Lymphocyte depletion after alemtuzumab induction disrupts intestinal fungal microbiota in cynomolgus monkeys

Transplantation

Volumn 98, Issue 9, 2014, Pages 951-959

  Li, Qiurong ^a   Wang, Chenyang ^a   Tang, Chun ^a   He, Qin ^a   Li, Jieshou ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Alemtuzumab; Denaturing gradient gel electrophoresis; Fungal microbiota; Lymphocyte depletion; Regulatory T cell

Indexed keywords

ALEMTUZUMAB; CD52 ANTIGEN; DNA 18S; GLYCOPROTEIN; IMMUNOSUPPRESSIVE AGENT; LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY; RIBOSOME DNA; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; ASPERGILLUS CLAVATUS; BOTRYTIS CINEREA; CANDIDA ALBICANS; COLON MUCOSA; CONTROLLED STUDY; DYSBIOSIS; ERYTHROCYTE; FECES MICROFLORA; FUNGAL COLONIZATION; FUNGAL COMMUNITY; INTESTINE FLORA; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; LYMPHOCYTE DIFFERENTIATION; MACACA FASCICULARIS; MALE; MICROBIAL DIVERSITY; MOLECULAR GENETICS; MUCOSAL IMMUNITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SINGLE DRUG DOSE; SPECIES COMPOSITION; T LYMPHOCYTE SUBPOPULATION; ANIMAL; ASPERGILLUS; CYTOLOGY; DRUG EFFECTS; FECES; IMMUNOLOGY; INTESTINE; INTESTINE MUCOSA; LYMPHOCYTE; METABOLISM; MICROBIOLOGY; MICROFLORA; PROCEDURES; TIME;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIGENS, CD; ANTIGENS, NEOPLASM; ASPERGILLUS; CANDIDA ALBICANS; DNA, RIBOSOMAL; ERYTHROCYTES; FECES; GLYCOPROTEINS; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL MUCOSA; INTESTINES; LYMPHOCYTE DEPLETION; LYMPHOCYTES; MACACA FASCICULARIS; MALE; MICROBIOTA; SACCHAROMYCES CEREVISIAE; TIME FACTORS;

EID: 84925021402     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0000000000000373     Document Type: Article

References (35)

1. Zaragoza R, Pemán J. Invasive fungal infections in critically ill patients: different therapeutic options and a uniform strategy. Rev Iberoam Micol 2006; 23: 59.
2. Pappas PG, Alexander BD, Andes DR, et al. Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clin Infect Dis 2010; 50: 1101.
3. Lora VH, Andrew JM. Immune adaptations that maintain homeo-stasis with the intestinal microbiota. Nat Rev Immunol 2010; 10: 159.
4. Andrew JM, Nicola LH. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 2004; 4: 478.
5. Chang JT, Palanivel VR, Kinjyo I, et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 2007; 315: 1687.
6. Reinherz EL, Schlossman SF. Regulation of the immune responseV inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med 1980; 303: 370.
7. Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 2009; 9: 313.
8. Ismail AS, Behrendt CL, Hooper LV. Reciprocal interactions between commensal bacteria and FC intraepithelial lymphocytes during mu-cosal injury. J Immunol 2009; 182: 3047.
9. Hrncir T, Stepankova R, Kozakova H, et al. Gut microbiota and lipo-polysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice. BMC Immunology 2008; 9: 65.
10. Samaranayake LP, MacFarlane TW. The adhesion of the yeast Candida albicans to epithelial cells of human origin in vitro. Arch Oral Biol 1981; 26: 815.
11. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immuno-logic self-tolerance and negative control of immune responses. Ann Rev Immunol 2004; 22: 531.
12. Cavassani KA, Campanelli AP, Moreira AP, et al. Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans. J Immunol 2006; 177: 5811.
13. Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat Immunol2005; 6: 353.
14. Khoo UY, Proctor IE, Macpherson AJ. CD4+ T cell downregulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens. J Immunol 1997; 158: 3626.
15. Huffnagle GB, Noverr MC. The emerging world of the fungal microbiome. Trends Microbiol 2013; 21: 334.
16. Iliev ID, Funari VA, Taylor KD, et al. Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science 2012; 336: 1314.
17. Moyes DL, Naglik JR. The mycobiome: influencing IBD severity. Cell Host Microbe 2012; 11: 551.
18. van der Velden WJ, Netea MG, de Haan AF, et al. Role of the mycobiome in human acute graft-versus-host disease. Biol Blood Marrow Transplant 2013; 19: 329.
19. Silva RF. Chapter 8: fungal infections in immunocompromised patients. J Bras Pneumol 2010; 36: 142.
20. Safdar N, Smith J, Knasinski V, et al. Infections after the use of alemtuzumab in solid organ transplant recipients: a comparative study. Diagn Microbiol Infect Dis 2010; 66: 7.
21. van der Windt DJ, Smetanka C, Macedo C, et al. Investigation of lymphocyte depletion and repopulation using alemtuzumab (Campath-1H) in cynomolgus monkeys. Am J Transplant 2010; 10: 773.
22. Watsona CJE, Bradleya JA, Friend PJ, et al. Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantationVefficacy and safety at five years. Am J Transplant 2005; 5: 1347.
23. Reams BD, Musselwhite LW, Zaas DW, et al. Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation. Am J Transplant 2007; 7: 2802.
24. Perry AC, Jones R, Hall L. Identification of an abundant monkey epididymal transcript encoding a homologue of human CAMPATH-1 antigen precursor. Biochim Biophys Acta 1992; 1171: 122.
25. Ley RE, Backhed F, Turnbaugh P, et al. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 2005; 102: 11070.
26. Winter SE, Lopez CA, Bäumler AJ. The dynamics of gut-associated microbial communities during inflammation. EMBO Rep 2013; 14: 319.
27. Wormley FLJr, Steele C, Wozniak K, et al. Resistance of T-cell receptor C-chain-deficient mice to experimental Candida albicans vaginitis. Infect Immun 2001; 69: 7162.
28. Romani L.Immunity to fungal infections. Nat Rev Immunol 2011; 11: 275.
29. Balish E, Balish MJ, Salkowski CA, et al. Colonization of congenitally athymic, gnotobiotic mice by Candida albicans. Appl Environ Microbiol 1984; 47: 647.
30. Li Q, Wang C, Zhang Q, et al. Use of 18S ribosomal DNA polymerase chain reaction-denaturing gradient gel electrophoresis to study composition of fungal community in 2 patients with intestinal transplants. Hum Pathol 2012; 43: 1273.
31. Moyes DL, Naglik JR. Mucosal immunity and Candida albicans infection. Clin Dev Immunol 2011; 2011: 307.
32. Wiesner SM, Jechorek RP, Garni RM, et al. Gastrointestinal colonization by Candida albicans mutant strains in antibiotic-treated mice. Clin Diagn Lab Immunol 2001; 8: 192.
33. Ott SJ, Kühbacher T, Musfeldt M, et al. Fungi and inflammatory bowel diseases: alterations of composition and diversity. Scand J Gastroenterol 2008; 43: 831.
34. Ashman RB. Protective and pathologic immune responses against Candida albicans infection. Front Biosci 2008; 13: 3334.
35. Mason KL, Erb Downward JR, Mason KD, et al. Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy. Infect Immun 2012; 80: 3371.