A systematic review of pre-operative anaemia and blood transfusion in patients with fractured hips

Anaesthesia

Volumn 70, Issue 4, 2015, Pages 483-500

  Potter, L J ^a   Doleman, B ^a   Moppett, I K ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HEMOGLOBIN; IRON; TRANEXAMIC ACID;

ABDOMINAL PAIN; ACUTE HEART INFARCTION; ANEMIA; BLOOD CONSERVATION; BLOOD TRANSFUSION; CARDIOVASCULAR DISEASE; CHEST INFECTION; COMORBIDITY; DEFECATION HABIT; ERYTHROCYTE TRANSFUSION; HEART FAILURE; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HIP FRACTURE; HOSPITAL READMISSION; HUMAN; INFECTIOUS COMPLICATION; IRON THERAPY; LENGTH OF STAY; MORTALITY; OUTCOME ASSESSMENT; PNEUMONIA; POSTOPERATIVE COMPLICATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SKIN IRRITATION; SYSTEMATIC REVIEW; URINARY TRACT INFECTION; VENOUS THROMBOEMBOLISM; WOUND INFECTION; ADVERSE EFFECTS; COMPLICATION; HIP FRACTURES; METABOLISM; MYOCARDIAL INFARCTION; PROGNOSIS;

ANEMIA; BLOOD TRANSFUSION; HEMOGLOBINS; HIP FRACTURES; HUMANS; MYOCARDIAL INFARCTION; PROGNOSIS;

EID: 84924462869     PISSN: 00032409     EISSN: 13652044     Source Type: Journal    
DOI: 10.1111/anae.12978     Document Type: Review

References (81)

1. Haentjens P, Magaziner J, Colõn-Emeric CS, et al. Meta-analysis: excess mortality after hip fracture among older women and men. Annals of Internal Medicine 2010; 152: 380-90.
2. Centers for Disease Control and Prevention. Injury prevention & control: hip fractures among older adults. http://www.cdc.gov/HomeandRecreationalSafety/Falls/adulthipfx.html (accessed 01/09/2011).
3. White SM, Griffiths R,. Projected incidence of proximal femoral fracture in England: a report from the NHS Hip Fracture Anaesthesia Network (HIPFAN). Injury 2011; 11: 1230-3.
4. Moppett IK, Parker M, Griffiths R, Bowers T, White SM, Moran CG,. The Nottingham Hip Fracture Score: longitudinal and multi-centre assessment. British Journal of Anaesthesia 2012; 109: 546-50.
5. Moppett IK, Wiles MD, Moran CG, Sahota O,. The Nottingham Hip Fracture Score as a predictor of early discharge following fractured neck of femur. Age and Ageing 2012; 41: 322-6.
6. Bentler SE, Liu L, Obrizan M, et al. The aftermath of hip fracture: discharge placement, functional status change, and mortality. American Journal of Epidemiology 2009; 170: 1290-9.
7. Dong X, Mendes de Leon C, Artz A, Tang Y, Shah R, Evans D,. A population-based study of hemoglobin, race, and mortality in elderly persons. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2008; 63: 873-8.
8. Roy CN,. Anemia in frailty. Clinics in Geriatric Medicine 2011; 27: 67-78.
9. Beghe C, Wilson A, Ershler WB,. Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature. American Journal of Medicine 2004; 116: 3S-10S.
10. Brown P, Brunnhuber K, Chalkidou K, et al. How to formulate research recommendations. British Medical Journal 2006; 333: 804-6.
11. World Health Organization. Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. Vitamin and Mineral Nutrition Information System, 2011 (WHO/NMH/NHD/MNM/11.1) (http://www.who.int/vmnis/indicators/haemoglobin.pdf (accessed 12/03/2014).
12. Wells GA, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of non randomised studies in meta-analyses. http://www.ohri.ca/programs/clinical-epidemiology/oxford.htm (accessed 04/11/14).
