Statistical Analysis of Individual Participant Data Meta-Analyses: A Comparison of Methods and Recommendations for Practice

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Stewart, Gavin B ^a   Altman, Douglas G ^b   Askie, Lisa M ^c   Duley, Lelia ^d   Simmonds, Mark C ^a   Stewart, Lesley A ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT;

ADULT; ANALYTIC METHOD; ARTICLE; FEMALE; GESTATIONAL AGE; HUMAN; INTERMETHOD COMPARISON; MATERNAL AGE; META ANALYSIS; ONE STAGE INDIVIDUAL PARTICIPANT DATA; PREECLAMPSIA; PREGNANCY; RISK FACTOR; STATISTICAL ANALYSIS; SYSTEMATIC REVIEW; TREATMENT OUTCOME; TREATMENT RESPONSE; TWO STAGE INDIVIDUAL PARTICIPANT DATA;

ADULT; FEMALE; HUMANS; META-ANALYSIS AS TOPIC; MODELS, STATISTICAL; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT (HEALTH CARE); PLATELET AGGREGATION INHIBITORS; PRE-ECLAMPSIA; PREGNANCY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REPRODUCIBILITY OF RESULTS; RISK FACTORS; YOUNG ADULT;

EID: 84867036811     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046042     Document Type: Article

References (34)

