In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 9, 2015, Pages 2717-2722

  Du, Yi Ling ^a   Alkhalaf, Lona M ^a   Ryan, Katherine S ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Antibiotic; Biosynthesis; Indolmycin

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; AMINOTRANSFERASE INHIBITOR; INDOLMYCIN; TRYPTOPHAN AMINOTRANSFERASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CHAPERONE; COENZYME A LIGASE; INDOLE DERIVATIVE; OXAZOLONE; PHENYLACETATE - COA LIGASE; TRIFLUOROMETHYLOXAZOLINONE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DNA BASE COMPOSITION; ELECTROSPRAY MASS SPECTROMETRY; GENE CLUSTER; GENE INACTIVATION; GENE LIBRARY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOMYCES GRISEUS; ANALOGS AND DERIVATIVES; CELL FREE SYSTEM; ESCHERICHIA COLI; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RHODOCOCCUS;

BACTERIA (MICROORGANISMS); PYRONIA TITHONUS;

BACTERIAL PROTEINS; BASE SEQUENCE; CELL-FREE SYSTEM; COENZYME A LIGASES; ESCHERICHIA COLI; INDOLES; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; OXAZOLONE; RHODOCOCCUS; STREPTOMYCES GRISEUS;

EID: 84924390218     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419964112     Document Type: Article

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