-
1
-
-
84901777524
-
DILIN Network: Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset
-
Fontana RJ, Hayashi PH, Gu J, Reddy KR, Barnhart H, Watkins PB, Serrano J, Lee WM, Chalasani N, Stolz A, Davern T, Talwakar JA; DILIN Network: Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset. Gastroenterology 2014, 147:96-108.
-
(2014)
Gastroenterology
, vol.147
, pp. 96-108
-
-
Fontana, R.J.1
Hayashi, P.H.2
Gu, J.3
Reddy, K.R.4
Barnhart, H.5
Watkins, P.B.6
Serrano, J.7
Lee, W.M.8
Chalasani, N.9
Stolz, A.10
Davern, T.11
Talwakar, J.A.12
-
3
-
-
84903897064
-
Practice parameters committee of the american college of gastroenterology: ACG clinical guideline: The diagnosis and management of idiosyncratic drug-induced liver injury
-
Chalasani NP, Hayashi PH, Bonkovsky HL, Navarro VJ, Lee WM, Fontana RJ; Practice Parameters Committee of the American College of Gastroenterology: ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol 2014, 109:950-66.
-
(2014)
Am J Gastroenterol
, vol.109
, pp. 950-966
-
-
Chalasani, N.P.1
Hayashi, P.H.2
Bonkovsky, H.L.3
Navarro, V.J.4
Lee, W.M.5
Fontana, R.J.6
-
5
-
-
0027362542
-
Causality assessment of adverse reactions to drugs - I. A novel method based on the conclusions of international consensus meetings: Application to druginduced liver injuries
-
Danan G, Benichou C: Causality assessment of adverse reactions to drugs - I. A novel method based on the conclusions of international consensus meetings: application to druginduced liver injuries. J Clin Epidemiol 1993, 46:1323-30.
-
(1993)
J Clin Epidemiol
, vol.46
, pp. 1323-1330
-
-
Danan, G.1
Benichou, C.2
-
6
-
-
0027448634
-
Causality assessment of adverse reactions to drugs - II. An original model for validation of drug causality assessment methods: Case reports with positive rechallenge
-
Benichou C, Danan G, Flahault A: Causality assessment of adverse reactions to drugs - II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol 1993, 46:1331-6.
-
(1993)
J Clin Epidemiol
, vol.46
, pp. 1331-1336
-
-
Benichou, C.1
Danan, G.2
Flahault, A.3
-
7
-
-
0030865914
-
Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis
-
Maria VA, Victorino RM: Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology 1997, 26:664-9.
-
(1997)
Hepatology
, vol.26
, pp. 664-669
-
-
Maria, V.A.1
Victorino, R.M.2
-
10
-
-
84873304792
-
Human leukocyte antigen (HLA)-B 57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury
-
Monshi MM, Faulkner L, Gibson A, Jenkins RE, Farrell J, Earnshaw CJ, Alfirevic A, Cederbrant K, Daly AK, French N, Pirmohamed M, Park BK, Naisbitt DJ: Human leukocyte antigen (HLA)-B 57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology 2013, 57: 727-39.
-
(2013)
Hepatology
, vol.57
, pp. 727-739
-
-
Monshi, M.M.1
Faulkner, L.2
Gibson, A.3
Jenkins, R.E.4
Farrell, J.5
Earnshaw, C.J.6
Alfirevic, A.7
Cederbrant, K.8
Daly, A.K.9
French, N.10
Pirmohamed, M.11
Park, B.K.12
Naisbitt, D.J.13
-
11
-
-
67649859295
-
DILIGEN Study; International SAE Consortium: HLA-B 5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
-
Daly AK, Donaldson PT, Bhatnagar P, Shen Y, Pe'er I, Floratos A, Daly MJ, Goldstein DB, John S, Nelson MR, Graham J, Park BK, Dillon JF, Bernal W, Cordell HJ, Pirmohamed M, Aithal GP, Day CP; DILIGEN Study; International SAE Consortium: HLA-B 5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet 2009, 41:816-9.
