CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis

Journal of Infectious Diseases

Volumn 211, Issue 6, 2015, Pages 995-1003

  Ramachandran, Girish ^a   Kaempfer, Raymond ^c   Chung, Chun Shiang ^b   Shirvan, Anat ^d   Chahin, Abdullah B ^b   Palardy, John E ^b   Parejo, Nicolas A ^b   Chen, Yaping ^b   Whitford, Melissa ^a   Arad, Gila ^c   Hillman, Dalia ^c   Shemesh, Ronen ^d   Blackwelder, William ^a   Ayala, Alfred ^b   Cross, Alan S ^a   Opal, Steven M ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BROWN UNIVERSITY   (United States)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d Atox Bio   (Israel)

Author keywords

CD28 homodimer interface; cecal ligation and puncture; gram negative sepsis; lipopolysaccharide; mimetic peptide; peritonitis

Indexed keywords

AB 103; CEFEPIME; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 6; MOXIFLOXACIN; PEPTIDOMIMETIC AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AB103; ANTIINFECTIVE AGENT; CD28 ANTIGEN; CHEMOKINE; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL PERITONITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENCY; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE SEPSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; INFECTION PREVENTION; LETHALITY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTECTION; SEPSIS; SINGLE DRUG DOSE; SURVIVAL RATE; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA COLI INFECTIONS; IMMUNOLOGY; METABOLISM; MOLECULAR MIMICRY; OUTBRED STRAIN; PERITONITIS; PROTEIN DOMAIN;

ANIMALS; ANIMALS, OUTBRED STRAINS; ANTI-BACTERIAL AGENTS; ANTIGENS, CD28; CELLS, CULTURED; CHEMOKINES; ESCHERICHIA COLI INFECTIONS; FEMALE; HUMANS; LIPOPOLYSACCHARIDES; MICE, INBRED BALB C; MOLECULAR MIMICRY; NEUTROPHIL INFILTRATION; PERITONITIS; PROTEIN INTERACTION DOMAINS AND MOTIFS; SEPSIS;

EID: 84924371210     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu556     Document Type: Article

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