메뉴 건너뛰기




Volumn 89, Issue 3, 2015, Pages 179-185

Large hospital outbreak of KPC-2-producing Klebsiella pneumoniae: Investigating mortality and the impact of screening for KPC-2 with polymerase chain reaction

Author keywords

Carriage; Colonization; Healthcare associated; Infection; Klebsiella pneumoniae carbapenemase; Length of stay; Mortality; Outbreak; Polymerase chain reaction; Resistance

Indexed keywords

ADULT; ARTICLE; BACTERIAL COLONIZATION; CARBAPENEMASE PRODUCING ENTEROBACTERIACEAE; CHOLANGITIS; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HEALTHCARE ASSOCIATED INFECTION; HOSPITAL; HOSPITAL PATIENT; HUMAN; KLEBSIELLA PNEUMONIAE CARBAPENEMASE 2 PRODUCING KLEBSIELLA PNEUMONIAE; LENGTH OF STAY; LIVER ABSCESS; MAJOR CLINICAL STUDY; MALE; MORTALITY; PERITONITIS; PNEUMONIA; POLYMERASE CHAIN REACTION; PULSED FIELD GEL ELECTROPHORESIS; RETROSPECTIVE STUDY; SEPSIS; URINARY TRACT INFECTION; WOUND INFECTION; AGED; AGED, 80 AND OVER; CROSS INFECTION; DISEASE OUTBREAKS; EPIDEMIOLOGY; GENETICS; GREECE; HOSPITALS; HUMANS; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; METHODS; MICROBIOLOGY; MIDDLE AGED; RETROSPECTIVE STUDIES; STATISTICS AND NUMERICAL DATA;

EID: 84925052224     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2014.11.012     Document Type: Article
Times cited : (37)

