A peptide ligase and the ribosome cooperate to synthesize the peptide pheganomycin

Nature Chemical Biology

Volumn 11, Issue 1, 2015, Pages 71-76

  Noike, Motoyoshi ^a   Matsui, Takashi ^b   Ooya, Koichi ^a   Sasaki, Ikuo ^a   Ohtaki, Shouta ^b   Hamano, Yoshimitsu ^c   Maruyama, Chitose ^c   Ishikawa, Jun ^d   Satoh, Yasuharu ^a   Ito, Hajime ^a   Morita, Hiroyuki ^b   Dairi, Tohru ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c FUKUI PREFECTURAL UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LIGASE; NUCLEOPHILE; PHEGANOMYCIN; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; PEPTIDE;

AMINO ACID SYNTHESIS; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DELETION MUTANT; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENE CLUSTER; GENE DISRUPTION; MUTAGENESIS; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RIBOSOME; STREPTOMYCES; STREPTOMYCES CIRRATUS; BIOSYNTHESIS; CHEMICAL STRUCTURE; GENETICS; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; PROTEIN CONFORMATION;

STREPTOMYCES CIRRATUS;

ANTI-BACTERIAL AGENTS; LIGASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTAGENESIS; PEPTIDES; PROTEIN CONFORMATION; RIBOSOMES; STREPTOMYCES;

EID: 84924925641     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1697     Document Type: Article

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