Alterations of homocysteine serum levels during alcohol withdrawal are influenced by folate and riboflavin: Results from the german investigation on neurobiology in alcoholism (GINA)

Alcohol and Alcoholism

Volumn 47, Issue 5, 2012, Pages 497-500

  Heese, Peter ^a   Linnebank, Michael ^a,b   Semmler, Alexander ^b   Muschler, Marc A N ^c   Heberlein, Annemarie ^c   Frieling, Helge ^c   Stoffel wagner, Birgit ^d   Kornhuber, Johannes ^e   Banger, Markus ^a   Bleich, Stefan ^c   Hillemacher, Thomas ^c  

^a LVR Clinic Bonn   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF BONN   (Germany)

^e UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CLOMETHIAZOLE; COBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE; RIBOFLAVIN; THIAMINE;

ADULT; AGED; ALCOHOL BLOOD LEVEL; ALCOHOL WITHDRAWAL; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; FEMALE; FOLIC ACID BLOOD LEVEL; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; HYPERHOMOCYSTEINEMIA; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STATISTICAL MODEL; VITAMIN BLOOD LEVEL;

ADULT; AGED; ALCOHOLISM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; LINEAR MODELS; MALE; MIDDLE AGED; PYRIDOXINE; RIBOFLAVIN; SUBSTANCE WITHDRAWAL SYNDROME; THIAMINE; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84865324432     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/ags058     Document Type: Article

References (30)

1. Araki R, Maruyama C, Igarashi S et al. (2006) Effects of short-term folic acid and/or riboflavin supplementation on serum folate and plasma total homocysteine concentrations in young Japanese male subjects. Eur J Clin Nutr 60:573-9.
2. Banger M, Philipp M, Herth T et al. (1992) Development of a rating scale for quantitative measurement of the alcohol withdrawal syndrome. Eur Arch Psychiatry Clin Neurosci 241:241-6.
3. Bates CJ, Fuller NJ. (1986) The effect of riboflavin deficiency on methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.20) and folate metabolism in the rat. Br J Nutr 55:455-64.
4. Bayerlein K, Hillemacher T, Reulbach U et al. (2005) Alcoholism-associated hyperhomocysteinemia and previous withdrawal seizures. Biol Psychiatry 57:1590-3.
5. Bleich S, Hillemacher T. (2009) Homocysteine, alcoholism and its molecular networks. Pharmacopsychiatry 42(Suppl 1):S102-9.
6. Bleich S, Degner D, Bandelow B et al. (2000a) Plasma homocysteine is a predictor of alcohol withdrawal seizures. Neuroreport 11:2749-52.
7. Bleich S, Degner D, Wiltfang J et al. (2000b) Elevated homocysteine levels in alcohol withdrawal. Alcohol Alcohol 35:351-4.
8. Bleich S, Bleich K, Kropp S et al. (2001) Moderate alcohol consumption in social drinkers raises plasma homocysteine levels: a contradiction to the 'French Paradox'? Alcohol Alcohol 36:189-92.
9. Bleich S, Bandelow B, Javaheripour K et al. (2003) Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism. Neurosci Lett 335:179-82.
10. Bleich S, Degner D, Sperling W et al. (2004) Homocysteine as a neurotoxin in chronic alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 28:453-64.
11. Bleich S, Carl M, Bayerlein K et al. (2005) Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS). Alcohol Clin Exp Res 29:334-6.
12. Bleich S, Bayerlein K, Hillemacher T et al. (2006) An assessment of the potential value of elevated homocysteine in predicting alcohol-withdrawal seizures. Epilepsia 47:934-8.
13. Chen YL, Yang SS, Peng HC et al. (2011) Folate and vitamin B12 improved alcohol-induced hyperhomocysteinemia in rats. Nutrition 27:1034-9.
14. Chuang CZ, Boyles A, Legardeur B et al. (2006) Effects of riboflavin and folic acid supplementation on plasma homocysteine levels in healthy subjects. Am J Med Sci 331:65-71.
15. Cravo ML, Camilo ME. (2000) Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins B(6) and B(12) status. Nutrition 16:296-302.
16. Franken DG, Blom HJ, Boers GH et al. (1996) Thiamine (vitamin B1) supplementation does not reduce fasting blood homocysteine concentration in most homozygotes for homocystinuria. Biochim Biophys Acta 1317:101-4.
17. Ganji V, Kafai MR. (2004) Frequent consumption of milk, yogurt, cold breakfast cereals, peppers, and cruciferous vegetables and intakes of dietary folate and riboflavin but not vitamins B-12 and B-6 are inversely associated with serum total homocysteine concentrations in the US population. Am J Clin Nutr 80:1500-7.
18. Hillemacher T, Frieling H, Bayerlein K et al. (2007) Biological markers to predict previous alcohol withdrawal seizures: a risk assessment. J Neural Transm 114:151-4.
19. Hustad S, McKinley MC, McNulty H et al. (2002) Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation. Clin Chem 48:1571-7.
20. Jacques PF, Kalmbach R, Bagley PJ et al. (2002) The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J Nutr 132:283-8.
21. Konstantinova SV, Vollset SE, Berstad P et al. (2007) Dietary predictors of plasma total homocysteine in the Hordaland Homocysteine Study. Br J Nutr 98:201-10.
22. Majumdar SK, Shaw GK, O'Gorman P et al. (1982) Blood vitamin status (B1, B2, B6, folic acid and B12) in patients with alcoholic liver disease. Int J Vitam Nutr Res 52:266-71.
23. Moat SJ, Ashfield-Watt PA, Powers HJ et al. (2003) Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype. Clin Chem 49:295-302.
24. Pompeia S, Grego BH, Pradella-Hallinan M et al. (2009) Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers. Prog Neuropsycho pharmacol Biol Psychiatry 33:933-8.
25. Sachdev P. (2004) Homocysteine, cerebrovascular disease and brain atrophy. J Neurol Sci 226:25-9.
26. Selhub J, Jacques PF, Rosenberg IH et al. (1999) Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med 131:331-9.
27. Ubbink JB, Becker PJ, Vermaak WJ et al. (1995) Results of B-vitamin supplementation study used in a prediction model to define a reference range for plasma homocysteine. Clin Chem 41:1033-7.
28. Vujkovic M, Steegers EA, van Meurs J et al. (2010) The maternal homocysteine pathway is influenced by riboflavin intake and MTHFR polymorphisms without affecting the risk of orofacial clefts in the offspring. Eur J Clin Nutr 64:266-73.
29. Wilhelm J, Bayerlein K, Hillemacher T et al. (2006) Short-term cognition deficits during early alcohol withdrawal are associated with elevated plasma homocysteine levels in patients with alcoholism. J Neural Transm 113:357-63.
30. Wilhelm J, Frieling H, von Ahsen N et al. (2008) Apolipoprotein E polymorphism, homocysteine serum levels and hippocampal volume in patients with alcoholism: an investigation of a gene-environment interaction. Pharmacogenomics J 8:117-21.