Intravenous peramivir inhibits viral replication, and leads to bacterial clearance and prevention of mortality during murine bacterial co-infection caused by influenza A(H1N1)pdm09 virus and Streptococcus pneumoniae

Antiviral Research

Volumn 117, Issue , 2015, Pages 52-59

  Onishi, Motoyasu ^a   Kitano, Mitsutaka ^a   Taniguchi, Keiichi ^a   Homma, Tomoyuki ^a   Kobayashi, Masanori ^a   Yoshinaga, Tomokazu ^a   Naito, Akira ^a   Sato, Akihiko ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Bacterial co infection; Influenza virus; Neuraminidase inhibitor; Peramivir; Streptococcus pneumoniae

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 6; OSELTAMIVIR; PERAMIVIR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; ANTIVIRUS AGENT; CYCLOPENTANE DERIVATIVE; CYTOKINE; GUANIDINE DERIVATIVE;

2009 H1N1 INFLUENZA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ANTIVIRAL THERAPY; ARTICLE; BACTERIAL CLEARANCE; CYTOKINE RESPONSE; DRUG EFFICACY; FEMALE; INFLUENZA VIRUS A H1N1; LUNG HOMOGENATE; MORTALITY; MOUSE; NONHUMAN; PNEUMOCOCCAL INFECTION; PREVENTION; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; SURVIVAL RATE; VIRUS ISOLATION; VIRUS REPLICATION; ANIMAL; BACTERIAL LOAD; BAGG ALBINO MOUSE; COINFECTION; COMPLICATION; DISEASE MODEL; DOG; DRUG EFFECTS; IMMUNOLOGY; INFLUENZA A VIRUS (H1N1); INTRAVENOUS DRUG ADMINISTRATION; MDCK CELL LINE; ORTHOMYXOVIRIDAE INFECTIONS; VIRUS LOAD;

BACTERIA (MICROORGANISMS); MURINAE; MUS; ORTHOMYXOVIRIDAE; STREPTOCOCCUS PNEUMONIAE;

ADMINISTRATION, INTRAVENOUS; ANIMALS; ANTIVIRAL AGENTS; BACTERIAL LOAD; COINFECTION; CYCLOPENTANES; CYTOKINES; DISEASE MODELS, ANIMAL; DOGS; GUANIDINES; INFLUENZA A VIRUS, H1N1 SUBTYPE; MADIN DARBY CANINE KIDNEY CELLS; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; OSELTAMIVIR; PNEUMOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; VIRAL LOAD; VIRUS REPLICATION;

EID: 84924814602     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2015.02.012     Document Type: Article

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