-
(2009)
Nat Genet
, vol.41
, pp. 816-819
-
-
Daly, A.K.1
Donaldson, P.T.2
Bhatnagar, P.3
Shen, Y.4
Pe'Er, I.5
Floratos, A.6
Daly, M.J.7
Goldstein, D.B.8
John, S.9
Nelson, M.R.10
Graham, J.11
Park, B.K.12
Dillon, J.F.13
Bernal, W.14
Cordell, H.J.15
Pirmohamed, M.16
Aithal, G.P.17
Day, C.P.18
-
12
-
-
0037006623
-
Association between presence of HLA-B 5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reversetranscriptase inhibitor abacavir
-
Mallal S, Nolan D, Witt C, Masel G, Martin AM, Moore C, Sayer D, Castley A, Mamotte C, Maxwell D, James I, Christiansen FT: Association between presence of HLA-B 5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reversetranscriptase inhibitor abacavir. Lancet 2002, 359:727-32.
-
(2002)
Lancet
, vol.359
, pp. 727-732
-
-
Mallal, S.1
Nolan, D.2
Witt, C.3
Masel, G.4
Martin, A.M.5
Moore, C.6
Sayer, D.7
Castley, A.8
Mamotte, C.9
Maxwell, D.10
James, I.11
Christiansen, F.T.12
-
13
-
-
38949196447
-
PREDICT-1 Study Team: HLA-B 5701 screening for hypersensitivity to abacavir
-
Mallal S, Phillips E, Carosi G, Molina JM, Workman C, Tomazic J, Jägel-Guedes E, Rugina S, Kozyrev O, Cid JF, Hay P, Nolan D, Hughes S, Hughes A, Ryan S, Fitch N, Thorborn D, Benbow A; PREDICT-1 Study Team: HLA-B 5701 screening for hypersensitivity to abacavir. N Engl J Med 2008, 358:568-79.
-
(2008)
N Engl J Med
, vol.358
, pp. 568-579
-
-
Mallal, S.1
Phillips, E.2
Carosi, G.3
Molina, J.M.4
Workman, C.5
Tomazic, J.6
Jägel-Guedes, E.7
Rugina, S.8
Kozyrev, O.9
Cid, J.F.10
Hay, P.11
Nolan, D.12
Hughes, S.13
Hughes, A.14
Ryan, S.15
Fitch, N.16
Thorborn, D.17
Benbow, A.18
-
14
-
-
78049469917
-
Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclavinduced liver injury
-
Donaldson PT, Daly AK, Henderson J, Graham J, Pirmohamed M, Bernal W, Day CP, Aithal GP: Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclavinduced liver injury. J Hepatol 2010, 53:1049-53.
-
(2010)
J Hepatol
, vol.53
, pp. 1049-1053
-
-
Donaldson, P.T.1
Daly, A.K.2
Henderson, J.3
Graham, J.4
Pirmohamed, M.5
Bernal, W.6
Day, C.P.7
Aithal, G.P.8
-
15
-
-
77955082302
-
A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury
-
Singer JB, Lewitzky S, Leroy E, Yang F, Zhao X, Klickstein L, Wright TM, Meyer J, Paulding CA: A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat Genet 2010, 42:711-4.
-
(2010)
Nat Genet
, vol.42
, pp. 711-714
-
-
Singer, J.B.1
Lewitzky, S.2
Leroy, E.3
Yang, F.4
Zhao, X.5
Klickstein, L.6
Wright, T.M.7
Meyer, J.8
Paulding, C.A.9
-
16
-
-
84924536075
-
Human leukocyte antigen genetic risk factors of drug-induced liver toxicology
-
[Epub ahead of print]
-
Grove JI, Aithal GP: Human leukocyte antigen genetic risk factors of drug-induced liver toxicology. Expert Opin Drug Metab Toxicol 2014, 10:1-15. [Epub ahead of print].
-
(2014)
Expert Opin Drug Metab Toxicol
, vol.10
, pp. 1-15
-
-
Grove, J.I.1
Aithal, G.P.2
-
17
-
-
79952173247
-
HLADQA1 02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer
-
Spraggs CF, Budde LR, Briley LP, Bing N, Cox CJ, King KS, Whittaker JC, Mooser VE, Preston AJ, Stein SH, Cardon LR: HLADQA1 02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer. J Clin Oncol 2011, 29:667-73.
-
(2011)
J Clin Oncol
, vol.29
, pp. 667-673
-
-
Spraggs, C.F.1
Budde, L.R.2
Briley, L.P.3
Bing, N.4
Cox, C.J.5
King, K.S.6
Whittaker, J.C.7
Mooser, V.E.8
Preston, A.J.9
Stein, S.H.10
Cardon, L.R.11
-
18
-
-
84919902756
-
Liver safety assessment in special populations (hepatitis B, C, and oncology trials)
-
Kullak-Ublick GA, Merz M, Griffel L, Kaplowitz N, Watkins PB: Liver safety assessment in special populations (hepatitis B, C, and oncology trials). Drug Saf 2014, 37:57-62.
