Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis

Blood

Volumn 124, Issue 22, 2014, Pages 3183-3190

  Travers, Richard J ^a   Shenoi, Rajesh A ^b   Kalathottukaren, Manu Thomas ^b   Kizhakkedathu, Jayachandran N ^b,c   Morrissey, James H ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; HEPARIN; POLYCATION; POLYETHYLENEIMINE; POLYPHOSPHATE; PROCOAGULANT; PROTAMINE SULFATE; UNCLASSIFIED DRUG; UNIVERSAL HEPARIN REVERSAL AGENT; UNIVERSAL HEPARIN REVERSAL AGENT 10; UNIVERSAL HEPARIN REVERSAL AGENT 14; UNIVERSAL HEPARIN REVERSAL AGENT 8; UNIVERSAL HEPARIN REVERSAL AGENT 9; DENDRIMER; FIBRINOLYTIC AGENT; PROTEIN BINDING; THROMBIN; UHRA-10; UHRA-9;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD CLOTTING; CAROTID ARTERY THROMBOSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; HEMOSTASIS; IN VITRO STUDY; MOUSE; NONHUMAN; THROMBOCYTE ACTIVATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; THROMBOSIS;

ANIMALS; BLOOD COAGULATION; DENDRIMERS; FIBRINOLYTIC AGENTS; HEMOSTASIS; HEPARIN; HUMANS; MICE; MICE, INBRED C57BL; POLYPHOSPHATES; PROTEIN BINDING; THROMBIN; THROMBOSIS;

EID: 84908594708     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-05-577932     Document Type: Article

References (29)

1. Rao NN, Gómez-García MR, Kornberg A. Inorganic polyphosphate: essential for growth and survival. Annu Rev Biochem. 2009;78:605-647.
2. Ruiz FA, Lea CR, Oldfield E, Docampo R. Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. J Biol Chem. 2004;279(43):44250-44257.
3. Smith SA, Mutch NJ, Baskar D, Rohloff P, Docampo R, Morrissey JH. Polyphosphate modulates blood coagulation and fibrinolysis. Proc Natl Acad Sci USA. 2006;103(4):903-908.
4. Morrissey JH, Choi SH, Smith SA. Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation. Blood. 2012;119(25):5972-5979.
5. McFadyen JD, Jackson SP. Differentiating haemostasis from thrombosis for therapeutic benefit. Thromb Haemost. 2013;110(5):859-867.
6. Smith SA, Choi SH, Collins JN, Travers RJ, Cooley BC, Morrissey JH. Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation. Blood. 2012;120(26):5103-5110.
7. Jain S, Pitoc GA, Holl EK, et al. Nucleic acid scavengers inhibit thrombosis without increasing bleeding. Proc Natl Acad Sci USA. 2012;109(32):12938-12943.
8. Jain K, Kesharwani P, Gupta U, Jain NK. Dendrimer toxicity: Let's meet the challenge. Int J Pharm. 2010;394(1-2):122-142.
9. Jones CF, Campbell RA, Brooks AE, et al. Cationic PAMAM dendrimers aggressively initiate blood clot formation. ACS Nano. 2012;6(11):9900-9910.
10. Shenoi RA, Kalathottukaren MT, Travers RJ, et al. Affinity-based design and discovery of a synthetic universal reversal agent for clinically used parenteral heparin anticoagulants. Sci Transl Med. In press.
11. Choi SH, Collins JN, Smith SA, Davis-Harrison RL, Rienstra CM, Morrissey JH. Phosphoramidate end labeling of inorganic polyphosphates: facile manipulation of polyphosphate for investigating and modulating its biological activities. Biochemistry. 2010;49(45):9935-9941.
12. Jasuja R, Passam FH, Kennedy DR, et al. Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents. J Clin Invest. 2012;122(6):2104-2113.
13. Chauhan AS, Jain NK, Diwan PV. Pre-clinical and behavioural toxicity profile of PAMAM dendrimers in mice. Proc R Soc Lond A. 2010;466(2117):1535-1550.
14. Sadekar S, Ghandehari H. Transepithelial transport and toxicity of PAMAM dendrimers: implications for oral drug delivery. Adv Drug Deliv Rev. 2012;64(6):571-588.
15. Kannemeier C, Shibamiya A, Nakazawa F, et al. Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc Natl Acad Sci USA. 2007;104(15):6388-6393.
16. Wang X, Xu L. An optimized murine model of ferric chloride-induced arterial thrombosis for thrombosis research. Thromb Res. 2005;115(1-2):95-100.
17. Furie B, Furie BC. In vivo thrombus formation. J Thromb Haemost. 2007;5(Suppl 1):12-17.
18. Keirstead ND, Wagoner MP, Bentley P, et al. Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers. Toxicol Sci. 2014;137(2):278-291.
19. Nielsen VG. Protamine enhances fibrinolysis by decreasing clot strength: role of tissue factor-initiated thrombin generation. Ann Thorac Surg. 2006;81(5):1720-1727.
20. Von Kaulla KN. Intravenous protein-free pyrogen; a powerful fibrinolytic agent in man. Circulation. 1958;17(2):187-198.
21. Stewart GJ, Niewiarowski S. Nonenzymatic polymerization of fibrinogen by protamine sulfate. An electron microscope study. Biochim Biophys Acta. 1969;194(2):462-469.
22. Jennewein C, Paulus P, Zacharowski K. Linking inflammation and coagulation: novel drug targets to treat organ ischemia. Curr Opin Anaesthesiol. 2011;24(4):375-380.
23. Gurbuz HA, Durukan AB, Sevim H, Ergin E, Gurpinar A, Yorgancioglu C. Heparin toxicity in cell culture: a critical link in translation of basic science to clinical practice. Blood Coagul Fibrinolysis. 2013;24(7):742-745.
24. Fuchs TA, Brill A, Duerschmied D, et al. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci USA. 2010;107(36):15880-15885.
25. Smith SA, Choi SH, Davis-Harrison R, et al. Polyphosphate exerts differential effects on blood clotting, depending on polymer size. Blood. 2010;116(20):4353-4359.
26. Semeraro F, Ammollo CT, Morrissey JH, et al. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood. 2011;118(7):1952-1961.
27. Smith SA, Morrissey JH. Polyphosphate enhances fibrin clot structure. Blood. 2008;112(7):2810-2816.
28. Yun TH, Morrissey JH. Polyphosphate and omptins: novel bacterial procoagulant agents. J Cell Mol Med. 2009;13(10):4146-4153.
29. Müller F, Mutch NJ, Schenk WA, et al. Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell. 2009;139(6):1143-1156.