Identification of a novel dehydroergosterol enhancing microglial anti-inflammatory activity in a dairy product fermented with Penicillium candidum

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Ano, Yasuhisa ^a   Kutsukake, Toshiko ^a   Hoshi, Ayaka ^a   Yoshida, Aruto ^a   Nakayama, Hiroyuki ^b  

^a KIRIN HOLDINGS CO LTD   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CD11B ANTIGEN; DEHYDROERGOSTEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; ERGOSTEROL; LECTIN; MANNOSE BINDING LECTIN; MANNOSE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPERGILLUS; CHEESE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; DAIRY PRODUCT; DRUG DETERMINATION; FEMALE; FUNGAL STRAIN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NEWBORN; NONHUMAN; PENICILLIUM CAMEMBERTI; PENICILLIUM ROQUEFORTI; ANALOGS AND DERIVATIVES; ANALYSIS; ANIMAL; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; FERMENTATION; HUMAN; METABOLISM; MICROBIOLOGY; PENICILLIUM; PHYSIOLOGY;

ASPERGILLUS; PENICILLIUM CANDIDUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD11B; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DAIRY PRODUCTS; ERGOSTEROL; FEMALE; FERMENTATION; HUMANS; LECTINS, C-TYPE; MANNOSE-BINDING LECTINS; MICE; MICROGLIA; PENICILLIUM; RECEPTORS, CELL SURFACE;

EID: 84924388326     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116598     Document Type: Article

References (34)