References (31)
  • 1
    • 84882712084 scopus 로고    scopus 로고
    • Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases
    • Munoz-Price L.S., Poirel L., Bonomo R.A., et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 2013, 13:785-796.
    • (2013) Lancet Infect Dis , vol.13 , pp. 785-796
    • Munoz-Price, L.S.1    Poirel, L.2    Bonomo, R.A.3
  • 2
    • 84930486688 scopus 로고    scopus 로고
    • Global spread of carbapenemase-producing Enterobacteriaceae
    • Nordmann P., Naas T., Poirel L. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 2011, 17:1791-1798.
    • (2011) Emerg Infect Dis , vol.17 , pp. 1791-1798
    • Nordmann, P.1    Naas, T.2    Poirel, L.3
  • 3
    • 84884416366 scopus 로고    scopus 로고
    • KPC-producing Klebsiella pneumoniae enteric colonization acquired during intensive care unit stay: the significance of risk factors for its development and its impact on mortality
    • Papadimitriou-Olivgeris M., Marangos M., Fligou F., et al. KPC-producing Klebsiella pneumoniae enteric colonization acquired during intensive care unit stay: the significance of risk factors for its development and its impact on mortality. Diagn Microbiol Infect Dis 2013, 77:169-173.
    • (2013) Diagn Microbiol Infect Dis , vol.77 , pp. 169-173
    • Papadimitriou-Olivgeris, M.1    Marangos, M.2    Fligou, F.3
  • 4
    • 62749195559 scopus 로고    scopus 로고
    • The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
    • Nordmann P., Cuzon G., Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009, 9:228-236.
    • (2009) Lancet Infect Dis , vol.9 , pp. 228-236
    • Nordmann, P.1    Cuzon, G.2    Naas, T.3
  • 5
    • 56749155916 scopus 로고    scopus 로고
    • Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies
    • Patel G., Huprikar S., Factor S.H., Jenkins S.G., Calfee D.P. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008, 29:1099-1106.
    • (2008) Infect Control Hosp Epidemiol , vol.29 , pp. 1099-1106
    • Patel, G.1    Huprikar, S.2    Factor, S.H.3    Jenkins, S.G.4    Calfee, D.P.5
  • 6
    • 78649481974 scopus 로고    scopus 로고
    • Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts
    • pii=19711
    • Grundmann H., Livermore D.M., Giske C.G., et al. Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. EuroSurveillance 2010, 15. pii=19711.
    • (2010) EuroSurveillance , vol.15
    • Grundmann, H.1    Livermore, D.M.2    Giske, C.G.3
  • 7
    • 84861659831 scopus 로고    scopus 로고
    • Rapid detection of intestinal carriage of Klebsiella pneumoniae producing KPC carbapenemase during an outbreak
    • Giani T., Tascini C., Arena F., et al. Rapid detection of intestinal carriage of Klebsiella pneumoniae producing KPC carbapenemase during an outbreak. JHosp Infect 2012, 81:119-122.
    • (2012) JHosp Infect , vol.81 , pp. 119-122
    • Giani, T.1    Tascini, C.2    Arena, F.3
  • 8
    • 79955012357 scopus 로고    scopus 로고
    • Multiplex PCR for detection of acquired carbapenemase genes
    • Poirel L., Walsh T.R., Cuvillier V., et al. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis 2011, 70:119-123.
    • (2011) Diagn Microbiol Infect Dis , vol.70 , pp. 119-123
    • Poirel, L.1    Walsh, T.R.2    Cuvillier, V.3
  • 9
    • 84890161363 scopus 로고    scopus 로고
    • ESCMID guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients
    • Tacconelli E., Cataldo M.A., Dancer S.J., et al. ESCMID guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients. Clin Microbiol Infect 2014, 20(Suppl. 1):1-55.
    • (2014) Clin Microbiol Infect , vol.20 , pp. 1-55
    • Tacconelli, E.1    Cataldo, M.A.2    Dancer, S.J.3
  • 11
    • 84875536106 scopus 로고    scopus 로고
    • Gastrointestinal colonization by KPC-producing Klebsiella pneumoniae following hospital discharge: duration of carriage and risk factors for persistent carriage
    • Feldman N., Adler A., Molshatzki N., et al. Gastrointestinal colonization by KPC-producing Klebsiella pneumoniae following hospital discharge: duration of carriage and risk factors for persistent carriage. Clin Microbiol Infect 2013, 19:190-196.
    • (2013) Clin Microbiol Infect , vol.19 , pp. 190-196
    • Feldman, N.1    Adler, A.2    Molshatzki, N.3
  • 12
    • 84859889019 scopus 로고    scopus 로고
    • Identification and screening of carbapenemase-producing Enterobacteriaceae
    • Nordmann P., Gniadkowski M., Giske C.G., et al. Identification and screening of carbapenemase-producing Enterobacteriaceae. Clin Microbiol Infect 2012, 18:432-438.
    • (2012) Clin Microbiol Infect , vol.18 , pp. 432-438
    • Nordmann, P.1    Gniadkowski, M.2    Giske, C.G.3