13. Review Manager (RevMan) [Computer Program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
14. Deeks JJ, Higgins JPT, Altman DG,. Analysing data and undertaking meta-analyses. In:, Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Chichester: Wiley-Blackwell, 2011: 284-7.
15. Adunsky A, Arad M, Blumstein T, et al. Discharge hemoglobin and functional outcome of elderly hip fractured patients undergoing rehabilitation. European Journal of Physical Rehabilitation Medicine 2008; 44: 417-22.
16. Berry SD, Samelson EJ, Bordes M, Broe K, Kiel DP,. Survival of aged nursing home residents with hip fracture. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2009; 64A: 771-7.
17. Bhaskar D, Parker MJ,. Haematological indices as surrogate markers of factors affecting mortality after hip fracture. Injury 2011; 42: 178-82.
18. Björkelund KB, Hommel A, Thorngren K-G, Lundberg D, Larsson S,. The influence of perioperative care and treatment on the 4-month outcome in elderly patients with hip fracture. Journal of the American Association of Nurse Anaesthetists 2011; 79: 51-61.
19. Björkelund KB, Hommel A, Thorngren KG, Lundberg D, Larsson S,. Factors at admission associated with 4 months outcome in elderly patients with hip fracture. Journal of the American Association of Nurse Anaesthetists 2009; 77: 49-58.
20. Dubljanin-Raspopovic E, Markovic-Denic L, Nikolic D, Tulic G, Kadija M, Bumbaširevic M,. Is anemia at admission related to short-term outcomes of elderly hip fracture patients? Central European Journal of Medicine 2011; 6: 483-9.
21. Foss NB, Kristensen MT, Kehlet H,. Anaemia impedes functional mobility after hip fracture surgery. Age and Ageing 2008; 37: 173-8.
22. Gruson KI, Aharonoff GB, Egol KA, Zuckerman JD, Koval KJ,. The relationship between admission hemoglobin level and outcome after hip fracture. Journal of Orthopaedic Trauma 2002; 16: 39-44.
23. Hagino T, Sato E, Tonotsuka H, Satoshi S, Tokai M, Hamada Y,. Prediction of ambulation prognosis in the elderly after hip fracture. International Orthopaedics 2006; 30: 315-9.
24. Hagino T, Ochiai S, Wako M, et al. A simple scoring system to predict ambulation prognosis after hip fracture in the elderly. Archives of Orthopaedic and Trauma Surgery 2007; 127: 603-6.
25. Hagino T, Ochiai S, Sato E, Maekawa S, Wako M, Haro H,. The relationship between anemia at admission and outcome in patients older than 60 years with hip fracture. Journal of Orthopaedics and Traumatology 2009; 10: 119-22.
26. Hagino T, Ochiai S, Sato E, Watanabe Y, Senga S, Haro H,. Prognostic prediction in patients with hip fracture: risk factors predicting difficulties with discharge to own home. Journal of Orthopaedics and Traumatology 2011; 12: 77-80.
27. Halm EA, Wang JJ, Boockvar K, et al. The effect of perioperative anemia on clinical and functional outcomes in patients with hip fracture. Journal of Orthopaedic Trauma 2004; 18: 269-74.
28. Jiang HX, Majumdar SR, Dick DA, et al. Development and initial validation of a risk score for predicting in-hospital and 1-year mortality in patients with hip fractures. Journal of Bone and Mineral Research 2005; 20: 494-500.
29. Khan MA, Hossain FS, Dashti Z, Muthukumar N,. Causes and predictors of early re-admission after surgery for a fracture of the hip. Journal of Bone and Joint Surgery British Edition 2012; 94-B: 690-7.
30. Kyo T, Takaoka K, Ono K,. Femoral neck fracture: factors related to ambulation and prognosis. Clinical Orthopaedics and Related Research 1993; 292: 215-22.
31. Lawrence VA, Silverstein JH, Cornell JE, Pederson T, Noveck H, Carson JL,. Higher Hb level is associated with better early functional recovery after hip fracture repair. Transfusion 2003; 43: 1717-22.
