Fluorescent carbon dots as an efficient siRNA nanocarrier for its interference therapy in gastric cancer cells

Journal of Nanobiotechnology

Volumn 12, Issue 1, 2014, Pages

  Wang, Qing ^a,b   Zhang, Chunlei ^b   Shen, Guangxia ^b   Liu, Huiyang ^b   Fu, Hualin ^b   Cui, Daxiang ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Jiao Tong University   (China)

Author keywords

Carbon dots; Gastric cancer; Nanocarriers; siRNA interference therapy

Indexed keywords

AMINO ACIDS; BIOCOMPATIBILITY; CARBON; CELL CULTURE; CELL DEATH; CELLS; CHEMICAL MODIFICATION; CYTOLOGY; DISEASES; DRUG DELIVERY; FLUORESCENCE; MOBILE SECURITY; NUCLEIC ACIDS; RNA;

CARBON DOTS; CELL-CYCLE PROGRESSION; GASTRIC CANCER CELL LINES; GASTRIC CANCER CELLS; GASTRIC CANCERS; NANO-CARRIERS; PHOTOLUMINESCENT MATERIALS; SIRNA INTERFERENCE THERAPY;

GENE THERAPY;

CITRIC ACID; FLUORESCENT CARBON DOT; FLUORESCENT DYE; NANOCARRIER; NANOPARTICLE; NITROGEN; POLYETHYLENEIMINE; SMALL INTERFERING RNA; SURVIVIN; TRYPTOPHAN; UNCLASSIFIED DRUG; VIRUS VECTOR; WATER; BIRC5 PROTEIN, HUMAN; CARBON; DRUG CARRIER; INHIBITOR OF APOPTOSIS PROTEIN; QUANTUM DOT;

ADSORPTION; APOPTOSIS; ARTICLE; BIOCOMPATIBILITY; CARBON SOURCE; CELL CYCLE PROGRESSION; CHEMICAL PHENOMENA; CONTROLLED STUDY; CYTOPLASM; G1 PHASE CELL CYCLE CHECKPOINT; GASTRIC CANCER CELL LINE; GENE SILENCING; HUMAN; HUMAN CELL; MGC 803 CELL LINE; MICROWAVE RADIATION; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; QUANTUM YIELD; RNA INTERFERENCE; SOLUBILITY; STOMACH CANCER; CELL CYCLE; CHEMISTRY; GENE EXPRESSION REGULATION; GENE TRANSFER; GENETICS; STOMACH NEOPLASMS; TUMOR CELL LINE;

APOPTOSIS; CARBON; CELL CYCLE; CELL LINE, TUMOR; DRUG CARRIERS; FLUORESCENT DYES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENE TRANSFER TECHNIQUES; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; NANOPARTICLES; POLYETHYLENEIMINE; QUANTUM DOTS; RNA, SMALL INTERFERING; SOLUBILITY; STOMACH NEOPLASMS;

EID: 84924903351     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/s12951-014-0058-0     Document Type: Article

References (30)

