-
1
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol. 1999;17(9):2639-2648.
-
(1999)
J Clin Oncol
, vol.17
, Issue.9
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
-
2
-
-
80053539103
-
Adjuvant trastuzumab in HER2- positive breast cancer
-
Slamon D, Eiermann W, Robert N, et al. Adjuvant trastuzumab in HER2- positive breast cancer. N Engl J Med. 2011;365(14):1273-1283.
-
(2011)
N Engl J Med
, vol.365
, Issue.14
, pp. 1273-1283
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.3
-
3
-
-
78649390831
-
Treatment of HER2-overexpressing breast cancer
-
21
-
Baselga J. Treatment of HER2-overexpressing breast cancer. Ann Oncol. 2010;21 Suppl 7:vii36-vii40.
-
(2010)
Ann Oncol
, Issue.SUPPL. 7
-
-
Baselga, J.1
-
4
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344(11):783-792.
-
(2001)
N Engl J Med
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
5
-
-
78651387936
-
Resistance to HER2-targeted therapy: Mechanisms of trastuzumab resistance and possible strategies to overcome unresponsiveness to treatment
-
Hubalek M, Brunner C, Mattha K, Marth C. Resistance to HER2-targeted therapy: mechanisms of trastuzumab resistance and possible strategies to overcome unresponsiveness to treatment. Wien Med Wochenschr. 2010;160(19-20):506-512.
-
(2010)
Wien Med Wochenschr
, vol.160
, Issue.19-20
, pp. 506-512
-
-
Hubalek, M.1
Brunner, C.2
Mattha, K.3
Marth, C.4
-
6
-
-
48649092620
-
A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy
-
Lee-Hoeflich ST, Crocker L, Yao E, et al. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Res. 2008;68(14):5878-5887.
-
(2008)
Cancer Res
, vol.68
, Issue.14
, pp. 5878-5887
-
-
Lee-Hoeflich, S.T.1
Crocker, L.2
Yao, E.3
-
7
-
-
47249112974
-
Flow cytometric FRET analysis of erbB receptor interaction on a cell-by-cell basis
-
Diermeier-Daucher S, Hasmann M, Brockhoff G. Flow cytometric FRET analysis of erbB receptor interaction on a cell-by-cell basis. Ann N Y Acad Sci. 2008;1130:280-286.
-
(2008)
Ann N Y Acad Sci
, vol.1130
, pp. 280-286
-
-
Diermeier-Daucher, S.1
Hasmann, M.2
Brockhoff, G.3
-
8
-
-
1842605531
-
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
-
Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell. 2004;5(4):317-328.
-
(2004)
Cancer Cell
, vol.5
, Issue.4
, pp. 317-328
-
-
Franklin, M.C.1
Carey, K.D.2
Vajdos, F.F.3
Leahy, D.J.4
de Vos, A.M.5
Sliwkowski, M.X.6
-
9
-
-
0037434791
-
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
-
Cho HS, Mason K, Ramyar KX, et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature. 2003;421(6924):756-760.
-
(2003)
Nature
, vol.421
, Issue.6924
, pp. 756-760
-
-
Cho, H.S.1
Mason, K.2
Ramyar, K.X.3
-
10
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
Agus DB, Akita RW, Fox WD, et al. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell. 2002;2(2):127-137.
-
(2002)
Cancer Cell
, vol.2
, Issue.2
, pp. 127-137
-
-
Agus, D.B.1
Akita, R.W.2
Fox, W.D.3
-
11
-
-
73649149433
-
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
-
Scheuer W, Friess T, Burtscher H, Bossenmaier B, Endl J, Hasmann M. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 2009;69(24):9330-9336.
-
(2009)
Cancer Res
, vol.69
, Issue.24
, pp. 9330-9336
-
-
Scheuer, W.1
Friess, T.2
Burtscher, H.3
Bossenmaier, B.4
Endl, J.5
Hasmann, M.6
-
12
-
-
22344457603
-
Combination treatment with erlotinib and pertuzumab against human tumor xenografts is superior to monotherapy
-
Friess T, Scheuer W, Hasmann M. Combination treatment with erlotinib and pertuzumab against human tumor xenografts is superior to monotherapy. Clin Cancer Res. 2005;11(14):5300-5309.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.14
, pp. 5300-5309
-
-
Friess, T.1
Scheuer, W.2
Hasmann, M.3
-
13
-
-
80054092983
-
Trastuzumab emtansine: A unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer
-
LoRusso PM, Weiss D, Guardino E, Girish S, Sliwkowski MX. Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer. Clin Cancer Res. 2011;17(20):6437-6447.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.20
, pp. 6437-6447
-
-
Lorusso, P.M.1
Weiss, D.2
Guardino, E.3
Girish, S.4
Sliwkowski, M.X.5
-
14
-
-
20244378677
-
Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
-
Agus DB, Gordon MS, Taylor C, et al. Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. J Clin Oncol. 2005;23(11):2534-2543.
