Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome

Journal of Neuroscience

Volumn 35, Issue 9, 2015, Pages 3938-3945

  Tang, Ai Hui ^a   Alger, Bradley E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

DHPG; Epilepsy; Fmr1; Hippocampus; Inhibitory synapses; Seizure

Indexed keywords

CANNABINOID RECEPTOR ANTAGONIST; ENDOCANNABINOID; FRAGILE X MENTAL RETARDATION PROTEIN; METABOTROPIC RECEPTOR; PROTEIN HOMER; CANNABINOID 1 RECEPTOR; CARRIER PROTEIN; FMR1 PROTEIN, MOUSE; METABOTROPIC RECEPTOR 5; PROTEIN BINDING;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; EPILEPTIC DISCHARGE; FRAGILE X SYNDROME; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; IMMUNOPRECIPITATION; MALE; MOUSE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE EXCITABILITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR BINDING; STRATUM PYRAMIDALE; SYNAPSE; SYNAPTIC TRANSMISSION; VOLTAGE CLAMP TECHNIQUE; WHOLE CELL PATCH CLAMP; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; GENETICS; HIPPOCAMPUS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; ENDOCANNABINOIDS; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN BINDING; RECEPTOR, CANNABINOID, CB1; RECEPTOR, METABOTROPIC GLUTAMATE 5; SIGNAL TRANSDUCTION;

EID: 84924763324     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4499-14.2015     Document Type: Article

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