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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 7, 2015, Pages 1621-1626

Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators

(13) Hubbs, Jed L a Fuller, Nathan O a Austin, Wesley F a Shen, Ruichao a Ma, Jianguo a Gong, Zhen b Li, Jian b McKee, Timothy D a Loureiro, Robyn M B a Tate, Barbara a Dumin, Jo Ann a Ives, Jeffrey a Bronk, Brian S a

a Satori Pharmaceuticals Incorporated (United States)

b WUXI APPTEC (China)

Author keywords

Alzheimers disease; Amyloid beta; Cytochrome P450 3A4; Drugdrug interactions; Gamma secretase modulator; Natural product; Semisynthesis; Sterol

Indexed keywords

APPARENT LIFE THREATENING EVENT; ARTICLE; BLEEDING; CATHETER COMPLICATION; CATHETER DISLODGEMENT; CATHETER INFECTION; CATHETER MIGRATION; CATHETER THROMBOSIS; CENTRAL VENOUS CATHETER; DEVICE SAFETY; HUMAN; SUTURE; TECHNOLOGY; THERAPY DELAY; VASCULAR ACCESS; VEIN INJURY; VEIN THROMBOSIS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; METABOLISM; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION;

RATTUS;

AZETIDINE DERIVATIVE; BIOLOGICAL PRODUCT; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; SPI-1865; STEROID;

ANIMALS; AZETIDINES; BIOLOGICAL PRODUCTS; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925057498 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.01.051 Document Type: Article

Times cited : (8)

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