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Volumn 33, Issue 4, 2015, Pages 1723-1730

Inhibition of c-Myc by let-7b mimic reverses mutidrug resistance in gastric cancer cells

Author keywords

C Myc; Gastric cancer; Let 7b; Mutidrug resistance

Indexed keywords

CISPLATIN; FLUOROURACIL; MICRORNA; MICRORNA LET7B; MYC PROTEIN; UNCLASSIFIED DRUG; VINCRISTINE; 3' UNTRANSLATED REGION; MESSENGER RNA; MIRNLET7 MICRORNA, HUMAN; MYC PROTEIN, HUMAN; RNA; TUMOR PROTEIN;

EID: 84924907597     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.3757     Document Type: Article
Times cited : (47)

References (50)
  • 1
    • 84863182031 scopus 로고    scopus 로고
    • Current management and future strategies of gastric cancer
    • Lee JH, Kim KM, Cheong JH and Noh SH: Current management and future strategies of gastric cancer. Yonsei Med J 53: 248-257, 2012.
    • (2012) Yonsei Med J , vol.53 , pp. 248-257
    • Lee, J.H.1    Kim, K.M.2    Cheong, J.H.3    Noh, S.H.4
  • 2
    • 84861089134 scopus 로고    scopus 로고
    • Genetic aspects of gastric cancer instability
    • Hudler P: Genetic aspects of gastric cancer instability. Sci World J: 2012: 761909, 2012.
    • (2012) Sci World J , vol.2012 , pp. 761909
    • Hudler, P.1
  • 3
    • 1642501531 scopus 로고    scopus 로고
    • EUROCARE working group Explaining gastric cancer survival differences among european countries
    • Verdecchia A, Corazziari I, Gatta G, Lisi D, Faivre J and Forman D (EUROCARE Working Group): Explaining gastric cancer survival differences among European countries. Int J Cancer 109: 737-741, 2004.
    • (2004) Int J Cancer , vol.109 , pp. 737-741
    • Verdecchia, A.1    Corazziari, I.2    Gatta, G.3    Lisi, D.4    Faivre, J.5    Forman, D.6
  • 4
    • 0033602548 scopus 로고    scopus 로고
    • Extended lymphnode dissection for gastric cancer
    • Bonenkamp JJ, Hermans J, Sasako M, et al: Extended lymphnode dissection for gastric cancer. N Engl J Med 340: 908-914, 1999.
    • (1999) N Engl J Med , vol.340 , pp. 908-914
    • Bonenkamp, J.J.1    Hermans, J.2    Sasako, M.3
  • 5
    • 0035128684 scopus 로고    scopus 로고
    • Time trend analysis of gastric cancer incidence in japan by histological types 1975-1989
    • Kaneko S and Yoshimura T: Time trend analysis of gastric cancer incidence in Japan by histological types, 1975-1989. Br J Cancer 84: 400-405, 2001.
    • (2001) Br J Cancer , vol.84 , pp. 400-405
    • Kaneko, S.1    Yoshimura, T.2
  • 6
    • 0005157571 scopus 로고    scopus 로고
    • New progresses in researches on multidrug resistance in gastric cancer
    • Fan D and Liu X: New progresses in researches on multidrug resistance in gastric cancer. Chin J Digest 20: 77-78, 2000.
    • (2000) Chin J Digest , vol.20 , pp. 77-78
    • Fan, D.1    Liu, X.2
  • 7
  • 8
    • 54349087788 scopus 로고    scopus 로고
    • Myc's broad reach
    • Eilers M and Eisenman RN: Myc's broad reach. Genes Dev 22: 2755-2766, 2008.
    • (2008) Genes Dev , vol.22 , pp. 2755-2766
    • Eilers, M.1    Eisenman, R.N.2
  • 9
    • 79952828836 scopus 로고    scopus 로고
    • Transcriptional repression: The dark side of myc
    • Herkert B and Eilers M: Transcriptional repression: the dark side of myc. Genes Cancer 1: 580-586, 2010.
    • (2010) Genes Cancer , vol.1 , pp. 580-586
    • Herkert, B.1    Eilers, M.2
  • 11
    • 0030049639 scopus 로고    scopus 로고
    • Tumour cells surviving in vivo cisplatin chemotherapy display elevated cmyc expression
    • Walker TL, White JD, Esdale WJ, Burton MA and DeCruz EE: Tumour cells surviving in vivo cisplatin chemotherapy display elevated cmyc expression. Br J Cancer 73: 610-614, 1996.