1. Peer D, Karp JM, Hong S, FaroKhzad OC, Margalit R, Langer R: Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007, 2:751-760.
2. Wang M, Thanou M: Targeting nanoparticles to cancer. Pharmacol Res 2010, 62:90-99.
3. Zhang C, Zhou Z, Qian Q, Gao G, Li C, Feng L, Wang Q, Cui D: Glutathione-capped fluorescent gold nanoclusters for dual-modal fluorescence/X-ray computed tomography imaging. J Mater Chem B 2013, 1:5045-5053.
4. Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S: Quantum dots for live cells, in vivo imaging, and diagnostics. Science 2005, 307:538-544.
5. Disney MD, Zheng J, Swager TM, Seeberger PH: Detection of bacteria with carbohydrate-functionalized fluorescent polymers. J Am Chem Soc 2004, 126:13343-13346.
6. Baker SN, Baker GA: Luminescent carbon nanodots: emergent Nanolights. Angew Chem Int Ed 2010, 49:6726-6744.
7. Li H, Kang Z, Liu Y, Lee S-T: Carbon nanodots: synthesis, properties and applications. J Mater Chem 2012, 22:24230-24253.
8. Derfus AM, Chan WCW, Bhatia SN: Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 2003, 4:11-18.
9. Song Y, Shi W, Chen W, Li X, Ma H: Fluorescent carbon nanodots conjugated with folic acid for distinguishing folate-receptor-positive cancer cells from normal cells. J Mater Chem 2012, 22:12568-12573.
10. Ruan S, Qian J, Shen S, Zhu J, Jiang X, He Q, Gao H: A simple one-step method to prepare fluorescent carbon dots and their potential application in non-invasive glioma imaging. Nanoscale 2014, 6:10040-10047.
11. 2+ with lysine enhancing bovine serum albumin modified-carbon dots fluorescent probe. Analyst 2012, 137:2637-2642.
12. Wang Q, Liu X, Zhang L, Lv Y: Microwave-assisted synthesis of carbon nanodots through an eggshell membrane and their fluorescent application. Analyst 2012, 137:5392-5397.
13. Du F, Zhang M, Li X, Li J, Jiang X, Li Z, Hua Y, Shao G, Jin J, Shao Q, Zhou M, Gong A: Economical and green synthesis of bagasse-derived fluorescent carbon dots for biomedical applications. Nanotechnology 2014, 25(31):315702-315712.
14. Peng J, Gao W, Gupta BK, Liu Z, Romero-Aburto R, Ge L, Song L, Alemany L, Zhan X, Gao G, Vithayathil S, Kaipparettu B, Marti A, Hayashi T, Zhu J, Ajayan P: Graphene quantum dots derived from carbon fibers. Nano Lett 2012, 12(2):844-849.
15. 60 molecules into graphene quantum dots. Nat Nanotechnol 2011, 6:247-252.
16. Wu ZL, Zhang P, Gao MX, Liu CF, Wang W, Leng F, Huang CZ: One-pot hydrothermal synthesis of highly luminescent nitrogen-doped amphoteric carbon dots for bioimaging from Bombyx mori silk - natural proteins. J Mater Chem B 2013, 1:2868-2873.
17. Sun Y-P, Wang X, Lu F, Cao L, Meziani MJ, Luo PG, Gu L, Veca L: Doped carbon nanoparticles as a new platform for highly photoluminescent dots. J Phys Chem C 2008, 112(47):18295-18298.
18. Liu H, Wang Q, Shen G, Zhang C, Li C, Ji W, Wang C, Cui D: A multifunctional ribonuclease A-conjugated carbon dot cluster nanosystem for synchronous cancer imaging and therapy. Nanoscale Res Lett 2014, 9:397.
19. Huang P, Lin J, Wang X, Wang Z, Zhang C, He M, Wang K, Chen F, Li Z, Shen G, Cui D, Chen X: Light-triggered theranostics based on photosensitizer-conjugated carbon dots for simultaneous enhanced-fluorescence imaging and photodynamic therapy. Adv Mater 2012, 24(37):5104-5110.
20. Hannon GJ: RNA interference. Nature 2002, 418:244-251.
21. Fellmann C, Lowe SW: Stable RNA interference rules for silencing. Nat Cell Biol 2014, 16:10-18.
22. Maillard PV, Ciaudo C, Marchais A, Li Y, Jay F, Ding SW, Voinnet O: Antiviral RNA interference in mammalian cells. Science 2013, 342:235-238.
23. Wang L, Wang X, Bhirde A, Cao J, Zeng Y, Huang X, Sun Y, Liu G, Chen X: Carbon-Dot-based Two-photon visible nanocarriers for safe and highly efficient delivery of siRNA and DNA. Adv Healthcare Mater 2014, 3:1203-1209.
24. Liu C, Zhang P, Zhai X, Tian F, Li W, Yang J, Liu Y, Wang H, Wang W, Liu W: Nano-carrier for gene delivery and bioimaging based on carbon dots with PEI-passivation enhanced fluorescence. Biomaterials 2012, 33:3604-3613.
25. Qi L, Shao W, Shi D: JAM-2 siRNA intracellular delivery and real-time imaging by proton-sponge coated quantum dots. J Mater Chem B 2013, 1:654-660.
26. Yang D, Welm A, Bishop JM: Cell division and cell survival in the absence of survivin. Proc Natl Acad Sci 2004, 101:15100-15105.
27. Suzuki A, Hayashida M, Ito T, Kawano H, Nakano T, Miura M, Akahane K, Shiraki K: Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/Cyclin E complex activation. Oncogene 2000, 19:3225-3234.
28. Lu CD, Altieri DC, Tanigawa N: Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas. Cancer Res 1998, 58:1808-1812.
29. Parhamifar L, Larsen AK, Hunter AC, Andresen TL, Moghimi SM: Polycation cytotoxicity: a delicate matter for nucleic acid therapy-focus on polyethylenimine. Soft Matter 2010, 6:4001-4009.
30. Montazeri Aliabadi H, Landry B, Mahdipoor P, Uludağ H: Induction of apoptosis by survivin silencing through siRNA delivery in a human breast cancer cell line. Mol Pharmaceutics 2011, 8:1821-1830.