Hyperinsulinemia induces hepatic iron overload by increasing liver TFR1 via the PI3K/IRP2 pathway

Journal of Molecular Endocrinology

Volumn 53, Issue 3, 2014, Pages 381-392

  Jiang, Xin ^a   Wan, Heyang ^a   Shi, Wencai ^a   Shen, Zhilei ^a   Shen, Hui ^a   Li, Min ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Goto Kakizaki rats; Hyperinsulinemia; Iron overload; IRPs; TFRs

Indexed keywords

CD71 ANTIGEN; CORTICOSTERONE; GLUCOSE; INSULIN; IRON; IRON REGULATORY FACTOR; IRON REGULATORY PROTEIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; TFR1 PROTEIN, RAT; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BODY WEIGHT; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DYSMETABOLIC IRON OVERLOAD SYNDROME; FEMALE; GLUCOSE BLOOD LEVEL; HYPERINSULINEMIA; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN TREATMENT; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON OVERLOAD; IRON TRANSPORT; LIVER DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; UPREGULATION; ANIMAL; CELL CULTURE; COMPLICATION; DRUG EFFECTS; GENETICS; HUMAN; HYPERINSULINISM; LIVER; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; FEMALE; HUMANS; HYPERINSULINISM; INSULIN; IRON OVERLOAD; IRON REGULATORY PROTEIN 2; LIVER; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFERRIN; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84924755197     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-14-0122     Document Type: Article

References (31)

