: IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin? J Clin Endocrinol Metab 2002;87:1184-1188.
39. Lyon CJ, Law RE, Hsueh WA: Minireview: adiposity, inflammation, and atherogenesis. Endocrinology 2003;144:2195-2200.
40. Cormier Y, Israel-Assayag E: Adiposity affects human response to inhaled organic dust. Am J Ind Med 2006;49:281-285.
41. Ciesla DJ, Moore EE, Johnson JL, Burch JM, Cothren CC, Sauaia A: Obesity increases risk of organ failure after severe trauma. J Am Coll Surg 2006;203:539-545.
42. Bertin E, Nguyen P, Guenounou M, Durlach V, Potron G, Leutenegger M: Plasma levels of tumor necrosis factor-α are essentially dependent on visceral fat amount in type 2 diabetic patients. Diabetes Metab 2000;26:178-182.
43. Esposito K, Pontillo A, Giugliano F, Giugliano G, Marfella R, Nicoletti G, Giugliano D: Association of low interleukin-10 levels with the metabolic syndrome in obese women. J Clin Endocrinol Metab 2003;88:1055-1058.
44. Manigrasso MR, Ferroni P, Santilli F, Taraborelli T, Guagnano MT, Michetti N, Davi G: Association between circulating adiponectin and interleukin-10 levels in android obesity: effects of weight loss. J Clin Endocrinol Metab 2005;90:5876-5879.
45. Blomgren KB, Sundstrom A, Steineck G, Wiholm BE: Obesity and treatment of diabetes with glyburide may both be risk factors for acute pancreatitis. Diabetes Care 2002;25:298-302.
46. Rau B, Cebulla M, Uhl W, Schoenberg MH, Beger HG: The clinical value of human pancreas-specific protein procarboxypeptidase B as an indicator of necrosis in acute pancreatitis: comparison to CRP and LDH. Pancreas 1998;17:134-139.