Phage Lytic Enzyme Cpl-1 as a Novel Antimicrobial for Pneumococcal Bacteremia

Infection and Immunity

Volumn 71, Issue 11, 2003, Pages 6199-6204

  Loeffler, Jutta M ^a   Djurkovic, Svetolik ^b   Fischetti, Vincent A ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUFFER; HYPERIMMUNE GLOBULIN; LYSOZYME; PHAGE LYTIC ENZYME CPL 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBODY PRODUCTION; ARTICLE; BACTEREMIA; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIOPHAGE; BACTERIUM ISOLATION; BLOOD SAMPLING; BOLUS INJECTION; COLONY FORMING UNIT; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG EXPOSURE; DRUG HALF LIFE; DRUG STABILITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME MECHANISM; ENZYME STABILITY; FEMALE; IMMUNOGENICITY; INFECTION CONTROL; MOUSE; NONHUMAN; OUTCOMES RESEARCH; PENICILLIN RESISTANCE; PHARMACOKINETICS; PRIORITY JOURNAL; SEROTYPE; SPECIES DIFFERENCE; STREPTOCOCCUS PNEUMONIAE; SURVIVAL RATE; THERMOSTABILITY;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTEREMIA; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, BACTERIAL; ENZYME STABILITY; FEMALE; HYDROGEN-ION CONCENTRATION; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MURAMIDASE; NASOPHARYNX; PNEUMOCOCCAL INFECTIONS; STREPTOCOCCUS PHAGES; STREPTOCOCCUS PNEUMONIAE;

EID: 0242286566     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.11.6199-6204.2003     Document Type: Article

References (20)

1. Black, S., H. Shinefield, B. Fireman, E. Lewis, P. Ray, J. R. Hansen, L. Elvin, K. M. Ensor, J. Hackell, G. Siber, F. Malinoski, D. Madore, I. Chang, R. Kohberger, W. Watson, R. Austrian, and K. Edwards. 2000. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group. Pediatr. Infect. Dis. J. 19:187-195.
2. Black, S. B., H. R. Shinefield, S. Ling, J. Hansen, B. Fireman, D. Spring, J. Noyes, E. Lewis, P. Ray, J. Lee, and J. Hackell. 2002. Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than five years of age for prevention of pneumonia. Pediatr. Infect. Dis. J. 21:810-815.
3. Brucato, F. H., and S. V. Pizzo. 1990. Catabolism of streptokinase and polyethylene glycol-streptokinase: evidence for transport of intact forms through the biliary system in the mouse. Blood 76:73-79.
4. Dagan, R., N. Givon-Lavi, O. Zamir, M. Sikuler-Cohen, L. Guy, J. Janco, P. Yagupsky, and D. Fraser. 2002. Reduction of nasopharyngeal carriage of Streptococcus pneumoniae after administration of a 9-valent pneumococcal conjugate vaccine to toddlers attending day care centers. J. Infect. Dis. 185:927-936.
5. Dunne, W. M., Jr. 2002. Bacterial adhesion: seen any good biofilms lately? Clin. Microbiol. Rev. 15:155-166.
6. Fireman, B., S. B. Black, H. R. Shinefield, J. Lee, E. Lewis, and P. Ray. 2003. Impact of the pneumococcal conjugate vaccine on otitis media. Pediatr. Infect. Dis. J. 22:10-16.
7. Garcia, J. L., E. Garcia, A. Arraras, P. Garcia, C. Ronda, and R. Lopez. 1987. Cloning, purification, and biochemical characterization of the pneumococcal bacteriophage Cp-1 lysin. J. Virol. 61:2573-2580.
8. Lakshman, R., C. Murdoch, G. Race, R. Burkinshaw, L. Shaw, and A. Finn. 2003. Pneumococcal nasopharyngeal carriage in children following heptavalent pneumococcal conjugate vaccination in infancy. Arch. Dis. Child. 88:211-214.
9. Loeffler, J. M., and V. A. Fischetti. 2003. Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillin-sensitive and -resistant Streptococcus pneumoniae strains. Antimicrob. Agents Chemother. 47:375-377.
10. Loeffler, J. M., D. Nelson, and V. A. Fischetti. 2001. Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase. Science 294:2170-2172.
11. McCormick, A. W., C. G. Whitney, M. M. Farley, R. Lynfield, L. H. Harrison, N. M. Bennett, W. Schaffner, A. Reingold, J. Hadler, P. Cieslak, M. H. Samore, and M. Lipsitch. 2003. Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United States. Nat. Med. 10:10.
12. Nelson, D., L. Loomis, and V. A. Fischetti. 2001. Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme. Proc. Natl. Acad. Sci. USA 98:4107-4112.
13. Nilsson, J. B., T. K. Nilsson, J. H. Jansson, K. Boman, S. Soderberg, and U. Naslund. 2002. The effect of streptokinase neutralizing antibodies on fibrinolytic activity and reperfusion following streptokinase treatment in acute myocardial infarction. J. Intern. Med. 252:405-411.
14. Orlicek, S. L., H. G. Herrod, R. J. Leggiadro, G. Luedtke, and B. K. English. 1997. Repeated invasive pneumococcal infections in young children without apparent underlying immunodeficiency. J. Pediatr. 130:284-288.
15. Sanz, J. M., and J. L. Garcia. 1990. Structural studies of the lysozyme coded by the pneumococcal phage Cp-1. Conformational changes induced by choline. Eur. J. Biochem. 187:409-416.
16. Schuch, R., D. Nelson, and V. A. Fischetti. 2002. A bacteriolytic agent that detects and kills Bacillus anthracis. Nature 418:884-889.
17. Sheehan, M. M., J. L. Garcia, R. Lopez, and P. Garcia. 1997. The lytic enzyme of the pneumococcal phage Dp-1: a chimeric lysin of intergeneric origin. Mol. Microbiol. 25:717-725.
18. Squire, I. B., W. Lawley, S. Fletcher, E. Holme, W. S. Hillis, C. Hewitt, and K. L. Woods. 1999. Humoral and cellular immune responses up to 7.5 years after administration of streptokinase for acute myocardial infarction. Eur. Heart J. 20:1245-1252.
19. Whitney, C. G., M. M. Farley, J. Hadler, L. H. Harrison, N. M. Bennett, R. Lynfield, A. Reingold, P. R. Cieslak, T. Pilishvili, D. Jackson, R. R. Facklam, J. H. Jorgensen, and A. Schuchat. 2003. Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. N. Engl. J. Med. 348:1737-1746.
20. Wu, H. Y., A. Virolainen, B. Mathews, J. King, M. W. Russell, and D. E. Briles. 1997. Establishment of a Streptococcus pneumoniae nasopharyngeal colonization model in adult mice. Microb. Pathog. 23:127-137.