-
(2014)
Drug Saf
, vol.37
, pp. 57-62
-
-
Kullak-Ublick, G.A.1
Merz, M.2
Griffel, L.3
Kaplowitz, N.4
Watkins, P.B.5
-
19
-
-
44049102035
-
Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis
-
Kindmark A, Jawaid A, Harbron CG, Barratt BJ, Bengtsson OF, Andersson TB, Carlsson S, Cederbrant KE, Gibson NJ, Armstrong M, Lagerström-Fermér ME, Dellsén A, Brown EM, Thornton M, Dukes C, Jenkins SC, Firth MA, Harrod GO, Pinel TH, Billing-Clason SM, Cardon LR, March RE: Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis. Pharmacogenomics J 2008, 8:186-95.
-
(2008)
Pharmacogenomics J
, vol.8
, pp. 186-195
-
-
Kindmark, A.1
Jawaid, A.2
Harbron, C.G.3
Barratt, B.J.4
Bengtsson, O.F.5
Andersson, T.B.6
Carlsson, S.7
Cederbrant, K.E.8
Gibson, N.J.9
Armstrong, M.10
Lagerström-Fermér, M.E.11
Dellsén, A.12
Brown, E.M.13
Thornton, M.14
Dukes, C.15
Jenkins, S.C.16
Firth, M.A.17
Harrod, G.O.18
Pinel, T.H.19
Billing-Clason, S.M.20
Cardon, L.R.21
March, R.E.22
more..
-
20
-
-
72949092649
-
A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran
-
Andersson U, Lindberg J, Wang S, Balasubramanian R, Marcusson-Ståhl M, Hannula M, Zeng C, Juhasz PJ, Kolmert J, Bäckström J, Nord L, Nilsson K, Martin S, Glinghammar B, Cederbrant K, Schuppe-Koistinen I: A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran. Biomarkers 2009, 14:572-86.
-
(2009)
Biomarkers
, vol.14
, pp. 572-586
-
-
Andersson, U.1
Lindberg, J.2
Wang, S.3
Balasubramanian, R.4
Marcusson-Ståhl, M.5
Hannula, M.6
Zeng, C.7
Juhasz, P.J.8
Kolmert, J.9
Bäckström, J.10
Nord, L.11
Nilsson, K.12
Martin, S.13
Glinghammar, B.14
Cederbrant, K.15
Schuppe-Koistinen, I.16
-
22
-
-
84924563827
-
-
U.S. Food and Drug Administration: Predictive Safety Testing Consortium (PSTC). [http://www.fda.gov/AboutFDA/Partnerships Collaborations/PublicPrivatePartnershipProgram/ucm231132.htm]
-
-
-
U.S. Food and Drug Administration1
-
23
-
-
84924563826
-
-
Critical path institute: Predictive Safety Testing Consortium. [http://c-path.org/programs/pstc/pstc-tools/?anchor=section-582# section-582]
-
-
-
Critical path institute1
-
24
-
-
33646024613
-
Hy's law: Predicting serious hepatotoxicity
-
Temple R: Hy's law: predicting serious hepatotoxicity. Pharmacoepidemiol Drug Saf 2006, 15:241-3.
-
(2006)
Pharmacoepidemiol Drug Saf
, vol.15
, pp. 241-243
-
-
Temple, R.1
-
26
-
-
84919924873
-
Evolution of the Food and Drug Administration approach to liver safety assessment for new drugs: Current status and challenges
-
Suppl 1
-
Senior JR: Evolution of the Food and Drug Administration approach to liver safety assessment for new drugs: current status and challenges. Drug Saf 2014, 37(Suppl 1):S9-17.
-
(2014)
Drug Saf
, vol.37
, pp. S9-S17
-
-
Senior, J.R.1
-
27
-
-
84896450857
-
Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives
-
Fontana RJ: Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives. Gastroenterology 2014, 146:914-28.
-
(2014)
Gastroenterology
, vol.146
, pp. 914-928
-
-
Fontana, R.J.1
-
29
-
-
84868211262
-
Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases
-
Bala S, Petrasek J, Mundkur S, Catalano D, Levin I, Ward J, Alao H, Kodys K, Szabo G: Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology 2012, 56:1946-57.
