The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: A study among patients with subcortical vascular cognitive impairments

Neurobiology of Aging

Volumn 34, Issue 7, 2013, Pages 1913-1920

  Kim, Hee Jin ^a   Kang, Sue J ^a   Kim, Changsoo ^b   Kim, Geon Ha ^a   Jeon, Seun ^c   Lee, Jong Min ^c   Oh, Seung Jun ^d   Kim, Jae Seung ^d   Choe, Yearn Seong ^a   Lee, Kyung Han ^a   Noh, Young ^a   Cho, Hanna ^a   Yoon, Cindy W ^a   Chin, Juhee ^a   Cummings, Jeffrey L ^e   Lee, Jae Hong ^d   Na, Duk L ^a   Seo, Sang Won ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Hanyang University   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

^e LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Amyloid burden; Lacunes; Neuropsychiatric symptoms; Subcortical vascular cognitive impairment; White matter hyperintensities

Indexed keywords

PITTSBURGH COMPOUND B;

AGED; AMYLOIDOSIS; APATHY; ARTICLE; BRAIN REGION; BRAIN VENTRICLE; CEREBROVASCULAR DISEASE; COGNITIVE DEFECT; CONFOUNDING VARIABLE; DELUSION; FEMALE; FRONTAL CORTEX; HUMAN; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; NEUROIMAGING; NEUROPSYCHIATRIC INVENTORY; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PSYCHOLOGIC TEST; RISK FACTOR; SUBCORTEX; SYMPTOM; WHITE MATTER;

AGED; AGED, 80 AND OVER; DEMENTIA, VASCULAR; FEMALE; HUMANS; MALE; MICROVESSELS; NERVE FIBERS, MYELINATED; NEUROPSYCHOLOGICAL TESTS; PLAQUE, AMYLOID; PROSPECTIVE STUDIES;

EID: 84875841467     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.01.002     Document Type: Article

References (48)

