CCL2/CCR2-Dependent recruitment of Th17 cells but not Tc17 cells to the lung in a murine asthma model

International Archives of Allergy and Immunology

Volumn 166, Issue 1, 2015, Pages 52-62

  Wang, Aili ^a   Wang, Zhengyun ^a   Cao, Yong ^a   Cheng, Sheng ^a   Chen, Huilong ^a   Bunjhoo, Hansvin ^a   Xie, Jungang ^a   Wang, Congyi ^a   Xu, Yongjian ^a   Xiong, Weining ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Airway inflammation; Asthma; CC chemokine ligand 2; Tc17 cells; Th17 cells

Indexed keywords

CHEMOKINE RECEPTOR CCR2; INTERLEUKIN 17; MONOCYTE CHEMOTACTIC PROTEIN 1; BENZOXAZINE DERIVATIVE; CCL2 PROTEIN, MOUSE; CCR2 PROTEIN, MOUSE; NEUTRALIZING ANTIBODY; OVALBUMIN; RS 504393; SPIRO COMPOUND;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ASTHMA; BRONCHIOLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RELEASE; EOSINOPHIL; FEMALE; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; INFLAMMATORY CELL; LUNG HOMOGENATE; LUNG LAVAGE; LUNG PARENCHYMA; LYMPHOCYTE; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; REVIEW; TH17 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMICALLY INDUCED; CHEMISTRY; CYTOLOGY; DISEASE MODEL; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; LUNG; LYMPHOCYTE COUNT; PATHOLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ASTHMA; BENZOXAZINES; BRONCHOALVEOLAR LAVAGE FLUID; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; HUMANS; INTERLEUKIN-17; LUNG; LYMPHOCYTE COUNT; MICE; MICE, INBRED BALB C; OVALBUMIN; RECEPTORS, CCR2; SPIRO COMPOUNDS; TH17 CELLS;

EID: 84924737508     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000371764     Document Type: Review

References (42)