-
(2012)
Hepatology
, vol.56
, pp. 1946-1957
-
-
Bala, S.1
Petrasek, J.2
Mundkur, S.3
Catalano, D.4
Levin, I.5
Ward, J.6
Alao, H.7
Kodys, K.8
Szabo, G.9
-
30
-
-
80055038826
-
Circulating microRNAs as potential markers of human drug-induced liver injury
-
Starkey Lewis PJ, Dear J, Platt V, Simpson KJ, Craig DG, Antoine DJ, French NS, Dhaun N, Webb DJ, Costello EM, Neoptolemos JP, Moggs J, Goldring CE, Park BK: Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology 2011, 54:1767-76.
-
(2011)
Hepatology
, vol.54
, pp. 1767-1776
-
-
Starkey Lewis, P.J.1
Dear, J.2
Platt, V.3
Simpson, K.J.4
Craig, D.G.5
Antoine, D.J.6
French, N.S.7
Dhaun, N.8
Webb, D.J.9
Costello, E.M.10
Neoptolemos, J.P.11
Moggs, J.12
Goldring, C.E.13
Park, B.K.14
-
31
-
-
84862776783
-
Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
-
Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, Craig DG, Simpson KJ, Jaeschke H, Park BK: Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J Hepatol 2012, 56:1070-1079.
-
(2012)
J Hepatol
, vol.56
, pp. 1070-1079
-
-
Antoine, D.J.1
Jenkins, R.E.2
Dear, J.W.3
Williams, D.P.4
McGill, M.R.5
Sharpe, M.R.6
Craig, D.G.7
Simpson, K.J.8
Jaeschke, H.9
Park, B.K.10
-
32
-
-
84894130706
-
Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts
-
[Epub ahead of print]
-
Thulin P, Nordahl G, Gry M, Yimer G, Aklillu E, Makonnen E, Aderaye G, Lindquist L, Mattsson CM, Ekblom B, Antoine DJ, Park BK, Linder S, Harrill AH, Watkins PB, Glinghammar B, Schuppe-Koistinen I: Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts. Liver Int 2013, [Epub ahead of print].
-
(2013)
Liver Int
-
-
Thulin, P.1
Nordahl, G.2
Gry, M.3
Yimer, G.4
Aklillu, E.5
Makonnen, E.6
Aderaye, G.7
Lindquist, L.8
Mattsson, C.M.9
Ekblom, B.10
Antoine, D.J.11
Park, B.K.12
Linder, S.13
Harrill, A.H.14
Watkins, P.B.15
Glinghammar, B.16
Schuppe-Koistinen, I.17
-
33
-
-
84881027019
-
Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital
-
Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK: Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology 2013, 58:777-87.
-
(2013)
Hepatology
, vol.58
, pp. 777-787
-
-
Antoine, D.J.1
Dear, J.W.2
Lewis, P.S.3
Platt, V.4
Coyle, J.5
Masson, M.6
Thanacoody, R.H.7
Gray, A.J.8
Webb, D.J.9
Moggs, J.G.10
Bateman, D.N.11
Goldring, C.E.12
Park, B.K.13
-
34
-
-
84920998277
-
Acute Liver Failure Study Group: Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome
-
McGill MR, Staggs VS, Sharpe MR, Lee WM, Jaeschke H; Acute Liver Failure Study Group: Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome. Hepatology 2014, 60:1336-45.
-
(2014)
Hepatology
, vol.60
, pp. 1336-1345
-
-
McGill, M.R.1
Staggs, V.S.2
Sharpe, M.R.3
Lee, W.M.4
Jaeschke, H.5
-
35
-
-
77956354416
-
Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells
-
Rashid ST, Corbineau S, Hannan N, Marciniak SJ, Miranda E, Alexander G, Huang-Doran I, Griffin J, Ahrlund-Richter L, Skepper J, Semple R, Weber A, Lomas DA, Vallier L: Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest 2010, 120:3127-36.
-
(2010)
J Clin Invest
, vol.120
, pp. 3127-3136
-
-
Rashid, S.T.1
Corbineau, S.2
Hannan, N.3
Marciniak, S.J.4
Miranda, E.5
Alexander, G.6
Huang-Doran, I.7
Griffin, J.8
Ahrlund-Richter, L.9
Skepper, J.10
Semple, R.11
Weber, A.12
Lomas, D.A.13
Vallier, L.14
|