Opportunities in abdominal aortic aneurysm research: Epidemiology, genetics, and pathophysiology

Annals of Vascular Surgery

Volumn 26, Issue 6, 2012, Pages 862-870

  Kuivaniemi, Helena ^a   Elmore, James R ^a  

^a WEIS CENTER FOR RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; AORTIC ANEURYSM ASSOCIATED PROTEIN 40; AUTOANTIGEN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIOLOGICAL MARKER; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DNA; DOXYCYCLINE; EZETIMIBE; FIBRILLIN 1; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HOMEODOMAIN PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MATRIX METALLOPROTEINASE; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN KINASE; PLACEBO; REACTIVE OXYGEN METABOLITE; SMAD PROTEIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG;

ABDOMINAL AORTA ANEURYSM; AGING; AMINO ACID SEQUENCE; ANEURYSM RUPTURE; ANEURYSM SURGERY; AORTA ANEURYSM; AORTA GRAFT; AORTA WALL; ARTERY DISSECTION; BLOOD PRESSURE REGULATION; BORRELIA; CARDIOVASCULAR DISEASE; CHLAMYDOPHILA PNEUMONIAE; CIGARETTE SMOKING; COMORBIDITY; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CYTOMEGALOVIRUS; DEATH; DIABETES MELLITUS; DISEASE PREDISPOSITION; ELECTIVE SURGERY; ENDOVASCULAR ANEURYSM REPAIR; EXTRACELLULAR MATRIX; FAMILY HISTORY; GENE MUTATION; GENETIC ASSOCIATION; GENOME; GENOMICS; HERPES SIMPLEX; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; IMAGING SYSTEM; INFLAMMATION; LYME DISEASE; MATHEMATICAL MODEL; MEDICAL RESEARCH; MEDICAL TECHNOLOGY; MICROARRAY ANALYSIS; MOUTH FLORA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; SCREENING; SEQUENCE HOMOLOGY; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING CESSATION; STENT; SURGICAL TECHNIQUE; SYPHILIS; THORACIC AORTA ANEURYSM; TREATMENT INDICATION; TREATMENT OUTCOME; TREPONEMA PALLIDUM; VASCULAR SURGERY;

ANIMALS; AORTIC ANEURYSM, ABDOMINAL; AORTIC RUPTURE; BIOMEDICAL RESEARCH; CONGRESSES AS TOPIC; DISEASE MODELS, ANIMAL; ENVIRONMENT; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HEREDITY; HUMANS; MASS SCREENING; PEDIGREE; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS;

EID: 84863942930     PISSN: 08905096     EISSN: 16155947     Source Type: Journal    
DOI: 10.1016/j.avsg.2012.02.005     Document Type: Review

References (77)