    • (1996) Br J Cancer , vol.73 , pp. 610-614
    • Walker, T.L.1    White, J.D.2    Esdale, W.J.3    Burton, M.A.4    Decruz, E.E.5
  • 12
    • 0025834958 scopus 로고
    • Coordinate change of c-myc, transferrin receptor and h3 gene expression precedes induction of haemoglobin-producing cells of the leukaemia k562 cell line treated with cisdiamminedichloroplatinum ii
    • Marazzi L, Parodi MT, Martino DD, Ferrari S and Tonini GP: Coordinate change of c-myc, transferrin receptor and H3 gene expression precedes induction of haemoglobin-producing cells of the leukaemia K562 cell line treated with cisdiamminedichloroplatinum II. Anticancer Res 11: 947-952, 1991.
    • (1991) Anticancer Res , vol.11 , pp. 947-952
    • Marazzi, L.1    Parodi, M.T.2    Martino, D.D.3    Ferrari, S.4    Tonini, G.P.5
  • 13
    • 0025318767 scopus 로고
    • Differential oncogene amplification in tumour cells from a patient treated with cisplatin and 5-fu
    • Kashani-Sabet M, Lu Y, Leong L, Haedicke K and Scanlon KJ: Differential oncogene amplification in tumour cells from a patient treated with cisplatin and 5-FU. Eur J Cancer 26: 383-390, 1990.
    • (1990) Eur J Cancer , vol.26 , pp. 383-390
    • Kashani-Sabet, M.1    Lu, Y.2    Leong, L.3    Haedicke, K.4    Scanlon, K.J.5
  • 15
    • 73349125465 scopus 로고    scopus 로고
    • Micrornas in cancer: Small molecules with a huge impact
    • Iorio MV and Croce CM: MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol 27: 5848-5856, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 5848-5856
    • Iorio, M.V.1    Croce, C.M.2
  • 16
    • 73049108489 scopus 로고    scopus 로고
    • Regulating cancer stem cells the mir way
    • Peter ME: Regulating cancer stem cells the miR way. Cell Stem Cell 6: 4-6, 2010.
    • (2010) Cell Stem Cell , vol.6 , pp. 4-6
    • Peter, M.E.1
  • 17
    • 69349087756 scopus 로고    scopus 로고
    • Mir-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy
    • Adam L, Zhong M, Choi W, et al: miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy. Clin Cancer Res 15: 5060-5072, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 5060-5072
    • Adam, L.1    Zhong, M.2    Choi, W.3
  • 18
    • 70350362953 scopus 로고    scopus 로고
    • Hyaluronan-cd44 interaction with protein kinase c(epsilon) promotes oncogenic signaling by the stem cell marker nanog and the production of microrna-21, leading to down-regulation of the tumor suppressor protein pdcd4, anti-apoptosis, and chemotherapy resistance in breast tumor cells
    • Bourguignon LY, Spevak CC, Wong G, Xia W and Gilad E: Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J Biol Chem 284: 26533-26546, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 26533-26546
    • Bourguignon, L.Y.1    Spevak, C.C.2    Wong, G.3    Xia, W.4    Gilad, E.5
  • 19
    • 38349190243 scopus 로고    scopus 로고
    • Micrornas modulate the chemosensitivity of tumor cells
    • Blower PE, Chung JH, Verducci JS, et al: MicroRNAs modulate the chemosensitivity of tumor cells. Mol Cancer Ther 7: 1-9, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1-9
    • Blower, P.E.1    Chung, J.H.2    Verducci, J.S.3
  • 20
    • 52949091534 scopus 로고    scopus 로고
    • The let-7 family of micrornas
    • Roush S and Slack FJ: The let-7 family of microRNAs. Trends Cell Biol 18: 505-516, 2008.
    • (2008) Trends Cell Biol , vol.18 , pp. 505-516
    • Roush, S.1    Slack, F.J.2
  • 21
    • 34247565615 scopus 로고    scopus 로고
    • The tumor suppressor microrna let-7 represses the hmga2 oncogene
    • Lee YS and Dutta A: The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev 21: 1025-1030, 2007.
    • (2007) Genes Dev , vol.21 , pp. 1025-1030
    • Lee, Y.S.1    Dutta, A.2
  • 22
    • 34247593034 scopus 로고    scopus 로고
    • Impaired microrna processing enhances cellular transformation and tumorigenesis
    • Kumar MS, Lu J, Mercer KL, Golub TR and Jacks T: Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 39: 673-677, 2007.