1. Cua DJ, Tato CM: Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 2010; 10:479-489.
2. Page SH, Wright EK Jr, Gama L, Clements JE: Regulation of CCL2 expression by an upstream tale homeodomain protein-binding site that synergizes with the site created by the A-2578G SNP. PLoS One 2011; 6:e22052.
3. Schneider D, Hong JY, Bowman ER, Chung Y, Nagarkar DR, McHenry CL, Goldsmith AM, Bentley JK, Lewis TC, Hershenson MB: Macrophage/epithelial cell CCL2 contributes to rhinovirus-induced hyperresponsiveness and inflammation in a mouse model of allergic airways disease. Am J Physiol Lung Cell Mol Physiol 2013; 304:L162-L169.
4. Leonard EJ, Skeel A, Yoshimura T: Biological aspects of monocyte chemoattractant pro-tein-1 (MCP-1). Adv Exp Med Biol 1991; 305: 57-64.
5. Sironi M, Munoz C, Pollicino T, Siboni A, Sciacca FL, Bernasconi S, Vecchi A, Colotta F, Mantovani A: Divergent effects of interleu-kin-10 on cytokine production by mononu-clear phagocytes and endothelial cells. Eur J Immunol 1993; 23:2692-2695.
6. Holgate ST, Bodey KS, Janezic A, Frew AJ, Kaplan AP, Teran LM: Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge. Am J Respir Crit Care Med 1997; 156: 1377-1383.
7. Patel JK, Clifford RL, Deacon K, Knox AJ: Ciclesonide inhibits TNFalpha-and IL-1beta-induced monocyte chemotactic protein-1 (MCP-1/CCL2) secretion from human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2012; 302:L785-L792.
8. Pelletier M, Maggi L, Micheletti A, Lazzeri E, Tamassia N, Costantini C, Cosmi L, Lunardi C, Annunziato F, Romagnani S, Cassatella MA: Evidence for a cross-talk between human neutrophils and Th17 cells. Blood 2010; 115: 335-343.
9. Radman M, Hassanshahi G, Vazirinejad R, Arababadi MK, Karimabad MN, Khorram-delazad H, Rafatpanah H, Iranmanesh F, Ha-kimizadeh E, Ahmadi Z: Serum levels of the CC chemokines CCL2, CCL5, and CCL11 in food allergic children with different clinical manifestations. Inflammation 2013; 36:561-566.
10. Chelbi H, Ghadiri A, Lacheb J, Ghandil P, Hamzaoui K, Hamzaoui A, Combadiere C: A polymorphism in the CCL2 chemokine gene is associated with asthma risk: a case-control and a family study in Tunisia. Genes Immun 2008; 9:575-581.
11. Rose CE Jr, Sung SS, Fu SM: Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung. Microcirculation 2003; 10:273-288.
12. Kato M, Yamada Y, Maruyama K, Hayashi Y: Serum eosinophil cationic protein and 27 cy-tokines/chemokines in acute exacerbation of childhood asthma. Int Arch Allergy Immunol 2010; 152(suppl 1):62-66.
13. Chan CK, Kuo ML, Yeh KW, Ou LS, Chen LC, Yao TC, Huang JL: Sequential evaluation of serum monocyte chemotactic protein 1 among asymptomatic state and acute exacerbation and remission of asthma in children. J Asthma 2009; 46:225-228.
14. Jahnz-Rozyk KM, Kuna P, Pirozynska E: Monocyte chemotactic and activating factor/monocyte chemoattractant protein (MCAF/MCP-1) in bronchoalveolar lavage fluid from patients with atopic asthma and chronic bronchitis. J Investig Allergol Clin Immunol 1997; 7:254-259.
15. Alam R, York J, Boyars M, Stafford S, Grant JA, Lee J, Forsythe P, Sim T, Ida N: Increased MCP-1, RANTES, and MIP-1alpha in bron-choalveolar lavage fluid of allergic asthmatic patients. Am J Respir Crit Care Med 1996; 153:1398-1404.
16. Lukacs NW, Strieter RM, Warmington K, Lincoln P, Chensue SW, Kunkel SL: Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in allergic airway inflammation. J Immunol 1997; 158:4398-4404.
17. Mellado M, Martin de Ana A, Gomez L, Martinez C, Rodriguez-Frade JM: Chemokine receptor 2 blockade prevents asthma in a cyno-molgus monkey model. J Pharmacol Exp Ther 2008; 324:769-775.
18. Wakashin H, Hirose K, Maezawa Y, Kagami S, Suto A, Watanabe N, Saito Y, Hatano M, Tokuhisa T, Iwakura Y, Puccetti P, Iwamoto I, Nakajima H: IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am J Respir Crit Care Med 2008; 178:1023-1032.
19. Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN: Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsive-ness. Am J Respir Crit Care Med 2009; 180: 720-730.
20. Nakagome K, Matsushita S, Nagata M: Neu-trophilic inflammation in severe asthma. Int Arch Allergy Immunol 2012; 158(suppl 1):96-102.
21. Naji N, Smith SG, Gauvreau GM, O'Byrne PM: T helper 17 cells and related cytokines after allergen inhalation challenge in allergic asthmatics. Int Arch Allergy Immunol 2014; 165:27-34.
