Erythromelalgia mutation Q875E stabilizes the activated state of sodium channel Nav1.7

Journal of Biological Chemistry

Volumn 290, Issue 10, 2015, Pages 6316-6325

  Stadler, Theresa ^a   O'Reilly, Andrias O ^a,b   Lampert, Angelika ^a,c  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT BONDS;

ACTIVATED CONFORMATION; DISULFIDE BRIDGE; ELECTRICAL FIELD; ELECTROSTATIC SCREENING; EXTRACELLULAR CONCENTRATION; GAIN-OF FUNCTION; THREE-DIMENSIONAL HOMOLOGY MODEL; VOLTAGE DEPENDENCE;

CHEMICAL ACTIVATION;

ARGININE; CALCIUM ION; GLUTAMIC ACID; GLUTAMINE; MAGNESIUM ION; SODIUM CHANNEL NAV1.7; CALCIUM; MAGNESIUM; SCN9A PROTEIN, HUMAN; SODIUM CHANNEL;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC FIELD; ELECTRIC POTENTIAL; EMBRYO; ERYTHROMELALGIA; EXTRACELLULAR CALCIUM; GAIN OF FUNCTION MUTATION; GENE MUTATION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MOLECULAR INTERACTION; MUTANT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; PAIN; PATCH CLAMP TECHNIQUE; PATHOLOGY;

CALCIUM; ERYTHROMELALGIA; HEK293 CELLS; HUMANS; MAGNESIUM; MODELS, MOLECULAR; MUTATION; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; PAIN; PATCH-CLAMP TECHNIQUES; SODIUM CHANNELS;

EID: 84924871549     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.605899     Document Type: Article

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