    • (2007) Nat Genet , vol.39 , pp. 673-677
    • Kumar, M.S.1    Lu, J.2    Mercer, K.L.3    Golub, T.R.4    Jacks, T.5
  • 23
    • 57749105325 scopus 로고    scopus 로고
    • Microrna microarray identifies let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer
    • Yang N, Kaur S, Volinia S, et al: MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer. Cancer Res 68: 10307-10314, 2008.
    • (2008) Cancer Res , vol.68 , pp. 10307-10314
    • Yang, N.1    Kaur, S.2    Volinia, S.3
  • 24
    • 81555234231 scopus 로고    scopus 로고
    • Mirna signature associated with outcome of gastric cancer patients following chemotherapy
    • Kim CH, Kim HK, Rettig RL, et al: miRNA signature associated with outcome of gastric cancer patients following chemotherapy. BMC Med Genomics 4: 79, 2001.
    • (2001) BMC Med Genomics , vol.4 , pp. 79
    • Kim, C.H.1    Kim, H.K.2    Rettig, R.L.3
  • 25
    • 70349826431 scopus 로고    scopus 로고
    • Understanding the causes of multidrug resistance in cancer: A comparison of doxorubicin and sunitinib
    • Broxterman HJ, Gotink KJ and Verheul HM: Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib. Drug Resist Updat 12: 114-126, 2009.
    • (2009) Drug Resist Updat , vol.12 , pp. 114-126
    • Broxterman, H.J.1    Gotink, K.J.2    Verheul, H.M.3
  • 26
    • 34247391483 scopus 로고    scopus 로고
    • Multiple paths to a drug resistance phenotype: Mutations, translocations, deletions and amplification of coding genes or promoter regions, epigenetic changes and micrornas
    • Fojo T: Multiple paths to a drug resistance phenotype: mutations, translocations, deletions and amplification of coding genes or promoter regions, epigenetic changes and microRNAs. Drug Resist Updat 10: 59-67, 2007.
    • (2007) Drug Resist Updat , vol.10 , pp. 59-67
    • Fojo, T.1
  • 27
    • 20544437870 scopus 로고    scopus 로고
    • Overview of tumor cell chemoresistance mechanisms
    • Gatti L and Zunino F: Overview of tumor cell chemoresistance mechanisms. Methods Mol Med 111: 127-148, 2005.
    • (2005) Methods Mol Med , vol.111 , pp. 127-148
    • Gatti, L.1    Zunino, F.2
  • 28
    • 16344373935 scopus 로고    scopus 로고
    • Bird's-eye view on gastric cancer research of the past 25 years
    • Fan D, Zhang X, Chen X, et al: Bird's-eye view on gastric cancer research of the past 25 years. J Gastroenterol Hepatol 20: 360-365, 2005.
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 360-365
    • Fan, D.1    Zhang, X.2    Chen, X.3
  • 29
    • 0029920244 scopus 로고    scopus 로고
    • Expression of the multidrug resistance associated protein (mrp) gene in human colorectal, gastric and non-small-cell lung carcinomas
    • Chuman Y, Sumizawa T, Takebayashi Y, et al: Expression of the multidrug resistance associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas. Int J Cancer 66: 274-279, 1996.
    • (1996) Int J Cancer , vol.66 , pp. 274-279
    • Chuman, Y.1    Sumizawa, T.2    Takebayashi, Y.3
  • 30
    • 24644495281 scopus 로고    scopus 로고
    • The evaluation of gastric cancer sensitivity to 5-fu/cddp in terms of induction of apoptosis: Time-and p53 expression-dependency of anti-cancer drugs
    • Matsuhashi N, Saio M, Matsuo A, Sugiyama Y and Saji S: The evaluation of gastric cancer sensitivity to 5-FU/CDDP in terms of induction of apoptosis: Time-and p53 expression-dependency of anti-cancer drugs. Oncol Rep 14: 609-615, 2005.
    • (2005) Oncol Rep , vol.14 , pp. 609-615
    • Matsuhashi, N.1    Saio, M.2    Matsuo, A.3    Sugiyama, Y.4    Saji, S.5
  • 31
    • 33751167241 scopus 로고    scopus 로고
    • Trf2 promotes multidrug resistance in gastric cancer cells
    • Ning H, Li T, Zhao L, et al: TRF2 promotes multidrug resistance in gastric cancer cells. Cancer Biol Ther 5: 950-956, 2006.
