Disassociation of static and dynamic cerebral autoregulatory performance in healthy volunteers after lipopolysaccharide infusion and in patients with sepsis

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 303, Issue 11, 2012, Pages

  Berg, Ronan M G ^a,b   Plovsing, Ronni R ^a   Ronit, Andreas ^a   Bailey, Damian M ^c   Holstein Rathlou, Niels Henrik ^b   Møller, Kirsten ^a  

^a University of Copenhagen   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF GLAMORGAN   (United Kingdom)

Author keywords

Cerebral autoregulation; Endotoxin; Human; Lipopolysaccharide; Sepsis associated encephalopathy

Indexed keywords

FENTANYL; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NORADRENALIN; PROPOFOL; REMIFENTANIL; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTERIAL OXYGEN SATURATION; ARTERIAL PH; ARTICLE; AUTOREGULATION; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRAIN BLOOD FLOW; BRAIN DISEASE; BRAIN PERFUSION; CEREBRAL AUTOREGULATION; CLINICAL ARTICLE; CONFUSION; DOPPLER FLOWMETRY; ELECTROCARDIOGRAM; HUMAN; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; OSCILLATION; PRIORITY JOURNAL; SEPSIS;

ADULT; AGED; BLOOD PRESSURE; CEREBRAL CORTEX; FEMALE; HOMEOSTASIS; HUMANS; INFUSIONS, INTRAVENOUS; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; SEPSIS; YOUNG ADULT;

EID: 84870570482     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00242.2012     Document Type: Article

References (42)