32. Mantilla CB, Wass CT, Goodrich KA, et al. Risk for perioperative myocardial infarction and mortality in patients undergoing hip or knee arthroplasty: the role of anemia. Transfusion 2011; 51: 82-91.
33. Maxwell MJ, Moran CG, Moppett IK,. Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery. British Journal of Anaesthesia 2008; 101: 511-7.
34. Miyanishi K, Jingushi S, Torisu T,. Mortality after hip fracture in Japan: the role of nutritional status. Journal of Orthopaedic Surgery 2010; 18: 265-70.
35. Monte-Secades R, Peña-Zemsch M, Rabuñal-Rey R, Bal-Alvaredo M, Pazos-Ferro A, Mateos-Colino A,. Factores de riesgo para la presentaciõn de complicaciones médicas en enfermos con fractura de cadera [Risk factors for the development of medical complications in patients with hip fracture]. Revista de Calidad Asistencial 2011; 26: 76-82.
36. Mosfeldt M, Pedersen OB, Riis T, et al. Value of routine blood tests for prediction of mortality risk in hip fracture patients. Acta Orthopaedica 2012; 83: 31-5.
37. Oztürk A, Ozkan Y, Akgöz S, Yalçýn N, Ozdemir RM, Aykut S,. The risk factors for mortality in elderly patients with hip fractures: postoperative one-year results. Singapore Medical Journal 2010; 51: 137-43.
38. Reuling EM, Sierevelt IN, van den Bekerom MP, et al. Predictors of functional outcome following femoral neck fractures treated with an arthroplasty: limitations of the Harris hip score. Archives of Orthopaedic and Trauma Surgery 2012; 132: 249-56.
39. Shebubakar L, Hutagalung E, Sapardan S, Sutrisna B,. Effects of older age and multiple comorbidities on functional outcome after partial hip replacement surgery for hip fractures. Acta Medica Indonesiana 2009; 41: 195-9.
40. Vochteloo AJH, van der Burg BLSB, Mertens BJA, et al. Outcome in hip fracture patients related to anemia at admission and allogeneic blood transfusion: an analysis of 1262 surgically treated patients. BMC Musculoskeletal Disorders 2011; 12: 262. doi: 10.1186/1471-2474-12-262.
41. Willems JM, de Craen AJM, Nelissen RGHH, van Luijt PA, Westendorp RGJ, Blauw GJ,. Haemoglobin predicts length of hospital stay after hip fracture surgery in older patients. Maturitas 2012; 72: 225-8.
42. Adunsky A, Lichtenstein A, Mizrahi E, Arad M, Heim M,. Blood transfusion requirements in elderly hip fracture patients. Archives of Gerontology and Geriatrics 2003; 36: 75-81.
43. Ali SM, Hussain N,. Efficacy of tranexamic acid in reducing blood loss during hip fracture surgery. Journal of the Pakistani Orthopaedic Association 2012; 24: 103-5.
44. Blanco Rubio N, Llorens Eizaguerri M, Seral García B, Burillo Fuertes P, Ranera García M, Albareda Albareda J,. Hierro intravenoso preoperatorio como estrategia de ahorro de sangre en cirugi'a de fractura de cadera. [Preoperative intravenous iron as a strategy for blood saving in surgery for hip fracture]. Medicina Clinica (Barcelona) 2013; 141: 371-5.
45. Carson JL, Duff A, Berlin JA, et al. Perioperative blood transfusion and postoperative mortality. Journal of the American Medical Association 1998; 279: 199-205.
46. Carson JL, Terrin ML, Barton FB, et al. A pilot randomized trial comparing symptomatic vs. hemoglobin level-driven red blood cell transfusions following hip fracture. Transfusion 1998; 38: 522-9.
47. Carson JL, Altman DG, Duff A, et al. Risk of bacterial infection associated with allogeneic blood transfusion among patients undergoing hip fracture repair. Transfusion 1999; 39: 694-700.
