C-reactive protein polymorphism rs3091244 is associated with abdominal aortic aneurysm

Journal of Vascular Surgery

Volumn 60, Issue 5, 2014, Pages 1332-1339

  Saratzis, Athanasios ^a,b   Bown, Matthew ^c   Wild, Ben ^c   Sayers, Robert D ^c   Nightingale, Peter ^d   Smith, Jacqueline ^b   Johnson, Christopher ^b   Kitas, George ^b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b DUDLEY GROUP OF HOSPITALS NHS TRUST   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; DNA; AUTACOID;

ABDOMINAL AORTA ANEURYSM; AGED; ALLELE; ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; CONTROLLED STUDY; DNA EXTRACTION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC MARKER; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LIMIT OF QUANTITATION; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; AORTIC ANEURYSM, ABDOMINAL; BLOOD; CHI SQUARE DISTRIBUTION; COMORBIDITY; GENETIC PREDISPOSITION; GENETICS; GREECE; META ANALYSIS; MIDDLE AGED; PHENOTYPE; RISK; RISK ASSESSMENT; RISK FACTOR; UNITED KINGDOM;

AGED; AORTIC ANEURYSM, ABDOMINAL; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; COMORBIDITY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GREAT BRITAIN; GREECE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT; RISK FACTORS;

EID: 84924727899     PISSN: 07415214     EISSN: 10976809     Source Type: Journal    
DOI: 10.1016/j.jvs.2013.07.105     Document Type: Article

References (25)

1. Cosford PA, Leng GC. Screening for abdominal aortic aneurysm. Cochrane Database Syst Rev 2007;2:CD002945
2. Svensjo S, Bjorck M, Gurtelschmid M, Djavani Gidlund K, Hellberg A, Wanhainen A. Low prevalence of abdominal aortic aneurysm among 65-year-old Swedish men indicates a change in the epidemiology of the disease. Circulation 2011;124:1118-23
3. Norman PE, Jamrozik K, Lawrence-Brown MM, Le MT, Spencer CA, Tuohy RJ, et al. Population based randomised controlled trial on impact of screening on mortality from abdominal aortic aneurysm. BMJ 2004;329:1259
4. Saratzis A, Abbas AA, Kiskinis D, Melas N, Saratzis N, Kitas GD. Abdominal aortic aneurysm: A review of the genetic basis. Angiology 2011;62:18-32
5. Wahlgren CM, Larsson E, Magnusson PK, Hultgren R, Swedenborg J. Genetic and environmental contributions to abdominal aortic aneurysm development in a twin population. J Vasc Surg 2010;51:3-7; discussion: 7
6. Johansen K, Koepsell T. Familial tendency for abdominal aortic aneurysms. JAMA 1986;256:1934-6
7. Thompson AR, Drenos F, Hafez H, Humphries SE. Candidate gene association studies in abdominal aortic aneurysm disease: A review and meta-analysis. Eur J Vasc Endovasc Surg 2008;35:19-30
8. Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, et al. Abdominal aortic aneurysm is associated with a variant in lowdensity lipoprotein receptor-related protein 1. Am J Hum Genet 2011;89:619-27
9. Harrison SC, Holmes MV, Agu O, Humphries SE. Genome wide association studies of abdominal aortic aneurysms-biological insights and potential translation applications. Atherosclerosis 2011;217:47-56
10. Koenig W, Khuseyinova N, Lowel H, Trischler G, Meisinger C. Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population: Results from the 14-year follow-up of a large cohort from southern Germany. Circulation 2004;110:1903-8
11. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, Joshipura K, et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med 2004;351:2599-610
12. Koenig W, Khuseyinova N. Biomarkers of atherosclerotic plaque instability and rupture. Arterioscler Thromb Vasc Biol 2007;27:15-26
13. Saratzis A, Kitas GD, Saratzis N, Melas N. Can statins suppress the development of abdominal aortic aneurysms? A review of the current evidence. Angiology 2010;61:137-44
14. Badger SA, Soong CV, O'Donnell ME, Mercer C, Young IS, Hughes AE. C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important CRP genetic polymorphism. J Vasc Surg 2009;49:178-84
15. Wang Q, Hunt SC, Xu Q, Chen YE, Province MA, Eckfeldt JH, et al. Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study. Am J Physiol Heart Circ Physiol 2006;291:H2752-7
16. Crawford DC, Sanders CL, Qin X, Smith JD, Shephard C, Wong M, et al. Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey. Circulation 2006;114:2458-65
17. Carlson CS, Aldred SF, Lee PK, Tracy RP, Schwartz SM, Rieder M, et al. Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet 2005;77:64-77
18. Szalai AJ, Wu J, Lange EM, McCrory MA, Langefeld CD, Williams A, et al. Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level. J Mol Med (Berl) 2005;83:440-7
19. Edberg JC, Wu J, Langefeld CD, Brown EE, Marion MC, McGwin G Jr, et al. Genetic variation in the CRP promoter: Association with systemic lupus erythematosus. Hum Mol Genet 2008;17: 1147-55
20. Rhodes B, Morris DL, Subrahmanyan L, Aubin C, de Leon CF, Kelly JF, et al. Fine-mapping the genetic basis of CRP regulation in African Americans: A Bayesian approach. Hum Genet 2008;123: 633-42
21. Kuivaniemi H, Elmore JR. Opportunities in abdominal aortic aneurysm research: Epidemiology, genetics, and pathophysiology. Ann Vasc Surg 2012;26:862-70
22. Lederle FA, Johnson GR, Wilson SE, Gordon IL, Chute EP, Littooy FN, et al. Relationship of age, gender, race, and body size to infrarenal aortic diameter. The Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Investigators. J Vasc Surg 1997;26:595-601
23. Powell JT, Muller BR, Greenhalgh RM. Acute phase proteins in patients with abdominal aortic aneurysms. J Cardiovasc Surg (Torino) 1987;28:528-30
24. Vainas T, Lubbers T, Stassen FR, Herngreen SB, van Dieijen- Visser MP, Bruggeman CA, et al. Serum C-reactive protein level is associated with abdominal aortic aneurysm size and may be produced by aneurysmal tissue. Circulation 2003;107:1103-5
25. Takagi H, Manabe H, Kawai N, Goto SN, Umemoto T. Regarding "C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm". J Vasc Surg 2009;50:240; author reply: 240-1.