1. Aalten P., Verhey F.R., Boziki M., Bullock R., Byrne E.J., Camus V., Caputo M., Collins D., De Deyn P.P., Elina K., Frisoni G., Girtler N., Holmes C., Hurt C., Marriott A., Mecocci P., Nobili F., Ousset P.J., Reynish E., Salmon E., Tsolaki M., Vellas B., Robert P.H. Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I. Dement. Geriatr. Cogn. Disord. 2007, 24:457-463.
2. Ahn H.J., Chin J., Park A., Lee B.H., Suh M.K., Seo S.W., Na D.L. Seoul Neuropsychological Screening Battery-dementia version (SNSB-D): a useful tool for assessing and monitoring cognitive impairments in dementia patients. J. Korean Med. Sci. 2010, 25:1071-1076.
3. Arbus C., Andrieu S., Amouyal-Barkate K., Nourhashemi F., Schmitt L., Vellas B. [Depressive symptoms in Alzheimer's disease: preliminary results of the REAL.FR study]. Rev. Med. Interne 2003, 24(suppl 3):325s-332s. [in French].
4. Bruen P.D., McGeown W.J., Shanks M.F., Venneri A. Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease. Brain 2008, 131:2455-2463.
5. Chen Y.K., Lu J.Y., Mok V.C., Ungvari G.S., Chu W.C., Wong K.S., Tang W.K. Clinical and radiologic correlates of insomnia symptoms in ischemic stroke patients. Int. J. Geriatr. Psychiatry 2011, 26:451-457.
6. Chin J., Seo S.W., Kim S.H., Park A., Ahn H.J., Lee B.H., Kang S.J., Na D.L. Neurobehavioral dysfunction in patients with subcortical vascular mild cognitive impairment and subcortical vascular dementia. Clin. Neuropsychol. 2012, 26:224-238.
7. Craig D., Mirakhur A., Hart D.J., McIlroy S.P., Passmore A.P. A cross-sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer's disease. Am. J. Geriatr. Psychiatry 2005, 13:460-468.
8. Cummings J.L., Mega M., Gray K., Rosenberg-Thompson S., Carusi D.A., Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994, 44:2308-2314.
9. Farber N.B., Rubin E.H., Newcomer J.W., Kinscherf D.A., Miller J.P., Morris J.C., Olney J.W., McKeel D.W. Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis. Arch. Gen. Psychiatry 2000, 57:1165-1173.
10. Fazekas F., Chawluk J.B., Alavi A., Hurtig H.I., Zimmerman R.A. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am. J. Roentgenol. 1987, 149:351-356.
11. Fernandez M., Gobartt A.L., Balana M. Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment. BMC Neurol. 2010, 10:87.
12. Fernandez-Martinez M., Castro J., Molano A., Zarranz J.J., Rodrigo R.M., Ortega R. Prevalence of neuropsychiatric symptoms in Alzheimer's disease and vascular dementia. Curr. Alzheimers Res. 2008, 5:61-69.
13. Fuh J.L., Wang S.J., Cummings J.L. Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia. J. Neurol. Neurosurg. Psychiatry 2005, 76:1337-1341.
14. Gonfrier S., Andrieu S., Renaud D., Vellas B., Robert P.H. Course of neuropsychiatric symptoms during a 4-year follow up in the REAL-FR cohort. J. Nutr. Health Aging 2012, 16:134-137.
15. Grool A.M., van der Graaf Y., Mali W.P., Witkamp T.D., Vincken K.L., Geerlings M.I. Location and progression of cerebral small-vessel disease and atrophy, and depressive symptom profiles: the Second Manifestations of ARTerial disease (SMART)-Medea study. Psychol. Med. 2011, 1-12.
16. Hirono N., Mori E., Ishii K., Ikejiri Y., Imamura T., Shimomura T., Hashimoto M., Yamashita H., Sasaki M. Frontal lobe hypometabolism and depression in Alzheimer's disease. Neurology 1998, 50:380-383.
17. Jeon S., Yoon U., Park J.S., Seo S.W., Kim J.H., Kim S.T., Kim S.I., Na D.L., Lee J.M. Fully automated pipeline for quantification and localization of white matter hyperintensity in brain magnetic resonance image. Int. J. Imaging Syst. Technol. 2011, 21:193-200.
18. Kang S.J., Choi S.H., Lee B.H., Jeong Y., Hahm D.S., Han I.W., Cummings J.L., Na D.L. Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI). J. Geriatr. Psychiatry Neurol. 2004, 17:32-35.
19. Klugman A., Marshall J., Tabet N. Impact of cerebrovascular pathology on behavioural and neuropsychiatric symptoms in patients with Alzheimer's dementia: findings from a retrospective, naturalistic study. Int. J. Clin. Pract. 2009, 63:1024-1030.
20. Koenigs M., Holliday J., Solomon J., Grafman J. Left dorsomedial frontal brain damage is associated with insomnia. J. Neurosci. 2010, 30:16041-16043.
21. Korczyn A.D. Mixed dementia-the most common cause of dementia. Ann. N. Y. Acad. Sci. 2002, 977:129-134.
22. Ku H.M., Kim J.H., Kwon E.J., Kim S.H., Lee H.S., Ko H.J., Jo S., Kim D.K. A study on the reliability and validity of Seoul-Instrumental Activities of Daily Living (S-IADL). Journal of the Korean Neuropsychiatric Association 2004, 43:189-199.
23. Lavretsky H., Zheng L., Weiner M.W., Mungas D., Reed B., Kramer J.H., Jagust W., Chui H., Mack W.J. The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia. Int. J. Geriatr. Psychiatry 2008, 23:1040-1050.
24. Lawton M.P., Brody E.M. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969, 9:179-186.
25. Lee D.Y., Choo I.H., Jhoo J.H., Kim K.W., Youn J.C., Lee D.S., Kang E.J., Lee J.S., Kang W.J., Woo J.I. Frontal dysfunction underlies depressive syndrome in Alzheimer disease: a FDG-PET study. Am. J. Geriatr. Psychiatry 2006, 14:625-628.
26. Lee J.H., Kim S.H., Kim G.H., Seo S.W., Park H.K., Oh S.J., Kim J.S., Cheong H.K., Na D.L. Identification of pure subcortical vascular dementia using 11C-Pittsburgh compound B. Neurology 2011, 77:18-25.