48. Carson JL, Terrin ML, Noveck H, et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. New England Journal of Medicine 2011; 365: 2453-62.
49. Cuenca J, García-Erce JA, Munoz M,. Patients with pertrochanteric hip fracture may benefit from preoperative intravenous iron therapy: a pilot study. Transfusion 2004; 44: 1447-52.
50. Cuenca Espiérrez J, García Erce JA, Martínez Martín AA, Solano VM, Modrego Aranda FJ,. Seguridad y eficacia del hierro intravenoso en la anemia aguda por fractura trocantérea de cadera en el anciano. [Safety and usefulness of parenteral iron in the management of anemia due to hip fracture in the elderly]. Medicina Clinica (Barcelona) 2004; 123: 281-5.
51. Cuenca J, García Erce JA, Martínez AA, Solano VM, Herrera A,. Preoperative blood test results and type of fracture as transfusional risk factors in patients older than 65 years with trochanteric hip fracture. Revista Espanola de Anestesiologia y Reanimacion 2004; 51: 515-22.
52. Cuenca J, García-Erce JA, Martínez AA, Solano VM, Molina J, Muñoz M,. Role of parenteral iron in the management of anaemia in the elderly patient undergoing displaced subcapital hip fracture repair: preliminary data. Archives of Orthopaedic Trauma Surgery 2005; 125: 342-7.
53. Cuenca J, García-Erce JA, Haman-Alcober S, et al. Eficacia y cumplimiento de un protocolo de ahorro de sangre en pacientes con fractura de cadera en la practica clinica diaria. Anemia Revisita 2010; 3: 133-9.
54. Engoren M, Mitchell E, Perring P, Sferra J,. The effect of erythrocyte blood transfusions on survival after surgery for hip fracture. The Journal of Trauma 2008; 65: 1411-5.
55. Foss NB, Kristensen MT, Jensen PS, Palm H, Krasheninnikoff M, Kehlet H,. The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery. Transfusion 2009; 49: 227-34.
56. García-Erce JA, Cuenca J, Haman-Alcober S, Martínez AA, Herrera A, Muñoz M,. Efficacy of preoperative recombinant human erythropoietin administration for reducing transfusion requirements in patients undergoing surgery for hip fracture repair. An observational cohort study. Vox Sanguinis 2009; 97: 260-7.
57. Halm EA, Wang JJ, Boockvar K, et al. Effects of blood transfusion on clinical and functional outcomes in patients with hip fracture. Transfusion 2003; 43: 1358-65.
58. Izuel Rami M, García Erce JA, Gõmez-Barrera M, Cuenca Espiérrez J, Sazatornila RA, Hernández MJR,. Relaciõn de la transfusiõn y la ferropenia con la infecciõn nosocomial en pacientes con fractura de cadera. [Relationship between allogeneic blood transfusion, iron deficiency and nosocomial infection in patients with hip fracture]. Medicina Clinica (Barcelona) 2008; 131: 647-52.
59. Johnson P, Wynn-Jones H, Chakravarty D, Boyle A, Parker MJ,. Is perioperative blood transfusion a risk factor for mortality or infection after hip fracture? Journal of Orthopaedic Trauma 2006; 20: 675-9.
60. Kateros K, Sakellariou VI, Sofianos IP, Papagelopoulos PJ,. Epoetin alfa reduces blood transfusion requirements in patients with intertrochanteric fracture. Journal of Critical Care 2010; 25: 348-53.
61. Koval KJ, Rosenberg AD, Zuckerman JD, et al. Does blood transfusion increase the risk of infection after hip fracture? Journal of Orthopaedic Trauma 1997; 11: 260-5.
62. Levi N, Sandberg T,. Blood transfusion and postoperative wound infection in intracapsular femoral neck fractures. Bulletin Hospital of Joint Diseases 1998; 57: 69-73.