1. M. Heron Deaths: leading causes for 2007 Natl Vital Stat Rep 59 2011 1 95
2. J.A. Beckman Aortic aneurysms: pathophysiology, epidemiology, and prognosis M.A. Creager, V.J. Dzau, J. Loscalzo, Vascular medicine 2006 Saunders Elsevier Inc. Philadelphia, PA p 543-59
3. J.A. Beckman, and M.A. Creager Aortic aneurysms: clinical evaluation M.A. Creager, V.J. Dzau, J. Loscalzo, Vascular medicine 2006 Saunders Elsevier Inc. Phildelphia, PA p 560-9
4. F.A. Lederle, G.R. Johnson, and S.E. Wilson The aneurysm detection and management study screening program: validation cohort and final results. Aneurysm Detection and Management Veterans Affairs Cooperative Study Investigators Arch Intern Med 160 2000 1425 1430 (Pubitemid 30327444)
5. F.A. Lederle, D.B. Nelson, and A.M. Joseph Smokers' relative risk for aortic aneurysm compared with other smoking-related diseases: a systematic review J Vasc Surg 38 2003 329 334 (Pubitemid 41123258)
6. F.A. Lederle, G.R. Johnson, and S.E. Wilson Prevalence and associations of abdominal aortic aneurysm detected through screening. Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Group Ann Intern Med 126 1997 441 449 (Pubitemid 27114472)
7. K.K. Hannawa, J.L. Eliason, and G.R. Upchurch Jr. Gender differences in abdominal aortic aneurysms Vascular 17 Suppl. 1 2009 S30 S39
8. C. Fleming, E.P. Whitlock, T.L. Beil, and F.A. Lederle Screening for abdominal aortic aneurysm: a best-evidence systematic review for the U.S. Preventive Services Task Force Ann Intern Med 142 2005 203 211 (Pubitemid 40189113)
9. Screening for abdominal aortic aneurysm: recommendation statement Ann Intern Med 142 2005 198 202
10. S. Svensjö, M. Björck, and M. Gurtelschmid Low prevalence of abdominal aortic aneurysm among 65-year-old Swedish men indicates a change in the epidemiology of the disease Circulation 124 2011 1118 1123
11. F.A. Lederle The rise and fall of abdominal aortic aneurysm Circulation 124 2011 1097 1099
12. F.A. Lederle, S.E. Wilson, and G.R. Johnson Immediate repair compared with surveillance of small abdominal aortic aneurysms N Engl J Med 346 2002 1437 1444 (Pubitemid 34755711)
13. United Kingdom Small Aneurysm Trial Participants Long-term outcomes of immediate repair compared with surveillance of small abdominal aortic aneurysms N Engl J Med 346 2002 1445 1452
14. F.A. Lederle, R.L. Kane, R. MacDonald, and T.J. Wilt Systematic review: repair of unruptured abdominal aortic aneurysm Ann Intern Med 146 2007 735 741 (Pubitemid 351640001)
15. I. Hinterseher, G. Gabel, and F. Corvinus Presence of Borrelia burgdorferi sensu lato antibodies in the serum of patients with abdominal aortic aneurysms Eur J Clin Microbiol Infect Dis 31 2012 781 789
16. H. Kuivaniemi, C.D. Platsoucas, and M.D. Tilson 3rd Aortic aneurysms: an immune disease with a strong genetic component Circulation 117 2008 242 252
17. B.T. Baxter, M.C. Terrin, and R.L. Dalman Medical management of small abdominal aortic aneurysms Circulation 117 2008 1883 1889 (Pubitemid 351507477)
18. H. Takagi, M. Matsui, and T. Umemoto A meta-analysis of clinical studies of statins for prevention of abdominal aortic aneurysm expansion J Vasc Surg 52 2010 1675 1681
19. C.P. Twine, and I.M. Williams Systematic review and meta-analysis of the effects of statin therapy on abdominal aortic aneurysms Br J Surg 98 2011 346 353
20. J.A. Dawson, E. Choke, and I.M. Loftus A randomised placebo-controlled double-blind trial to evaluate lipid-lowering pharmacotherapy on proteolysis and inflammation in abdominal aortic aneurysms Eur J Vasc Endovasc Surg 41 2011 28 35
21. M. Mosorin, J. Juvonen, and F. Biancari Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study J Vasc Surg 34 2001 606 610 (Pubitemid 33664907)
22. Propanolol Aneurysm Trial Investigators. Propranolol for small abdominal aortic aneurysms: results of a randomized trial J Vasc Surg 35 2002 72 79
23. E.L. Chaikof, D.C. Brewster, and R.L. Dalman The care of patients with an abdominal aortic aneurysm: the society for vascular surgery practice guidelines J Vasc Surg 50 2009 S2 S49
24. J.P. Vande Geest, D.E. Schmidt, M.S. Sacks, and D.A. Vorp The effects of anisotropy on the stress analyses of patient-specific abdominal aortic aneurysms Ann Biomed Eng 36 2008 921 932
25. J. Molacek, J. Baxa, and K. Houdek Assessment of abdominal aortic aneurysm wall distensibility with electrocardiography-gated computed tomography Ann Vasc Surg 25 2011 1036 1042