  • 13
    • 84904049855 scopus 로고    scopus 로고
    • Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net), ECDC, Stockholm
    • European Centre for Disease Prevention and Control Antimicrobial resistance surveillance in Europe 2012 2013, Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net), ECDC, Stockholm.
    • (2013) Antimicrobial resistance surveillance in Europe 2012
  • 14
    • 84860516573 scopus 로고    scopus 로고
    • Carbapenem resistance in Enterobacteriaceae: here is the storm!
    • Nordmann P., Dortet L., Poirel L. Carbapenem resistance in Enterobacteriaceae: here is the storm!. Trends Mol Med 2012, 18:263-272.
    • (2012) Trends Mol Med , vol.18 , pp. 263-272
    • Nordmann, P.1    Dortet, L.2    Poirel, L.3
  • 15
    • 79951507915 scopus 로고    scopus 로고
    • Multiplex real-time PCR assay for detection and classification of Klebsiella pneumoniae carbapenemase gene (blaKPC) variants
    • Chen L., Mediavilla J.R., Endimiani A., et al. Multiplex real-time PCR assay for detection and classification of Klebsiella pneumoniae carbapenemase gene (blaKPC) variants. JClin Microbiol 2011, 49:579-585.
    • (2011) JClin Microbiol , vol.49 , pp. 579-585
    • Chen, L.1    Mediavilla, J.R.2    Endimiani, A.3
  • 16
    • 84982872981 scopus 로고    scopus 로고
    • Guidance for control of carbapenem-resistant Enterobacteriaceae (CRE). 2012 Toolkit
    • Centers for Disease Control and Prevention Guidance for control of carbapenem-resistant Enterobacteriaceae (CRE). 2012 Toolkit. MMWR Morbid Mortal Wkly Rep 2013, 62:165-170.
    • (2013) MMWR Morbid Mortal Wkly Rep , vol.62 , pp. 165-170
  • 17
    • 84864416294 scopus 로고    scopus 로고
    • Rectal screening for Klebsiella pneumoniae carbapenemases: comparison of real-time PCR and culture using two selective screening agar plates
    • Singh K., Mangold K.A., Wyant K., et al. Rectal screening for Klebsiella pneumoniae carbapenemases: comparison of real-time PCR and culture using two selective screening agar plates. JClin Microbiol 2012, 50:2596-2600.
    • (2012) JClin Microbiol , vol.50 , pp. 2596-2600
    • Singh, K.1    Mangold, K.A.2    Wyant, K.3
  • 18
    • 40549126250 scopus 로고    scopus 로고
    • Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality
    • Schwaber M.J., Klarfeld-Lidji S., Navon-Venezia S., Schwartz D., Laevitt A., Carmeli Y. Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality. Antimicrob Agents Chemother 2008, 52:1028-1033.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1028-1033
    • Schwaber, M.J.1    Klarfeld-Lidji, S.2    Navon-Venezia, S.3    Schwartz, D.4    Laevitt, A.5    Carmeli, Y.6
  • 19
    • 84892479911 scopus 로고    scopus 로고
    • Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options
    • Kontopidou F., Giamarellou H., Katerelos P., et al. Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options. Clin Microbiol Infect 2014, 20:117-123.
    • (2014) Clin Microbiol Infect , vol.20 , pp. 117-123
    • Kontopidou, F.1    Giamarellou, H.2    Katerelos, P.3
  • 20
    • 61349200780 scopus 로고    scopus 로고
    • Outbreak of infections due to KPC-2-producing Klebsiella pneumoniae in a hospital in Crete (Greece)
    • Maltezou H.C., Giakkoupi P., Maragos A., et al. Outbreak of infections due to KPC-2-producing Klebsiella pneumoniae in a hospital in Crete (Greece). JInfect 2009, 58:213-219.
    • (2009) JInfect , vol.58 , pp. 213-219
    • Maltezou, H.C.1    Giakkoupi, P.2    Maragos, A.3
  • 21
    • 84897473243 scopus 로고    scopus 로고
    • Colonization of liver transplant recipients with KPC-producing Klebsiella pneumoniae is associated with high infection rates and excess mortality: a case-control analysis
    • Lübbert C., Becker-Rux D., Rodloff A.C., et al. Colonization of liver transplant recipients with KPC-producing Klebsiella pneumoniae is associated with high infection rates and excess mortality: a case-control analysis. Infection 2014, 42:309-316.
    • (2014) Infection , vol.42 , pp. 309-316
    • Lübbert, C.1    Becker-Rux, D.2    Rodloff, A.C.3
  • 22
    • 84901632631 scopus 로고    scopus 로고
    • Lessons learned from excess mortality associated with Klebsiella pneumoniae carbapenemase-2-producing K.pneumoniae in liver transplant recipients
    • Lübbert C., Rodloff A.C., Laudi S., et al. Lessons learned from excess mortality associated with Klebsiella pneumoniae carbapenemase-2-producing K.pneumoniae in liver transplant recipients. Liver Transplant 2014, 20:736-738.
    • (2014) Liver Transplant , vol.20 , pp. 736-738
    • Lübbert, C.1    Rodloff, A.C.2    Laudi, S.3