1. Aaslid R, Lindegaard KF, Sorteberg W, Nornes H. Cerebral autoregulation dynamics in humans. Stroke 20: 45-52, 1989.
2. 2. Brain Res 16: 115-124, 2008.
3. Andreasen AS, Krabbe KS, Krogh-Madsen R, Taudorf S, Pedersen BK, Møller K. Human endotoxemia as a model of systemic inflammation. Curr Med Chem 15: 1697-1705, 2008.
4. Avramon MN, White PF. Methods for monitoring the level of sedation. Crit Care Clin 11: 803-826, 1995.
5. Bailey DM, Evans KA, James PE, McEneny J, Young IS, Fall L, Gutowski M, Kewley E, McCord JM, Møller K, Ainslie PN. Altered free radical metabolism in acute mountain sickness: implications for dynamic autoregulation and blood-brain barrier function. J Physiol 587: 73-85, 2009.
6. Berg RMG, Møller K, Bailey DM. Neuro-oxidative-nitrosative stress in sepsis. J Cereb Blood Flow Metab 31: 1532-1544, 2011.
7. Brassard P, Kim YS, van Lieshout J, Secher NH, Rosenmeier JB. Endotoxemia reduces cerebral perfusion but enhances dynamic cerebrovascular autoregulation at reduced arterial carbon dioxide tension. Crit Care Med 40: 1873-1878, 2012.
8. Brodie FG, Panerai RB, Foster S, Evans DH, Robinson TG. Long-term changes in dynamic cerebral autoregulation: a 10 years follow up study. Clin Physiol Funct Imaging 29: 366-371, 2009.
9. Conti A, Iacopino DG, Fodale V, Micalizzi S, Penna O, Santamaria LB. Cerebral haemodynamic changes during propofol-remifentanil or sevoflurane anaesthesia: transcranial Doppler study under bispectral index monitoring. Br J Anaesth 97: 333-339, 2006.
10. Dawson SL, Blake MJ, Panerai RB, Potter JF. Dynamic but not static autoregulation is impaired in acute ischaemic stroke. Cerebrovasc Dis 10: 126-132, 2000.
11. Dawson SL, Panerai RB, Potter JF. Serial changes in static and dynamic autoregulation after acute ischaemic stroke. Cerebrovasc Dis 16: 69-75, 2003.
12. Diehl RR, Linden D, Lucke D, Berlit P. Phase relationship between cerebral blood flow velocity and blood pressure: a clinical test of autoregulation. Stroke 26: 1801-1804, 1995.
13. Ebersoldt M, Sharshar T, Annane D. Sepsis-associated delirium. Intensive Care Med 33: 941-950, 2007.
14. Giller CA, Bowman G, Dyer H, Mootz L, Krippner W. Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery 32: 737-742, 1993.
15. Heistad DD, Kontos HA. Cerebral circulation. In: Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 2, vol. III, pt. 1, chapt. 5, p. 137-181.
16. Iacobone E, Bailly-Salin J, Polito A, Friedman D, Stevens RD, Sharshar T. Sepsis-associated encephalopathy and its differential diagnosis. Crit Care Med 37 Suppl 10: S331-S336, 2009.
17. Larsen FS, Olsen KS, Hansen BA, Paulson OB, Knudsen GM. Transcranial Doppler is valid for determination of the lower limit of cerebral blood flow autoregulation. Stroke 25: 1985-1988, 1994.
18. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G; SCCM/ESICM/ACCP/ ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31: 1250-1256, 2003.
19. Low DA, Wingo JE, Keller DM, Davis SL, Cui J, Zhang R, Crandall CG. Dynamic autoregulation during passive heat stress in humans. Am J Physiol Regul Integr Comp Physiol 296: R1598-R1605, 2009.
20. Lucas SJ, Tzeng YC, Galvin SD, Thomas KN, Ogoh S, Ainslie PN. Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55: 698-705, 2010.
21. Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL. Patterns of cytokine evolution (tumor necrosis factor-β and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 25: 1813-1819, 1997.
22. Matta BF, Stow PJ. Sepsis-induced vasoparalysis does not involve the cerebral vasculature: indirect evidence from autoregulation and carbon dioxide reactivity studies. Br J Anaesth 76: 790-794, 1996.
23. Møller K, Strauss GI, Qvist J, Fonsmark L, Knudsen GM, Larsen FS, Krabbe KS, Skinhøj P, Pedersen BK. Cerebral blood flow and oxidative metabolism during human endotoxemia. J Cereb Blood Flow Metab 22: 1262-1270, 2002.
24. Newell DW, Aaslid R, Lam A, Mayberg TS, Winn HR. Comparison of flow and velocity during dynamic autoregulation testing in humans. Stroke 25: 793-797, 1994.
25. Panerai RB. Assessment of cerebral pressure autoregulation in humans-a review of measurement methods. Physiol Meas 19: 305-338, 1998.
26. Panerai RB. Complexity of the human cerebral circulation. Philos Transact A Math Phys Eng Sci 367: 1319-1336, 2009.
27. Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev 2: 161-192, 1990.
28. Pfister D, Siegemund M, Dell-Kuster S, Smielewski P, Rüegg S, Strebel SP, Marsch SC, Pargger H, Steiner LA. Cerebral perfusion in sepsis-associated delirium. Crit Care 12: R63, 2008.
29. Rosengarten B, Krekel D, Kuhnert S, Schulz R. Early neurovascular uncoupling in the brain during community acquired pneumonia. Crit Care 16: R64, 2012.
30. Rosengarten B, Wolff S, Klatt S, Schermuly RT. Effects of inducible nitric oxide synthase inhibition or norepinephrine on the neurovascular coupling in an endotoxic rat shock model. Crit Care 13: R139, 2009.
31. Schmidt JF, Waldemar G, Vorstrup S, Andersen AR, Gjerris F, Paulson OB. Computerized analysis of cerebral blood flow autoregulation in humans: validation of a method for pharmacologic studies. J Cardovasc Pharmacol 15: 983-988, 1990.
32. Sharshar T, Annane D, de la Grandmaison GL, Brouland JP, Hopkinson NS, Françoise G. The neuropathology of septic shock. Brain Pathol 14: 21-33, 2004.
33. Sharshar T, Gray F, Lorin de la Grandmaison G, Hopkinson NS, Ross E, Dorandeu A, Orlikowski D, Raphael JC, Gajdos P, Annane D. Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 362: 1799-1805, 2003.
34. Steiner LA, Pfister D, Strebel SP, Radolovich D, Smielewski P, Czosnyka M. Near-infrared spectroscopy can monitor dynamic autoregulation in adults. Neurocrit Care 10: 122-128, 2009.
35. Strebel S, Lam AM, Matta B, Mayberg TS, Aaslid R, Newell DW. Dynamic and static autoregulation during isoflurane, desflurane, and propofol anesthesia. Anesthesiology 83: 66-76, 1995.
36. Taccone FS, Castanares-Zapatero D, Peres-Bota D, Vincent JL, Berre' J, Melot C. Cerebral autoregulation is influenced by carbon dioxide levels in patients with septic shock. Neurocrit Care 12: 35-42, 2010.
37. Taudorf S, Krabbe KS, Berg RMG, Pedersen BK, Møller K. Human models of low-grade inflammation: bolus versus continuous infusion of endotoxin. Clin Vaccine Immunol 14: 250-255, 2007.
38. Thijs LG, Hack CE. Time course of cytokine levels in sepsis. Intensive Care Med 21 Suppl 2: S258-S263, 1995.
39. Tiecks FP, Lam AM, Aaslid R, Newell DW. Comparison of static and dynamic autoregulation measurements. Stroke 26: 1014-1019, 1995.
40. van Beek AHE, Claassen JAH, Rikkert MGM, Jansen RWM. Cerebral autoregulation: an overview of current concepts and methodology with special focus on the elderly. J Cereb Blood Flow Metab 28: 1071-1085, 2008.
41. Willie CK, Colino FL, Bailey DM, Tzeng YC, Binsted G, Jones LW, Haykowsky MJ, Bellapart J, Ogoh S, Smith KJ, Smirl JD, Day TA, Lucas SJ, Eller LK, Ainslie PN. Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. J Neurosci Methods 196: 221-237, 2011.
42. Zhang R, Zuckerman JH, Giller CA, Levine BD. Transfer function analysis of dynamic autoregulation in humans. Am J Physiol Heart Circ Physiol 274: H233-H241, 1998.