-
1
-
-
33749021085
-
Somatic activation of KIT in distinct subtypes of melanoma
-
Curtin JA, Busam K, Pinkel D et al. (2006) Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 24:4340-6
-
(2006)
J Clin Oncol
, vol.24
, pp. 4340-4346
-
-
Curtin, J.A.1
Busam, K.2
Pinkel, D.3
-
2
-
-
84886376886
-
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14ARF and RARbeta signaling
-
Dahl C, Christensen C, Jönsson G et al. (2013) Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14ARF and RARbeta signaling. Mol Cancer Res 11:1166-78
-
(2013)
Mol Cancer Res
, vol.11
, pp. 1166-1178
-
-
Dahl, C.1
Christensen, C.2
Jönsson, G.3
-
3
-
-
36549085004
-
The genome and epigenome of malignant melanoma
-
Dahl C, Guldberg P (2007) The genome and epigenome of malignant melanoma. APMIS 115:1160-75
-
(2007)
APMIS
, vol.115
, pp. 1160-1175
-
-
Dahl, C.1
Guldberg, P.2
-
4
-
-
78649475003
-
Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis
-
Du P, Zhang X, Huang CC et al. (2010) Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinformatics 11:587
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 587
-
-
Du, P.1
Zhang, X.2
Huang, C.C.3
-
5
-
-
0036081355
-
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
-
Edgar R, Domrachev M, Lash AE (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30:207-10
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 207-210
-
-
Edgar, R.1
Domrachev, M.2
Lash, A.E.3
-
6
-
-
79959820058
-
KIT expression and methylation in medulloblastoma and PNET cell lines and tumors
-
Enguita-German M, Gurrea M, Schiapparelli P et al. (2011) KIT expression and methylation in medulloblastoma and PNET cell lines and tumors. J Neurooncol 103:247-53
-
(2011)
J Neurooncol
, vol.103
, pp. 247-253
-
-
Enguita-German, M.1
Gurrea, M.2
Schiapparelli, P.3
-
7
-
-
42349087828
-
The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms
-
Felicetti F, Errico MC, Bottero L et al. (2008) The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms. Cancer Res 68:2745-54
-
(2008)
Cancer Res
, vol.68
, pp. 2745-2754
-
-
Felicetti, F.1
Errico, M.C.2
Bottero, L.3
-
8
-
-
0027102715
-
c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas
-
Funasaka Y, Boulton T, Cobb M et al. (1992) c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas. Mol Biol Cell 3:197-209
-
(1992)
Mol Biol Cell
, vol.3
, pp. 197-209
-
-
Funasaka, Y.1
Boulton, T.2
Cobb, M.3
-
9
-
-
33745728166
-
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas
-
Furuta J, Nobeyama Y, Umebayashi Y et al. (2006) Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res 66:6080-6
-
(2006)
Cancer Res
, vol.66
, pp. 6080-6086
-
-
Furuta, J.1
Nobeyama, Y.2
Umebayashi, Y.3
-
10
-
-
84879713307
-
Genome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma
-
Gao L, Smit MA, van den Oord JJ et al. (2013) Genome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma. Pigment Cell Melanoma Res 26:542-54
-
(2013)
Pigment Cell Melanoma Res
, vol.26
, pp. 542-554
-
-
Gao, L.1
Smit, M.A.2
Van Den Oord, J.J.3
-
11
-
-
51749102145
-
Melanoma, nevogenesis, and stem cell biology
-
Grichnik JM (2008) Melanoma, nevogenesis, and stem cell biology. J Invest Dermatol 128:2365-80
-
(2008)
J Invest Dermatol
, vol.128
, pp. 2365-2380
-
-
Grichnik, J.M.1
-
12
-
-
0030777104
-
Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
-
Guldberg P, Thor Straten P, Birck A et al. (1997) Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 57:3660-3