63. Parker MJ,. Iron supplementation for anemia after hip fracture surgery: a randomized trial of 300 patients. Journal of Bone and Joint Surgery American 2010; 92: 265-9.
64. Parker MJ,. Randomised trial of blood transfusion versus a restrictive transfusion policy after hip fracture surgery. Injury 2013; 44: 1916-8.
65. Prasad N, Rajamani V, Hullin D, Murray JM,. Post-operative anaemia in femoral neck fracture patients: does it need treatment? A single blinded prospective randomised controlled trial. Injury 2009; 40: 1073-6.
66. Sadeghi M, Mehr-Aein A,. Does a single bolus dose of tranexamic acid reduce blood loss and transfusion requirements during hip fracture surgery? A prospective randomized double blind study in 67 patients. Acta Medica Iranica 2007; 45: 437-42.
67. Serrano-Trenas JA, Ugalde PF, Cabello LM, Chofles LC, Lázaro PS, Benítez PC,. Role of perioperative intravenous iron therapy in elderly hip fracture patients: a single-center randomized controlled trial. Transfusion 2011; 51: 97-104.
68. Shookoohi A, Stanworth S, Mistry D, Lamb S, Staves J, Murphy MF,. The risks of red cell transfusion for hip fracture surgery in the elderly. Vox Sanguinis 2012; 103: 223-30.
69. Vijay BS, Bedi V, Mitra S, Das B,. Role of tranexamic acid in reducing postoperative blood loss and transfusion requirement in patients undergoing hip and femoral surgeries. Saudi Journal of Anaesthesia 2013; 7: 29-32.
70. Zufferey PJ, Miquet M, Quenet S, et al. Tranexamic acid in hip fracture surgery: a randomized controlled trial. British Journal of Anaesthesia 2010; 104: 23-30.
71. Su H, Aharonoff GB, Zuckerman JD, Egol KA, Koval KJ,. The relation between discharge hemoglobin and outcome after hip fracture. American Journal of Orthopedics 2004; 33: 576-80.
72. Baron DM, Hochrieser H, Posch M, et al. Preoperative anaemia is associated with poor clinical outcome in non-cardiac surgery patients. British Journal of Anaesthesia 2014; 113: 416-23.
73. Association of Anaesthetists of Great Britain and Ireland. Management of proximal femoral fractures 2011. Anaesthesia 2012; 67: 85-98.
74. Kumar D, Mbako AN, Riddick A, Patil S, Williams P,. On admission haemoglobin in patients with hip fracture. Injury 2011; 42: 167-70.
75. Dillon MF, Collins D, Rice J, Murphy PG, Nicholson P, MacElwaine J,. Preoperative characteristics identify patients with hip fractures at risk of transfusion. Clinical Orthopaedics and Related Research 2005; 439: 201-6.
76. Hill GE, Frawley WH, Griffith KE, Forestner JE, Minei JP,. Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. Journal of Trauma 2003; 54: 908-14.
77. Taylor RW, Manganaro L, O'Brien J, Trottier SJ, Parker N, Veremakis C,. Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient. Critical Care Medicine 2002; 30: 2249-54.
78. Barbour KE, Boudreau R, Danielson ME, et al. Inflammatory markers and risk of hip fracture. Bone and Mineral Research 2012; 27: 1167-76.
79. Gaskell H, Derry S, Moore RA, McQuay HJ,. Prevalence of anaemia in older persons: systematic review. BMC Geriatriatrics 2008; 8: 1.
80. Bernabeu-Wittel M, Aparicio R, Romero M, et al. Ferric carboxymaltose with or without erythropoietin for the prevention of red-cell transfusions in the perioperative period of osteoporotic hip fractures: a randomized controlled trial. The PAHFRAC-01 project. BMC Musculoskeletal Disorders 2012; 13: 27.
81. Rowlands M, Forward DP, Sahota O, Moppett IK,. The effect of intravenous iron on postoperative transfusion requirements in hip fracture patients: study protocol for a randomized controlled trial. Trials 2013; 14: 288.