Role of perioperative intravenous iron therapy in elderly hip fracture patients: A single-center randomized controlled trial

Transfusion

Volumn 51, Issue 1, 2011, Pages 97-104

  Serrano Trenas, José Antonio ^a   Ugalde, Pilar Font ^a   Cabello, Laura Muñoz ^a   Chofles, Luis Castro ^a   Lázaro, Pilar Serrano ^a   Benítez, Pedro Carpintero ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC HYDROXIDE SUCROSE; HEMOGLOBIN;

ADVERSE OUTCOME; AGED; ARTICLE; BLOOD ANALYSIS; BLOOD EXAMINATION; DRUG EFFICACY; ELDERLY CARE; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOGLOBIN BLOOD LEVEL; HIP FRACTURE; HIP SURGERY; HOSPITALIZATION; HUMAN; INFECTION RATE; IRON THERAPY; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PERIOPERATIVE PERIOD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

AGED; AGED, 80 AND OVER; ANEMIA; BLOOD TRANSFUSION; FEMALE; FERRIC COMPOUNDS; HIP FRACTURES; HUMANS; INFUSIONS, INTRAVENTRICULAR; MALE; PERIOPERATIVE PERIOD; POSTOPERATIVE COMPLICATIONS;

EID: 78651376712     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2010.02769.x     Document Type: Article

References (38)

