Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: Results from the German Investigation on Neurobiology in Alcoholism (GINA)

Alcohol

Volumn 49, Issue 2, 2015, Pages 97-101

  Semmler, Alexander ^a   Heese, Peter ^b   Stoffel Wagner, Birgit ^c   Muschler, Marc ^d   Heberlein, Annemarie ^d   Bigler, Laurent ^a   Prost, Jean Christophe ^a   Frieling, Helge ^d   Kornhuber, Johannes ^d   Banger, Markus ^b   Bleich, Stefan ^d   Hillemacher, Thomas ^d   Linnebank, Michael ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b LVR Clinic Bonn   (Germany)

^c UNIVERSITY HOSPITAL BONN   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Alcohol; DNA methylation; Homocysteine; Single nucleotide polymorphism; Smoking; Vitamins

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; CYSTATHIONINE BETA SYNTHASE; DIHYDROFOLATE REDUCTASE; FOLIC ACID; GENOMIC DNA; HOMOCYSTEINE; PYRIDOXINE; RIBOFLAVIN; THIAMINE;

ADULT; AGED; ALCOHOL ABUSE; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOLISM; AMINO ACID METABOLISM; ARTICLE; BLOOD SAMPLING; CBS GENE; CONTROLLED STUDY; DETOXIFICATION; DHFR GENE; DNA METHYLATION; FEMALE; FOLIC ACID BLOOD LEVEL; GENE; GENE DELETION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MTHFR GENE; MTR GENE; NEUROBIOLOGY; RFC1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TANDEM MASS SPECTROMETRY; TRANSCOBALAMIN 2 GENE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VITAMIN BLOOD LEVEL; BLOOD; COHORT ANALYSIS; GENETICS; GERMANY; MIDDLE AGED; PHYSIOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ALCOHOLISM; COHORT STUDIES; DNA METHYLATION; FEMALE; GENETIC VARIATION; GERMANY; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; SMOKING;

EID: 84925014764     PISSN: 07418329     EISSN: 18736823     Source Type: Journal    
DOI: 10.1016/j.alcohol.2015.01.004     Document Type: Article

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