22. Liu SJ, Tsai JP, Shen CR, Sher YP, Hsieh CL, Yeh YC, Chou AH, Chang SR, Hsiao KN, Yu FW, Chen HW: Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. J Leukoc Biol 2007; 82: 354-360.
23. Reber LL, Daubeuf F, Plantinga M, De Cau-wer L, Gerlo S, Waelput W, Van Calenbergh S, Tavernier J, Haegeman G, Lambrecht BN, Frossard N, De Bosscher K: A dissociated glu-cocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma. J Immunol 2012; 188:3478-3487.
24. Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, Biswal S: Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med 2005; 202:47-59.
25. Penido C, Costa MF, Souza MC, Costa KA, Candea AL, Benjamim CF, Henriques M: Involvement of cc chemokines in gam-madelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR 2 pathway. Int Immunol 2008; 20: 129-139.
26. Gonzalo JA, Lloyd CM, Wen D, Albar JP, Wells TN, Proudfoot A, Martinez AC, Dorf M, Bjerke T, Coyle AJ, Gutierrez-Ramos JC: The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J Exp Med 1998; 188:157-167.
27. Souto FO, Alves-Filho JC, Turato WM, Aux-iliadora-Martins M, Basile-Filho A, Cunha FQ: Essential role of CCR2 in neutrophil tissue infiltration and multiple organ dysfunction in sepsis. Am J Respir Crit Care Med 2011; 183:234-242.
28. Nakagome K, Imamura M, Okada H, Kawa-hata K, Inoue T, Hashimoto K, Harada H, Hi-gashi T, Takagi R, Nakano K, Hagiwara K, Kanazawa M, Dohi M, Nagata M, Matsushita S: Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and ovalbumin antigen-induced neutrophilic airway inflammation. J Immunol 2011; 186: 5975-5982.
29. You QH, Zhang D, Niu CC, Zhu ZM, Wang N, Yue Y, Sun GY: Expression of IL-17A and IL-17F in lipopolysaccharide-induced acute lung injury and the counteraction of anisoda-mine or methylprednisolone. Cytokine 2014; 66:78-86.
30. Wilder JA, Collie DD, Bice DE, Tesfaigzi Y, Lyons CR, Lipscomb MF: Ovalbumin aerosols induce airway hyperreactivity in naive DO11.10 T cell receptor transgenic mice without pulmonary eosinophilia or ova-specific antibody. J Leukoc Biol 2001; 69:538-547.
31. Price MM, Oskeritzian CA, Falanga YT, Hari-kumar KB, Allegood JC, Alvarez SE, Conrad D, Ryan JJ, Milstien S, Spiegel S: A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. J Allergy Clin Immunol 2013; 131:501-511.e501.
32. Li K, Wang Z, Cao Y, Bunjhoo H, Zhu J, Chen Y, Xiong S, Xu Y, Xiong W: The study of the ratio and distribution of Th17 cells and Tc17 cells in asthmatic patients and the mouse model. Asian Pac J Allergy Immunol 2013; 31: 125-131.
33. Uller L, Persson CG, Erjefalt JS: Resolution of airway disease: removal of inflammatory cells through apoptosis, egression or both? Trends Pharmacol Sci 2006; 27:461-466.
34. Sica A, Wang JM, Colotta F, Dejana E, Man-tovani A, Oppenheim JJ, Larsen CG, Zachari-ae CO, Matsushima K: Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor. J Immunol 1990; 144:3034-3038.
35. Collington SJ, Hallgren J, Pease JE, Jones TG, Rollins BJ, Westwick J, Austen KF, Williams TJ, Gurish MF, Weller CL: The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo. J Immunol 2010; 184: 6114-6123.
36. Campbell EM, Charo IF, Kunkel SL, Strieter RM, Boring L, Gosling J, Lukacs NW: Mono-cyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/-mice: the role of mast cells. J Immunol 1999; 163:2160-2167.
37. Webb A, Johnson A, Fortunato M, Platt A, Crabbe T, Christie MI, Watt GF, Ward SG, Jopling LA: Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists. J Leukoc Biol 2008; 84:1202-1212.
38. Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T: CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis. J Immunol 2012; 189:5057-5065.
39. Li H, Nourbakhsh B, Safavi F, Li K, Xu H, Cul-limore M, Zhou F, Zhang G, Rostami A: Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression. J Immunol 2011; 187:274-282.
40. Rampersad RR, Tarrant TK, Vallanat CT, Quintero-Matthews T, Weeks MF, Esserman DA, Clark J, Di Padova F, Patel DD, Fong AM, Liu P: Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis. PLoS One 2011; 6:e25833.
41. Oo YH, Banz V, Kavanagh D, Liaskou E, Withers DR, Humphreys E, Reynolds GM, Lee-Turner L, Kalia N, Hubscher SG, Klener-man P, Eksteen B, Adams DH: CXCR3-de-pendent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. J Hepatol 2012; 57:1044-1051.
42. Wong CK, Cao J, Yin YB, Lam CW: Interleu-kin-17A activation on bronchial epithelium and basophils: a novel inflammatory mechanism. Eur Respir J 2010; 35:883-893.