1. Van Iperen CE, Kraaijenhagen RJ, Biesma DH, Beguin Y, Marx JJ, van de WA,. Iron metabolism and erythropoiesis after surgery. Br J Surg 1998; 85: 41-5.
2. Biesma DH, Van de Wiel A, Beguin Y, Deraaijenhagen RJ, Marx JJ,. Postoperative eritropoyesis is limited by the inflamatory effect of surgery on iron metabolism. Eur J Clin Invest 1995; 25: 383-9.
3. Flohé S, Kobbe P, Nast-Kolb D,. Inmunological reactions secondary to blood transfusion. Injury 2007; 38: 1405-8.
4. Bisbe E, Rodríguez C, Ruiz A, Sáez M, Castillo J, Santiveri X,. Uso preoperatorio de hierro endovenoso. Una nueva terapéutica en medicina transfusional. Rev Esp Anestesiol Reanim 2005; 52: 536-40.
5. Muñoz M, Naveira E, Seara J, Palmer JH, Cuenca J, García-Erce JA,. Role of parenteral iron in transfusiõn requeriments after total hip replacement. A pilot study. Transfus Med 2006; 16: 137-42.
6. Theusinger OM, Leyvraz PF, Schanz U, Seifert B, Spahn DR,. Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits. Anesthesiology 2007; 107: 923-7.
7. Muñoz M, García-Erce JA, Díez-Lobo AI, Campos A, Sebastianes C, Bisbe E, AWGE. Utilidad de la administraciõn de hierro sacarosa intravenoso para la correcciõn de la anemia preoperatoria en pacientes programados para cirugía mayor. Med Clin (Barc) 2009; 132: 303-6.
8. Cuenca J, García Erce JA, Martínez AA, Herrera A,. Parenteral iron useful in the management of trochanteric hip fracture. TATM 2003; 5: 63.
9. Cuenca J, García Erce JA, Martínez AA, Solano VM, Modrego FJ,. Seguridad y eficacia del hierro intravenoso en la anemia aguda por fractura trocantérea de cadera en el anciano. Med Clin (Barc) 2004; 123: 281-5.
10. Cuenca J, García Erce JA, Muñoz M, Izuel M, Martínez AA, Herrera A,. Patients with pertrochanteric hip fracture may benefit fron preoperative intravenous iron therapy: a pilot study. Transfusion 2004; 44: 1-6.
11. Cuenca J, García Erce JA, Martínez AA, Solano VM, Molina J, Muñoz M,. Role of parenteral iron in the management of anaemia in the elderly patient undergoing displaced subcapital hip fracture repair: preliminary data. Arch Orthop Trauma Surg 2005; 125: 342-7.
12. García-Erce JA, Cuenca J, Muñoz M, Izuel M, Martínez A, Herrera A, Solano VM, Martínez F,. Perioperative stimulation of erythropoiesis with intravenous iron and erythropoietin reduces transfusiõn requirements in patients with hip fracture. A prospective observational study. Vox Sang 2005; 88: 235-43.
13. Izuel-Rami M, Cuenca E, García-Erce JA, Gõmez-Barrera M, Carcelén Andrés J, Rabaneque Hernández MJ,. Efectividad de distintas pautas de tratamiento de la anemia perioperatoria en pacientes ancianos con fractura de cadera. Farm Hosp 2005; 29: 250-7.
14. Izuel-Rami M, Gõmez Barrera M, Villar Fernández I, Rabanaque MJ, Cuenca J, García-Erce JA,. Análisis del impacto presupuestario de la implantaciõn de medidas de ahorro de sangre en cirugía de urgencia. Med Clin (Barc) 2007; 128: 7-11.
15. García-Erce JA, Cuenca J, Haman-Alcober S, Martinez AA, Herrera A, Muñoz M,. Efficacy of preoperative recombinant human erythropoietin administration for reducing transfusion requirements in patients undergoing surgery for hip fracture repair. An observational cohort study. Vox Sang 2009; 97: 260-7.
16. Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, Gotzsche PC, Lang T,. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 2001; 134: 663-94.
17. Guerado EC,. Proceso Asistencial Integrado Fractura de Cadera en el Anciano. Sevilla: Consejería de Salud, Junta de Andalucía; 2002.
18. Ortiz P, Mingo A, Lozano M, Vesga MA, Grifols LR, Castrillo A, Algora M, Romõn I, Cárdenas JM,. Guía sobre la transfusiõn de componentes sanguíneos. Med Clin (Barc) 2005; 125: 389-96.
19. Goodnough LT, Merkel K,. Parenteral iron and recombinant human erythropoietin therapy to stimulate erythropoiesis in patients undergoing repair of hip fracture. Hematology 1996; 1: 163-6.
20. Schmidt AH, Templeman DC, Kile RF,. Blood conservation in hip trauma. Clin Orthop 1998; 357: 68-73.
21. Muñoz M, Garcia-Erce JA, Cuenca J, Izuel M, Martínez AA, Solano VM,. Is there a role for perioperative intravenous iron therapy in orthopedic and trauma surgery? Clinical experience in major lower limb surgery. TATM 2006; 8: 58-67.
22. Beris P, Munoz M, García-Erce JA, Thomas D, Maniatis A, Van der Liden P,. Perioperative anaemia management: consensus statement on the role of intravenous iron. Br J Anaesth 2008; 100: 599-604.
23. Muñoz M, Breymann C, García-Erce JA, Gõmez- Ramírez S, Comin J, Bisbe E,. Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogenic blood transfusion. Vox Sang 2008; 94: 172-83.
24. Auerbach M, Goodnough LT, Picard D, Maniatis A,. The role of intravenous iron in anemia management and transfusion avoidance. Transfusion 2008; 48: 988-1000.
25. Carson JL, Duff A, Berlin JA, Lawrence VA, Poses RM, Huber EC, O'Hara DA, Noveck H, Strom BL,. Perioperative blood transfusion and postoperative mortality. JAMA 1998; 279: 199-205.
26. García-Erce JA, Cuenca J, Solano VM,. Factores predictivos de la necesidad de transfusiõn en la fractura subcapital de cadera en pacientes mayores de 65 años. Med Clin (Barc) 2003; 120: 161-6.
27. Levi N, Sandberg T,. Blood transfusion and postoperative wound infection in intracapsular femoral neck fractures. Bull Hosp Jt Dis 1998; 57: 69-73.
28. Swain DG, Nightingale PG, Patel JV,. Blood transfusion requeriments in femoral neck fracture. Injury 2000; 31: 7-10.
29. Cuenca J, Garcia-Erce JA, Martínez AA, Solano VM, Herrera A,. Valores hematimétricos preoperatorios y tipo de fractura como factores de riesgo transfusional en fracturas trocantéreas de cadera en pacientes mayores de 65 años. Rev Esp Anestesiol Reanim 2004; 51: 515-22.
30. Adunsky A, Lichtenstein A, Mizrahi E, Arad M, Heim M,. Blood transfusion requeriments in elderly hip fracture patients. Arch Gerontol Geriatr 2003; 36: 75-81.
31. Cuenca J, Martínez AA, Herrera A, Panisello JJ, Sola A,. Estudio de la evoluciõn de la hemoglobina y el hematocrito segÃn el tipo de fractura de cadera. Rev Ortop Trauma 2002; 46: 54-7.
32. Lawrence VA, Silverstein JH, Cornell JE, Pederson T, Noveck H, Carson JL,. Higher Hb level is associated with better early functional recovery after hip fracture repair. Transfusion 2003; 43: 1717-22.
33. Halm EA, Wang JJ, Boockvar K, Penrod J, Silverzweig SB, Magaziner J, Koval KJ, Siu AL,. Effects of blood transfusion on clinical and functional outcomes in patients with hip fracture. Transfusion 2003; 43: 1358-65.
34. Hill GE, Frawley WH, Griffith KE, Forestner JE, Minei JP,. Allogenic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis. J Trauma 2003; 54: 908-14.
35. Johnson P, Wynn-Jones H, Chakravarty D, Boyle A, Phil M, Parker J,. Is perioperative blood transfusion a risk factor for mortality or infection after hip fracture? J Orthop Trauma 2006; 20: 675-9.
36. Haleem S, Lutchman L, Mayahi R, Grice JE, Parker MJ,. Mortality following hip fracture: trends and geographicals variations over the last 40 years. Injury 2008; 39: 1157-63.
37. Penrod JD, Litke A, Hawkes WG, Magaziner J, Doucette JT, Koval KJ, Silverzweig SB, Egol KA, Siu AL,. The association of race, gender and comorbidity with mortality and function after hip fracture. J Gerontol A Biol Sci Med Sci 2008; 63: 867-72.
38. Engoren M, Mitchell E, Perring P, Sferra J,. The effect of erythrocyte blood transfusions on survival after surgery for hip fracture. J Trauma 2008; 65: 1411-5.