-
(1997)
Cancer Res
, vol.57
, pp. 3660-3663
-
-
Guldberg, P.1
Thor Straten, P.2
Birck, A.3
-
13
-
-
79960708519
-
Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification
-
Guo J, Si L, Kong Y et al. (2011) Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol 29:2904-9
-
(2011)
J Clin Oncol
, vol.29
, pp. 2904-2909
-
-
Guo, J.1
Si, L.2
Kong, Y.3
-
14
-
-
0028577765
-
Intertumoral heterogeneity of receptor-tyrosine kinases expression in human melanoma cell lines with different metastatic capabilities
-
Gutman M, Singh RK, Radinsky R et al. (1994) Intertumoral heterogeneity of receptor-tyrosine kinases expression in human melanoma cell lines with different metastatic capabilities. Anticancer Res 14:1759-65
-
(1994)
Anticancer Res
, vol.14
, pp. 1759-1765
-
-
Gutman, M.1
Singh, R.K.2
Radinsky, R.3
-
15
-
-
33644701437
-
Normal human melanocyte homeostasis as a paradigm for understanding melanoma
-
Haass NK, Herlyn M (2005) Normal human melanocyte homeostasis as a paradigm for understanding melanoma. J Investig Dermatol Symp Proc 10:153-63
-
(2005)
J Investig Dermatol Symp Proc
, vol.10
, pp. 153-163
-
-
Haass, N.K.1
Herlyn, M.2
-
16
-
-
80054880084
-
DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter
-
Han H, Cortez CC, Yang X et al. (2011) DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter. Hum Mol Genet 20:4299-310
-
(2011)
Hum Mol Genet
, vol.20
, pp. 4299-4310
-
-
Han, H.1
Cortez, C.C.2
Yang, X.3
-
17
-
-
0642368571
-
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
-
Heinrich MC, Corless CL, Demetri GD et al. (2003) Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 21:4342-9
-
(2003)
J Clin Oncol
, vol.21
, pp. 4342-4349
-
-
Heinrich, M.C.1
Corless, C.L.2
Demetri, G.D.3
-
18
-
-
84881512367
-
Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin
-
Hodi FS, Corless CL, Giobbie-Hurder A et al. (2013) Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin. J Clin Oncol 31:3182-90
-
(2013)
J Clin Oncol
, vol.31
, pp. 3182-3190
-
-
Hodi, F.S.1
Corless, C.L.2
Giobbie-Hurder, A.3
-
19
-
-
0032479996
-
Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis
-
Huang S, Jean D, Luca M et al. (1998) Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. EMBO J 17:4358-69
-
(1998)
EMBO J
, vol.17
, pp. 4358-4369
-
-
Huang, S.1
Jean, D.2
Luca, M.3
-
20
-
-
0030459095
-
Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential
-
Huang S, Luca M, Gutman M et al. (1996) Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncogene 13:2339-47
-
(1996)
Oncogene
, vol.13
, pp. 2339-2347
-
-
Huang, S.1
Luca, M.2
Gutman, M.3
-
21
-
-
58549089539
-
MicroRNA-dependent regulation of cKit in cutaneous melanoma
-
Igoucheva O, Alexeev V (2009) MicroRNA-dependent regulation of cKit in cutaneous melanoma. Biochem Biophys Res Commun 379:790-4
-
(2009)
Biochem Biophys Res Commun
, vol.379
, pp. 790-794
-
-
Igoucheva, O.1
Alexeev, V.2
-
22
-
-
1842473620
-
Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders
-
Imokawa G (2004) Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. Pigment Cell Res 17:96-110
-
(2004)
Pigment Cell Res
, vol.17
, pp. 96-110
-
-
Imokawa, G.1
-
23
-
-
10344260184
-
CpG island methylator phenotype in cancer
-
Issa JP (2004) CpG island methylator phenotype in cancer. Nat Rev Cancer 4:988-93
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 988-993
-
-
Issa, J.P.1