27. Lopez O.L., Kuller L.H., Becker J.T., Jagust W.J., DeKosky S.T., Fitzpatrick A., Breitner J., Lyketsos C., Kawas C., Carlson M. Classification of vascular dementia in the Cardiovascular Health Study Cognition Study. Neurology 2005, 64:1539-1547.
28. Marshall G.A., Monserratt L., Harwood D., Mandelkern M., Cummings J.L., Sultzer D.L. Positron emission tomography metabolic correlates of apathy in Alzheimer disease. Arch. Neurol. 2007, 64:1015-1020.
29. Nagata T., Shinagawa S., Ochiai Y., Kada H., Kasahara H., Nukariya K., Nakayama K. Relationship of frontal lobe dysfunction and aberrant motor behaviors in patients with Alzheimer's disease. Int. Psychogeriatr. 2010, 22:463-469.
30. O'Brien J., Perry R., Barber R., Gholkar A., Thomas A. The association between white matter lesions on magnetic resonance imaging and noncognitive symptoms. Ann. N. Y. Acad. Sci. 2000, 903:482-489.
31. O'Brien J.T., Firbank M.J., Krishnan M.S., van Straaten E.C., van der Flier W.M., Petrovic K., Pantoni L., Simoni M., Erkinjuntti T., Wallin A., Wahlund L.O., Inzitari D. White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study. Am. J. Geriatr. Psychiatry 2006, 14:834-841.
32. Reilly T.J., Staff R.T., Ahearn T.S., Bentham P., Wischik C.M., Murray A.D. Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease. Behav. Brain Res. 2011, 222:375-379.
33. Reyes S., Viswanathan A., Godin O., Dufouil C., Benisty S., Hernandez K., Kurtz A., Jouvent E., O'Sullivan M., Czernecki V., Bousser M.G., Dichgans M., Chabriat H. Apathy: a major symptom in CADASIL. Neurology 2009, 72:905-910.
34. Robert P.H., Darcourt G., Koulibaly M.P., Clairet S., Benoit M., Garcia R., Dechaux O., Darcourt J. Lack of initiative and interest in Alzheimer's disease: a single photon emission computed tomography study. Eur. J. Neurol. 2006, 13:729-735.
35. Rosen H.J., Allison S.C., Schauer G.F., Gorno-Tempini M.L., Weiner M.W., Miller B.L. Neuroanatomical correlates of behavioural disorders in dementia. Brain 2005, 128:2612-2625.
36. Rowe C.C., Ellis K.A., Rimajova M., Bourgeat P., Pike K.E., Jones G., Fripp J., Tochon-Danguy H., Morandeau L., O'Keefe G., Price R., Raniga P., Robins P., Acosta O., Lenzo N., Szoeke C., Salvado O., Head R., Martins R., Masters C.L., Ames D., Villemagne V.L. Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiology of aging 2010, 31:1275-1283.
37. Sachdev P., Wen W., Shnier R., Brodaty H. Cerebral blood volume in T2-weighted white matter hyperintensities using exogenous contrast based perfusion MRI. J. Neuropsychiatry Clin. Neurosci. 2004, 16:83-92.
38. Senanarong V., Cummings J.L., Fairbanks L., Mega M., Masterman D.M., O'Connor S.M., Strickland T.L. Agitation in Alzheimer's disease is a manifestation of frontal lobe dysfunction. Dement. Geriatr. Cogn. Disord. 2004, 17:14-20.
39. Seo S.W., Cho S.S., Park A., Chin J., Na D.L. Subcortical vascular versus amnestic mild cognitive impairment: comparison of cerebral glucose metabolism. J. Neuroimaging 2009, 19:213-219.
40. Seo S.W., Lee J.M., Im K., Park J.S., Kim S.H., Kim S.T., Ahn H.J., Chin J., Cheong H.K., Weiner M.W., Na D.L. Cortical thinning related to periventricular and deep white matter hyperintensities. Neurobiol. Aging 2012, 33:1156-1167.
41. Skogseth R., Mulugeta E., Jones E., Ballard C., Rongve A., Nore S., Alves G., Aarsland D. Neuropsychiatric correlates of cerebrospinal fluid biomarkers in Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 2008, 25:559-563.
42. Sneed J.R., Culang-Reinlieb M.E. The vascular depression hypothesis: an update. Am. J. Geriatr. Psychiatry 2011, 19:99-103.
43. Staekenborg S.S., Gillissen F., Romkes R., Pijnenburg Y.A., Barkhof F., Scheltens P., van der Flier W.M. Behavioural and psychological symptoms are not related to white matter hyperintensities and medial temporal lobe atrophy in Alzheimer's disease. Int. J. Geriatr. Psychiatry 2008, 23:387-392.
44. Staekenborg S.S., Su T., van Straaten E.C., Lane R., Scheltens P., Barkhof F., van der Flier W.M. Behavioural and psychological symptoms in vascular dementia; differences between small- and large-vessel disease. J. Neurol. Neurosurg. Psychiatry 2010, 81:547-551.
45. Sultzer D.L., Brown C.V., Mandelkern M.A., Mahler M.E., Mendez M.F., Chen S.T., Cummings J.L. Delusional thoughts and regional frontal/temporal cortex metabolism in Alzheimer's disease. Am. J. Psychiatry 2003, 160:341-349.
46. Tagariello P., Girardi P., Amore M. Depression and apathy in dementia: same syndrome or different constructs? A critical review. Arch. Gerontol. Geriatr. 2009, 49:246-249.
47. Tschanz J.T., Corcoran C.D., Schwartz S., Treiber K., Green R.C., Norton M.C., Mielke M.M., Piercy K., Steinberg M., Rabins P.V., Leoutsakos J.M., Welsh-Bohmer K.A., Breitner J.C., Lyketsos C.G. Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study. Am. J. Geriatr. Psychiatry 2011, 19:532-542.
48. Vilalta-Franch J., Lopez-Pousa S., Turon-Estrada A., Lozano-Gallego M., Hernandez-Ferrandiz M., Pericot-Nierga I., Garre-Olmo J. Syndromic association of behavioral and psychological symptoms of dementia in Alzheimer disease and patient classification. Am. J. Geriatr. Psychiatry 2010, 18:421-432.