1. Stewart LA, Parmar MKB, (1993) Meta-analysis of the literature or of individual participant data: is there a difference? Lancet 341: 418-22.
2. Stewart LA, Clarke MJ, (1995) Practical methodology of meta-analyses (overviews) using updated individual participant data. Statistics in Medicine 14: 2057-79.
3. Stewart LA, Tierney JF, Burdett S (2005) Do systematic reviews based on individual participant data offer a means of circumventing biases associated with trial publications? In Rothstein H, Sutton A, Borenstein M. Publication Bias in Meta-Analysis: Prevention, Assessment and Adjustments. John Wiley & Sons, 261-86.
4. Clarke MJ, Stewart LA (2001) Obtaining individual participant data from randomised controlled trials. In: Egger M, Davey-Smith G, Altman DG, Eds. Systematic Reviews in Healthcare: Meta-analysis in context. London: BMJ Publishing Group, pp 109-21.
5. Riley RD, Lambert PC, Abo-Zaid G, (2010) Meta-analysis of individual participant data: rationale, conduct and reporting. British Medical Journal 340: c221.
6. Simmonds MC, Higgins JPT, Stewart LA, Tierney JF, Clarke MJ, et al. (2005) Meta-analysis of individual participant data from randomised trials: a review of methods used in practice. Clinical Trials 2: 209-17.
7. Riley RD, Steyerberg EW, (2010) Meta-analysis of a binary outcome using individual participant and aggregate data. Research Synthesis Methods 1: 2-19.
8. Turner RM, Omar RZ, Yang M, Goldstein H, Thompson SG, (2000) A multilevel model framework for meta-analysis of clinical trials with binary outcomes. Statistics in Medicine 19: 3417-3432.
9. Simmonds MC (2005) Statistical Methodology of individual participant data meta-analysis. PhD Thesis, University of Cambridge.
10. Gelman A, Hill J (2007) Data Analysis using Regression and multilevel hierarchical models. Analytical Methods for Social Research Series. Cambridge University Press.
11. Vale C, Tierney JF, Stewart LA, (2008) Chemoradiotherapy for Cervical Cancer Meta-Analysis Collaboration. Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual participant data from 18 randomized trials. Journal of Clinical Oncology 10 26(35): 5802-12.
12. Morton SC, Adams JL, Suttorp MJ, Shekelle PG (2004) Meta-regression approaches. What, Why, When and How? Agency for Healthcare Research and Quality Technical Reviews 8.
13. Greenland S, (2002) A review of multilevel theory for ecologic analyses. Statistics in medicine 21: 389-395.
14. Sutton AJ, Higgins JPT, (2008) Recent developments in meta-analysis. Statistics in Medicine 27: 625-650.
15. Lambert PC, Sutton AJ, Abrams KR, Jones DR, (2002) A comparison of summary participant level covariates in metaregression with individual participant data meta-analysis. Journal of Clinical Epidemiology 55: 86-94.
16. Simmonds MC, Higgins JP, (2007) Covariate heterogeneity in meta-analysis: criteria for deciding between meta-regression and individual participant data. Statistics in Medicine 26: 2982-2999.
17. Berlin JA, Santanna J, Schmid CH, Szczech LA, Feldman HI, (2002) Individual participant- versus group-level data meta-regressions for the investigation of treatment effect modifiers: ecological bias rears its ugly head. Statistics in Medicine 21: 371-87.
18. Robinson WS, (1950) Ecological Correlations and the Behavior of Individuals. American Sociological Review 15 (3): 351-357.
19. Fisher DJ, Copas AJ, Tierney JF, Parmar MK, (2011) A critical review of methods for the assessment of participant level interactions in individual participant data meta-analysis of randomised trials and guidance for practitioners. Journal of Clinical Epidemiology 64: 949-67.
20. Akaike H, (1974) A new look at the statistical model identification. IEEE Transactions on Automatic Control 19 (6): 716-723.
21. Higgins JPT, Whitehead A, Turner RM, Omar RZ, Thompson SG, (2001) Meta-analysis of continuous outcome data from individual participants. Statistics in Medicine 20: 2219-2241.
22. Eysenck HJ, (1994) Meta-analysis and its problems. British Medical Journal 309: 789-792.
23. Nuesch E, Juni P, (2009) Commentary: which meta-analyses are conclusive? International Journal of Epidemiology 38: 298-303.
24. Al Khalaf MM, Thalib L, Doi SAR, (2011) Combining heterogenous studies using the random-effects model is a mistake and leads to inconclusive meta-analyses. Journal of Clinical Epidemiology 64: 119-123.
25. Higgins JPT, Thompson SG, Spiegelhalter DJ, (2009) A re-evaluation of random-effects meta-analysis. Journal of the Royal Statistical Society. Series A (Statistics in Society) 172: 137-159.
26. Higgins JPT, Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
27. Tudor Smith C, Williamson PR, Marson AG, (2005) Investigating heterogeneity in an individual participant data meta-analysis of time to event outcomes. Statistics in Medicine 24: 1307-1319.
28. Bowden J, Tierney JF, Simmonds M, Copas AJ, Higgins JPT (2011) Individual participant data meta-analysis of time-to-event outcomes: one-stage versus two-stage approaches for estimating the hazard ratio under a random effect model. Research Synthesis Methods 2, 150-162.
29. Askie LM, Duley L, Henderson-Smart DJ, Stewart LA, (2007) Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual participant data. Lancet 369(9575): 1791-98.
30. DerSimonian R, Laird N, (1986) Meta-analysis in clinical trials. Controlled Clinical Trials 7: 177-188.
31. Saftlas AF, Olson DR, Franks AL, Atrash HK, Pokras R, (1990) Epidemiology of preeclampsia and eclampsia in the United states, 1979-1986. American Journal Obstetrics Gynecology 163: 460-5.
32. Viechtbauer W (2010) Conducting meta-analyses in R with the metafor package. Journal of Statistical Software 36(3), 1-48.
33. Askie and The Perinatal Antiplatelet Review of International Trials (PARIS) Collaboration Steering Group on behalf of the PARIS Collaboration (2005) Trial protocol. Antiplatelet agents for prevention of pre-eclampsia and its consequences: a systematic review and individual participant data meta-analysis. BMC Pregnancy and Childbirth 5: 7 1: 11.
34. Lunn D, Spiegelhalter D, Thomas A, Best N, (2009) The BUGS project: Evolution, critique and future directions. Statistics in Medicine 28: 3049-306.