1. Anderson CP, Shen M, Eisenstein RS & Leibold EA 2012 Mammalian iron metabolism and its control by iron regulatory proteins. Biochimica et Biophysica Acta 1823 1468–1483. (doi:10.1016/j.bbamcr.2012.05.010)
2. Andrews NC & Schmidt PJ 2007 Iron homeostasis. Annual Review of Physiology 69 69–85. (doi:10.1146/annurev.physiol.69.031905.164337)
3. Biswas S, Tapryal N, Mukherjee R, Kumar R & Mukhopadhyay CK 2013 Insulin promotes iron uptake in human hepatic cell by regulating transferrin receptor-1 transcription mediated by hypoxia inducible factor-1. Biochimica et Biophysica Acta 1832 293–301. (doi:10.1016/j.bbadis.2012.11.003)
4. Clairmont KB & Czech MP 1990 Insulin injection increases the levels of serum receptors for transferrin and insulin-like growth factor-II/mannose-6-phosphate in intact rats. Endocrinology 127 1568–1573. (doi:10.1210/endo-127-4-1568)
5. Corkey BE 2012 Hyperinsulinemia: cause or consequence? Diabetes 61 4–13. (doi:10.2337/db11-1483)
6. Davis RJ, Corvera S & Czech MP 1986 Insulin stimulates cellular iron uptake and causes the redistribution of intracellular transferrin receptors to the plasma membrane. Journal of Biological Chemistry 261 8708–8711.
7. Day CP 2006 From fat to inflammation. Gastroenterology 130 207–210. (doi:10.1053/j.gastro.2005.11.017)
8. Dongiovanni P, Fracanzani AL, Fargion S & Valenti L 2011 Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target. Journal of Hepatology 55 920–932. (doi:10.1016/j.jhep.2011.05.008)
9. Festa M, Ricciardelli G, Mele G, Pietropaolo C, Ruffo A & Colonna A 2000 Overexpression of H ferritin and up-regulation of iron regulatory protein genes during differentiation of 3T3-L1 pre-adipocytes. Journal of Biological Chemistry 275 36708–36712. (doi:10.1074/jbc.M004988200)
10. Fleming RE, Migas MC, Holden CC, Waheed A, Britton RS, Tomatsu S, Bacon BR & Sly WS 2000 Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. PNAS 97 2214–2219. (doi:10.1073/pnas.040548097)
11. Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K & Hentze MW 2005 Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood 106 2580–2589. (doi:10.1182/blood-2005-04-1365)
12. Haile DJ, Rouault TA, Tang CK, Chin J, Harford JB & Klausner RD 1992 Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster. PNAS 89 7536–7540. (doi:10.1073/pnas.89.16.7536)
13. Hentze MW, Muckenthaler MU, Galy B & Camaschella C 2010 Two to tango: regulation of mammalian iron metabolism. Cell 142 24–38. (doi:10.1016/j.cell.2010.06.028)
14. Karpe F, Dickmann JR & Frayn KN 2011 Fatty acids, obesity, and insulin resistance: time for a reevaluation. Diabetes 60 2441–2449. (doi:10.2337/db11-0425)
15. Mascitelli L, Pezzetta F & Goldstein MR 2009 Hyperinsulinaemia and iron perturbation in patients with type 2 diabetes. International Journal of Clinical Practice 63 672. (doi:10.1111/j.1742-1241.2008.01983.x)
16. Merkel PA, Simonson DC, Amiel SA, Plewe G, Sherwin RS, Pearson HA & Tamborlane WV 1988 Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion. New England Journal of Medicine 318 809–814. (doi:10.1056/NEJM198803313181303)
17. Mitsuyoshi H, Yasui K, Harano Y, Endo M, Tsuji K, Minami M, Itoh Y, Okanoue T & Yoshikawa T 2009 Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. Hepatology Research 39 366–373. (doi:10.1111/j.1872-034X.2008.00464.x)
18. Mullner EW & Kuhn LC 1988 A stem-loop in the 3’ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm. Cell 53 815–825. (doi:10.1016/0092-8674(88)90098-0)
19. Mullner EW, Neupert B & Kuhn LC 1989 A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA. Cell 58373–58382. (doi:10.1016/0092-8674(89)90851-9)
20. Niederau C, Berger M, Stremmel W, Starke A, Strohmeyer G, Ebert R, Siegel E & Creutzfeldt W 1984 Hyperinsulinaemia in non-cirrhotic haemochromatosis: impaired hepatic insulin degradation? Diabetologia 26 441–444. (doi:10.1007/BF00262217)
21. O’Brien J & Powell LW 2012 Non-alcoholic fatty liver disease: is iron relevant? Hepatology International 6 332–341. (doi:10.1007/s12072-011-9304-9)
22. Piperno A, Vergani A, Salvioni A, Trombini P, Vigano M, Riva A, Zoppo A, Boari G & Mancia G 2004 Effects of venesections and restricted diet in patients with the insulin-resistance hepatic iron overload syndrome. Liver International 24 471–476. (doi:10.1111/j.1478-3231.2004.0988.x)
23. Qiao Y & Li M 2010 The effect of iron metabolism related proteins on HL-7702 cell lines with high glucose cultivation. Journal of Shanxi Medical University 6 484–487.
24. Ruivard M, Lainé F, Ganz T, Olbina G, Westerman M, Nemeth E, Rambeau M, Mazur A, Gerbaud L, Tournilhac V et al. 2009 Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. Journal of Hepatology 50 1219–1225. (doi:10.1016/j.jhep.2009.01.029)
25. Salahudeen AA, Thompson JW, Ruiz JC, Ma HW, Kinch LN, Li Q, Grishin NV & Bruick RK 2009 An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Science 326 722–726. (doi:10.1126/science.1176326)
26. Sanyal AJ 2005 Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease. Nature Clinical Practice. Gastroenterology & Hepatology 2 46–53. (doi:10.1038/ncpgasthep0084)
27. Stys A, Galy B, Starzynski RR, Smuda E, Drapier JC, Lipinski P & Bouton C 2011 Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide. Journal of Biological Chemistry 286 22846–22854. (doi:10.1074/jbc.M111.231902)
28. Tanner LI & Lienhard GE 1987 Insulin elicits a redistribution of transferrin receptors in 3T3-L1 adipocytes through an increase in the rate constant for receptor externalization. Journal of Biological Chemistry 262 8975–8980.
29. Tsuchiya H, Ashla AA, Hoshikawa Y, Matsumi Y, Kanki K, Enjoji M, Momosaki S, Nakamuta M, Taketomi A, Maehara Y et al. 2010 Iron state in association with retinoid metabolism in non-alcoholic fatty liver disease. Hepatology Research 40 1227–1238. (doi:10.1111/j.1872-034X.2010.00719.x)
30. Valenti L, Moscatiello S, Vanni E, Fracanzani AL, Bugianesi E, Fargion S & Marchesini G 2011 Venesection for non-alcoholic fatty liver disease unresponsive to lifestyle counseling – a propensity score-adjusted observational study. QJM 104 141–149. (doi:10.1093/qjmed/hcq170)
31. Vashisht AA, Zumbrennen KB, Huang X, Powers DN, Durazo A, Sun D, Bhaskaran N, Persson A, Uhlen M, Sangfelt O et al. 2009 Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science 326 718–721. (doi:10.1126/science.1176333)