    • (2006) Cancer Biol Ther , vol.5 , pp. 950-956
    • Ning, H.1    Li, T.2    Zhao, L.3
  • 32
    • 84896028412 scopus 로고    scopus 로고
    • Microrna-200c regulates the sensitivity of chemotherapy of gastric cancer sgc7901/ddp cells by directly targeting rhoe
    • Chang L, Guo F, Wang Y, et al: MicroRNA-200c regulates the sensitivity of chemotherapy of gastric cancer SGC7901/DDP cells by directly targeting RhoE. Pathol Oncol Res 20: 93-98, 2014.
    • (2014) Pathol Oncol Res , vol.20 , pp. 93-98
    • Chang, L.1    Guo, F.2    Wang, Y.3
  • 33
    • 84880097674 scopus 로고    scopus 로고
    • Reversal of multidrug resistance in gastric cancer cells by cdx2 downregulation
    • Yan LH, Wang XT, Yang J, et al: Reversal of multidrug resistance in gastric cancer cells by CDX2 downregulation. World J Gastroenterol 19: 4155-4165, 2013.
    • (2013) World J Gastroenterol , vol.19 , pp. 4155-4165
    • Yan, L.H.1    Wang, X.T.2    Yang, J.3
  • 34
    • 67549139894 scopus 로고    scopus 로고
    • Tumor microrna expression patterns associated with resistance to platinum based chemotherapy and survival in ovarian cancer patients
    • Eitan R, Kushnir M, Lithwick-Yanai G, et al: Tumor microRNA expression patterns associated with resistance to platinum based chemotherapy and survival in ovarian cancer patients. Gynecol Oncol 114: 253-259, 2009.
    • (2009) Gynecol Oncol , vol.114 , pp. 253-259
    • Eitan, R.1    Kushnir, M.2    Lithwick-Yanai, G.3
  • 35
    • 79955801336 scopus 로고    scopus 로고
    • Inhibitory effects of mirna-200c on chemotherapy-resistance and cell proliferation of gastric cancer sgc7901/ddp cells
    • Chen Y, Zuo J, Liu Y, Gao H and Liu W: Inhibitory effects of miRNA-200c on chemotherapy-resistance and cell proliferation of gastric cancer SGC7901/DDP cells. Chin J Cancer 29: 1006-1011, 2010.
    • (2010) Chin J Cancer , vol.29 , pp. 1006-1011
    • Chen, Y.1    Zuo, J.2    Liu, Y.3    Gao, H.4    Liu, W.5
  • 36
    • 43049133807 scopus 로고    scopus 로고
    • Microrna let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth
    • Schultz J, Lorenz P, Gross G, Ibrahim S and Kunz M: MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res 18: 549-557, 2008.
    • (2008) Cell Res , vol.18 , pp. 549-557
    • Schultz, J.1    Lorenz, P.2    Gross, G.3    Ibrahim, S.4    Kunz, M.5
  • 37
    • 35449003175 scopus 로고    scopus 로고
    • Microrna let-7a downregulates myc and reverts myc-induced growth in burkitt lymphoma cells
    • Sampson VB, Rong NH, Han J, et al: MicroRNA let-7a downregulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res 67: 9762-9770, 2007.
    • (2007) Cancer Res , vol.67 , pp. 9762-9770
    • Sampson, V.B.1    Rong, N.H.2    Han, J.3
  • 38
    • 20044395613 scopus 로고    scopus 로고
    • Ras is regulated by the let-7 microrna family
    • Johnson SM, Grosshans H, Shingara J, et al: RAS is regulated by the let-7 microRNA family. Cell 120: 635-647, 2005.
    • (2005) Cell , vol.120 , pp. 635-647
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3
  • 39
    • 48649103982 scopus 로고    scopus 로고
    • A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment
    • RybakA, Fuchs H, Smirnova L, et al: A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol 10: 987-993, 2008.
    • (2008) Nat Cell Biol , vol.10 , pp. 987-993
    • Rybaka Fuchs, H.1    Smirnova, L.2
  • 40
    • 78549261109 scopus 로고    scopus 로고
    • Double negative feedback loop between reprogramming factor lin28 and microrna let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells
    • Yang XJ, Lin XJ, Zhong XM, et al: Double negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res 70: 9463-9472, 2010.