-
24
-
-
34447515273
-
Genomic profiling of malignant melanoma using tiling-resolution array CGH
-
Jönsson G, Dahl C, Staaf J et al. (2007) Genomic profiling of malignant melanoma using tiling-resolution array CGH. Oncogene 26:4738-48
-
(2007)
Oncogene
, vol.26
, pp. 4738-4748
-
-
Jönsson, G.1
Dahl, C.2
Staaf, J.3
-
25
-
-
68149108556
-
Genome-wide screen of promoter methylation identifies novel markers in melanoma
-
Koga Y, Pelizzola M, Cheng E et al. (2009) Genome-wide screen of promoter methylation identifies novel markers in melanoma. Genome Res 19:1462-70
-
(2009)
Genome Res
, vol.19
, pp. 1462-1470
-
-
Koga, Y.1
Pelizzola, M.2
Cheng, E.3
-
26
-
-
84883343415
-
E- to N-cadherin switch in melanoma is associated with decreased expression of phosphatase and tensin homolog and cancer progression
-
Lade-Keller J, Riber-Hansen R, Guldberg P et al. (2013) E- to N-cadherin switch in melanoma is associated with decreased expression of phosphatase and tensin homolog and cancer progression. Br J Dermatol 169:618-28
-
(2013)
Br J Dermatol
, vol.169
, pp. 618-628
-
-
Lade-Keller, J.1
Riber-Hansen, R.2
Guldberg, P.3
-
27
-
-
0026518279
-
Loss of c-kit expression in cultured melanoma cells
-
Lassam N, Bickford S (1992) Loss of c-kit expression in cultured melanoma cells. Oncogene 7:51-6
-
(1992)
Oncogene
, vol.7
, pp. 51-56
-
-
Lassam, N.1
Bickford, S.2
-
28
-
-
84867718489
-
Stem cell factor receptor/c-Kit: From basic science to clinical implications
-
Lennartsson J, Rönnstrand L (2012) Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol Rev 92:1619-49
-
(2012)
Physiol Rev
, vol.92
, pp. 1619-1649
-
-
Lennartsson, J.1
Rönnstrand, L.2
-
29
-
-
33747882661
-
MITF: Master regulator of melanocyte development and melanoma oncogene
-
Levy C, Khaled M, Fisher DE (2006) MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med 12:406-14
-
(2006)
Trends Mol Med
, vol.12
, pp. 406-414
-
-
Levy, C.1
Khaled, M.2
Fisher, D.E.3
-
30
-
-
33847188116
-
Melanocyte biology and skin pigmentation
-
Lin JY, Fisher DE (2007) Melanocyte biology and skin pigmentation. Nature 445:843-50
-
(2007)
Nature
, vol.445
, pp. 843-850
-
-
Lin, J.Y.1
Fisher, D.E.2
-
31
-
-
0030765407
-
Proto-oncogene c-kit expression in malignant melanoma: Protein loss with tumor progression
-
Montone KT, Van Belle P, Elenitsas R et al. (1997) Proto-oncogene c-kit expression in malignant melanoma: protein loss with tumor progression. Mod Pathol 10:939-44
-
(1997)
Mod Pathol
, vol.10
, pp. 939-944
-
-
Montone, K.T.1
Van Belle, P.2
Elenitsas, R.3
-
32
-
-
0026793058
-
Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor
-
Natali PG, Nicotra MR, Winkler AB et al. (1992) Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor. Int J Cancer 52:197-201
-
(1992)
Int J Cancer
, vol.52
, pp. 197-201
-
-
Natali, P.G.1
Nicotra, M.R.2
Winkler, A.B.3
-
33
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME et al. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
-
34
-
-
0141958794
-
Analysis of protein tyrosine kinase expression in melanocytic lesions by tissue array
-
Shen SS, Zhang PS, Eton O et al. (2003) Analysis of protein tyrosine kinase expression in melanocytic lesions by tissue array. J Cutan Pathol 30:539-47
-
(2003)
J Cutan Pathol
, vol.30
, pp. 539-547
-
-
Shen, S.S.1
Zhang, P.S.2
Eton, O.3
-
35
-
-
84884679127
-
Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness
-
