Contribution of sodium channel neuronal isoform Nav1.1 to late sodium current in ventricular myocytes from failing hearts

Journal of Physiology

Volumn 593, Issue 6, 2015, Pages 1409-1427

  Mishra, Sudhish ^a   Reznikov, Vitaliy ^a   Maltsev, Victor A ^b   Undrovinas, Nidas A ^a   Sabbah, Hani N ^a   Undrovinas, Albertas ^a  

^a HENRY FORD HOSPITAL   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; MESSENGER RNA; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.3; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.6; SODIUM CHANNEL NAV2.1; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; ISOPROTEIN; MESYLIC ACID ETHYL ESTER; METHANETHIOSULFONATE ETHYLAMMONIUM; SODIUM CHANNEL BLOCKING AGENT;

ACTION POTENTIAL DURATION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DOG; EXCITATION CONTRACTION COUPLING; GENE EXPRESSION; GENE SILENCING; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HUMAN; HUMAN TISSUE; LATE SODIUM CURRENT; MATHEMATICAL MODEL; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; SODIUM CURRENT; UPREGULATION; ACTION POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; CALCIUM SIGNALING; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; HEART VENTRICLE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACTION POTENTIALS; ANIMALS; CALCIUM SIGNALING; CELLS, CULTURED; DOGS; ETHYL METHANESULFONATE; HEART FAILURE; HEART VENTRICLES; HUMANS; MYOCYTES, CARDIAC; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; PROTEIN ISOFORMS; SODIUM CHANNEL BLOCKERS; TETRODOTOXIN;

EID: 84924567223     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2014.278259     Document Type: Article

References (47)

