Lutein has a protective effect on hepatotoxicity induced by arsenic via Nrf2 signaling

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Li, Shugang ^a   Ding, Yusong ^a   Niu, Qiang ^a   Xu, Shangzhi ^a   Pang, Lijuan ^a   Ma, Rulin ^a   Jing, Mingxia ^a   Feng, Gangling ^a   Tang, Jing Xia ^a   Zhang, Qian ^b   Ma, Xiaomei ^b   Yan, Yizhong ^a   Zhang, Jingyu ^a   Wei, Meng ^a   Wang, Hai Xia ^a   Li, Feng ^a   Guo, Shuxia ^a  

^a SHIHEZI UNIVERSITY   (China)

^b XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; HYPOXANTHINE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; XANTHOPHYLL; ANTIOXIDANT; ARSENIC; ORGANOARSENIC DERIVATIVE; OXIDE; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; LIPID PEROXIDATION; LIVER FUNCTION; LIVER HOMOGENATE; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; LIVER; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS;

ANIMALS; ANTIOXIDANTS; ARSENIC; ARSENICALS; BLOTTING, WESTERN; FEMALE; GENE EXPRESSION REGULATION; GLUTATHIONE; IMMUNOHISTOCHEMISTRY; LIVER; LUTEIN; MALE; MALONDIALDEHYDE; MICE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; OXIDES; PROTECTIVE AGENTS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 84924598088     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/315205     Document Type: Article

References (66)

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30. X.-J. Wang, Z. Sun, W. Chen, K. E. Eblin, J. A. Gandolfi, and D. D. Zhang, "Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity," Toxicology and Applied Pharmacology, Vol. 225, no. 2, pp. 206-213, 2007.
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38. L. Benramdane, M. Accominotti, L. Fanton, D. Malicier, and J.-J. Vallon, "Arsenic speciation in human organs following fatal arsenic trioxide poisoning - a case report," Clinical Chemistry, Vol. 45, no. 2, pp. 301-306, 1999.
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42. M. Wang, C. Zhang, and X. Lin, "Protective effect of lutein against blue light-induced retinal damage in rat," Journal of Hygiene Research, Vol. 37, no. 4, pp. 409-412, 2008.
43. M. Sasaki, K. Yuki, and T. Kurihara, "Biological role of lutein in the light-induced retinal degeneration," The Journal of Nutritional Biochemistry, Vol. 23, no. 3, pp. 423-429, 2013.
44. S. Y. Li, Z. J. Fu, H. Ma et al., "Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion," Investigative Ophthalmology and Visual Science, Vol. 50, no. 2, pp. 836-843, 2009.
45. Y. Mitsuishi, H. Motohashi, and M. Yamamoto, "The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism," Frontiers in Oncology, Vol. 2, no. 2, pp. 200-204, 2012.
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49. Q. Zhang, J. Pi, C. G. Woods, and M. E. Andersen, "A systems biology perspective on Nrf2-mediated antioxidant response," Toxicology and Applied Pharmacology, Vol. 244, no. 1, pp. 84-97, 2010.
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52. K. C. Wu, J. Y. Cui, and C. D. Klaassen, "Beneficial role of Nrf2 in regulating NADPH generation and consumption," Toxicological Sciences, Vol. 123, no. 2, pp. 590-600, 2011.
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61. A. M. Bataille and J. E. Manautou, "Nrf2 a potential target for new therapeutics in liver disease," Clinical Pharmacology and Therapeutics, Vol. 92, no. 3, pp. 340-348, 2012.
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