-
(2005)
J Clin Oncol
, vol.23
, Issue.11
, pp. 2534-2543
-
-
Agus, D.B.1
Gordon, M.S.2
Taylor, C.3
-
15
-
-
33644600485
-
Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab
-
Adams CW, Allison DE, Flagella K, et al. Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab. Cancer Immunol Immunother. 2006;55(6):717-727.
-
(2006)
Cancer Immunol Immunother
, vol.55
, Issue.6
, pp. 717-727
-
-
Adams, C.W.1
Allison, D.E.2
Flagella, K.3
-
16
-
-
33745343753
-
Rationale for fixed dosing of pertuzumab in cancer patients based on population pharmacokinetic analysis
-
Ng CM, Lum BL, Gimenez V, Kelsey S, Allison D. Rationale for fixed dosing of pertuzumab in cancer patients based on population pharmacokinetic analysis. Pharm Res. 2006;23(6):1275-1284.
-
(2006)
Pharm Res
, vol.23
, Issue.6
, pp. 1275-1284
-
-
Ng, C.M.1
Lum, B.L.2
Gimenez, V.3
Kelsey, S.4
Allison, D.5
-
17
-
-
77949901499
-
Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer
-
Gianni L, Llado A, Bianchi G, et al. Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol. 2010;28(7):1131-1137.
-
(2010)
J Clin Oncol
, vol.28
, Issue.7
, pp. 1131-1137
-
-
Gianni, L.1
Llado, A.2
Bianchi, G.3
-
18
-
-
77949903478
-
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
-
Baselga J, Gelmon KA, Verma S, et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol. 2010;28(7):1138-1144.
-
(2010)
J Clin Oncol
, vol.28
, Issue.7
, pp. 1138-1144
-
-
Baselga, J.1
Gelmon, K.A.2
Verma, S.3
-
19
-
-
84855297353
-
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): A randomised multicentre, open-label, phase 2 trial
-
Gianni L, Pienkowski T, Im YH, et al. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol. 2012;13(1):25-32.
-
(2012)
Lancet Oncol
, vol.13
, Issue.1
, pp. 25-32
-
-
Gianni, L.1
Pienkowski, T.2
Im, Y.H.3
-
20
-
-
84856700379
-
Neoadjuvant pertuzumab and trastuzumab concurrent or sequential with an anthracycline containing or concurrent with an anthracycline-free standard regimen: A randomized phase II study (TRYPHAENA
-
Paper presented at the 2011 San Antonio Breast Cancer Symposium; December 6-10, 2011; San Antonio, TX. Abstract S5-S6
-
Schneeweiss A. Neoadjuvant pertuzumab and trastuzumab concurrent or sequential with an anthracycline containing or concurrent with an anthracycline-free standard regimen: a randomized phase II study (TRYPHAENA). Paper presented at the 2011 San Antonio Breast Cancer Symposium; December 6-10, 2011; San Antonio, TX. Abstract S5-S6. Cancer Res. 2011.
-
(2011)
Cancer Res
-
-
Schneeweiss, A.1
-
21
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J, Cortes J, Kim SB, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 2012; 366(2):109-119.
-
(2012)
N Engl J Med
, vol.366
, Issue.2
, pp. 109-119
-
-
Baselga, J.1
Cortes, J.2
Kim, S.B.3
-
22
-
-
1942474587
-
The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
-
Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res. 2004;64(7):2343-2346.
-
(2004)
Cancer Res
, vol.64
, Issue.7
, pp. 2343-2346
-
-
Nahta, R.1
Hung, M.C.2
Esteva, F.J.3
-
23
-
-
84862512891
-
Trastuzumab plus capecitabine with or without pertuzumab in patients with HER2-positive MBC whose disease has progressed during or following trastuzumab- based therapy for first-line metastatic disease: A multicenter, randomized, two-arm, phase II study (PHEREXA
-
Abstr TPS118
-
Munoz-Mateu M, Urruticoechea A, Separovic R, et al. Trastuzumab plus capecitabine with or without pertuzumab in patients with HER2-positive MBC whose disease has progressed during or following trastuzumab- based therapy for first-line metastatic disease: a multicenter, randomized, two-arm, phase II study (PHEREXA). J Clin Oncol. 2011;29 Suppl:Abstr TPS118.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Munoz-Mateu, M.1
Urruticoechea, A.2
Separovic, R.3
-
24
-
-
84867842898
-
MARIANNE: A phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatment of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC
-
Abstr TPS102
-
Ellis PA, Barrios CH, Im Y, Patre M, Branle F, Perez EA. MARIANNE: a phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatment of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC). J Clin Oncol. 2011;29 Suppl:Abstr TPS102.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Ellis, P.A.1
Barrios, C.H.2
Im, Y.3
Patre, M.4
Branle, F.5
Perez, E.A.6
-
26
-
-
84856693253
-
Adjuvant pertuzumab and Herceptin in initial therapy of breast cancer: APHINITY
-
von Minckwitz G, Balsega J, Bradbury I, et al. Adjuvant pertuzumab and Herceptin in initial therapy of breast cancer: APHINITY. Cancer Res. 2011;71(24 Suppl):602S.
