5'-C-ethyl-tetrazolyl-N 6-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 58, Issue 5, 2015, Pages 2560-2566

  Petrelli, Riccardo ^a   Torquati, Ilaria ^a   Kachler, Sonja ^b   Luongo, Livio ^c   Maione, Sabatino ^c   Franchetti, Palmarisa ^a   Grifantini, Mario ^a   Novellino, Ettore ^d   Lavecchia, Antonio ^d   Klotz, Karl Norbert ^b   Cappellacci, Loredana ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLOROADENOSINE DERIVATIVE; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR AFFECTING AGENT; ADENOSINE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; COMPUTER SIMULATION; CRICETULUS; HAMSTER; HUMAN; RADIOASSAY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADENOSINE; ADENOSINE A1 RECEPTOR AGONISTS; ADENOSINE A3 RECEPTOR ANTAGONISTS; ANIMALS; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84924678339     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00074     Document Type: Article

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