Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: The LADIS study

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 76, Issue 11, 2005, Pages 1497-1500

  Van Der Flier, Wiesje M ^a   Van Straaten, E C W ^a   Barkhof, F ^b   Ferro, J M ^c   Pantoni, L ^d   Basile, A M ^d   Inzitari, D ^d   Erkinjuntti, T ^e   Wahlund, L O ^f   Rostrup, E ^g   Schmidt, R ^h   Fazekas, F ^h   Scheltens, P ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Centro de Estudos Egas Moniz   (Portugal)

^d UNIVERSITY OF FLORENCE   (Italy)

^e UNIVERSITY OF HELSINKI   (Finland)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^g Mental Health Services CPH   (Denmark)

^h MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ANALYSIS OF VARIANCE; ARTICLE; BRAIN ATROPHY; COGNITION; COGNITIVE DEFECT; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE; TEMPORAL LOBE; WHITE MATTER;

AGED; ATROPHY; COGNITION DISORDERS; DISABILITY EVALUATION; FEMALE; HUMANS; LEUKOARAIOSIS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROFIBRILLARY TANGLES; NEUROPSYCHOLOGICAL TESTS; PROSPECTIVE STUDIES; SENILE PLAQUES; SEVERITY OF ILLNESS INDEX; TEMPORAL LOBE;

EID: 27444445761     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.2005.064998     Document Type: Article

References (15)

1. Snowdon DA, Greiner LH, Mortimer JA, et al. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997;277:813-17.
2. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet 2001;357:109-75.
3. Gosche KM, Mortimer JA, Smith CD, et al. Hippocampal volume as an index of Alzheimer neuropathology: Findings from the Nun Study. Neurology 2002;58:1476-82.
4. Pantoni L, Garcia JH. Pathogenesis of leukoaraiosls: a review. Stroke 1997;28:652-9.
5. van der Flier WM, Middelkoop HA, Weverling-Rijnsburger AW, et al. Interaction of medial temporal lobe atrophy and white matter hyperintenslties in AD. Neurology 2004;62:1862-4.
6. de Leeuw FE, Barkhof F, Scheltens P. White matter lesions and hippocampal atrophy in Alzheimer's disease. Neurology 2004;62:310-12.
7. Pantoni L, Basile AM, Pracucci G, et al. Impact of age-related cerebral white matter changes on the transition to disability - the LADIS study: rationale, design and methodology. Neuroepidemiology 2005;24:51-62.
8. Fazekas F, Chawluk JB, Alavi A, et al. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. Am J Roentgenol 1987;149:351-6.
9. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969;9:179-86.
10. Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
11. Scheltens P, Launer U, Barkhof F, et al. Visual assessment of medial temporal lobe atrophy on magnetic resonance imaging: interobserver reliability. J Neurol 1995;242:557-60.
12. Esiri MM, Nagy Z, Smith MZ, et al. Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease. Lancet 1999;354:919-20.
13. Chetelat G, Baron JC. Early diagnosis of Alzheimer's disease: contribution of structural neuroimaging. Neuroimage 2003;18:525-41.
14. Petersen RC, Jack CRJ, Xu YC, et al. Memory and MRI-based hippocampal volumes in aging and AD. Neurology 2000;54:581-7.
15. Mungas D, Jagust WJ, Reed BR, et al. MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease. Neurology 2001;57:2229-35.