-
(2011)
Cancer Res
, vol.71
, Issue.SUPPL.
-
-
von Minckwitz, G.1
Balsega, J.2
Bradbury, I.3
-
27
-
-
0028884413
-
Requirement for neuregulin receptor erbB2 in neural and cardiac development
-
Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature. 1995;378(6555):394-398.
-
(1995)
Nature
, vol.378
, Issue.6555
, pp. 394-398
-
-
Lee, K.F.1
Simon, H.2
Chen, H.3
Bates, B.4
Hung, M.C.5
Hauser, C.6
-
28
-
-
0028785406
-
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
-
Gassmann M, Casagranda F, Orioli D, et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature. 1995;378(6555):390-394.
-
(1995)
Nature
, vol.378
, Issue.6555
, pp. 390-394
-
-
Gassmann, M.1
Casagranda, F.2
Orioli, D.3
-
29
-
-
0036344533
-
Heart- valve mesenchyme formation is dependent on hyaluronanaugmented activation of ErbB2-ErbB3 receptors
-
Camenisch TD, Schroeder JA, Bradley J, Klewer SE, McDonald JA. Heart- valve mesenchyme formation is dependent on hyaluronanaugmented activation of ErbB2-ErbB3 receptors. Nat Med. 2002;8(8): 850-855.
-
(2002)
Nat Med
, vol.8
, Issue.8
, pp. 850-855
-
-
Camenisch, T.D.1
Schroeder, J.A.2
Bradley, J.3
Klewer, S.E.4
McDonald, J.A.5
-
30
-
-
0032562770
-
Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
-
Zhao YY, Sawyer DR, Baliga RR, et al. Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J Biol Chem. 1998;273(17):10261-10269.
-
(1998)
J Biol Chem
, vol.273
, Issue.17
, pp. 10261-10269
-
-
Zhao, Y.Y.1
Sawyer, D.R.2
Baliga, R.R.3
-
31
-
-
42449155137
-
Cardiac toxicity of ErbB2-targeted therapies: What do we know?
-
Perez EA. Cardiac toxicity of ErbB2-targeted therapies: what do we know? Clin Breast Cancer. 2008;8 Suppl 3:S114-S120.
-
(2008)
Clin Breast Cancer
, vol.8
, Issue.SUPPL. 3
-
-
Perez, E.A.1
-
32
-
-
84857601768
-
Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab
-
Lenihan D, Suter T, Brammer M, Neate C, Ross G, Baselga J. Pooled analysis of cardiac safety in patients with cancer treated with pertuzumab. Ann Oncol. 2012;23(3):791-800.
-
(2012)
Ann Oncol
, vol.23
, Issue.3
, pp. 791-800
-
-
Lenihan, D.1
Suter, T.2
Brammer, M.3
Neate, C.4
Ross, G.5
Baselga, J.6
-
33
-
-
52049088286
-
Cardiac toxicity and efficacy of trastuzumab combined with pertuzumab in patients with [corrected] human epidermal growth factor receptor 2-positive metastatic breast cancer
-
Portera CC, Walshe JM, Rosing DR, et al. Cardiac toxicity and efficacy of trastuzumab combined with pertuzumab in patients with [corrected] human epidermal growth factor receptor 2-positive metastatic breast cancer. Clin Cancer Res. 2008;14(9):2710-2716.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.9
, pp. 2710-2716
-
-
Portera, C.C.1
Walshe, J.M.2
Rosing, D.R.3
-
34
-
-
77953872348
-
Pertuzumab and trastuzumab: Re-responses to 2 biological agents in patients with HER2-positive breast cancer which had previously progressed during therapy with each agent given separately: A new biological and clinical observation
-
Abstract 5114
-
Baselga J, Cortes J, Fumoleau P, et al. Pertuzumab and trastuzumab: re-responses to 2 biological agents in patients with HER2-positive breast cancer which had previously progressed during therapy with each agent given separately: a new biological and clinical observation. Cancer Res. 2009;69(24 Suppl):Abstract 5114.
-
(2009)
Cancer Res
, vol.69
, Issue.24 SUPPL
-
-
Baselga, J.1
Cortes, J.2
Fumoleau, P.3
|