Poly(ethylene glycol)-block-poly(ε-caprolactone)-and phospholipid-based stealth nanoparticles with enhanced therapeutic efficacy on murine breast cancer by improved intracellular drug delivery

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 1791-1804

  He, Xiaodan ^a   Li, Li ^a   Su, Hong ^a   Zhou, Dinglun ^a   Song, Hongmei ^b   Wang, Ling ^a   Jiang, Xuehua ^a  

^a SICHUAN UNIVERSITY   (China)

^b F7 10   (China)

Author keywords

Murine breast cancer chemotherapy; Nanoparticles PEG b PCL; Paclitaxel; Phospholipid

Indexed keywords

CHOLESTEROL; LIPOSOME; MACROGOL; PACLITAXEL; PHOSPHATIDYLCHOLINE; POLYCAPROLACTONE; ANTINEOPLASTIC AGENT; LACTONE; MACROGOL DERIVATIVE; NANOPARTICLE; POLY(ETHYLENE GLYCOL)-BLOCK-POLY(EPSILON-CAPROLACTONE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER LOCALIZATION; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STABILITY; DRUG TARGETING; ENDOCYTOSIS; FEMALE; HYDRATION; INTERNALIZATION; INTRACELLULAR DRUG DELIVERY SYSTEM; LIPOSOMAL DELIVERY; MOLECULAR WEIGHT; MOUSE; NANOFABRICATION; NONHUMAN; PHYSICAL CHEMISTRY; RAT; RETICULOENDOTHELIAL SYSTEM; ZETA POTENTIAL; ANIMAL; BREAST NEOPLASMS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; PROCEDURES;

GLYCINE MAX; MURINAE; MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; FEMALE; LACTONES; MICE; NANOPARTICLES; PACLITAXEL; POLYETHYLENE GLYCOLS;

EID: 84924326112     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S75186     Document Type: Article

References (36)