1. Aman TK, Grieco-Calub TM, Chen C, Rusconi R, Slat EA, Isom LL & Raman IM (2009). Regulation of persistent Na current by interactions between β subunits of voltage-gated Na channels. J Neurosci 29, 2027-2042.
2. + in normal and failing cardiac myocytes. Ann N Y Acad Sci 1080, 165-177.
3. Brette F & Orchard CH (2006). No apparent requirement for neuronal sodium channels in excitation-contraction coupling in rat ventricular myocytes. Circ Res 98, 667-674.
4. V1.1 channels and epilepsy. J Physiol 588, 1849-1859.
5. Coraboeuf E, Deroubaix E & Coulombe A (1979). Effect of tetrodotoxin on action potentials of the conducting system in the dog heart. Am J Physiol Heart Circ Physiol 236, H561-H567.
6. Elbashir SM, Lendeckel W & Tuschl T (2001). RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15, 188-200.
7. Felipe A, Knittle TJ, Doyle KL & Tamkun MM (1994). Primary structure and differential expression during development and pregnancy of a novel voltage-gated sodium channel in the mouse. J Biol Chem 269, 30125-30131.
8. George AL Jr, Knittle TJ & Tamkun MM (1992). Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family. Proc Natl Acad Sci U S A 89, 4893-4897.
9. + channels in the developing mouse heart. J Physiol 564, 683-696.
10. Na is greater in dog heart Purkinje fibers than in ventricles. Cardiovasc Res 65, 117-127.
11. Imai M, Rastogi S, Gupta RC, Mishra S, Sharov VG, Stanley WC, Mika Y, Rousso B, Burkhoff D, Ben-Haim S & Sabbah HN (2007). Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure. J Am Coll Cardiol 49, 2120-2128.
12. Logeart D, Gueffet JP, Rouzet F, Pousset F, Chavelas C, Solal AC & Jondeau G (2009). Heart rate per se impacts cardiac function in patients with systolic heart failure and pacing: a pilot study. Eur J Heart Fail 11, 53-57.
13. Maier SK, Westenbroek RE, McCormick KA, Curtis R, Scheuer T & Catterall WA (2004). Distinct subcellular localization of different sodium channel α and β subunits in single ventricular myocytes from mouse heart. Circulation 109, 1421-1427.
14. Maier SK, Westenbroek RE, Schenkman KA, Feigl EO, Scheuer T & Catterall WA (2002). An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci U S A 99, 4073-4078.
15. v1.5-antisense inhibition. Am J Physiol Heart Circ Physiol 295, H667-H676.
16. 1 subunit. J Physiol Sci 59, 217-225.
17. 2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences. Am J Physiol Heart Circ Physiol 294, H1597-H1608.
18. Maltsev VA, Sabbah HN, Higgins RSD, Silverman N, Lesch M & Undrovinas AI (1998a). Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes. Circulation 98, 2545-2552.
19. 2+ transient in cardiomyocytes of dogs with chronic heart failure. Cell Mol Life Sci 54, 597-605.
20. Maltsev VA, Sabbah HN & Undrovinas AI (2001). Late sodium current is a novel target for amiodarone: Studies in failing human myocardium. J Mol Cell Cardiol 33, 923-932.
21. Maltsev VA, Sabbah HN & Undrovinas AI (2002). Down-regulation of sodium current in chronic heart failure: effects of long-term therapy with carvedilol. Cell Mol Life Sci 59, 1561-1568.
22. Maltsev VA, Silverman N, Sabbah HN & Undrovinas AI (2007). Chronic heart failure slows late sodium current in human and canine ventricular myocytes: Implications for repolarization variability. Eur J Heart Fail 9, 219-227.
23. Maltsev VA & Undrovinas A (2008). Late sodium current in failing heart: Friend or foe? Prog Biophys Mol Biol 96, 421-451.
24. Maltsev VA & Undrovinas AI (1997). Cytoskeleton modulates coupling between availability and activation of cardiac sodium channel. Am J Physiol Heart Circ Physiol 273, H1832-H1840.
25. + current in human ventricular cardiomyocytes. Cardiovasc Res 69, 116-127.
26. Martino A, Cabiati M, Campan M, Prescimone T, Minocci D, Caselli C, Rossi AM, Giannessi D & Del Ry S (2011). Selection of reference genes for normalization of real-time PCR data in minipig heart failure model and evaluation of TNF- α mRNA expression. J Biotechnol 153, 92-99.
27. 2+ exchanger expression in left ventricle myocardium of dogs with progression of heart failure. Heart Vessels 20, 23-32.
28. Mishra S, Undrovinas NA, Maltsev VA, Reznikov V, Sabbah HN & Undrovinas A (2011). Post-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure. Am J Physiol Heart Circ Physiol 301, H1596-H1605.
29. Noble D & Noble PJ (2006). Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium-calcium overload. Heart 92, Suppl. 4, iv1-iv5.
30. Rao K, Fisher ML, Robinson S, Shorofsky S & Gottlieb SS (2007). Effect of chronic changes in heart rate on congestive heart failure. J Card Fail 13, 269-274.
31. Sabbah HN, Goldberg AD, Schoels W, Kono T, Webb C, Brachmann J & Goldstein S (1992). Spontaneous and inducible ventricular arrhythmias in a canine model of chronic heart failure: relation to haemodynamics and sympathoadrenergic activation. Eur Heart J 13, 1562-1572.
32. Sabbah HN, Stein PD, Kono T, Gheorghiade M, Levine TB, Jafri S, Hawkins ET & Goldstein S (1991). A canine model of chronic heart failure produced by multiple sequential coronary microembolizations. Am J Physiol Heart Circ Physiol 260, H1379-H1384.
33. Spampanato J, Kearney JA, de Haan G, McEwen DP, Escayg A, Aradi I, MacDonald BT, Levin SI, Soltesz I, Benna P, Montalenti E, Isom LL, Goldin AL & Meisler MH (2004). A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for β subunit interaction. J Neurosci 24, 10022-10034.
34. Trimmer JS & Agnew WS (1989). Molecular diversity of voltage-sensitive Na channels. Annu Rev Physiol 51, 401-418.
35. Undrovinas AI, Belardinelli L, Undrovinas NA & Sabbah HN (2006). Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current. J Cardiovasc Electrophysiol 17, S169-S177.
36. Undrovinas AI, Fleidervish IA & Makielski JC (1992). Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine. Circ Res 71, 1231-1241.
37. Undrovinas A & Maltsev VA (2008). Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart. Cardiovasc Hematol Agents Med Chem 6, 348-359.
38. 2+ accumulation in chronic heart failure. J Physiol Sci 60, 245-257.
39. + channel in normal and failing human myocardium. J Mol Cell Cardiol 34, 1477-1489.
40. Undrovinas AI, Maltsev VA & Sabbah HN (1999). Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: Role of sustained inward current. Cell Mol Life Sci 55, 494-505.
41. Undrovinas AI, Shander GS & Makielski JC (1995). Cytoskeleton modulates gating of voltage-dependent sodium channel in heart. Am J Physiol Heart Circ Physiol 269, H203-H214.
42. Valdivia CR, Chu WW, Pu J, Foell JD, Haworth RA, Wolff MR, Kamp TJ & Makielski JC (2005). Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. J Mol Cell Cardiol 38, 475-483.
43. V1.1 and mechanism of channel dysfunction in SCN1A-associated epilepsy. J Gen Physiol 127, 1-14.
44. v2/NaG channel is involved in control of salt-intake behavior in the CNS. J Neurosci 20, 7743-7751.
45. v1.6-mediated persistent current. Neuropharmacology 55, 1165-1171.
46. Winslow RL, Rice J, Jafri S, Marbán E & O'Rourke B (1999). Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ Res 84, 571-586.
47. + channel subunits in chronic heart failure. J Mol Cell Cardiol 37, 91-100.