1. Tremblay MÈ (2011) The role of microglia and synapses in the healthy CNS: novel insights from recent studies. Neuron Glia Biol 7: 67-76. doi: 10.1017/S1740925X12000038 PMID: 22418067
2. Blank T, Prinz M (2013) Microglia as modulators of cognition and neuropsychiatric disorders. Glia 61: 62-70. doi: 10.1002/glia.22372 PMID: 22740320
3. Welberg L (2014) Synaptic plasticity: a synaptic role for microglia. Nat Rev Neurosci 15: 69. doi: 10. 1038/nrn3678 PMID: 24434913
4. Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, et al (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155: 1596-15609. doi: 10. 1016/j.cell.2013.11.030 PMID: 24360280
5. McGeer EG, MCGeer PL (2010) Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy. J Alzheimers Dis 19: 355-361. doi: 10.3233/JAD-2010-1219 PMID: 20061650
6. Perry VH, Nicoll JA, Holmes C (2010) Microglia in neurodegenerative disaese. Nat Rev Neurol 6: 193-201. doi: 10.1038/nrneurol.2010.17 PMID: 20234358
7. Rezai-Zadeh K, Gate D, Gowing G, Town T (2011) How to get from here to there: macrophage recruitment in Alzheimer's disease. Curr Alzheimr Res 8: 156-163. PMID: 21345166
8. Smith MA, Hirai K, Hsiao K, Pappolla MA, Harris, et al. (1998) Amyloid-β deposition is Alzheimer transgenic mice is associated with oxidative stress. J Neurochem 70: 2212-2215. PMID: 9572310
9. Sugama S, Takenouchi T, Cho BP, Joh TH, Hashimoto M, et al. (2009) Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models. Inflamm Allergy Drug Targets 8: 277-284. PMID: 19754411
10. Malm T, Koistinaho M, Muona A, Magga J, Koistinaho J (2010) The role and therapeutic potential of monocytic cells in Alzheimer's disease. Glia 58: 889-900. doi: 10.1002/glia.20973 PMID: 20155817
11. Naert G, Rivest S (2011) The role of microglia cell subsets in Alzheimer' s disease. Curr Alzheimer Res 8: 151-155. PMID: 21418002
12. Fernández PL, Britton GB, Rao KS (2013) Potential immunotargets for Alzheimer's disease treatment strategies. J Alzheimers Dis 33: 297-312. doi: 10.3233/JAD-2012-121222 PMID: 23001712
13. Breitner JCS, Welsh KA, Helms MJ, Gaskell PC, Gau BA, et al. (1995) Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and Histamine H2 blocking drugs. Neurobiol Aging 16: 523-530. PMID: 8544901
14. Stewart WF, Kawas C, Corrada M, Meter EJ (1997) Risk of Alzheimer's disease and duration of NSAID use. Neurobiology 48: 626-632.
15. Lim GP, Yang F, Chu T, Chen P, Beech W, et al. (2000) Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci 20: 5709-5714. PMID: 10908610
16. Camfield DA, Owen L, Scholey AB, Pipingas A, Stough C (2011) Dietary constituents and neurocognitive health in ageing. Br J Nutr 106: 159-174. doi: 10.1017/S0007114511000158 PMID: 21338538
17. Crichton GE, Murphy KJ, Bryan J (2010) Diary intake and cognitive health in middle-aged South Australians. Asia Pac J Clin Nutr 19: 161-171. PMID: 20460228
18. Ozawa M, Ninomiya T, Ohara T, Doi Y, Uchida K, et al. (2013) Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study. Am J Clin Nutr 97: 1076-1082. doi: 10.3945/ ajcn.112.045575 PMID: 23553168
19. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917. PMID: 13671378
20. Wüstner D (2007) Fluorescent sterols as tools in membrane biophysics and cell biology. Chem Phys Lipids 146: 1-25. PMID: 17241621
21. Mclntosh AL, Atshaves BP, Huang H, Gallegos AM, Kier AB, et al. (2008) Fluorescence techniques using dehydroergosterol to study cholesterol trafficking. Lipids 43: 1185-1208. doi: 10.1007/s11745-008-3194-1 PMID: 18536950
22. Tachibana Y (2006) Synthesis and structure-activity relationships of bioactive compounds using sterols. Yakugaku Zasshi 126: 1139-1154. PMID: 17077615
23. Desestret V, Riou A, Chauveau F, Cho TH, Devillard E, et al. (2013) In vitro and in vivo models of cerebral ischemia show discrepancy in therapeutic effects of M2 macrophages. PLoS One 8:e67063. doi: 10.1371/journal.pone.0067063 PMID: 23825621
24. Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, et al. (2013) M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci 16: 1211-1218. doi: 10.1038/nn. 3469 PMID: 23872599
25. Weekman EM, Sudduth TL, Abner EL, Popa GJ, Mendenhall MD, et al. (2014) Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice. J. Neuroinflammation 11: 127 doi: 10.1186/1742-2094-11-127 PMID: 25062954
26. Jiang Z, Jiang JX, Zhang GX (2014) Macrophages: a double-edged sword in experimental autoimmune encephalomyelitis. Immunol Lett 160: 17-22. doi: 10.1016/j.imlet.2014.03.006 PMID: 24698730
27. Li, Ma L, Kulesskaya N, Voikar V, Tian L (2014) Microglia are polazied to M1 type in high anxiety inbred mice in response to lipopolysaccharide challenge. Brain Behav Immun 38: 237-248. doi: 10.1016/j. bbi.2014.02.008 PMID: 24561490
28. Epelman S, Lavine KJ, Randolph GJ (2014) Origin and functions of tissue macrophages. Immunity 41: 21-35. doi: 10.1016/j.immuni.2014.06.013 PMID: 25035951
29. Ginhoux F, Jung S (2014) Monocytes and macrophages: development pathways and tissue homeostasis. Nat Rev Immunol 14: 392-404. doi: 10.1038/nri3671 PMID: 24854589
30. Prinz M, Priller J (2014) Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci 15: 300-312. doi: 10.1038/nrn3722 PMID: 24713688
31. Agostinho P, Cunha RA, Oliveria C (2010) Neuroinlammation, oxidative stress and the pathogenesis of Alzheimer's disease. Curr Pharm Des 16: 2766-2778. PMID: 20698820
32. Dumont M, Beal MF (2011) Neuroprotective strategies involving ROS in Alzheimer disease. Free Radic Bio Med 51: 1014-1026. doi: 10.1016/j.freeradbiomed.2010.11.026 PMID: 21130159
33. Voloboueva LA, Giffard RG (2011) Inflammation, mitochondria, and the inhibition of adult neurogenesis. J Neurosci Res 89: 1989-1996. doi: 10.1002/jnr.22768 PMID: 21910136
34. Rao JS, Kellom M, Kim HW, Rapoport SI, Reese EA (2012) Neuroinflammation and synaptic loss. Neurochem Res 37: 903-910. doi: 10.1007/s11064-012-0708-2 PMID: 22311128