  • 23
    • 81255171675 scopus 로고    scopus 로고
    • Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment
    • Zarkotou O., Pournaras S., Tselioti P., et al. Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment. Clin Microbiol Infect 2011, 17:1798-1803.
    • (2011) Clin Microbiol Infect , vol.17 , pp. 1798-1803
    • Zarkotou, O.1    Pournaras, S.2    Tselioti, P.3
  • 24
    • 83655201460 scopus 로고    scopus 로고
    • Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections
    • Ben-David D., Kordevani R., Keller N., et al. Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections. Clin Microbiol Infect 2012, 18:54-60.
    • (2012) Clin Microbiol Infect , vol.18 , pp. 54-60
    • Ben-David, D.1    Kordevani, R.2    Keller, N.3
  • 25
    • 84861576336 scopus 로고    scopus 로고
    • Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K.pneumoniae
    • Borer A., Saidel-Odes L., Eskira S., et al. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K.pneumoniae. Am J Infect Control 2012, 40:421-425.
    • (2012) Am J Infect Control , vol.40 , pp. 421-425
    • Borer, A.1    Saidel-Odes, L.2    Eskira, S.3
  • 26
    • 84876343295 scopus 로고    scopus 로고
    • Asymptomatic rectal carriage of blaKPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected?
    • Schechner V., Kotlovsky T., Kazma M., et al. Asymptomatic rectal carriage of blaKPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected?. Clin Microbiol Infect 2013, 19:451-456.
    • (2013) Clin Microbiol Infect , vol.19 , pp. 451-456
    • Schechner, V.1    Kotlovsky, T.2    Kazma, M.3
  • 27
    • 84055177500 scopus 로고    scopus 로고
    • Arandomized, double-blind, placebo-controlled trial of selective digestive decontamination using oral gentamicin and oral polymyxin E for eradication of carbapenem-resistant Klebsiella pneumoniae carriage
    • Saidel-Odes L., Polachek H., Peled N., et al. Arandomized, double-blind, placebo-controlled trial of selective digestive decontamination using oral gentamicin and oral polymyxin E for eradication of carbapenem-resistant Klebsiella pneumoniae carriage. Infect Control Hosp Epidemiol 2012, 33:14-19.
    • (2012) Infect Control Hosp Epidemiol , vol.33 , pp. 14-19
    • Saidel-Odes, L.1    Polachek, H.2    Peled, N.3
  • 28
    • 84889080918 scopus 로고    scopus 로고
    • Rapid emergence of secondary resistance to gentamicin and colistin following selective digestive decontamination in patients with KPC-2-producing Klebsiella pneumoniae: a single-centre experience
    • Lübbert C., Faucheux S., Becker-Rux D., et al. Rapid emergence of secondary resistance to gentamicin and colistin following selective digestive decontamination in patients with KPC-2-producing Klebsiella pneumoniae: a single-centre experience. Int J Antimicrob Agents 2013, 42:565-570.
    • (2013) Int J Antimicrob Agents , vol.42 , pp. 565-570
    • Lübbert, C.1    Faucheux, S.2    Becker-Rux, D.3
  • 29
    • 84888416637 scopus 로고    scopus 로고
    • Eradication of carbapenem-resistant Enterobacteriaceae gastrointestinal colonization with non-absorbable oral antibiotic treatment: a prospective controlled trial
    • Oren I., Sprecher H., Finkelstein R., et al. Eradication of carbapenem-resistant Enterobacteriaceae gastrointestinal colonization with non-absorbable oral antibiotic treatment: a prospective controlled trial. Am J Infect Control 2013, 41:1167-1172.
    • (2013) Am J Infect Control , vol.41 , pp. 1167-1172
    • Oren, I.1    Sprecher, H.2    Finkelstein, R.3
  • 30
    • 84908170888 scopus 로고    scopus 로고
    • Routine active surveillance for carbapenemase-producing Enterobacteriaceae from rectal swabs: diagnostic implications of multiplex polymerase chain reaction
    • Lowman W., Marais M., Ahmed K., Marcus L. Routine active surveillance for carbapenemase-producing Enterobacteriaceae from rectal swabs: diagnostic implications of multiplex polymerase chain reaction. JHosp Infect 2014, 88:66-71.
    • (2014) JHosp Infect , vol.88 , pp. 66-71
    • Lowman, W.1    Marais, M.2    Ahmed, K.3    Marcus, L.4
  • 31
    • 84896479162 scopus 로고    scopus 로고
    • Long-term carriage of KPC-2-producing Klebsiella pneumoniae after a large single-center outbreak in Germany
    • Lübbert C., Busch T., Kaisers U., et al. Long-term carriage of KPC-2-producing Klebsiella pneumoniae after a large single-center outbreak in Germany. Am J Infect Control 2014, 42:376-380.
    • (2014) Am J Infect Control , vol.42 , pp. 376-380
    • Lübbert, C.1    Busch, T.2    Kaisers, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.