Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance

Antioxidants and Redox Signaling

Volumn 22, Issue 9, 2015, Pages 744-759

  Tang, Hsiang Yu ^a   Ho, Hung Yao ^a,b   Wu, Pei Ru ^a   Chen, Shih Hsiang ^c   Kuypers, Frans A ^d   Cheng, Mei Ling ^a,b   Chiu, Daniel Tsun Yee ^a,b,c  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d CHILDREN S HOSPITAL OAKLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENYLATE KINASE; DIAMIDE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; ADENOSINE TRIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METHIONINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PYRUVATE KINASE; REACTIVE OXYGEN METABOLITE; THIOL REAGENT;

ARTICLE; CELL METABOLISM; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; METABOLIC DISORDER; METABOLOMICS; OXIDATIVE STRESS; PRIORITY JOURNAL; PURINE METABOLISM; DRUG EFFECTS; ERYTHROCYTE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HEMOLYTIC ANEMIA; METABOLISM; PATHOLOGY; PENTOSE PHOSPHATE CYCLE; PHYSIOLOGICAL STRESS;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANEMIA, HEMOLYTIC; DIAMIDE; ERYTHROCYTES; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; GLUTATHIONE; HUMANS; METHIONINE; NADP; OXIDATIVE STRESS; PENTOSE PHOSPHATE PATHWAY; PYRUVATE KINASE; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL; SULFHYDRYL REAGENTS;

EID: 84924690365     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2014.6142     Document Type: Article

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