Siemens H, Jackstadt R, Kaller M et al. (2013) Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness. Oncotarget 4:1399-415
-
(2013)
Oncotarget
, vol.4
, pp. 1399-1415
-
-
Siemens, H.1
Jackstadt, R.2
Kaller, M.3
-
36
-
-
63449140854
-
CpG island methylator phenotype predicts progression of malignant melanoma
-
Tanemura A, Terando AM, Sim MS et al. (2009) CpG island methylator phenotype predicts progression of malignant melanoma. Clin Cancer Res 15:1801-7
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1801-1807
-
-
Tanemura, A.1
Terando, A.M.2
Sim, M.S.3
-
37
-
-
0344412948
-
Imatinib mesylate causes hypopigmentation in the skin
-
Tsao AS, Kantarjian H, Cortes J et al. (2003) Imatinib mesylate causes hypopigmentation in the skin. Cancer 98:2483-7
-
(2003)
Cancer
, vol.98
, pp. 2483-2487
-
-
Tsao, A.S.1
Kantarjian, H.2
Cortes, J.3
-
38
-
-
84861845490
-
Melanoma: From mutations to medicine
-
Tsao H, Chin L, Garraway LA et al. (2012) Melanoma: from mutations to medicine. Genes Dev 26:1131-55
-
(2012)
Genes Dev
, vol.26
, pp. 1131-1155
-
-
Tsao, H.1
Chin, L.2
Garraway, L.A.3
-
40
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789-99
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
41
-
-
23044514626
-
Chromosome-wide and promoterspecific analyses identify sites of differential DNA methylation in normal and transformed human cells
-
Weber M, Davies JJ, Wittig D et al. (2005) Chromosome-wide and promoterspecific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet 37:853-62
-
(2005)
Nat Genet
, vol.37
, pp. 853-862
-
-
Weber, M.1
Davies, J.J.2
Wittig, D.3
-
42
-
-
50849127845
-
Melanocytes in development, regeneration, and cancer
-
White RM, Zon LI (2008) Melanocytes in development, regeneration, and cancer. Cell Stem Cell 3:242-52
-
(2008)
Cell Stem Cell
, vol.3
, pp. 242-252
-
-
White, R.M.1
Zon, L.I.2
-
43
-
-
80053928911
-
The melanomas: A synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin
-
Whiteman DC, Pavan WJ, Bastian BC (2011) The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. Pigment Cell Melanoma Res 24:879-97
-
(2011)
Pigment Cell Melanoma Res
, vol.24
, pp. 879-897
-
-
Whiteman, D.C.1
Pavan, W.J.2
Bastian, B.C.3
-
44
-
-
0034949862
-
In-tube DNA methylation profiling by fluorescence melting curve analysis
-
Worm J, Aggerholm A, Guldberg P (2001) In-tube DNA methylation profiling by fluorescence melting curve analysis. Clin Chem 47:1183-9
-
(2001)
Clin Chem
, vol.47
, pp. 1183-1189
-
-
Worm, J.1
Aggerholm, A.2
Guldberg, P.3
-
45
-
-
3142710392
-
Genetic and epigenetic alterations of the APC gene in malignant melanoma
-
Worm J, Christensen C, Grønbæk K et al. (2004) Genetic and epigenetic alterations of the APC gene in malignant melanoma. Oncogene 23: 5215-26
-
(2004)
Oncogene
, vol.23
, pp. 5215-5226
-
-
Worm, J.1
Christensen, C.2
Grønbæk, K.3
-
46
-
-
0027197555
-
KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells
-
Zakut R, Perlis R, Eliyahu S et al. (1993) KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene 8:2221-9
-
(1993)
Oncogene
, vol.8
, pp. 2221-2229
-
-
Zakut, R.1
Perlis, R.2
Eliyahu, S.3
-
47
-
-
33644853795
-
Expression of c-kit (CD117) in Spitz nevus and malignant melanoma
-
Zhu YI, Fitzpatrick JE (2006) Expression of c-kit (CD117) in Spitz nevus and malignant melanoma. J Cutan Pathol 33:33-7
-
(2006)
J Cutan Pathol
, vol.33
, pp. 33-37
-
-
Zhu, Y.I.1
Fitzpatrick, J.E.2
|