High-yield production of a functional bacteriophage lysin with antipneumococcal activity using a plant virus-based expression system

Journal of Biotechnology

Volumn 200, Issue , 2015, Pages 10-16

  Starkevič, Urte ^a,b   Bortesi, Luisa ^c   Virgailis, Marius ^d   Ružauskas, Modestas ^d   Giritch, Anatoli ^c   Ražanskiene, Aušra ^a  

^a Nomads UAB   (Lithuania)

^b VILNIUS UNIVERSITY   (Lithuania)

^c Nomad Bioscience   (Germany)

^d Veterinary Academy   (Lithuania)

Author keywords

Bacteriophage lysin; Mice bacteremia and survival; Plant virus based transient expression; Streptococcus pneumoniae

Indexed keywords

ANTIBIOTICS; ANTIMICROBIAL AGENTS; BACTERIOLOGY; BLOOD; MAMMALS; PLANTS (BOTANY);

HIGH LEVEL EXPRESSION; INFECTIOUS DISEASE; KILLING ACTIVITIES; MICE BACTEREMIA AND SURVIVAL; NICOTIANA BENTHAMIANA; STREPTOCOCCUS PNEUMONIAE; TOBACCO MOSAIC VIRUS; TRANSIENT EXPRESSION;

BACTERIOPHAGES;

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BACTERIOPHAGE LYSIN; UNCLASSIFIED DRUG; AMIDASE; LYSIN; MUCOPROTEIN; PAL PROTEIN, PNEUMOCOCCAL BACTERIOPHAGE DP-1; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIOPHAGE; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION SYSTEM; MOUSE; NONHUMAN; PLANT VIRUS; PRIORITY JOURNAL; PROTEIN PURIFICATION; SEPSIS; STREPTOCOCCUS PNEUMONIAE; SURVIVAL; TOBACCO MOSAIC VIRUS; AGROBACTERIUM TUMEFACIENS; ANIMAL; BACTEREMIA; BAGG ALBINO MOUSE; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY; PLANT LEAF; STREPTOCOCCUS PHAGE; TOBACCO; VIROLOGY;

BACTERIA (MICROORGANISMS); MUS; NICOTIANA BENTHAMIANA; STREPTOCOCCUS PNEUMONIAE; TOBACCO MOSAIC VIRUS;

AGROBACTERIUM TUMEFACIENS; AMIDOHYDROLASES; ANIMALS; ANTI-BACTERIAL AGENTS; BACTEREMIA; MICE, INBRED BALB C; MUCOPROTEINS; PLANT LEAVES; STREPTOCOCCUS PHAGES; STREPTOCOCCUS PNEUMONIAE; TOBACCO; TOBACCO MOSAIC VIRUS; VIRAL PROTEINS;

EID: 84924385995     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2015.02.028     Document Type: Article

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