1. Li Z, Yao L, Li J, et al. Celastrol nanoparticles inhibit corneal neovascularization induced by suturing in rats. Int J Nanomedicine. 2012;7:1163-1173.
2. Zhang Y, Zhang W, Johnston AH, Newman TA, Pyykkö I, Zou J. Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve. Int J Nanomedicine. 2012;7:1015-1022.
3. Slingerland M, Guchelaar HJ, Gelderblom H. Liposomal drug formulations in cancer therapy: 15 years along the road. Drug Discov Today. 2012;17(3-4):160-166.
4. Forrest ML, Zhao A, Won CY, Malick AW, Kwon GS. Lipophilic prodrugs of Hsp90 inhibitor geldanamycin for nanoencapsulation in poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles. J Control Release. 2006;116(2):139-149.
5. Sengupta S, Kulkarni A. Design principles for clinical efficacy of cancer nanomedicine: a look into the basics. ACS Nano. 2013;7(4):2878-2882.
6. Koudelka S, Turánek J. Liposomal paclitaxel formulations. J Control Release. 2012;163(3):322-334.
7. Rom J, Bechstein S, Domschke C, et al. Efficacy and toxicity profile of pegylated liposomal doxorubicin (Caelyx) in patients with advanced breast cancer. Anticancer Drugs. 2014;25(2):219-224.
8. Ichikawa K, Asai T, Shimizu K, et al. Suppression of immune response by antigen-modified liposomes encapsulating model agents: a novel strategy for the treatment of allergy. J Control Release. 2013;167(3):284-289.
9. Woodle MC, Lasic DD. Sterically stabilized liposomes. Biochim Biophys Acta. 1992;1113(2):171-199.
10. Zhang Q, Tang J, Fu L, et al. A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system. Biomaterials. 2013;34(32):7980-7993.
11. Joo KI, Xiao L, Liu S, et al. Crosslinked multilamellar liposomes for controlled delivery of anticancer drugs. Biomaterials. 2013;34(12):3098-3109.
12. Kempegowda GB, Karve S, Bandekar A, Adhikari A, Khaimchayev T, Sofou S. pH-dependent formation of lipid heterogeneities controls surface topography and binding reactivity in functionalized bilayers. Langmuir. 2009;25(14):8144-8151.
13. Bandekar A, Zhu C, Gomez A, Menzenski MZ, Sempkowski M, Sofou S. Masking and triggered unmasking of targeting ligands on liposomal chemotherapy selectively suppress tumor growth in vivo. Mol Pharm. 2013;10(1):152-160.
14. Richter A, Olbrich C, Krause M, Kissel T. Solubilization of sagopilone, a poorly water-soluble anticancer drug, using polymeric micelles for parenteral delivery. Int J Pharm. 2010;389(1-2):244-253.
15. Yang J, Hou Y, Ji G, et al. Targeted delivery of the RGD-labeled biodegradable polymersomes loaded with the hydrophilic drug oxymatrine on cultured hepatic stellate cells and liver fibrosis in rats. Eur J Pharm Sci. 2014;52:180-190.
16. Hou J, Qian C, Zhang Y, Guo S. Application of poly(ethylene glycol)-b-poly(epsilon-caprolactone) copolymers with different poly(ethylene glycol) contents for the preparation of PEG-coated nanoparticles. J Biomed Nanotechnol. 2013;9(2):231-237.
17. Cho H, Lai TC, Kwon GS. Poly(ethylene glycol)-block-poly(epsilon-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. J Control Release. 2013;166(1):1-9.
18. Mikhail AS, Allen C. Poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles containing chemically conjugated and physically entrapped docetaxel: synthesis, characterization, and the influence of the drug on micelle morphology. Biomacromolecules. 2010;11(5):1273-1280.
19. Luo L, Tam J, Maysinger D, Eisenberg A. Cellular internalization of poly(ethylene oxide)-b-poly(epsilon-caprolactone) diblock copolymer micelles. Bioconjug Chem. 2002;13(6):1259-1265.
20. Xiao L, Xiong X, Sun X, et al. Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles. Biomaterials. 2011;32(22):5148-5157.
21. Kim SC, Kim DW, Shim YH, et al. In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy. J Control Release. 2001;72(1-3):191-202.
22. Kim DW, Kim SY, Kim HK, et al. Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer. Ann Oncol. 2007;18(12):2009-2014.
23. Lee KS, Chung HC, Im SA, et al. Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer. Breast Cancer Res Treat. 2008;108(2):241-250.
24. Yuan F, Dellian M, Fukumura D, et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 1995;55(17):3752-3756.
25. Mobed M, Chang TM. Comparison of polymerically stabilized PEG-grafted liposomes and physically adsorbed carboxymethylchitin and carboxymethyl/glycolchitin liposomes for biological applications. Biomaterials. 1998;19(13):1167-1177.
26. Molino NM, Bilotkach K, Fraser DA, Ren D, Wang SW. Complement activation and cell uptake responses toward polymer-functionalized protein nanocapsules. Biomacromolecules. 2012;13(4):974-981.
27. Zhao J, Feng SS. Effects of PEG tethering chain length of vitamin E TPGS with a Herceptin-functionalized nanoparticle formulation for targeted delivery of anticancer drugs. Biomaterials. 2014;35(10):3340-3347.
28. Pozzi D, Colapicchioni V, Caracciolo G, et al. Effect of polyethyleneglycol (PEG) chain length on the bio-nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells. Nanoscale. 2014;6(5):2782-2792.
29. Cao J, Xiu KM, Zhu K, et al. Copolymer Nanoparticles Composed of Sulfobetaine and Poly(ε-caprolactone) as Novel Anticancer Drug Carriers. J Biomed Mater Res: Part A, 2012;(8):2079-2087.
30. Cao J, Chen YW, Chen NC, et al. The preparation of phosphorylcholine-containing poly(L-lactide) nanoparticles with solvent evaporation method. e-Polymers, 2010:074.
31. Kabanov AV, et al. Micelle formation and solubilization of fluorescent probes in poly(oxyethylene-b-oxypropylene-b-oxyethylene) solutions. Macromolecules. 1995;28:2303-2314.
32. Jongpa L, Zhou ZH, Wang YZ. Self-association and micelle formation of biodegradable poly(ethylene glycol)-poly(L-lactic acid) amphiphilic di-block co-polymers. J Biomat Sci: Polym Ed. 2006;17:747-763.
33. Mo R, Sun Q, Li N, Zhang C. Intracellular delivery and antitumor effects of pH-sensitive liposomes based on zwitterionic oligopeptide lipids. Biomaterials. 2013;34(11):2773-2786.
34. Huth US, Schubert R, Peschka-Süss R. Investigating the uptake and intracellular fate of pH-sensitive liposomes by flow cytometry and spectral bio-imaging. J Control Release. 2006;110(3):490-504.
35. Pollock S, Antrobus R, Newton L, et al. Uptake and trafficking of liposomes to the endoplasmic reticulum. FASEB J. 2010;24(6):1866-1878.
36. Tai W, Mo R, Lu Y, Jiang T, Gu Z. Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs. Biomaterials. 2014;35(25):7194-7203.