Conjugation of Aurein 2.2 to HPG Yields an Antimicrobial with Better Properties

Biomacromolecules

Volumn 16, Issue 3, 2015, Pages 913-923

  Kumar, Prashant ^a   Shenoi, Rajesh A ^a   Lai, Benjamin F L ^a   Nguyen, Michael ^a   Kizhakkedathu, Jayachandran N ^a   Straus, Suzana K ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIOCOMPATIBILITY; BLOOD; CARDIOVASCULAR SYSTEM; CHEMICAL ACTIVATION; CIRCULAR DICHROISM SPECTROSCOPY; CONJUGATED POLYMERS; CYTOTOXICITY; ENZYME INHIBITION; FUNCTIONAL GROUPS; MICROORGANISMS; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; POLYPEPTIDES; PROTEINS;

ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; COMPLEMENT ACTIVATIONS; GRAM-POSITIVE BACTERIUM; HYPERBRANCHED POLYGLYCEROL; MINIMAL INHIBITORY CONCENTRATION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

PEPTIDES;

ADENOSINE PHOSPHATE; AUREIN 2.2; GLYCEROL; HYPERBRANCHED POLYGLYCEROL; POLYMER; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; AUREIN 2.2 PEPTIDE; AUREIN 2.3 PEPTIDE; POLYGLYCEROL;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; BIOCOMPATIBILITY; BLOOD CLOTTING; BLOOD COMPATIBILITY; CIRCULAR DICHROISM; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CONJUGATION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; DRUG STRUCTURE; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; INNATE IMMUNITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; SYNTHESIS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; AMINO ACID SEQUENCE; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; ERYTHROCYTE; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; PARTIAL THROMBOPLASTIN TIME; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; THROMBOCYTE; UMBILICAL VEIN ENDOTHELIAL CELL;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD PLATELETS; CELLS, CULTURED; COMPLEMENT ACTIVATION; ERYTHROCYTES; GLYCEROL; HEMOLYSIS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PARTIAL THROMBOPLASTIN TIME; PLATELET AGGREGATION; POLYMERS; PROTEIN STRUCTURE, SECONDARY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 84924362726     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm5018244     Document Type: Article

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