26. K.Y. Volokh, and D.A. Vorp A model of growth and rupture of abdominal aortic aneurysm J Biomech 41 2008 1015 1021
27. J. Ferruzzi, D.A. Vorp, and J.D. Humphrey On constitutive descriptors of the biaxial mechanical behaviour of human abdominal aorta and aneurysms J R Soc Interface 8 2011 435 450
28. V.R. Goel, R.K. Greenberg, and D.P. Greenberg Mathematical analysis of DICOM CT datasets: can endograft sizing be automated for complex anatomy? J Vasc Surg 47 2008 1306 1312
29. M.C. Moon, J.P. Morales, and R.K. Greenberg The aortic arch and ascending aorta: are they within the endovascular realm? Semin Vasc Surg 20 2007 97 107 (Pubitemid 46908031)
30. A. Daugherty, and L.A. Cassis Mouse models of abdominal aortic aneurysms Arterioscler Thromb Vasc Biol 24 2004 429 434 (Pubitemid 38326134)
31. J. Golledge, J. Muller, A. Daugherty, and P. Norman Abdominal aortic aneurysm: pathogenesis and implications for management Arterioscler Thromb Vasc Biol 26 2006 2605 2613
32. J. Nischan, G.M. Lenk, and A.M. Boddy Abdominal aortic aneurysms- a complex genetic disease A. Laurent, E. Morel, Aneurysms: types, risks, formation and treatment 2010 Nova Science Publishers, Inc. Hauppage, NY p 35-93
33. M.P. Bergoeing, B. Arif, and A.E. Hackmann Cigarette smoking increases aortic dilatation without affecting matrix metalloproteinase-9 and -12 expression in a modified mouse model of aneurysm formation J Vasc Surg 45 2007 1217 1227
34. I. Sinha, B.S. Cho, and K.J. Roelofs Female gender attenuates cytokine and chemokine expression and leukocyte recruitment in experimental rodent abdominal aortic aneurysms Ann N Y Acad Sci 1085 2006 367 379 (Pubitemid 47091999)
35. B.S. Cho, K.J. Roelofs, and J.W. Ford Decreased collagen and increased matrix metalloproteinase-13 in experimental abdominal aortic aneurysms in males compared with females Surgery 147 2010 258 267
36. A. Daugherty, D.L. Rateri, and I.F. Charo Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice Clin Sci (Lond) 118 2010 681 689
37. D.L. Rateri, J.J. Moorleghen, and A. Balakrishnan Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/-mice Circ Res 108 2011 574 581
38. H.A. Uchida, F. Kristo, and D.L. Rateri Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice Atherosclerosis 211 2010 399 403
39. T. Henriques, X. Zhang, and F.B. Yiannikouris Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice Arterioscler Thromb Vasc Biol 28 2008 1251 1256
40. A.P. Owens 3rd, D.L. Rateri, and D.A. Howatt MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4 Arterioscler Thromb Vasc Biol 31 2011 2813 2819
41. R. Bazeli, M. Coutard, and B.D. Duport In vivo evaluation of a new magnetic resonance imaging contrast agent (P947) to target matrix metalloproteinases in expanding experimental abdominal aortic aneurysms Invest Radiol 45 2010 662 668
42. M. Nahrendorf, E. Keliher, and B. Marinelli Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography Arterioscler Thromb Vasc Biol 31 2011 750 757
43. T. Ogata, G.L. MacKean, and C.W. Cole The lifetime prevalence of abdominal aortic aneurysms among siblings of aneurysm patients is eightfold higher than among siblings of spouses: an analysis of 187 aneurysm families in Nova Scotia, Canada J Vasc Surg 42 2005 891 897 (Pubitemid 41571954)
44. C.M. Wahlgren, E. Larsson, and P.K. Magnusson Genetic and environmental contributions to abdominal aortic aneurysm development in a twin population J Vasc Surg 51 2010 3 7
45. H. Kuivaniemi, A.M. Boddy, and J.H. Lillvis Abdominal aortic aneurysms are deep, deadly and genetic N. Sakalihasan, H. Kuivaniemi, J.B. Michel, Aortic aneurysms, new insights into an old problem 2008 Liège University Press Liège, Belgium p 299-323
46. M.J. Bown, G.T. Jones, and S.C. Harrison Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1 Am J Hum Genet 89 2011 619 627
47. J.R. Elmore, M.A. Obmann, and H. Kuivaniemi Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association J Vasc Surg 49 2009 1525 1531
48. S. Gretarsdottir, A.F. Baas, and G. Thorleifsson Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm Nat Genet 42 2010 692 697
49. G.T. Jones, and A.M. van Rij Regarding "Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association." J Vasc Surg 50 2009 1246 1247 author reply 1247
50. A. Helgadottir, G. Thorleifsson, and K.P. Magnusson The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm Nat Genet 40 2008 217 224 (Pubitemid 351171400)