    • (2010) Cancer Res , vol.70 , pp. 9463-9472
    • Yang, X.J.1    Lin, X.J.2    Zhong, X.M.3
  • 41
    • 62549160957 scopus 로고    scopus 로고
    • Lin-28b transactivation is necessary for myc-mediated let-7 repression and proliferation
    • Chang TC, Zeitels LR, Hwang HW, et al: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci USA 106: 3384-3389, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3384-3389
    • Chang, T.C.1    Zeitels, L.R.2    Hwang, H.W.3
  • 42
    • 67149099142 scopus 로고    scopus 로고
    • N-myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b
    • Cotterman R and Knoepfler PS: N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. PLoS One 4: e5799, 2009.
    • (2009) PLoS One , vol.4 , pp. e5799
    • Cotterman, R.1    Knoepfler, P.S.2
  • 43
    • 84868210731 scopus 로고    scopus 로고
    • Lin28b induces neuroblastoma and enhances mycn levels via let-7 suppression
    • Molenaar JJ , Domingo-Fernández R, Ebus ME, et al: LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat Genet 44: 1199-1206, 2012.
    • (2012) Nat Genet , vol.44 , pp. 1199-1206
    • Molenaar, J.J.1    Domingo-Fernández, R.2    Ebus, M.E.3
  • 44
    • 56549084319 scopus 로고    scopus 로고
    • Hematopoietic stem cell function and survival depend on c-myc and n-myc activity
    • Laurenti E, Varnum-Finney B, Wilson A, et al: Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 3: 611-624, 2008.
    • (2008) Cell Stem Cell , vol.3 , pp. 611-624
    • Laurenti, E.1    Varnum-Finney, B.2    Wilson, A.3
  • 45
    • 0027066738 scopus 로고
    • Loss of nmyc function results in embryonic lethality and failure of the epithelial component of the embryo to develop
    • Stanton BR, Perkins AS, Tessarollo L, Sassoon DA and Parada LF: Loss of Nmyc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Gene Dev 6: 2235-2247, 1992.
    • (1992) Gene Dev , vol.6 , pp. 2235-2247
    • Stanton, B.R.1    Perkins, A.S.2    Tessarollo, L.3    Sassoon, D.A.4    Parada, L.F.5
  • 46
    • 70349735988 scopus 로고    scopus 로고
    • Therapeutic targeting of micro environmental interactions in leukemia: Mechanisms and approaches
    • Konopleva M, Tabe Y, Zeng Z and Andreeff M: Therapeutic targeting of micro environmental interactions in leukemia: mechanisms and approaches. Drug Resist Updat 12: 103-113, 2009.
    • (2009) Drug Resist Updat , vol.12 , pp. 103-113
    • Konopleva, M.1    Tabe, Y.2    Zeng, Z.3    Andreeff, M.4
  • 47
    • 70349165716 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic
    • Voulgari A and Pintzas A: Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta 1796: 75-90, 2009.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 75-90
    • Voulgari, A.1    Pintzas, A.2
  • 48
    • 67349193226 scopus 로고    scopus 로고
    • Emerging role of notch in stem cells and cancer
    • Wang Z, Li Y, Banerjee S and Sarkar FH: Emerging role of Notch in stem cells and cancer. Cancer Lett 279: 8-12, 2009.
    • (2009) Cancer Lett , vol.279 , pp. 8-12
    • Wang, Z.1    Li, Y.2    Banerjee, S.3    Sarkar, F.H.4
  • 49
    • 77957969261 scopus 로고    scopus 로고
    • Targeting mirnas involved in cancer stem cell and emt regulation: An emerging concept in overcoming drug resistance
    • Wang ZW, Li YW, Ahmad A, et al: Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance. Drug Resist Updat 13: 109-118, 2010.
    • (2010) Drug Resist Updat , vol.13 , pp. 109-118
    • Wang, Z.W.1    Li, Y.W.2    Ahmad, A.3
  • 50
    • 84869445970 scopus 로고    scopus 로고
    • Cancerous ovarian stem cells: Obscure targets for therapy but relevant to chemoresistance
    • Ahmed N, Abubaker K, Findlay J and Quinn M: Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance. J Cell Biochem 114: 21-34, 2013.
    • (2013) J Cell Biochem , vol.114 , pp. 21-34
    • Ahmed, N.1    Abubaker, K.2    Findlay, J.3    Quinn, M.4


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