51. J. Golledge, P.S. Tsao, R.L. Dalman, and P.E. Norman Circulating markers of abdominal aortic aneurysm presence and progression Circulation 118 2008 2382 2392
52. A.L. Golledge, P. Walker, P.E. Norman, and J. Golledge A systematic review of studies examining inflammation associated cytokines in human abdominal aortic aneurysm samples Dis Markers 26 2009 181 188
53. J. Golledge, R. Muller, and P. Clancy Evaluation of the diagnostic and prognostic value of plasma D-dimer for abdominal aortic aneurysm Eur Heart J 32 2011 354 364
54. G. Tromp, and H. Kuivaniemi Developments in genomics to improve understanding, diagnosis and management of aneurysms and peripheral artery disease Eur J Vasc Endovasc Surg 38 2009 676 682
55. G.M. Lenk, G. Tromp, and S. Weinsheimer Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms BMC Genomics 8 2007 237
56. J. Nischan, Z. Gatalica, and M. Curtis Binding sites for ETS family of transcription factors dominate the promoter regions of differentially expressed genes in abdominal aortic aneurysms Circ Cardiovasc Genet 2 2009 565 572
57. A.M. Boddy, G.M. Lenk, and J.H. Lillvis Basic research studies to understand aneurysm disease Drug News Perspect 21 2008 142 148 (Pubitemid 351809137)
58. M.B. Pagano, H.F. Zhou, and T.L. Ennis Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm Circulation 119 2009 1805 1813
59. I. Hinterseher, R. Erdman, and L.A. Donoso Role of complement cascade in abdominal aortic aneurysms Arterioscler Thromb Vasc Biol 31 2011 1653 1660
60. M.L. McCormick, D. Gavrila, and N.L. Weintraub Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms Arterioscler Thromb Vasc Biol 27 2007 461 469
61. N.L. Weintraub Understanding abdominal aortic aneurysm N Engl J Med 361 2009 1114 1116
62. A. Manea, S.A. Manea, and A.V. Gafencu AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells: role of p22phox subunit Arterioscler Thromb Vasc Biol 28 2008 878 885 (Pubitemid 351544102)
63. J.H. Lindeman, T.J. Rabelink, and J.H. van Bockel Immunosuppression and the abdominal aortic aneurysm: doctor jekyll or mister hyde? Circulation 124 2011 e463 e465
64. K. Yoshimura, H. Aoki, and Y. Ikeda Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase Nat Med 11 2005 1330 1338 (Pubitemid 41752914)
65. D.M. Milewicz Stopping a killer: improving the diagnosis, treatment, and prevention of acute ascending aortic dissections Circulation 124 2011 1902 1904
66. D.M. Milewicz, D.C. Guo, and V. Tran-Fadulu Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction Annu Rev Genomics Hum Genet 9 2008 283 302
67. Milewicz DM, Regalado E. Thoracic aortic aneurysms and aortic dissections. In: Pagon RA, Bird TD, Dolan CR, Stephens K, editors. GeneReviews. Seattle, WA; University of Washington, 1993.
68. E.S. Regalado, D.C. Guo, and C. Villamizar Exome sequencing identifies SMAD3 mutations as a cause of familial thoracic aortic aneurysm and dissection with intracranial and other arterial aneurysms Circ Res 109 2011 680 686
69. B.L. Kroner, H.E. Tolunay, and C.T. Basson The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC): results from phase I and scientific opportunities in phase II Am Heart J 162 2011 627 632 e621
70. R. Deka, D.L. Koller, and D. Lai The relationship between smoking and replicated sequence variants on chromosomes 8 and 9 with familial intracranial aneurysm Stroke 41 2010 1132 1137
71. T. Foroud, L. Sauerbeck, and R. Brown Genome screen in familial intracranial aneurysm BMC Med Genet 10 2009 3
72. M.I. Kurki, S.K. Hakkinen, and J. Frosen Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-kappaB, hypoxia-inducible factor-1A, and ETS transcription factors Neurosurgery 68 2011 1667 1675
73. S. Weinsheimer, G.M. Lenk, and M. van der Voet Integration of expression profiles and genetic mapping data to identify candidate genes in intracranial aneurysm Physiol Genomics 32 2007 45 57
74. J.H. Lillvis, R. Erdman, and C.M. Schworer Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysm BMC Physiol 11 2011 9
75. G. Greco, N.N. Egorova, and A.C. Gelijns Development of a novel scoring tool for the identification of large >/=5 cm abdominal aortic aneurysms Ann Surg 252 2010 675 682
76. K.C. Kent, R.M. Zwolak, and N.N. Egorova Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals J Vasc Surg 52 2010 539 548
77. I. Hinterseher, G. Tromp, and H. Kuivaniemi Genes and abdominal aortic aneurysm Ann Vasc Surg 25 2010 388 412